Tissue transglutaminase antibodies are a useful serological marker for the diagnosis of celiac disease in patients with Down syndrome.

Abstract:

BACKGROUND:Celiac disease (CD) is overrepresented among patients with Down syndrome (DS), who frequently lack any typical symptoms. Therefore, screening for CD is recommended in this high-risk group. The aim of the study was to determine the prevalence of CD in Arab children with DS and evaluate the contribution of immunoglobulin (Ig) A and IgG anti-gliadin antibodies (AGA), IgA and IgG tissue transglutaminase (TTG) antibodies, and IgA anti-endomysial antibodies (EMA) to screen for CD in children with DS. PATIENTS AND METHODS:A total of 52 Arab patients with DS and 52 healthy Arab control subjects were studied for CD using various serological markers. Data on age, sex, weight, height, gastrointestinal symptoms, and endocrine abnormalities were recorded. Human leukocyte antigen (HLA) was studied in patients undergoing small intestinal biopsy. RESULTS:Five patients with DS were IgA TTG-positive and only 1 patient with DS was IgG TTG-positive. EMA was negative in all patients with DS. TTG (IgA and IgG) and EMA were negative in all control children. IgA AGA was positive in 12 patients with DS and 3 control subjects (P = 0.02), whereas IgG AGA was positive in 41 patients with DS and 26 control subjects (P = 0.004). Only children testing positive for TTG underwent upper endoscopy with duodenal biopsy. Two children with DS were diagnosed with CD. Both patients were IgA TTG-positive. One was HLA DQ2-positive and another was negative for HLA DQ2 and DQ8. CONCLUSIONS:CD is prevalent (3.8%) in Arab patients with DS. Based on our cohort, IgA TTG is useful in diagnosing patients with CD and DS.

authors

Shamaly H,Hartman C,Pollack S,Hujerat M,Katz R,Gideoni O,Shamir R

doi

10.1097/MPG.0b013e3180320679

subject

Has Abstract

pub_date

2007-05-01 00:00:00

pages

583-6

issue

5

eissn

0277-2116

issn

1536-4801

pii

00005176-200705000-00008

journal_volume

44

pub_type

杂志文章
  • Zinc supplementation for the treatment of diarrhea in infants in Pakistan, India and Ethiopia.

    abstract:OBJECTIVE:This randomized, placebo controlled trial was designed to assess the safety and efficacy of 10-mg zinc supplementation for the treatment of acute diarrhea in infants. METHODS:A total of 1110 infants aged 28 days to 5 months with acute diarrhea were enrolled and randomized to receive either zinc (n = 554) or ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/01.mpg.0000232018.40907.00

    authors: Fischer Walker CL,Bhutta ZA,Bhandari N,Teka T,Shahid F,Taneja S,Black RE,Zinc Study Group.

    更新日期:2006-09-01 00:00:00

  • Clinical and Genetic Study of Children With Peutz-Jeghers Syndrome Identifies a High Frequency of STK11 De Novo Mutation.

    abstract:OBJECTIVES:The present study aims to identify the genotype-phenotype correlation in children with Peutz-Jeghers Syndrome (PJS) through the analysis of STK11 gene mutations in the context of clinical and pathological characteristics. METHOD:In this observational cohort study, the clinical characteristics of 18 families...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000002166

    authors: Zhao HM,Yang YJ,Duan JQ,Ouyang HJ,Liu L,Yi LC,Xiao ZH,Zheng Y,Peng L,Attard TM,Li DY,You JY

    更新日期:2019-02-01 00:00:00

  • Safety of lansoprazole in the treatment of gastroesophageal reflux disease in children.

    abstract:OBJECTIVES:To evaluate the safety of lansoprazole in children between 1 and 11 years of age. METHODS:In a phase I/II, open-label, multicenter (11 sites) study, children with symptomatic gastroesophageal reflux disease (GERD), erosive esophagitis (> or = grade 2), and/or esophageal pH < 4 for > 4.2% of the 24-hour peri...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1097/00005176-200211004-00002

    authors: Tolia V,Fitzgerald J,Hassall E,Huang B,Pilmer B,Kane R 3rd

    更新日期:2002-01-01 00:00:00

  • Seasonality of birth month of children with celiac disease differs from that in the general population and between sexes and is linked to family history and environmental factors.

