Supplementation of milk with iron bound to lactoferrin using weanling mice: L. Effects on hematology and tissue iron.

Abstract:

:Lactoferrin is an iron-binding protein present in high concentrations in human milk. The efficacy of supplementing iron bound to lactoferrin to iron-deficient and iron-sufficient young mice was evaluated in comparison with supplementation of iron as iron chloride. Mice fed a nonsupplemented milk diet (approximately 1 mg Fe/L) for 4 weeks had a microcytic, hypochromic anemia and low tissue iron concentrations. Iron supplementation of the diet with lactoferrin-iron, or iron chloride at a level of 5 mg Fe/L prevented the anemia and resulted in tissue iron levels similar to levels found for mice fed a stock commercial diet. There was no significant difference in any of the parameters analyzed between the groups of mice receiving the two iron supplements following a diet deficient in iron. Apolactoferrin when supplemented to the diet had no negative effect on the iron status of the mice. These results show that lactoferrin may be a useful vehicle for supplementation of iron.

authors

Fransson GB,Keen CL,Lönnerdal B

doi

10.1097/00005176-198311000-00021

subject

Has Abstract

pub_date

1983-11-01 00:00:00

pages

693-700

issue

4

eissn

0277-2116

issn

1536-4801

journal_volume

2

pub_type

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