Laxative treatment with polyethylene glycol does not affect lipid absorption in rats.

Abstract:

OBJECTIVES:Polyethylene glycol (PEG) is a frequently used laxative agent. It is unknown, however, whether PEG affects the absorptive capacity of the intestine. Reduced lipid (dietary fat and cholesterol) absorption induced by long-term PEG treatment could negatively affect growth in children. We tested whether PEG accelerates gastrointestinal transit and alters lipid absorption and plasma lipid levels. METHODS:Wistar rats were administered drinking water with or without PEG (7%) for 2 weeks. We studied whole gut transit time by recording the first appearance of red feces after intragastric carmine red administration. We measured plasma concentrations of cholesterol and triglycerides, dietary fat absorption by 48-hour fat balance and by plasma appearance of intragastrically administered stable-isotope labeled fats, and cholesterol absorption with a dual stable isotope technique. RESULTS:PEG decreased whole gut transit time by 20% (P=0.028) without causing diarrhea. PEG treatment did neither affects overall dietary fat balance nor fat uptake kinetics, cholesterol absorption, or plasma lipid concentrations. CONCLUSIONS:PEG does not affect lipid absorption nor steady-state plasma lipid levels in rats, although it accelerates the gastrointestinal transit.

authors

van der Wulp MY,Cuperus FJ,Stellaard F,van Dijk TH,Dekker J,Rings EH,Groen AK,Verkade HJ

doi

10.1097/MPG.0b013e3182555ba9

subject

Has Abstract

pub_date

2012-10-01 00:00:00

pages

457-62

issue

4

eissn

0277-2116

issn

1536-4801

pii

00005176-201210000-00022

journal_volume

55

pub_type

杂志文章
  • Endoscopic Incision for the Treatment of Refractory Esophageal Anastomotic Strictures in Children.

    abstract:OBJECTIVES:The aim of the present study was to assess the safety and efficacy of endoscopic incision (EI) for the treatment of refractory anastomotic esophageal strictures in pediatric patients. METHODS:We retrospectively reviewed the medical records of pediatric patients with refractory anastomotic strictures after s...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000000801

    authors: Tan Y,Zhang J,Zhou J,Duan T,Liu D

    更新日期:2015-09-01 00:00:00

  • Serum transaminases in children with Wilson's disease.

    abstract:OBJECTIVES:The response of serum transaminase levels to penicillamine and zinc treatment in Wilson's disease is poorly understood. The aim of this multicenter retrospective study was to evaluate transaminase levels after penicillamine and zinc treatment in children with Wilson's disease. PATIENTS AND METHODS:One hundr...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-200410000-00006

    authors: Iorio R,D'Ambrosi M,Marcellini M,Barbera C,Maggiore G,Zancan L,Giacchino R,Vajro P,Marazzi MG,Francavilla R,Michielutti F,Resti M,Frediani T,Pastore M,Mazzarella G,Fusco G,Cirillo F,Vegnente A,Hepatology Committee of

    更新日期:2004-10-01 00:00:00

  • NASPGHAN practice guidelines: Diagnosis and management of hepatitis C infection in infants, children, and adolescents.

    abstract::Hepatitis C virus (HCV) is an RNA virus that affects >180 million individuals worldwide with a high propensity for chronic infection. Children with HCV infection differ from adults in several ways including some modes of transmission, rates of clearance, progression of fibrosis, and the duration of potential chronic i...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,实务指引

    doi:10.1097/MPG.0b013e318258328d

    authors: Mack CL,Gonzalez-Peralta RP,Gupta N,Leung D,Narkewicz MR,Roberts EA,Rosenthal P,Schwarz KB,North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.