    abstract:BACKGROUND:Patients with autoimmune diseases, such as type 1 diabetes mellitus, atopic dermatitis, autoimmune thyroid diseases, and multiple sclerosis have a different seasonality of month of birth (MOB) from the general population. This study was undertaken to determine the seasonality of MOB in children with celiac d...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e3181709530

    authors: Lewy H,Meirson H,Laron Z

    更新日期:2009-02-01 00:00:00

  • World Health Organization 2006 child growth standards and 2007 growth reference charts: A discussion paper by the committee on Nutrition of the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition.

    abstract::Growth charts are essential for evaluating children's health including their nutrition; however, the evaluation of child growth trajectories and consequently the decision to intervene are highly dependent on the growth charts used. The aim of this discussion paper of the European Society for Paediatric Gastroenterolog...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e318298003f

    authors: Turck D,Michaelsen KF,Shamir R,Braegger C,Campoy C,Colomb V,Decsi T,Domellöf M,Fewtrell M,Kolacek S,Mihatsch W,Moreno LA,van Goudoever J

    更新日期:2013-08-01 00:00:00

  • Clinical features and genotype-phenotype correlations in children with progressive familial intrahepatic cholestasis type 3 related to ABCB4 mutations.

    abstract:OBJECTIVES:The aim of the study was to estimate the frequency of ABCB4 mutations among children with chronic intrahepatic cholestasis with elevated gamma-glutamyl-transpeptidase (γ-GT) activity and to characterize the genotypes with respect to severity of symptoms, response to ursodeoxycholic acid therapy, and outcome....

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MPG.0b013e3181f50363

    authors: Colombo C,Vajro P,Degiorgio D,Coviello DA,Costantino L,Tornillo L,Motta V,Consonni D,Maggiore G,SIGENP Study Group for Genetic Cholestasis.

    更新日期:2011-01-01 00:00:00

  • Gastric acid hypersecretion in short bowel syndrome in infants: association with extent of resection and enteral feeding.

    abstract::To determine the frequency of gastric acid hypersecretion in infants with chronic malabsorption due to short bowel syndrome, acid secretory function was determined in 23 infants with malabsorption 2-22 months following small bowel resection and in a control group of 14 chronically ill, age- and weight-matched infants ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:

    authors: Hyman PE,Everett SL,Harada T

    更新日期:1986-03-01 00:00:00

  • Enteral nutrient supply for preterm infants: commentary from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition Committee on Nutrition.

    abstract::The number of surviving children born prematurely has increased substantially during the last 2 decades. The major goal of enteral nutrient supply to these infants is to achieve growth similar to foetal growth coupled with satisfactory functional development. The accumulation of knowledge since the previous guideline ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,实务指引

    doi:10.1097/MPG.0b013e3181adaee0

    authors: Agostoni C,Buonocore G,Carnielli VP,De Curtis M,Darmaun D,Decsi T,Domellöf M,Embleton ND,Fusch C,Genzel-Boroviczeny O,Goulet O,Kalhan SC,Kolacek S,Koletzko B,Lapillonne A,Mihatsch W,Moreno L,Neu J,Poindexter B,Punti

    更新日期:2010-01-01 00:00:00

  • Parenteral nutrition for infants: effect of high versus low calcium and phosphorus content.

    abstract::Calcium (Ca) and phosphorus (P) homeostasis were determined in 18 infants (birth weight, 2,810 +/- 135 g; gestational age, 37.4 +/- 0.5 weeks; mean +/- SEM) who received high or low Ca and P content (Ca, P) parenteral nutrition (PN) with a fixed, low dose of vitamin D (25 IU/dl). Nine infants were randomized into low ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Koo WW,Tsang RC,Steichen JJ,Succop P,Babcock D,Oestreich AE,Noseworthy J,Horn J,Farrell MK

