Dual Sofosbuvir/Daclatasvir Therapy in Adolescent Patients With Chronic Hepatitis C Infection.

Abstract:

OBJECTIVES:Dual sofosbuvir/daclatasvir (SOF/DCV) therapy is currently recommended by the European Association for Study of Liver (EASL) as an option for the treatment of chronic hepatitis C virus (HCV) infection in adults for all genotypes; however, it is still not considered for patients younger than 18 years old. We aimed to test safety and efficacy of SOF/DCV in adolescent patients 12 to 17 years old with chronic HCV, genotype 4 infection. METHODS:We conducted a prospective, uncontrolled, open-label multicenter study. A total of 30 chronic HCV-infected adolescents, aged from 12 to 17 years old were included and treated with dual SOF/DCV for 12 weeks. Patients were monitored throughout the treatment and follow-up period for safety and efficacy outcome measures including the sustained virologic response 12 (SVR12) rate. RESULTS:The intention-to-treat (ITT) SVR12 rate was 29 of 30 (96.7%; 95% confidence interval [CI] 83.3%-99.4%). The only patient who did not achieve SVR12 was lost to follow-up after showing viral negativity at the end of treatment (EOT) visit. Whereas all the remaining 29 patients (100%, 95% CI 88.3%-100%) who completed the follow-up visits achieved SVR12. All patients showed normalized liver enzymes with normal hematological, liver and renal function tests at the end of the study. No fatalities or treatment-emergent serious or severe adverse events were reported throughout the study. CONCLUSIONS:SOF/DCV combined therapy could be a safe and effective treatment in adolescent patients 12 to 17 years old with chronic HCV genotype 4 infection. (See Video, Supplemental Digital Content, http://links.lww.com/MPG/B348).

authors

Yakoot M,El-Shabrawi MH,AbdElgawad MM,Mahfouz AA,Helmy S,Abdo AM,El-Khayat HR

doi

10.1097/MPG.0000000000001968

subject

Has Abstract

pub_date

2018-07-01 00:00:00

pages

86-89

issue

1

eissn

0277-2116

issn

1536-4801

journal_volume

67

pub_type

杂志文章,多中心研究
  • Intussusception of the vermiform appendix: a preoperative diagnosis in an adolescent girl.

    abstract::Intussusception of the vermiform appendix (IVA) in a 14-year-old girl is reported. The diagnosis was made preoperatively, which is rare: only five other cases have been reported. IVA can present with variable symptoms. This patient presented with episodes of recurrent severe paroxysmal pain and vomiting, each episode ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198601000-00032

    authors: Casteels M,Eggermont E,Kerremans R,Ponnette E

    更新日期:1986-01-01 00:00:00

  • Changes in Proteases, Antiproteases, and Bioactive Proteins From Mother's Breast Milk to the Premature Infant Stomach.

    abstract:OBJECTIVE:Our previous studies suggested that human milk proteases begin to hydrolyze proteins in the mammary gland and continue within the term infant' stomach. No research has measured milk protease and pepsin activity in the gastric aspirates of preterm infants after human milk feeding. This study investigated how t...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000001719

    authors: Demers-Mathieu V,Nielsen SD,Underwood MA,Borghese R,Dallas DC

    更新日期:2018-02-01 00:00:00

  • Expression of class II MHC antigens in the intestinal epithelium of pediatric celiac disease.

    abstract::Class II MHC antigen expression in the intestinal epithelium of 28 small bowel biopsies from 23 celiac patients were studied by means of indirect immunofluorescence and immunoperoxidase using monoclonal antibodies. Patients were divided on the basis of diet into two subgroups: 15 subjects on a gluten-containing diet (...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198910000-00002

    authors: Bonamico M,Mazzilli MC,Morellini M,Vania A,Carpino F,Nicotra MR,Natali PG

    更新日期:1989-10-01 00:00:00

  • Oral choline supplementation in children with intestinal failure.

    abstract::Choline deficiency leads to steatohepatitis, elevated transaminases, susceptibility to septic shock, and an increased risk of central catheter thrombosis. Children with intestinal failure (IF) are at risk for choline deficiency. In an unblinded, open-label study, we studied 7 children with IF on parenteral nutrition, ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 临床试验,杂志文章

    doi:10.1097/MPG.0b013e31821404d4

    authors: Guerrerio AL,Mattis L,Conner KG,Hampsey J,Stasinopoulos DM,DeJong R,Boctor EM,Sheth S,Hamper UM,Scheimann AO

    更新日期:2011-07-01 00:00:00

  • Modulation by human milk of IgG subclass response to hepatitis B vaccine in infants.