    更新日期:2012-06-01 00:00:00

  • Rotavirus A Infections in Community Childhood Diarrhea in the Brazilian Semiarid Region During Postvaccination Era.

    abstract:BACKGROUND:Rotavirus A (RVA) is one of the leading causes of acute gastroenteritis worldwide; however, few studies assessed RVA genetics with community surveillance. OBJECTIVES:This study aimed to investigate clinical data, genetic diversity, and coinfection patterns of RVA infections in children from 2 to 36 months o...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000002416

    authors: Pankov RC,Gondim RNDG,Prata MMG,Medeiros PHQS,Veras HN,Santos AKS,Havt A,da Silva MFM,Fumian TM,Miagostovich MP,Leite JPG,Lima AAM

    更新日期:2019-10-01 00:00:00

  • Eicosanoids in hypoxic insult to neonatal rabbit bowel.

    abstract::Eicosanoids, derivatives of arachidonic acid, play a role in several inflammatory diseases of the bowel. To determine whether prostaglandin E2 (PGE2), leukotriene B4 (LTB4), and leukotriene C4D4E4 (LTC4D4E4), have a role in hypoxic insult to the intestine, we examined the levels of these mediators in a hypoxic neonata...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199208000-00005

    authors: Dollberg S,Udassin R,Ginat-Israeli T,Weidenfeld J,Branski D

    更新日期:1992-08-01 00:00:00

  • Clinical features of interleukin 10 receptor gene mutations in children with very early-onset inflammatory bowel disease.

    abstract:OBJECTIVES:In the present study, we studied a cohort of patients with very early onset inflammatory bowel disease (IBD) to determine the frequency of mutations in the interleukin 10 (IL10) receptor genes as a cause of early-onset IBD. METHODS:Sanger sequencing was performed to determine the presence of IL10 and/or IL1...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000000621

    authors: Beser OF,Conde CD,Serwas NK,Cokugras FC,Kutlu T,Boztug K,Erkan T

    更新日期:2015-03-01 00:00:00

  • Diagnosis of Helicobacter pylori infection by means of reduced-dose ¹³C-urea breath test and early sampling of exhaled breath.

    abstract:OBJECTIVE:The aim of this study was to evaluate the accuracy of reduced-dose ¹³C-urea breath test (¹³C-UBT) and early sampling of exhaled breath for the detection of Helicobacter pylori infection in children and adolescents. METHODS:Patients up to 20 years old that underwent upper gastrointestinal endoscopy with gastr...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MPG.0b013e3182a02608

    authors: Pacheco SL,Ogata SK,Machado RS,Patrício FR,Pardo ML,Kawakami E

    更新日期:2013-11-01 00:00:00

  • Dumping in infancy diagnosed by radionuclide gastric emptying technique.

    abstract::Two infants were diagnosed with dumping syndrome by a radionuclide gastric emptying method. Both patients presented with anorexia, weight loss, agitation and diaphoresis following bolus feeding by gastrostomy tube. One had documented hyperglycemia and glycosuria. Symptoms and signs of dumping in one patient were due t...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:

    authors: Lavine JE,Hattner RS,Heyman MB

    更新日期:1988-07-01 00:00:00

  • Infliximab in pediatric ulcerative colitis: two-year follow-up.

    abstract:OBJECTIVES:The role of infliximab in treating pediatric ulcerative colitis (UC) is not defined. The authors previously have described their experience with the open label use of infliximab in nine children with moderate to severe UC. The aim of this study was to describe the outcome of these patients after a minimum 2-...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-200403000-00013

    authors: Mamula P,Markowitz JE,Cohen LJ,von Allmen D,Baldassano RN

    更新日期:2004-03-01 00:00:00

  • Enteral glutamine and/or arginine supplementation have favorable effects on oxidative stress parameters in neonatal rat intestine.

    abstract:OBJECTIVE:To investigate and compare the effects of enteral glutamine and arginine supply on lipid peroxidation and antioxidant enzyme levels in the small intestine of healthy breast-fed rats. MATERIALS AND METHODS:The study comprised 40 newborn Sprague-Dawley rats born to 5 mother rats. Newborn rats were randomly div...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e318198cd36

    authors: Kul M,Vurucu S,Demirkaya E,Tunc T,Aydinoz S,Meral C,Kesik V,Alpay F

    更新日期:2009-07-01 00:00:00

  • Gallbladder Ejection Fraction Is Unrelated to Gallbladder Pathology in Children and Adolescents.

