Abstract：
:This study established the influence of dietary neomycin sulphate on the rate of hydrolysis of ochratoxin A (OA) by digesta from the intestine, and its effect on the excretion of OA and its hydrolyzed metabolite, alpha ochratoxin (O alpha), in the urine and feces of the rat. The first in vitro study demonstrated that digesta from the cecum and the large intestine were able to hydrolyze OA whereas digesta from the small intestine and stomach had very low hydrolytic activity against this substrate. Homogenates of the liver had no hydrolytic activity. The second in vivo study demonstrated that digesta from the large intestine and cecum of the neomycin treated rats was much less effective (P < 0.001) in promoting the hydrolysis of OA than digesta from the control rats. Neomycin when added directly to the in vitro system, however, did not affect the rate at which OA was hydrolyzed. In a third study, OA was administered in vivo to control and neomycin-treated rats. Rats fed the neomycin containing diet compared to those fed the control diet had a higher concentration (P < 0.005) of blood OA, and a greater cumulative excretion of OA plus O alpha over the entire 5 day collection period in the feces (P < 0.0001) and a corresponding decrease in the cumulative excretion of OA plus O alpha in the urine (P < 0.0001). Individually, there was a marked increase in cumulative fecal excretion of OA (P < 0.05) and a corresponding decrease in excretion of O alpha (P < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Arch Environ Contam Toxicoljournal_title
Archives of environmental contamination and toxicologyauthors
Madhyastha MS,Marquardt RR,Frohlich AAdoi
10.1007/BF00203811subject
Has Abstractpub_date
1992-11-01 00:00:00pages
468-72issue
4eissn
0090-4341issn
1432-0703journal_volume
23pub_type
杂志文章abstract：:Recycling of sewage sludge is needed in a sustainable society. Quality aspects of sludge include hygiene (pathogens), nutrients (N and P), and toxicants (metals and organics). Metals are of particular concern because they are not degradable, but their hazards are related to their bioavailability and chemical speciatio...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-005-0037-4
更新日期：2006-10-01 00:00:00
abstract：:Seeds of five wheat (Triticum aestivum) cultivars (PBW-373, UP-2338, DL-LOK-01, DL-373, and HD-2338) were sown in earthen pots and 10-day-old seedlings were exposed to 0, 50, and 100 μM of nickel (Ni) in the form of nickel chloride. At the 20-day stage, seedlings were sprayed with 0.01 μM of 28-homobrassinolide (HBL)....
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-010-9535-0
更新日期：2011-01-01 00:00:00
abstract：:Aflatoxin B(1) (AFB(1)) is a potent mutagenic and carcinogenic agent found in numerous agricultural and dairy products consumed by humans. Therefore, we evaluated the capacity of mannan to cope with its genotoxic potential. We prepared a diet constituted of corn (90%) plus the recommended amount of other nutrients, as...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-006-0074-7
更新日期：2007-10-01 00:00:00
abstract：:The morphological alterations of hepatocytes of female zebrafish, Brachydanio rerio, and fingerling rainbow trout, Salmo gairdneri, following prolonged exposure to 0.04, 0.2 and 1 mg/L of 4-chloroaniline were investigated by means of light and electron microscopy. Changes in peroxisomes were visualized by cytochemical...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/BF01054986
更新日期：1990-05-01 00:00:00
abstract：:The accumulation of 14C-benzo(a)pyrene (BaP) sorbed to sediment was examined in fathead minnows (Pimephales promelas) to compare uptake from sediment with a high organic carbon (OC) content (7.7%), to that with a low OC content (2%). Ingestion of sediments was quantified by co-labeling the sediment with 141Cerium, whi...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-003-2148-0
更新日期：2003-10-01 00:00:00
abstract：:Mercury (Hg) is a ubiquitous and highly toxic contaminant that can have negative effects on wildlife. Only a few studies have measured Hg concentrations in birds from the south central United States, and the potential threat of Hg contamination to birds in this region is largely unknown. In the present study, we asses...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-015-0189-9
更新日期：2015-11-01 00:00:00
abstract：:The effects of both parathion and methyl parathion on the inhibition of plasma cholinesterase were elaborated in a rat model employing a modified isocratic reverse-phase HPLC method coupled with UV detection for the determination of the urinary metabolite p-nitrophenol (U-4NP). A linearity of r2 > 0.995 was found for ...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s002449900207
更新日期：1997-05-01 00:00:00
