Abstract：
:Post-vaccination tuberculin sensitivity is being used to evaluate the immediate effects of the extensive WHO/UNICEF mass BCG vaccination programmes currently in progress. During the past five years the Tuberculosis Research Office has been studying the tuberculin sensitivity produced by BCG vaccination, and the present paper discusses some of the most important characteristics of BCG-induced allergy. The material for the paper was drawn from the results in five countries of vaccinating more than 6,000 schoolchildren and retesting them at one or more intervals after vaccination.Tuberculin sensitivity produced by BCG is not the kind of response that may logically be described as "positive" or "negative". Rather, vaccination always produces, or increases, sensitivity to tuberculin, although, with some vaccines and in some persons, the degree of sensitivity produced may be low. BCG-induced allergy can best be described by the distribution of the sizes of the tuberculin reactions and summarized by the mean and standard deviation of the distribution. The common practice of classifying post-vaccination reactions as "positive" or "negative" is biologically meaningless and may be the cause of many fallacious notions about the allergy produced by BCG.The degree of post-vaccination allergy varies with the potency of the vaccine used: a potent vaccine has been shown to produce allergy about as strong as that produced by natural infection wherever carefully controlled studies have been made. No evidence was found that allergy wanes or is lost after intradermal vaccination: the impression that it does so may often have been the consequence of the practice of revaccination and of ignoring the influence of experimental error. Unless very weak vaccines are used, there is no indication that superinfection can be identified after vaccination. The diagnostic value of the tuberculin test is thus being destroyed in many places where mass campaigns are being done, particularly in those places where a high degree of tuberculin sensitivity is being produced.
journal_name
Bull World Health Organjournal_title
Bulletin of the World Health Organizationauthors
subject
Has Abstractpub_date
1955-01-01 00:00:00pages
123-41issue
1-2eissn
0042-9686issn
1564-0604journal_volume
12pub_type
杂志文章abstract：PROBLEM:In many countries, the tuberculosis (TB) annual case detection rate is below the target of 70%. In the Lao People's Democratic Republic in 2005, it did not exceed 55% APPROACH:The DOTS strategy promotes passive case detection of TB. In order to increase the detection rate, we validated a questionnaire targetin...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/blt.06.038539
更新日期：2007-09-01 00:00:00
abstract：:The frequent experience in the tropics of poor results of BCG vaccination is sometimes explained by a hypothetical interaction with "non-specific" tuberculin sensitivity. However, samples of data from five tropical countries, reported in this paper, demonstrate a slight, positive correlation between the individual tub...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1966-01-01 00:00:00
abstract：OBJECTIVE:To assess maternal and neonatal health services in 49 developing countries. METHODS:The services were rated on a scale of 0 to 100 by 10 - 25 experts in each country. The ratings covered emergency and routine services, including family planning, at health centres and district hospitals, access to these servi...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：:The relationship between cardiovascular characteristics and mortality was investigated in an epidemiological study of heart disease in a representative adult rural community in Jamaica. Of 449 men and 469 women followed up for 5 years, 36 men and 28 women died and the data concerning their status as regards arterial p...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1972-01-01 00:00:00
abstract：:It remains unclear why there is such marked variation in the severity of the human immunodeficiency virus (HIV) epidemic between African countries. The prevalence of HIV infection has reached high levels in many parts of southern Africa but in most countries of West Africa the levels are much lower. Although there is ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章,评审
doi：
更新日期：2001-01-01 00:00:00
abstract：:A trial of the CHAT, type 1, attenuated poliovirus strain of Koprowski was begun in August 1958 in Léopoldville, a city of 350 000 people, and possessing modern medical facilities, including an institute of public health.Paralytic poliomyelitis is endemic in the city; since 1951 there has been an average annual incide...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1960-01-01 00:00:00
abstract：:Inherited resistance to anticoagulant rodenticides was discovered in populations of Rattus norvegicus about 14 years ago. Similar resistance has now been reported from several countries in north-western Europe and from the USA. In order to detect resistance and to control it effectively, basic data on the susceptibili...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1972-01-01 00:00:00
abstract：OBJECTIVE:To assess the value of self-rated health assessments by examining the association between education and self-rated poor health. METHODS:We used the globally representative population-based sample from the 2002 World Health Survey, composed of 219,713 men and women aged 25 and over in 69 countries, to examine...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/BLT.09.067058
更新日期：2010-02-01 00:00:00
abstract：:Bladder cancer is the twelfth most common cancer globally, with approximately 170 000 new cases each year; a third of these cases are in the developing countries. There are two major etiological types. The first is more common in the industrialized countries and is associated with exposure to certain occupational and ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章,评审
doi：
更新日期：1987-01-01 00:00:00
abstract：:This chapter presents the findings arrived at by applying the resource allocation model to tuberculosis control in the Republic of Korea. Optimum subprogrammes are obtained for the four objectives of the programme: reduction of disability, impairment, excess mortality, and economic loss. These subprogrammes are discus...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1973-01-01 00:00:00
abstract：:The results of comparative assays have revealed considerable variation in the potencies of tetanus toxoids produced in different laboratories. Some manufacturers are able consistently to produce toxoids high in potency; others are not able to do so. While further work is required in order to correlate the animal assay...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1955-01-01 00:00:00
abstract：:A meeting was held to outline a comprehensive research plan, based on recent advances in biomedical sciences, for the development of improved methods for the control of tuberculosis. Such a plan requires a stepwise approach. The meeting focused on the initial activities to be carried out and on setting priorities.In t...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