    abstract:OBJECTIVES:Biliary dyskinesia is a common diagnosis that frequently results in cholecystectomy. In adults, most clinicians use a cut off value for the gallbladder ejection fraction (GBEF) of <35% to define the disease. This disorder is not well characterized in children. Our aim was to determine the relation between GB...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000001065

    authors: Jones PM,Rosenman MB,Pfefferkorn MD,Rescorla FJ,Bennett WE Jr

    更新日期:2016-07-01 00:00:00

  • Appropriateness of emergency department use in pediatric inflammatory bowel disease: a quality improvement opportunity.

    abstract:OBJECTIVES:We sought to characterize emergency department (ED) encounters for pediatric inflammatory bowel disease (IBD) to identify areas for prevention. METHODS:Retrospective chart review of 5 consecutive ED encounters at 7 centers was performed. RESULTS:Of 35 unique encounters by 32 patients, 3 main factors contri...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000000457

    authors: Hoffenberg EJ,Park KT,Dykes DM,Fridge J,Kappelman MD,Leibowitz IH,Tsou VM,Colletti RB

    更新日期:2014-09-01 00:00:00

  • Posttransplantation lymphoproliferative disorder: endoscopic findings.

    abstract:BACKGROUND:Posttransplantation lymphoproliferative disorder (PTLD) may manifest a variety of nonspecific symptoms and must be suspected in the patient who undergoes solid organ transplantation. Common sites of occurrence include the gastrointestinal tract, the central nervous system, and lymphoid tissue of the oral pha...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-200010000-00026

    authors: O'Connor JA,Cogley C,Burton M,Lancaster-Weiss K,Cordle RA

    更新日期:2000-10-01 00:00:00

  • Evaluation of a daily dose of 25 micrograms vitamin K1 to prevent vitamin K deficiency in breast-fed infants.

    abstract::Vitamin K prophylaxis is recommended to prevent the hazard of hemorrhage caused by vitamin K deficiency in young infants. A single administration after birth seems inadequate to completely prevent late haemorrhagic disease in breast-fed infants. The preventive effect of a daily oral dose of 25 micrograms vitamin K1, w...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199304000-00014

    authors: Cornelissen EA,Kollée LA,van Lith TG,Motohara K,Monnens LA

    更新日期:1993-04-01 00:00:00

  • Avoiding Small Intestinal Biopsies for Diagnosis of Celiac Disease in Children: A Reliable Strategy for All Patients?

    abstract:BACKGROUND:Current reports applying ESPGHAN exception criteria (EEC) to diagnose celiac disease (CD) without duodenal biopsies indicate that a high percentage of patients with CD may be identified when applied correctly in specialized settings. Application of the EEC, however, in "daily life conditions" at the differen...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000001834

    authors: Araya M,Díaz J,Oyarzun A,Lucero Y,Alarcon T,González M,Canales P,Fierro L,Pérez-Bravo F

    更新日期:2018-05-01 00:00:00

  • Severity of Villous Atrophy at Diagnosis in Childhood Does Not Predict Long-term Outcomes in Celiac Disease.

    abstract:OBJECTIVES:Current pediatric guidelines allow noninvasive diagnosis of celiac disease in selected children. We investigated in a large cohort study whether the severity of villous atrophy at diagnosis is associated with clinical characteristics or long-term health outcomes, thus having a prognostic significance. METHO...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000002675

    authors: Kröger S,Kurppa K,Repo M,Huhtala H,Kaukinen K,Lindfors K,Arvola T,Kivelä L

    更新日期:2020-07-01 00:00:00

  • Effects of oral administration of bifidobacterium breve on fecal lactic acid and short-chain fatty acids in low birth weight infants.