    abstract::The influence of breast and formula feeding on specific anti-hepatitis B surface antigen (HBsAg) IgG subclass production and distribution has been investigated in 40 healthy infants, born to HBsAg-positive mothers and vaccinated against hepatitis B virus (HBV). Twenty children were bottle fed and 20 were breast fed. S...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199004000-00008

    authors: Azzari C,Resti M,Rossi ME,Lami CA,Vierucci A

    更新日期:1990-04-01 00:00:00

  • Regulation of intestinal ontogeny by intraluminal nutrients.

    abstract::Major events in gastrointestinal ontogeny occur in the infant rat in association with weaning, resulting in striking alterations in small intestinal structure and function. Although the dietary changes attendant to weaning are not essential for the initiation of these events, dietary nutrients have been shown to parti...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199002000-00010

    authors: Castillo RO,Feng JJ,Stevenson DK,Kerner JA,Kwong LK

    更新日期:1990-02-01 00:00:00

  • Retrospective Comparison of Fluticasone Propionate and Oral Viscous Budesonide in Children With Eosinophilic Esophagitis.

    abstract:BACKGROUND:Eosinophilic esophagitis (EoE) is treated with dietary modification and/or pharmacologic management with swallowed topical steroids. Swallowed fluticasone propionate (FP) and oral viscous budesonide (OVB) have proven to be effective in resolving symptoms and reversing histologic changes in children and adult...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000001626

    authors: Fable JM,Fernandez M,Goodine S,Lerer T,Sayej WN

    更新日期:2018-01-01 00:00:00

  • Plasma and urine riboflavin and pyridoxine concentrations in enterally fed very-low-birth-weight neonates.

    abstract::Preterm infant formulas (PIFs) for very-low-birth-weight (VLBW) infants (birth weight, < 1,500 g) are augmented to provide daily riboflavin and pyridoxine at levels up to five-fold greater than in term infant formula and 18-fold greater than in human milk. We evaluated plasma riboflavin and pyridoxine concentrations i...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 临床试验,杂志文章

    doi:10.1097/00005176-199608000-00008

    authors: Porcelli PJ,Adcock EW,DelPaggio D,Swift LL,Greene HL

    更新日期:1996-08-01 00:00:00

  • Acute liver injury after protracted seizures in children.

    abstract::Three children were observed to have extensive liver injury following protracted seizures. Two recovered with supportive care and one died from central nervous system complications. When first measured, the levels of aminotransferases were minimally elevated, but they increased to 250 to 8,000 times normal within 12 t...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198911000-00004

    authors: Ussery XT,Henar EL,Black DD,Berger S,Whitington PF

    更新日期:1989-11-01 00:00:00

  • Lactobacillus rhamnosus GG on rotavirus-induced injury of ileal epithelium in gnotobiotic pigs.

    abstract:OBJECTIVE:The aim of this study was to study the effect of continued Lactobacillus rhamnosus GG strain (LGG) feeding on rotavirus gastroenteritis in the gnotobiotic (Gn) pig model of virulent human rotavirus (HRV) infection. METHODS:Gn pigs were assigned to treatment groups: mock control, LGG only, HRV only, or LGG pl...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e3182a356e1

    authors: Liu F,Li G,Wen K,Wu S,Zhang Y,Bui T,Yang X,Kocher J,Sun J,Jortner B,Yuan L

    更新日期:2013-12-01 00:00:00

  • Transient hypergastrinemia of 2 years' duration in a young pediatric patient.

    abstract::A 24-month-old female child experienced watery diarrhea, growth failure, and abdominal pain from age 3 months. Hypergastrinemia, hypochlorhydria, and fundic gastritis were documented. A secretin stimulation test was normal but protein meal stimulation revealed an abnormal serum gastrin response. Antral biopsies reveal...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198403000-00025

    authors: Euler AR,Lechago J,Byrne W,France GL

    更新日期:1984-03-01 00:00:00

  • Duodenal morphometry and small bowel permeability in children with portal hypertension.

    abstract:OBJECTIVE:We prospectively studied children with portal hypertension (PHT) for portal hypertensive duodenopathy (PHTD) and small bowel intestinal permeability (SIP) with the objectives of defining histopathological parameters for PHTD and to find out whether any association existed among structural changes, SIP, and nu...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000000578

    authors: Borkar VV,Poddar U,Kumari N,Singh S,Roy R,Yachha SK

    更新日期:2015-02-01 00:00:00

  • Changing the paradigm: new directions in federal oversight of human research.

    abstract::The system of institutional review boards (IRBs) was established about 30 years ago for the protection of human subjects and as a mechanism for assuring an independent peer review of research activities. To keep pace with an evolving environment, a new model for human research oversight is needed that focuses less on ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-200311001-00002

    authors: Koski G

    更新日期:2003-11-01 00:00:00

  • Pathophysiology of gastroesophageal reflux and distal esophageal motility in children with gastroesophageal reflux disease.