abstract：:Previous studies have indicated that chemicals, e.g., hydroxylated polychlorinated biphenyls (PCBs) decrease plasma thyroxin levels through interaction with transthyretin. As a consequence, plasma vitamin A and thyroxin are depleted. Both thyroxin and vitamin A are important regulators of normal epithelial differentia...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/BF00225989
更新日期：1992-07-01 00:00:00
abstract：:In addition to survival and hatching parameters, cytological alterations in liver and kidney of 4- and 6-d old zebrafish larvae (Brachydanio rerio) following single microinjection of fertilized eggs at the germ-ring stage with 5, 12.5, and 25 ng 4-chloroaniline/egg were investigated by means of electron microscopy. Wh...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/BF00212299
更新日期：1996-03-01 00:00:00
abstract：:DNA-protein cross-links (DPXs) in fish erythrocytes represent a potential biomarker for exposure to metal cations, such as hexavalent chromium (Cr[VI]) and divalent nickel (Ni[II]). Species-specific sensitivities to DPX formation were studied by coexposure of juvenile specimens of rainbow trout, hybrid bluegill, and c...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-008-9175-9
更新日期：2009-02-01 00:00:00
abstract：:A series of eleven nitrogen-containing heterocyclic compounds, which may be potentially associated with aqueous effluents from coal conversion technologies, were examined to determine the relationships between their n-octanol/H2O partition coefficients, molecular weights, boiling points, and their toxicity monitored a...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/BF01056938
更新日期：1980-01-01 00:00:00
abstract：:Earlier incubation and greenhouse studies in our laboratory confirmed the effectiveness of drinking-water treatment residual (WTR) in decreasing soil arsenic (As) bioaccessibility as determined with in vitro tests, which led us to hypothesize a similar outcome if animal studies were to be conducted. Our objective was ...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-009-9318-7
更新日期：2009-11-01 00:00:00
abstract：:To understand the physiological mechanism that confers Cd sensitivity/tolerance, Cd uptake and translocation by Cd-sensitive mutant and wild-type rice seedlings were characterized using radioactive tracer. Time-dependent Cd accumulation during 210 min was 1.8-fold higher in roots of the mutant than of wild-type rice. ...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-008-9273-8
更新日期：2009-08-01 00:00:00
abstract：:The acute effects of both untreated and dispersant-treated Prudhoe Bay crude oil on the early life-stages of three marine species were investigated. Identification of which water-accommodated fraction (undispersed or chemically dispersed) was considered "more toxic" was dependent on species, time, and endpoint (and by...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s002449900302
更新日期：1998-02-01 00:00:00
abstract：:A replicated field experiment was conducted at two locations to determine the disappearance of methomyl from flue-cured tobacco. Immediately after application, methomyl residues were 88 and 113 ppm at Clayton and 44 and 105 ppm at Reidsville, respectively, for 0.56 and 1.12 kg/ha application rates. After 5 days these ...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/BF02220903
更新日期：1977-01-01 00:00:00
abstract：:A life table response experiment (LTRE) was used to quantify the population-level effects of continuous, multigeneration cadmium exposure on two strains of the freshwater gastropod, Biomphalaria glabrata: the parasite-resistant BS90 and parasite-susceptible NMRI strains. Snails were exposed to waterborne cadmium for t...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-008-9203-9
更新日期：2009-05-01 00:00:00
abstract：:The result of feeding Aroclor 1254 to female Rhesus monkeys at doses of 0, 5, 20, 40 and 80 micrograms/kg body weight/day for a period of 37 months was measured in terms of polychlorinated biphenyl (PCB) levels in blood, adipose tissue, and feces. PCB concentrations in whole blood increased more rapidly during the fir...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/BF01160301
更新日期：1989-11-01 00:00:00
abstract：:6-Chloropicolinic acid is the sole detectable metabolite, other than carbon dioxide, arising from decomposition of 2-chloro-6-(trichloromethyl) pyridine in soil. The pyridine compound is a potent inhibitor of nitrification now in use with ammonium fertilizers. The purpose of this study was to evaluate the relative inf...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/BF02220894
更新日期：1976-01-01 00:00:00
abstract：:The origin and fate of the gin waste residues of three chemicals--toxaphene, DEF, and paraquat--used frequently in cotton production in California were studied. Residues were determined for foliage and bolls in the live plants, for lint and seed in harvested seed cotton, and for gin waste and its lint and non-lint com...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/BF01056319
