Autologous intestinal reconstructive surgery to reduce bowel dilatation improves intestinal adaptation in children with short bowel syndrome.

Abstract:

OBJECTIVES:Intestinal failure (IF) is a common consequence of neonatal small bowel pathology. In our experience, bowel dilatation is often responsible for the IF state in patients who fail to adapt despite adequate residual bowel length. The aim of the present study was to investigate the role of surgery to reduce bowel dilatation, and thus favour PN independence, for these children. METHODS:Data were collected prospectively for all of the patients referred to our unit for a 7-year period (2004-2011). Eight patients (2 congenital atresia, 2 gastroschisis with atresia, 1 simple gastroschisis, 3 necrotising enterocolitis) with gut dilatation who failed adaptation despite a bowel length >40 cm were identified. Preoperatively, all patients were totally dependent on parenteral nutrition (PN). Patients were managed by longitudinal intestinal lengthening and tailoring (n = 3), serial transverse enteroplasty (n = 2), or tapering enteroplasty (n = 3). RESULTS:Median age at time of surgery was 273 days (103-1059). Mean gut length increased from 51 (35-75) to 73 cm (45-120) following surgery (P = 0.02). Incidence of sepsis (P = 0.01) and peak serum bilirubin levels (P = 0.005) were reduced postoperatively. PN was discontinued after a median of 110 days (35-537) for 7 patients; 1 patient remains on PN 497 days after surgery. CONCLUSIONS:These data indicate that reconstructive surgery to reduce bowel diameter may be an effective technique for treating IF in patients with short bowel syndrome, without sacrificing intestinal length. We suggest that this technique may reduce the need for bowel transplantation in this group of patients.

authors

Almond SL,Haveliwala Z,Khalil B,Morabito A

doi

10.1097/MPG.0b013e318287de8d

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

631-4

issue

6

eissn

0277-2116

issn

1536-4801

journal_volume

56

pub_type

杂志文章
  • Remodeling of the rat small intestinal mucosa during the suckling period.

    abstract::The development of the suckling rat small intestine has been reexamined to investigate changes to cell kinetics and morphology more fully. In this period of rapid growth and reorganization, villi and crypts steadily increase in size in proximal regions; however, in distal regions a dramatic shortening of villi occurs ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,评审

    doi:10.1097/00005176-198908000-00017

    authors: Trahair JF

    更新日期:1989-08-01 00:00:00

  • Reduced bile output with chronic enteral and parenteral infusion of amino acids, glucose, and fat emulsion in rabbits.

    abstract::To assess the effect of chronic administration of amino acids, glucose, and fat on hepatic excretory function, bile flow and bile salt secretion were directly measured in adult rabbits alimented either intravenously or intragastrically. Five groups of animals were studied after 9-11 days on different nutritional regim...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198510000-00023

    authors: Zahavi I,Shaffer EA,Kelly J,Gall DG

    更新日期:1985-10-01 00:00:00

  • Ranitidine treatment in newborn infants: effects on gastric acidity and serum prolactin levels.

    abstract::Data about the use of ranitidine in the early postnatal period are lacking. In this study, 30 term newborn infants < 2 days old with bleeding erosions in their upper gastrointestinal tracts were treated with ranitidine by continuous i.v. infusion (0.2 mg/kg/h) for 48 h and thereafter by mouth (5 mg/kg b.i.d.) for 1 mo...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 临床试验,杂志文章

    doi:

    authors: Fontana M,Tornaghi R,Petrillo M,Lora E,Bianchi Porro G,Principi N

    更新日期:1993-05-01 00:00:00

  • Portopulmonary Hypertension in Liver Disease Presenting in Childhood.

    abstract:OBJECTIVE:Portopulmonary hypertension (POPH) is a known complication of cirrhosis in adults, but there is little information on its incidence and outcome in children with liver disease. We report 14 patients with POPH and present a synthesis of the medical literature. METHODS:Diagnosis of POPH in the 14 patients was b...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000000821

    authors: Ecochard-Dugelay E,Lambert V,Schleich JM,Duché M,Jacquemin E,Bernard O

    更新日期:2015-09-01 00:00:00

  • One-week treatment with omeprazole, clarithromycin, and metronidazole in children with Helicobacter pylori infection.

    abstract:BACKGROUND:The efficacy of a 1-week "triple therapy" in children with Helicobacter pylori gastritis and recurrent abdominal pain was studied. The effect of treatment was also studied in correlation to recurrent abdominal pain. METHODS:Thirty-two children with recurrent abdominal pain were investigated with H. pylori s...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199810000-00010

    authors: Casswall TH,Alfvén G,Drapinski M,Bergström M,Dahlström KA

    更新日期:1998-10-01 00:00:00

  • Donor Human Milk and Fortifier Use in United States Level 2, 3, and 4 Neonatal Care Hospitals.