    abstract:OBJECTIVES:Short-chain fatty acids (SCFAs) are known to provide energy to colonocytes, whereas overproduction of SCFAs can cause mucosal injury in premature infants. Our objective was to investigate the effects of the oral administration of Bifidobacterium breve M-16V (B breve) on fecal lactic acid and SCFAs in low bir...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/01.mpg.0000252184.89922.5f

    authors: Wang C,Shoji H,Sato H,Nagata S,Ohtsuka Y,Shimizu T,Yamashiro Y

    更新日期:2007-02-01 00:00:00

  • Economic Impact and Prognostic Factors of Functional Dyspepsia in Children.

    abstract:OBJECTIVES:Functional dyspepsia (FD) is a functional abdominal pain disorder. There is paucity of data on the economic impact of FD in children. Primary aim of our study was to estimate annual evaluation cost ("diagnosis and visit" cost) and secondary aim was to identify potential prognostic factors of FD in children. ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000002599

    authors: Mani J,Madani S,Thomas R

    更新日期:2020-04-01 00:00:00

  • Quantitative Analysis of Apparent Diffusion Coefficient for Disease Assessment in Paediatric Inflammatory Bowel Disease.

    abstract:OBJECTIVE:The aim of the study was to establish an apparent diffusion coefficient (ADC) cut-off value to classify active and non-active lesions in inflammatory bowel disease. METHODS:We reviewed 167 paediatric magnetic resonance enterographies executed for suspected inflammatory bowel disease by using a 1.5- and 3-T s...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000002178

    authors: Scionti A,Di Maurizio M,Basile M,Bernardini A,Miccoli M,Lionetti P,Defilippi C,Caramella D

    更新日期:2019-03-01 00:00:00

  • World Health Organization 2006 child growth standards and 2007 growth reference charts: A discussion paper by the committee on Nutrition of the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition.

    abstract::Growth charts are essential for evaluating children's health including their nutrition; however, the evaluation of child growth trajectories and consequently the decision to intervene are highly dependent on the growth charts used. The aim of this discussion paper of the European Society for Paediatric Gastroenterolog...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e318298003f

    authors: Turck D,Michaelsen KF,Shamir R,Braegger C,Campoy C,Colomb V,Decsi T,Domellöf M,Fewtrell M,Kolacek S,Mihatsch W,Moreno LA,van Goudoever J

    更新日期:2013-08-01 00:00:00

  • Changes in Proteases, Antiproteases, and Bioactive Proteins From Mother's Breast Milk to the Premature Infant Stomach.

    abstract:OBJECTIVE:Our previous studies suggested that human milk proteases begin to hydrolyze proteins in the mammary gland and continue within the term infant' stomach. No research has measured milk protease and pepsin activity in the gastric aspirates of preterm infants after human milk feeding. This study investigated how t...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000001719

    authors: Demers-Mathieu V,Nielsen SD,Underwood MA,Borghese R,Dallas DC

    更新日期:2018-02-01 00:00:00

  • Adequacy of Infant Formula With Protein Content of 1.6 g/100 kcal for Infants Between 3 and 12 Months.

    abstract:OBJECTIVES:Infant formulas provide more protein than breast milk. High protein intakes may place infants at risk of later obesity. The present study tested whether a formula with protein content below the regulatory level supports normal growth from age 3 months. METHODS:Randomized double-blind trial enrolled healthy ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MPG.0000000000000881

    authors: Ziegler EE,Fields DA,Chernausek SD,Steenhout P,Grathwohl D,Jeter JM,Nelson SE,Haschke F

    更新日期:2015-11-01 00:00:00

  • Diet and Exercise in Pediatric Liver Transplant Recipients: Behaviors and Association With Metabolic Syndrome.

    abstract:OBJECTIVE:The aim of the study is to analyze the impact of physical activity and eating behaviors on precursors of cardiovascular disease-including overweight/obesity, hypertension, low high-density lipoprotein, and impaired glucose tolerance-in pediatric liver transplant (LT) recipients and matched controls. METHOD:C...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000002150

    authors: Chambers JH,Zerofsky M,Lustig RH,Rosenthal P,Perito ER

    更新日期:2019-01-01 00:00:00

  • Erythromycin fails to improve feeding outcome in feeding-intolerant preterm infants.