    abstract::We investigated the mechanisms of gastroesophageal reflux (GER) and esophageal motility during endogenous esophageal acid exposure in 17 patients with reflux disease alone (age range 3-20 months) (group A) and in 10 patients with reflux disease complicated by esophagitis (age range 4-19 months) (group B), by simultane...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198811000-00006

    authors: Cucchiara S,Staiano A,Di Lorenzo C,De Luca G,della Rocca A,Auricchio S

    更新日期:1988-11-01 00:00:00

  • Cardiac, respiratory, and arousal responses to an esophageal acid infusion test in near-term infants during active sleep.

    abstract::This study was designed to determine the cardiac, respiratory, and arousal responses to an esophageal acid infusion test in near-term infants free from neurological, gastroesophageal, and cardiopulmonary disease at time of testing during active sleep. Eight infants (gestational age 28-37.5 weeks, postconceptional age ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199208000-00006

    authors: Ramet J,Egreteau L,Curzi-Dascalova L,Escourrou P,Dehan M,Gaultier C

    更新日期:1992-08-01 00:00:00

  • Membrane distribution in human milks throughout lactation as revealed by phospholipid and cholesterol analyses.

    abstract::Membrane distribution in human milk was investigated. Milk samples from six women taken at intervals throughout 9 months of lactation were fractionated into fat globules, skim milk, fluff, and cells. These fractions and the intact milks were analyzed for protein, total lipid, and membrane material as revealed by phosp...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198607000-00017

    authors: Huston GE,Patton S

    更新日期:1986-07-01 00:00:00

  • Polymorphonuclear leukocytes and human colostrum: effects of in vivo and in vitro exposure.

    abstract::Polymorphonuclear leukocytes (PMN) from human colostrum were compared with blood and oral exudate PMN from the same donors for their locomotive, respiratory burst, phagocytic, and shape change (polarization) capabilities. Blood PMN were functionally superior to PMN from other sites. Colostrum PMN were similar to oral ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199311000-00016

    authors: Buescher ES,McIlheran SM

    更新日期:1993-11-01 00:00:00

  • Magnet ingestions in children presenting to US emergency departments, 2002-2011.

    abstract:BACKGROUND AND OBJECTIVE:In the last 10 years, there have been an increasing number of case reports concerning gastrointestinal injury related to magnet ingestions; however, the magnitude of the problem remains to be clearly defined. The aim of the study was to examine the epidemiology of magnet ingestion-related emerg...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e3182952ee5

    authors: Abbas MI,Oliva-Hemker M,Choi J,Lustik M,Gilger MA,Noel RA,Schwarz K,Nylund CM

    更新日期:2013-07-01 00:00:00

  • Use of cyproheptadine in young children with feeding difficulties and poor growth in a pediatric feeding program.

    abstract:OBJECTIVE:The aim of this study was to assess the efficacy and safety of cyproheptadine (CY) use in infants and young children with poor growth treated at our multidisciplinary pediatric feeding program, and to describe changes in their weight and feeding behaviors. METHODS:A retrospective chart review of children tre...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000000467

    authors: Sant'Anna AM,Hammes PS,Porporino M,Martel C,Zygmuntowicz C,Ramsay M

    更新日期:2014-11-01 00:00:00

  • Management of cyclic vomiting syndrome.

    abstract::The general goals of treatment of cyclic vomiting syndrome (CVS) are: interruption of established episodes, amelioration of symptoms in patients whose episodes cannot be interrupted, aborting episodes during prodromal symptoms, prophylaxis to abolish or lessen the frequency of episodes, and recovery. Complications of ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,评审

    doi:10.1097/00005176-199501001-00015

    authors: Fleisher DR

    更新日期:1995-01-01 00:00:00

  • Somatostatin in the treatment of a pancreatic pseudocyst in a child.

    abstract::Pancreatic pseudocyst is a know complication of acute pancreatitis and pancreatic trauma. The treatment of pancreatitis remains a challenge and the pancreatic pseudocyst is often approached surgically. Lately, the use of somatostatin and its long-acting analogue octreotide have proved useful in the treatment of pancre...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199611000-00011

    authors: Bosman-Vermeeren JM,Veereman-Wauters G,Broos P,Eggermont E

    更新日期:1996-11-01 00:00:00

  • Failure to label baboon milk intrinsically with iron.

    abstract::The widely held belief that 50% of the iron in human milk is absorbed is based on studies that have used an extrinsic radioactive iron tag. To determine the validity of an extrinsic tag, it is necessary to label the milk intrinsically with one isotope and to compare absorption of this isotope with absorption of anothe...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198911000-00022

    authors: Figueroa-Colón R,Elwell JH,Jackson E,Osborne JW,Fomon SJ

    更新日期:1989-11-01 00:00:00

  • Outcomes following infliximab therapy for pediatric patients hospitalized with refractory colitis-predominant IBD.