    abstract:OBJECTIVE:In 2011, the United States Surgeon General issued a call to action to "identify and address obstacles to greater availability of safe banked donor milk for fragile infants." The purpose of the present study is to analyze patterns in donor human milk (DHM) and fortifier use in level 2, 3, and 4 neonatal facili...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000001790

    authors: Perrin MT

    更新日期:2018-04-01 00:00:00

  • Serum transaminases in children with Wilson's disease.

    abstract:OBJECTIVES:The response of serum transaminase levels to penicillamine and zinc treatment in Wilson's disease is poorly understood. The aim of this multicenter retrospective study was to evaluate transaminase levels after penicillamine and zinc treatment in children with Wilson's disease. PATIENTS AND METHODS:One hundr...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-200410000-00006

    authors: Iorio R,D'Ambrosi M,Marcellini M,Barbera C,Maggiore G,Zancan L,Giacchino R,Vajro P,Marazzi MG,Francavilla R,Michielutti F,Resti M,Frediani T,Pastore M,Mazzarella G,Fusco G,Cirillo F,Vegnente A,Hepatology Committee of

    更新日期:2004-10-01 00:00:00

  • Diagnostic tests in Hirschsprung disease: a systematic review.

    abstract:OBJECTIVE:We conducted a systematic review to determine and compare the diagnostic accuracy of contrast enema (CE), anorectal manometry (ARM) and rectal suction biopsy (RSB) in infants suspected of Hirschsprung disease. DESIGN:This is a systematic review. DATA SOURCES:Articles were identified through electronic searc...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,评审

    doi:10.1097/01.mpg.0000214164.90939.92

    authors: de Lorijn F,Kremer LC,Reitsma JB,Benninga MA

    更新日期:2006-05-01 00:00:00

  • Dietary regulation of intestinal lactase and sucrase in adult rats: quantitative comparison of effect of lactose and sucrose.

    abstract::To characterize the mechanisms leading to dietary evoked increases of lactase and sucrase activities by carbohydrates, we performed a quantitative comparison of the effects of lactose and sucrose on the corresponding disaccharidases in the jejunum of 2-month-old rats. For 7-10 days the rats were fed a low-starch (5 ca...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198512000-00024

    authors: Goda T,Bustamante S,Koldovský

    更新日期:1985-12-01 00:00:00

  • Defecation disorders in children after surgery for Hirschsprung disease.

    abstract:BACKGROUND AND OBJECTIVE:The majority of children with Hirschsprung disease (HD) after corrective surgery (CS) develop protracted defecation disorders (DDs) such as constipation, fecal incontinence, and/or enterocolitis. The aim of this investigation was to determine the diagnoses, therapies, and long-term clinical out...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e318212eb53

    authors: Chumpitazi BP,Nurko S

    更新日期:2011-07-01 00:00:00

  • Hypereosinophilic syndrome in childhood appearing as inflammatory bowel disease.

    abstract::A 7-year-old girl with hypereosinophilic syndrome is described, the first such patient to present with inflammatory bowel disease. Hepatosplenomegaly, anaemia, and hypergammaglobulinaemia were also prominent features. Colonoscopy revealed a frank colitis of nonspecific histologic appearance. An elemental diet was unhe...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199102000-00023

    authors: Falade AG,Darbyshire PJ,Raafat F,Booth IW

    更新日期:1991-02-01 00:00:00

  • Crohn disease and mycobacterial infection in children: an intriguing relationship.

    abstract::The relation between Crohn disease (CD) and mycobacterial infection is complex and intriguing. The 2 conditions share common immunopathogenic features, and the hypothesis that Mycobacterium avium subspecies paratuberculosis may cause CD is still under debate. Moreover, differential diagnosis between CD and intestinal ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,评审

    doi:10.1097/MPG.0b013e3181b0f908

    authors: Chiappini E,de Martino M,Mangiantini F,Lionetti P

    更新日期:2009-11-01 00:00:00

  • Healing of erosive esophagitis and improvement of symptoms of gastroesophageal reflux disease after esomeprazole treatment in children 12 to 36 months old.

    abstract:OBJECTIVES:The aim of the study was to evaluate erosive esophagitis healing and symptom improvement with once-daily esomeprazole in children ages 12 to 36 months with endoscopically or histologically proven gastroesophageal reflux disease (GERD). PATIENTS AND METHODS:Data from children ages 12 to 36 months were includ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/MPG.0b013e3181ddcf11

    authors: Tolia V,Gilger MA,Barker PN,Illueca M

    更新日期:2010-11-01 00:00:00

  • Acute phase proteins in chronic inflammatory bowel disease in childhood.