更新日期：1979-01-01 00:00:00
abstract：:Osprey (Pandion haliaetus) eggs were collected from 1991 to 1997 at nests (n = 121) upstream and downstream of bleached kraft pulp mills and at reference sites in the Fraser and Columbia River drainage systems of British Columbia, Washington, and Oregon. Blood samples were collected from nestling ospreys during the 19...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s002449900424
更新日期：1998-11-01 00:00:00
abstract：:The concentrations of the metals cadmium, copper, mercury, lead, silver, selenium and zinc were measured in the muscle and gonad tissues of five species of fish, yellowfin bream (Acanthopagrus australis), silverbiddy (Gerres subfasciatus) and trumpeter whiting (Sillago maculata), southern log finned goby (Favonigobiou...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-007-9027-z
更新日期：2008-02-01 00:00:00
abstract：:The extraction of plastic microparticles, so-called microplastics, from sludge is a challenging task due to the complex, highly organic material often interspersed with other benign microparticles. The current procedures for microplastic extraction from sludge are time consuming and require expensive reagents for dens...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-017-0415-8
更新日期：2017-11-01 00:00:00
abstract：:The United States Environmental Protection Agency has defined national in-stream water-quality criteria (WQC) for 157 pollutants. No WQC to protect aquatic life exist for total dissolved solids (TDS). Some water-treatment processes (e.g., pH modifications) discharge wastewaters of potentially adverse TDS into freshwat...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-004-0034-z
更新日期：2005-08-01 00:00:00
abstract：:Bacteria communities living in mucus secretions of common carp Cyprinus carpio (Cyprinidae) were exposed to the organic nanomaterial fullerene (C(60)) to evaluate its potential bactericidal effects. End points analyzed were viability, growth, reactive oxygen species (ROS) concentration, and total antioxidant competenc...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-010-9618-y
更新日期：2011-08-01 00:00:00
abstract：:The Army is replacing traditional munitions with insensitive munitions (IM) resistant to accidental detonation. The aquatic toxicity of 1-methyl-3-nitroguanidine (MeNQ), which is being assessed for potential use in IM formulations, remains largely untested. The present study fills a number of critical data gaps for Me...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-020-00796-x
更新日期：2021-01-02 00:00:00
abstract：:Invertebrate communities of lentic habitats comprise, amongst others, the crustacean Asellus aquaticus (Isopoda) and the turbellarian Dendrocoelum lacteum (Tricladida). Because D. lacteum preferentially preys on A. aquaticus, contaminants introduced into the aquatic environment may affect this predator-prey interactio...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-011-9743-2
更新日期：2012-07-01 00:00:00
abstract：:We determined dose-response curves for sublethal effects of the organophosphorus (OP) insecticide, chlorpyrifos, on bats. Big brown bats (Eptesicus fuscus, n = 64) were given a single dose of chlorpyrifos (nominal concentrations) of 0, 5, 10, 15, 20, 25, 30, or 60 µg/g body weight and examined at 12 or 24 h after dosi...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-016-0307-3
更新日期：2016-10-01 00:00:00
abstract：:The effects of dietary exposure to copper (Cu), lead (Pb), and zinc (Zn) on feeding activities, growth response, and mortality of Theba pisana snails were studied in 5-week feeding tests. Snails were fed on an artificial diet containing the following Cu, Pb, or Zn concentrations: 0, 50, 100, 500, 1000, 5000, 10,000, a...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-010-9542-1
更新日期：2011-02-01 00:00:00
abstract：:The effects of short-term exposure (28 days) of free-feeding Limnonectus limnocharis (Indian cricket frog) tadpoles to field concentrations of malathion were investigated. This frog species is a major biotic component of the agroecosystems of the Western Ghats (13 degrees 18', 75 degrees 25' and 13 degrees 22', 75 deg...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-006-0015-5
更新日期：2007-02-01 00:00:00
abstract：:Concentrations of six phenolic endocrine-disrupting chemicals [4-tert-octylphenol (OP), 4-t-nonylphenol (4-t-NP), 4-n-nonylphenol (4-n-NP), nonylphenol mono- to di-ethoxylates (NP1EO, NP2EO), and bisphenol A (BPA)] and five estrogens [estrone (E1), β-estradiol (E2), estriol (E3) 17α-ethynylestradiol (EE2), and diethyl...
journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
doi：10.1007/s00244-014-9998-5
更新日期：2014-04-01 00:00:00