    更新日期:1987-01-01 00:00:00

  • Effects of cerulein and epidermal growth factor on pancreatic growth in the reserpinized rat model.

    abstract::This study was undertaken to determine the effect of reserpine on rat pancreatic growth, to evaluate if reserpine-caused alterations can be prevented by epidermal growth factor (EGF) and/or cerulein treatment, to evaluate the time course of rat pancreas recovery after reserpine, and to determine if EGF and/or cerulein...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199307000-00006

    authors: Bérubé FL,Benrezzak O,Vanier M,Morisset J

    更新日期:1993-07-01 00:00:00

  • Discriminant score for celiac disease based on immunohistochemical analysis of duodenal biopsies.

    abstract:OBJECTIVES:Celiac disease (CD) represents a spectrum, which includes cases with minor histological abnormalities (potential CD). The aim of this work is to evaluate the contribution of immunohistochemical analysis of duodenal biopsies to the diagnosis of gluten-related minor enteropathy. METHODS:Duodenal biopsies from...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000000675

    authors: Tosco A,Maglio M,Paparo F,Greco L,Troncone R,Auricchio R

    更新日期:2015-05-01 00:00:00

  • Barrett's esophagus: new definitions and approaches in children.

    abstract::BE is a disorder that occurs in children likely as a consequence of prolonged GE reflux of gastroduodenal contents. It usually presents with complications of GE reflux, but it also may be relatively silent in childhood and then present with adenocarcinoma in childhood or present in adulthood. Although seldom recognize...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,评审

    doi:

    authors: Hassall E

    更新日期:1993-05-01 00:00:00

  • Polymorphonuclear neutrophil leucocytes in childhood Crohn's disease: a morphological study.

    abstract::Light and electron microscopy was applied to surgical resections and endoscopic biopsies from the ileum and colon of 15 children with Crohn's disease in order to investigate the involvement of neutrophils in the disease process. Clear evidence was found of neutrophil infiltration of the lamina propria and epithelium, ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198705000-00021

    authors: Lewis DC,Walker-Smith JA,Phillips AD

    更新日期:1987-05-01 00:00:00

  • Role of the colon in short bowel syndrome and intestinal transplantation.

    abstract::Colon is a crucial partner for small intestinal adaptation and function in patients who underwent extensive small intestinal resection or transplantation. This short review deals with the different properties and roles of the colon in these settings, involving fluid and electrolytes absorption, absorption of medium-ch...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,评审

    doi:10.1097/MPG.0b013e3181a118ef

    authors: Goulet O,Colomb-Jung V,Joly F

    更新日期:2009-04-01 00:00:00

  • Re-treatment of children with chronic hepatitis C who did not respond to interferon-alpha treatment.

    abstract:BACKGROUND:Many patients with chronic hepatitis C do not respond to antiviral treatment. In adult patients the re-treatment of these patients has been extensively investigated. Because the response to re-treatment in children is not well defined we evaluated the efficacy and safety of interferon (IFN)-alpha plus ribavi...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 临床试验,杂志文章

    doi:10.1097/MPG.0b013e3181d9c7f6

    authors: Gerner P,Hilbich J,Wenzl TG,Behrens R,Walther F,Kliemann G,Enninger A,Wirth S

    更新日期:2010-08-01 00:00:00

  • Resting energy expenditure in infants with cystic fibrosis.

    abstract::To evaluate the contribution of energy expenditure to the energy imbalance seen in cystic fibrosis patients, resting energy expenditure was measured using open-circuit indirect calorimetry in eight infants with cystic fibrosis, aged 2-7 months (mean, 4), without overt lung disease and in 10 healthy age-matched control...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199402000-00015

    authors: Girardet JP,Tounian P,Sardet A,Veinberg F,Grimfeld A,Tournier G,Fontaine JL

    更新日期:1994-02-01 00:00:00

  • Dexamethasone changes the composition of insulin-like growth factor binding proteins in the newborn mouse ileum.