    abstract::The serum levels of five acute phase proteins (APP) were measured in 18 children with Crohn's Disease (CD) or ulcerative colitis (UC) and in two control groups. The levels of C-reactive protein, alpha 1-acid glycoprotein, alpha 1-antitrypsin, C9, and Factor B were significantly raised in patients with CD and UC with g...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198201020-00007

    authors: Campbell CA,Walker-Smith JA,Hindocha P,Adinolfi M

    更新日期:1982-01-01 00:00:00

  • Changing patterns of free fatty acids in breast milk during storage.

    abstract::Milk was collected from eight mothers. Total lipid and free fatty acids were determined on collection. The samples were divided into aliquots and stored at 25, 4, or -11 degrees C for 6, 12, 24, or 48 h. Additional samples were stored at -11 or -70 degrees C for 1, 2, 4, 6, or 8 weeks. The effect of temperature, lengt...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198709000-00019

    authors: Lavine M,Clark RM

    更新日期:1987-09-01 00:00:00

  • Alkaline phosphatase activity in fresh intestinal mucosa and cultured mucosal explants.

    abstract::Alkaline phosphatase (AP) activity is an accepted marker of epithelial cell differentiation and integrity in intestinal mucosal explant systems. In experiments involving AP it is usually expressed as activity per unit protein in tissue culture. It has been previously demonstrated that during organ culture a considerab...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198403000-00007

    authors: Ashkenazi A,Idar D,Maimon M,Hegesh E,Frank E,Hahn T,Wolman Y,Levin S

    更新日期:1984-03-01 00:00:00

  • Supplementation of milk with iron bound to lactoferrin using weanling mice: L. Effects on hematology and tissue iron.

    abstract::Lactoferrin is an iron-binding protein present in high concentrations in human milk. The efficacy of supplementing iron bound to lactoferrin to iron-deficient and iron-sufficient young mice was evaluated in comparison with supplementation of iron as iron chloride. Mice fed a nonsupplemented milk diet (approximately 1 ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198311000-00021

    authors: Fransson GB,Keen CL,Lönnerdal B

    更新日期:1983-11-01 00:00:00

  • Role of Vitamin D in Hospitalized Children With Lower Tract Acute Respiratory Infections.

    abstract:BACKGROUND:Vitamin D is known to have modulatory actions in the immune system. Its influence on the severity of lower tract acute respiratory infections (LT-ARIs) is unclear. OBJECTIVES:The aim of the present study was to evaluate the role of vitamin D on LT-ARI in paediatric patients. METHODS:Children admitted to ho...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000001003

    authors: Cebey-López M,Pardo-Seco J,Gómez-Carballa A,Martinón-Torres N,Rivero-Calle I,Justicia A,Redondo L,Martinón-Sánchez JM,Martínez-Padilla Mdel C,Giménez-Sánchez F,Salas A,Martinón-Torres F,GENDRES Network.

    更新日期:2016-03-01 00:00:00

  • Correction of Iron Deficiency Anemia With Intravenous Iron Sucrose in Children With Inflammatory Bowel Disease.

    abstract:OBJECTIVES:Iron deficiency anemia (IDA) is common in children with inflammatory bowel disease (IBD) affecting their cognitive development and school performance. Oral iron supplementation has serious limitations including poor adherence and iron malabsorption related to chronic inflammation. Our objective was to evalua...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000001383

    authors: Danko I,Weidkamp M

    更新日期:2016-11-01 00:00:00

  • Prevalence of celiac disease in Brazilian children and adolescents with type 1 diabetes mellitus.

    abstract:OBJECTIVE:A previously unrecognized high prevalence of celiac disease (CD) has been found by screening among European and North American patients with type 1 diabetes mellitus (DM 1). The prevalence of CD among Brazilian children with DM1 is not known. This study was conducted to determine the prevalence of CD in Brazi...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/01.mpg.0000181400.57884.c3

    authors: Baptista ML,Koda YK,Mitsunori R,Nisihara,Ioshii SO

    更新日期:2005-11-01 00:00:00

  • Neonatal enteropathies: defining the causes of protracted diarrhea of infancy.

    abstract::The underlying causes of chronic diarrhea beginning early in life are increasingly well defined. Infectious and post-infectious enteropathies and food sensitive/allergic enteropathy account for the majority of cases. Recent attention has focused on characterizing defined entities, which cause protracted diarrhea in in...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,评审

    doi:10.1097/00005176-200401000-00007

    authors: Sherman PM,Mitchell DJ,Cutz E

    更新日期:2004-01-01 00:00:00

  • Reporting outcome measures in trials of infant colic.

    abstract:OBJECTIVES:Infant colic (IC), with an estimated prevalence of 5% to 25%, has a high impact on health care costs. Furthermore, reported negative sequelae are disturbed parent-infant interaction, increased susceptibility to abdominal pain, and even child abuse. Its etiology remains unknown, leading to a wide variety in i...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,评审

    doi:10.1097/MPG.0000000000000412

    authors: Steutel NF,Benninga MA,Langendam MW,de Kruijff I,Tabbers MM

    更新日期:2014-09-01 00:00:00

  • Oral insulin enhances cell proliferation and decreases enterocyte apoptosis during methotrexate-induced mucositis in the rat.