abstract：:Until very recently, rabies research had made few notable advances since the time of Pasteur, but during the past few years the use of modern virological techniques has led to rapid progress in research on the rabies virus. This article summarizes the present state of knowledge of pathogenesis, immunology, cultivation...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1968-01-01 00:00:00
abstract：:The association between the period elapsed since weaning and the risk of shigellosis was assessed between 1 November 1987 and 30 November 1989 for a cohort of 1085 Bangladeshi children aged < 3 years. The children were followed for 1 month after exposure to Shigella spp. in their residential neighbourhoods, and the 26...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：:A meeting of an informal working group on immune responses to viral antigens was convened in Amsterdam on 15-18 November 1982 to discuss recent developments in this field and to formulate proposals for international collaborative studies relevant to the needs of the WHO Programme on Vaccine Development. The meeting co...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
abstract：:The ultrastructure of the trophozoite of Entamoeba histolytica cultivated in vitro on artificial media is described from electron-microscope studies made by the authors and from other published accounts. The authors point out that the description does not present a complete picture of the trophozoite of this species o...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1970-01-01 00:00:00
abstract：:New global public health institutions are increasingly emphasizing transparency in decision-making, developing-country ownership of projects and programmes, and merit- and performance-based funding. Such principles imply an institutional response to the challenge of bridging the "know-do gap", by basing decisions expl...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/blt.05.028704
更新日期：2006-08-01 00:00:00
abstract：OBJECTIVE:To determine if educating caregivers in providing zinc supplements to infants < 6 months old with acute diarrhoea is effective in treating diarrhoea and preventing acute lower respiratory infections (ALRIs), and whether it leads to a decrease in the use of oral rehydration salts (ORS). METHODS:In this retros...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章,随机对照试验
doi：10.2471/BLT.10.075986
更新日期：2010-10-01 00:00:00
abstract：:This report from the Tuberculosis Chemotherapy Centre, Madras, summarizes the progress over a 5-year period of 193 patients with newly diagnosed, sputum-positive pulmonary tuberculosis who were admitted to a concurrent comparison of home and sanatorium treatment for one year with isoniazid plus PAS. Previous reports h...
journal_title：Bulletin of the World Health Organization
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1966-01-01 00:00:00
abstract：:In order to contribute to knowledge of the sporogonic cycle of malaria parasites, 3 batches of Anopheles labranchiae atroparvus were infected with the VS Romanian strain of Plasmodium malariae by feeding them on 2 patients undergoing malariotherapy in Romania. Of the 310 infected mosquitos 59 were dissected for ookine...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1968-01-01 00:00:00
abstract：:The treatment received by children aged under 5 years with diarrhoea was studied in the Hospital Infantil de México (Federico Goméz), Mexico City. The costs of treatment were calculated and estimates were made of how these had changed since the establishment of an oral rehydration unit in the hospital in 1985. The res...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:Although no full-scale survey of the prevalence of bilharziasis in Swaziland has been carried out, examinations of schoolchildren have revealed S. mansoni infection rates of up to 49% in some areas, and S. haematobium infection rates ranging from 3% to 75%. The highest prevalence occurs in areas where there are thickl...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1958-01-01 00:00:00
abstract：:There was a dramatic rise in the prevalence of urinary schistosomiasis around Volta Lake within a year of its full impoundment in 1968. Research was undertaken to investigate the epidemiology of the disease in preparation for a control programme. The interplay of three factors-age, sex, and ethnic affiliation-largely ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
abstract：:From time to time, reports of anthelmintic trials are published indicating that a compound is, or is not, effective against Echinococcus granulosus in dogs. In some of these reports, an attempt is made to assess the efficacy of the compound from inadequate data. This paper reviews the problems associated with selectin...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1968-01-01 00:00:00
abstract：OBJECTIVE:To test whether relations between economic development, economic inequality, and child and youth homicide rates are sex- and age-specific, and whether a country's wealth modifies the impact of economic inequality on homicide rates. METHODS:Outcome variables were homicide rates around 1994 in males and female...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：OBJECTIVE:To quantify long-term health service use (HSU) following non-fatal injury in adults. METHODS:A retrospective, population-based, matched cohort study identified an inception cohort (1988-91) of injured people who had been hospitalized (ICD-9-CM 800-995) aged 18-64 years (n = 21 032) and a matched non-injured ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/blt.06.030833
更新日期：2006-10-01 00:00:00
abstract：:Present methods of controlling meningococcal cerebrospinal meningitis have failed to contain the disease. This has led to the search for effective vaccines and to the development of methods for assaying the potency of these vaccines, as well as for measuring the immune response of the individual. The feasibility of us...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1969-01-01 00:00:00
abstract：:To assess its potential applications in plague surveillance and control programmes, an enzyme-linked immunosorbent assay (ELISA) that captures the specific Yersinia pestis F1 antigen was used to determine the amounts of this antigen present in samples of blood and spleens from laboratory rats with acute plague, in the...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:In laboratory experiments sterile males produced by crossing member species of the Anopheles gambiae complex competed very successfully with normal males for normal females and the latter when mated with sterile males laid sterile eggs.A field trial was arranged in a small isolated village near Bobo-Dioulasso, Upper V...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1970-01-01 00:00:00
abstract：:Twenty-five strains of poliomyelitis virus isolated from paralytic cases in the Netherlands, Belgium, and Germany were classified either by testing resistance of immunized monkeys, or by neutralization. Seventeen strains (68%) were classified as type 1, 7 (28%) as type 2, and 1 (4%) as type 3. Strains of type 2 are pr...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1953-01-01 00:00:00