    abstract:OBJECTIVE:Approximately half of extremely low birth weight infants have feeding intolerance, which delays their achievement of full enteral feedings. Erythromycin, a motilin receptor agonist, triggers migrating motor complexes and accelerates gastric emptying in adults with feeding intolerance. Few studies have assesse...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00005176-200309000-00015

    authors: ElHennawy AA,Sparks JW,Armentrout D,Huseby V,Berseth CL

    更新日期:2003-09-01 00:00:00

  • Acarboxy prothrombin in cord plasma from normal neonates.

    abstract::Acarboxy prothrombin was detected in the plasma of 48 of 128 umbilical cord plasma samples and in all of 65 patients receiving coumadin. None was found in 20 normal adults. Although the prevalence was the same in blacks, whites, and neonates of mixed origin, levels were significantly higher in blacks. There was a nega...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198406000-00025

    authors: Atkinson PM,Bradlow BA,Moulineaux JD,Walker NP

    更新日期:1984-06-01 00:00:00

  • Taurolidine and catheter-related bloodstream infection: a systematic review of the literature.

    abstract:BACKGROUND:Catheter-related bloodstream infection remains the most common serious complication associated with long-term parenteral nutrition. Taurolock (Bio-Implant HealthCare, Winsen, Germany), which contains taurolidine, is being marketed as a central venous catheter lock solution for decreasing the risk of catheter...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MPG.0b013e318162c428

    authors: Bradshaw JH,Puntis JW

    更新日期:2008-08-01 00:00:00

  • Esophageal motor activity in children with gastro-esophageal reflux disease and esophagitis.

    abstract:OBJECTIVE:To evaluate esophageal body motor contractions occurring during esophageal reflux in pediatric patients with gastro-esophageal reflux disease (GERD). METHODS:Patients referred for the evaluation of GERD who were evaluated with combined 24-hour pH probe and esophageal manometry test (MP24) were included. Pati...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-200501000-00013

    authors: Chitkara DK,Fortunato C,Nurko S

    更新日期:2005-01-01 00:00:00

  • Chapter 9. Words From Partner Societies.

    abstract::On the occasion of the 50th anniversary of the European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN), its close partner associations submitted comments and felicitations which are presented here. These include words from the Latin American (LASPGHAN), North American (NASPGHAN) and Panarab...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 社论,历史文章

    doi:10.1097/MPG.0000000000001920

    authors: Golden B,Stiris T,Panés J,Namazova-Baranova L,Van Gossum A,Boeing H,Bhutta ZA,Madrazo A,Heubi JE,Mouane N,Fockens P,Koletzko B

    更新日期:2018-04-01 00:00:00

  • Monitoring Eosinophilic Esophagitis Disease Activity With Blood Eosinophil Progenitor Levels.

    abstract:OBJECTIVES:A minimally invasive biomarker to monitor disease activity is one of the greatest unmet clinical needs of the pediatric eosinophilic esophagitis (EoE) population. We aimed to determine whether circulating eosinophil progenitors (EoPs) could be used as a biomarker to identify pediatric patients with active Eo...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000002583

    authors: Henderson A,Magier A,Schwartz JT,Martin LJ,Collins MH,Putnam PE,Mukkada VA,Abonia JP,Rothenberg ME,Fulkerson PC

    更新日期:2020-04-01 00:00:00

  • Renin-angiotensin system activation in congenital hepatic fibrosis in the PCK rat model of autosomal recessive polycystic kidney disease.

    abstract:OBJECTIVES:Congenital hepatic fibrosis (CHF) is an important cause of morbidity and mortality in patients with autosomal recessive polycystic kidney disease (ARPKD). The pathogenesis of CHF remains undefined. Several recent studies suggest that the renin-angiotensin system (RAS) is an important mediator of progressive ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e3181cc80e4

    authors: Goto M,Hoxha N,Osman R,Wen J,Wells RG,Dell KM

    更新日期:2010-06-01 00:00:00