    abstract:OBJECTIVE:Oral insulin (INS) has been shown to protect intestinal epithelial cells from injury caused by ischemia-reperfusion and endotoxemia. In the present study, we tested whether oral insulin can protect gut epithelial cells from methotrexate (MTX)-induced intestinal damage. MATERIALS AND METHODS:Adult male Spragu...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e31806008f1

    authors: Sukhotnik I,Shehadeh N,Coran AG,Mogilner JG,Karry R,Shamian B,Ure BM,Shamir R

    更新日期:2008-08-01 00:00:00

  • Intestinal mucin inhibits adhesion of human enteropathogenic Escherichia coli to HEp-2 cells.

    abstract::Mucins are complex glycoproteins that cover the intestinal mucosal surface and are thought to provide protection against enteropathogenic infections by preventing bacterial adherence and subsequent colonization, invasion and toxin delivery. The aims of this study was to evaluate the capacity of intestinal mucin to inh...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199510000-00004

    authors: Smith CJ,Kaper JB,Mack DR

    更新日期:1995-10-01 00:00:00

  • The Role of Distress and Pain Catastrophizing on the Health-related Quality of Life of Children With Inflammatory Bowel Disease.

    abstract:OBJECTIVES:Inflammatory bowel disease (IBD) can be particularly challenging during the pediatric age with a relevant impact on patient's health-related quality of life (HRQoL). Disease activity accounts for only a small part of the variability in HRQoL, and psychological factors can play a significant role. We aimed to...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MPG.0000000000002447

    authors: De Carlo C,Bramuzzo M,Canaletti C,Udina C,Cozzi G,Pavanello PM,Rampado S,Martelossi S,Giudici F,Di Leo G,Barbi E

    更新日期:2019-10-01 00:00:00

  • Effects of cerulein and epidermal growth factor on pancreatic growth in the reserpinized rat model.

    abstract::This study was undertaken to determine the effect of reserpine on rat pancreatic growth, to evaluate if reserpine-caused alterations can be prevented by epidermal growth factor (EGF) and/or cerulein treatment, to evaluate the time course of rat pancreas recovery after reserpine, and to determine if EGF and/or cerulein...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199307000-00006

    authors: Bérubé FL,Benrezzak O,Vanier M,Morisset J

    更新日期:1993-07-01 00:00:00

  • Clinical Experience With Performing Esophageal Function Testing in Children.

    abstract:OBJECTIVES:Pediatric high-resolution manometry (HRM) and 24-hour pH-impedance with/without ambulatory manometry (pH-MII+/-mano) tests are generally performed using adult-derived protocols. We aimed to assess the feasibility of these protocols in children, the occurrence of patient-related imperfections and their influe...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000003000

    authors: van Lennep M,Leijdekkers ML,Oors JM,Benninga MA,van Wijk MP,Singendonk MMJ

    更新日期:2021-02-01 00:00:00

  • Isolation, identification, and characterization of small bioactive peptides from Lactobacillus GG conditional media that exert both anti-Gram-negative and Gram-positive bactericidal activity.

    abstract:OBJECTIVES:Diarrheal diseases remain a major human plague that still claim millions of lives every year. Probiotics, including Lactobacillus GG (LGG), are known to have a beneficial effect on diarrheal diseases, but their mechanism of action has not yet been completely established. Therefore, the main objective of this...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e3181924d1e

    authors: Lu R,Fasano S,Madayiputhiya N,Morin NP,Nataro J,Fasano A

    更新日期:2009-07-01 00:00:00

  • Bacterial [correction of baterial] translocation in humans.

    abstract::Bacterial translocation is a phenomenon in which live bacteria cross the intestinal barrier. The definition may be broadened to include transmural passage of bacterial cell wall components such as lipopolysaccharide and peptidoglycan polysaccharide. After translocation, bacteria or their products reach the mesenteric ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,评审

    doi:10.1097/00005176-200107000-00001

    authors: Lichtman SM

    更新日期:2001-07-01 00:00:00

  • Failure to label baboon milk intrinsically with iron.

    abstract::The widely held belief that 50% of the iron in human milk is absorbed is based on studies that have used an extrinsic radioactive iron tag. To determine the validity of an extrinsic tag, it is necessary to label the milk intrinsically with one isotope and to compare absorption of this isotope with absorption of anothe...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198911000-00022

    authors: Figueroa-Colón R,Elwell JH,Jackson E,Osborne JW,Fomon SJ

    更新日期:1989-11-01 00:00:00