Taurolidine and catheter-related bloodstream infection: a systematic review of the literature.

Abstract:

BACKGROUND:Catheter-related bloodstream infection remains the most common serious complication associated with long-term parenteral nutrition. Taurolock (Bio-Implant HealthCare, Winsen, Germany), which contains taurolidine, is being marketed as a central venous catheter lock solution for decreasing the risk of catheter sepsis. AIM:To review available literature and examine the evidence for efficacy of taurolidine in prevention of central venous catheter-related infection. MATERIALS AND METHODS:Search of MEDLINE, Embase, and the Internet for all studies involving use of taurolidine to prevent central venous catheter infection. RESULTS:Six in vitro and 11 in vivo studies were assessed. Although in vivo studies suggest a possible useful role for taurolidine, the evidence base from clinical studies is poor, with much of it observational or of poor methodology. CONCLUSIONS:The evidence is insufficient to warrant routine use of taurolidine. However, results of in vitro studies are encouraging and further adequately powered and well-designed randomized trials are required.

authors

Bradshaw JH,Puntis JW

doi

10.1097/MPG.0b013e318162c428

subject

Has Abstract

pub_date

2008-08-01 00:00:00

pages

179-86

issue

2

eissn

0277-2116

issn

1536-4801

pii

00005176-200808000-00011

journal_volume

47

pub_type

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