    abstract:BACKGROUND:Early postnatal glucocorticoid exposure accelerates the maturation of the bowel mucosa but results in bowel wall thinning in the newborn mouse ileum and increases the risk of focal ileal perforation in extremely premature infants. We have previously demonstrated a redistribution of insulin-like growth factor...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-200210000-00014

    authors: Gordon PV,Moats-Staats BM,Stiles AD,Price WA

    更新日期:2002-10-01 00:00:00

  • Exocrine pancreatic function in children with progressive familial intrahepatic cholestasis type 2.

    abstract::In progressive familial intrahepatic cholestasis type 2 (PFIC-2), severe steatorrhea is often documented. However, pancreatic exocrine secretion has not yet been studied. In 14 children with PFIC-2, pancreatic function was assessed using standard fecal tests. Normal fecal lipase concentrations excluded isolated lipase...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/01.mpg.0000218154.26792.6a

    authors: Walkowiak J,Jankowska I,Pawlowska J,Strautnieks S,Bull L,Thompson R,Herzig KH,Socha J

    更新日期:2006-04-01 00:00:00

  • Gene transfer to the gastrointestinal tract after peroral administration of recombinant adeno-associated virus type 2 vectors.

    abstract:OBJECTIVES:The transfer of exogenous genetic material to cells within the gastrointestinal (GI) tract has many potential therapeutic applications. An attractive feature of the GI tract for gene transfer is its accessibility through the orogastric route. In this study, we evaluated the stability of recombinant adeno-ass...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/01.mpg.0000228118.59853.ba

    authors: Shao G,Greathouse K,Huang Q,Wang CM,Sferra TJ

    更新日期:2006-08-01 00:00:00

  • Dietary regulation of intestinal lactase and sucrase in adult rats: quantitative comparison of effect of lactose and sucrose.

    abstract::To characterize the mechanisms leading to dietary evoked increases of lactase and sucrase activities by carbohydrates, we performed a quantitative comparison of the effects of lactose and sucrose on the corresponding disaccharidases in the jejunum of 2-month-old rats. For 7-10 days the rats were fed a low-starch (5 ca...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198512000-00024

    authors: Goda T,Bustamante S,Koldovský

    更新日期:1985-12-01 00:00:00

  • Role of Vitamin D in Hospitalized Children With Lower Tract Acute Respiratory Infections.

    abstract:BACKGROUND:Vitamin D is known to have modulatory actions in the immune system. Its influence on the severity of lower tract acute respiratory infections (LT-ARIs) is unclear. OBJECTIVES:The aim of the present study was to evaluate the role of vitamin D on LT-ARI in paediatric patients. METHODS:Children admitted to ho...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000001003

    authors: Cebey-López M,Pardo-Seco J,Gómez-Carballa A,Martinón-Torres N,Rivero-Calle I,Justicia A,Redondo L,Martinón-Sánchez JM,Martínez-Padilla Mdel C,Giménez-Sánchez F,Salas A,Martinón-Torres F,GENDRES Network.

    更新日期:2016-03-01 00:00:00

  • T cell subsets in human colostrum.

    abstract::Lymphocytes from 10 paired colostrum and peripheral blood specimens were examined to determine if the colostral T cell population differs from the peripheral blood T cell population in subset distribution. The percentages of lymphocytes staining with OKT3, OKT4, and OKT8 murine monoclonal antibody were determined. Lym...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198605000-00018

    authors: Keller MA,Faust J,Rolewic LJ,Stewart DD

    更新日期:1986-05-01 00:00:00

  • Esophageal motor activity in children with gastro-esophageal reflux disease and esophagitis.

    abstract:OBJECTIVE:To evaluate esophageal body motor contractions occurring during esophageal reflux in pediatric patients with gastro-esophageal reflux disease (GERD). METHODS:Patients referred for the evaluation of GERD who were evaluated with combined 24-hour pH probe and esophageal manometry test (MP24) were included. Pati...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-200501000-00013

    authors: Chitkara DK,Fortunato C,Nurko S

    更新日期:2005-01-01 00:00:00

  • Impact of Breast Milk, Respiratory Insufficiency, and Gastroesophageal Reflux Disease on Enteral Feeding in Infants With Omphalocele.

