Immunogenicity of hepatitis A vaccine in children with celiac disease.

Abstract:

OBJECTIVES:The response to hepatitis A vaccine has not been studied in children with celiac disease (CD). The aim of the present study was to evaluate the immunogenicity of an inactivated hepatitis A virus (HAV) vaccine and the effect of the human leukocyte antigen (HLA) type on immunogenicity in children with CD. PATIENTS AND METHODS:Thirty-three patients with CD and 62 healthy controls were enrolled in the study. Inactivated HAV vaccine (Havrix; GlaxoSmithKline Biologicals, Rixensart, Belgium) containing 720 enzyme-linked immunosorbent assay units of alum-adsorbed hepatitis A antigen was administered intramuscularly in a 2-dose schedule at 0 and 6 months. Seroconversion rates and antibody titers of HAV were measured at 1 and 7 months. RESULTS:At 1 month, seroconversion rates were 78.8% and 77.4% and geometric mean titers were 50.7 and 49.9 mIU/mL in the CD and control groups, respectively (P > 0.05). At 7 months, seroconversion rates were 97% and 98.4% and geometric mean titers were 138.5 and 133 mIU/mL in the CD and control groups, respectively (P > 0.05). The most frequent HLA types were HLA-DQ2, -DR3, and -DR7 alleles in patients with CD and HLA-DQ3, -DQ6, -DR11, and -DR14 in the controls. There was no association between HLA alleles and antibody titers of hepatitis A vaccine. CONCLUSION:Children with CD have a good immune response to hepatitis A vaccine, similar to healthy controls.

authors

Sari S,Dalgic B,Basturk B,Gonen S,Soylemezoglu O

doi

10.1097/MPG.0b013e318223b3ed

subject

Has Abstract

pub_date

2011-11-01 00:00:00

pages

532-5

issue

5

eissn

0277-2116

issn

1536-4801

journal_volume

53

pub_type

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