Abstract:
:Patients enrolled in a fixed-dose clinical trial of oral ciprofloxacin had trough concentrations measured to document absorption and monitor compliance. The objective was to determine whether any demographic characteristics might be important predictors of the concentrations. Stepwise multivariate linear regression revealed no correlation between ciprofloxacin trough concentrations and serum creatinine, estimated creatinine clearance (Clcr), weight, height, body surface area, or gender. However, age exhibited a direct linear relationship with trough concentrations (Y in microgram/ml), Y = 0.020.age--0.541 (p < 0.003). We conclude that for patients with Clcr 30 ml/minute or above, age is a more important predictor of ciprofloxacin trough concentration than renal function. Dosage adjustment should not be arbitrary but should be guided by minimum inhibitory concentration, clinical response, and side effects.
journal_name
Pharmacotherapyjournal_title
Pharmacotherapyauthors
Paladino JA,Forrest A,Wilton JHsubject
Has Abstractpub_date
1993-09-01 00:00:00pages
504-7issue
5eissn
0277-0008issn
1875-9114journal_volume
13pub_type
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