    abstract:OBJECTIVES:The aim of this study was to document the process of achieving full enteral feeding in infants with omphalocele and to identify factors that affect feeding success. METHODS:After institutional review board approval (study no. 5100169), 123 infants with omphalocele, born between 1993 and 2011 were reviewed. ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000001463

    authors: Haug S,St Peter S,Ramlogan S,Goff D,Thorpe D,Hopper A,Baerg J

    更新日期:2019-06-01 00:00:00

  • Homeostatic mechanisms in the utilization of exogenous iron in children recovering from severe malnutrition.

    abstract::We evaluated the role of initial iron stores on iron accumulation during recovery from severe edematous protein-energy malnutrition in children. Twenty-six preschool children were divided in two groups according to their initial iron reserves, as estimated from serum ferritin concentration, using a cutoff criterion of...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198502000-00018

    authors: Caballero B,Solomons NW,Batres R,Torún B

    更新日期:1985-02-01 00:00:00

  • Breast-feeding and growth factors in preterm newborn infants.

    abstract:BACKGROUND:We analyzed the role that nutrition and the insulin-like growth factors IGF-I and IGFBP-3 play on neonatal growth. METHODS:Full-term and preterm infants with 1 and 3 weeks of postnatal life (n = 54 and n = 33, respectively) were studied. Anthropmetric variables, daily intake of energy and nutrients, and ser...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199703000-00016

    authors: Díaz-Gómez NM,Domenech E,Barroso F

    更新日期:1997-03-01 00:00:00

  • Treatment of acute diarrhea with Saccharomyces boulardii in infants.

    abstract:OBJECTIVE:The aim of the study was to determine whether an oral treatment with a commercial pharmaceutical product containing Saccharomyces boulardii would reduce the duration of diarrhea in infants with acute diarrhea. PATIENTS AND METHODS:In the present double-blind, placebo-controlled study, 186 infants, 6 to 48 mo...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MPG.0b013e31822b7ab0

    authors: Corrêa NB,Penna FJ,Lima FM,Nicoli JR,Filho LA

    更新日期:2011-11-01 00:00:00

  • Pharmacokinetics and safety of a new solution of vitamin K1(20) in children with cholestasis.

    abstract::In cholestatic diseases, the absorption of fat-soluble compounds, including vitamin K1(20), is low and periodic administration of vitamin K1(20) is often necessary. Due to the low absorption of vitamin K1(20) from the Konakion formulation, late hemorrhagic disease of the newborn also occurs especially after oral vitam...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199202000-00007

    authors: Amédée-Manesme O,Lambert WE,Alagille D,De Leenheer AP

    更新日期:1992-02-01 00:00:00

  • γ-Glutamyl transpeptidase level as a screening marker among diverse etiologies of infantile intrahepatic cholestasis.

    abstract:OBJECTIVES:Low γ-glutamyl transpeptidase (GGT) level is an important marker for progressive familial intrahepatic cholestasis, yet the cutoff level and clinical application is not well defined. This study aimed to evaluate the role of GGT as a screening marker among diverse etiologies of infantile cholestasis. METHODS...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000000538

    authors: Lu FT,Wu JF,Hsu HY,Ni YH,Chang MH,Chao CI,Chen HL

    更新日期:2014-12-01 00:00:00

  • Impact of early and high amino acid supplementation on ELBW infants at 2 years.

    abstract:OBJECTIVE:The aim of the present study was to examine the effects of early and high intravenous (IV) amino acid (AA) supplementation on growth, health, and neurodevelopment of extremely-low-birth-weight (ELBW) infants throughout their first 2 years of life. METHODS:Infants were prospectively randomized in a double-mas...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MPG.0b013e31824887a0

    authors: Blanco CL,Gong AK,Schoolfield J,Green BK,Daniels W,Liechty EA,Ramamurthy R

    更新日期:2012-05-01 00:00:00