    abstract:OBJECTIVES:Although randomized trials demonstrated the efficacy of infliximab for both pediatric Crohn disease and ulcerative colitis (UC), few patients in these studies exhibited colitis requiring hospitalization. The aims of this study were to determine the rate of subsequent infliximab failure and dose escalation in...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e3182a98df2

    authors: Falaiye TO,Mitchell KR,Lu Z,Saville BR,Horst SN,Moulton DE,Schwartz DA,Wilson KT,Rosen MJ

    更新日期:2014-02-01 00:00:00

  • Results of extremely-low-birth-weight infants randomized to receive extra enteral calcium supply.

    abstract:BACKGROUND AND OBJECTIVE:Bone mineral deficiency continues to occur in extremely-low-birth-weight (ELBW) infants despite formulas enriched in calcium (Ca) and phosphorus (P). This study tested whether extra enteral Ca supplementation increases bone mineral content (BMC) and prevents dolichocephalic head flattening and ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MPG.0b013e3182187ecd

    authors: Carroll WF,Fabres J,Nagy TR,Frazier M,Roane C,Pohlandt F,Carlo WA,Thome UH

    更新日期:2011-09-01 00:00:00

  • Outcomes and Safety of Blenderized Tube Feedings in Pediatric Patients: A Single Center's Experience.

    abstract:INTRODUCTION:Recently, significant interest from families and healthcare providers has arisen to use blenderized tube feedings (BTF). Although many institutions are providing this nutritional option, literature documenting outcomes and safety is lacking. METHODS:A retrospective chart review was performed on pediatric ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000002853

    authors: Kernizan D,Mintz D,Colin M,Lee M,Yoakam L,Chen YP,Iofel E,Koniaris S,Weidner M

    更新日期:2020-10-01 00:00:00

  • Are bilirubin and plasma lipid profiles of premature infants dependent on the lipid emulsion infused?

    abstract::The effect of a lipid emulsion containing long-chain triglycerides (LCT) and supplemented with L-carnitine on plasma lipids and bilirubin in premature neonates on total parenteral nutrition was compared to that of lipid emulsions containing either LCT or a mixture of LCT and medium-chain triglycerides (MCT). In a doub...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00005176-199507000-00004

    authors: Rubin M,Naor N,Sirota L,Moser A,Pakula R,Harell D,Sulkes J,Davidson S,Lichtenberg D

    更新日期:1995-07-01 00:00:00

  • Item Generation and Reduction Toward Developing a Patient-reported Outcome for Pediatric Ulcerative Colitis (TUMMY-UC).

    abstract:BACKGROUND:The Pediatric Ulcerative Colitis Activity Index (PUCAI) is a noninvasive clinician-based index, which reflects disease severity in pediatric ulcerative colitis (UC) when no endoscopy is performed. Here, we aimed to explore signs and symptoms important to children with UC and their caregivers as the first sta...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1097/MPG.0000000000001259

    authors: Marcovitch L,Nissan A,Mack D,Otley A,Hussey S,Mclean B,Lewis M,Croft N,Barakat FM,Griffiths AM,Turner D

    更新日期:2017-03-01 00:00:00

  • Liver function in early congenital syphilis: does penicillin cause a deterioration?

    abstract::In this prospective study, neonates with clinical congenital syphilis were investigated to determine if penicillin therapy caused a deterioration in liver function. The relationship between circulating immune complexes and liver involvement was monitored, and the efficacy of steroid therapy as an adjunct in the treatm...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00005176-199104000-00003

    authors: Venter A,Pettifor JM,Duursma J,Pudifin DJ,Smyth A,Becker PJ

    更新日期:1991-04-01 00:00:00

  • Extensive and partial protein hydrolysate preterm formulas: the effect on growth rate, protein metabolism indices, and plasma amino acid concentrations.

    abstract:BACKGROUND:The use of protein hydrolysate preterm formulas is restricted because data on their nutritional adequacy are scarce. The authors evaluated the rate of growth and indices of protein metabolism in low-birth weight infants fed extensive and partial protein hydrolysate preterm formula followed for 12 weeks. MET...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00005176-200103000-00013

    authors: Szajewska H,Albrecht P,Stoitiska B,Prochowska A,Gawecka A,Laskowska-Klita T

    更新日期:2001-03-01 00:00:00

  • Placebo-controlled trial of misoprostol in cystic fibrosis.

    abstract::Seventeen children with cystic fibrosis were studied in a 6-week double-blind, placebo-controlled, crossover trial to determine the efficacy of misoprostol, 100 micrograms, four times a day, in improving fat absorption in patients already on pancreatic enzyme therapy. In those patients who had greater than 90% absorpt...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 临床试验,杂志文章

    doi:10.1097/00005176-199007000-00007

    authors: Robinson P,Sly PD

    更新日期:1990-07-01 00:00:00