Abstract:
:Previous studies have indicated that chemicals, e.g., hydroxylated polychlorinated biphenyls (PCBs) decrease plasma thyroxin levels through interaction with transthyretin. As a consequence, plasma vitamin A and thyroxin are depleted. Both thyroxin and vitamin A are important regulators of normal epithelial differentiation and proliferation and might act in the promotion phase of carcinogenesis. In the present report, extracts of indoor and outdoor airborne particulate matter (APM), originating from different pollution sources, were tested for a possible interaction in vitro and in vivo with thyroxin and vitamin A. Results indicated that all APM extracts significantly interfered with thyroxin binding to transthyretin. In all cases, the more polluted samples inhibited binding more than the corresponding control samples. Exposure of rats to a cigarette smoke extract induced clear changes in plasma thyroxin and triiodothyronin hormone levels. Triiodothyronin levels were reduced most. Effects on plasma vitamin A levels were also found, but these were less clear. In addition a decrease in lung vitamin A levels was found, but this decrease was not statistically significant. Exposure of rats to an outdoor APM extract induced significant changes in plasma triiodothyronin levels. Effects on thyroxin levels were not significant, although the same trend was seen as for the cigarette smoke APM extract. No changes in plasma or liver vitamin A concentrations were induced by the outdoor APM extract. Lung vitamin A levels were decreased, but again this decrease was not statistically significant. Taken together, the present report shows that APM extracts have the potency to interfere with thyroid hormone metabolism both in vitro and in vivo and probably with vitamin A metabolism as well.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Arch Environ Contam Toxicoljournal_title
Archives of environmental contamination and toxicologyauthors
Heussen GA,Hikspoors ML,Spenkelink A,Brouwer A,Koeman JHdoi
10.1007/BF00225989subject
Has Abstractpub_date
1992-07-01 00:00:00pages
6-12issue
1eissn
0090-4341issn
1432-0703journal_volume
23pub_type
杂志文章abstract::One-year-old whitefish, Coregonus lavaretus, were exposed to three types of iron-rich water, two dilutions for each, in a subchronic (30-day) experiment. In natural iron-rich humic water, both the bioaccumulation and physiological effects of iron exposure were negligible. In humic-free water with high amount of additi...
journal_title:Archives of environmental contamination and toxicology
pub_type: 杂志文章
doi:10.1007/s002449900506
更新日期:1999-08-01 00:00:00
abstract::Recent studies have examined mercury accumulation in crocodilians. However, though most researchers have focused on tissue concentrations, few have examined mercury levels in crocodilian eggs. In July 1995, we analyzed mercury in 31 nonviable Morelet's crocodile ( Crocodylus moreletii) eggs collected from eight nests ...
journal_title:Archives of environmental contamination and toxicology
pub_type: 杂志文章
doi:10.1007/s00244-001-0020-7
更新日期:2002-04-01 00:00:00
abstract::We investigated interactions between low pH, high nitrate level, and ultraviolet-B (UV-B) light on the survival and activity level of larval Cascades frogs (Rana cascadae). We used a fully factorial experimental design, with pH levels of 5 and 7; initial "pulse" nitrate exposure levels of 0, 5, and 20 mg/L; and UV-B p...
journal_title:Archives of environmental contamination and toxicology
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journal_title:Archives of environmental contamination and toxicology
pub_type: 杂志文章
doi:10.1007/s00244-013-9915-3
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abstract::Concentrations of six phenolic endocrine-disrupting chemicals [4-tert-octylphenol (OP), 4-t-nonylphenol (4-t-NP), 4-n-nonylphenol (4-n-NP), nonylphenol mono- to di-ethoxylates (NP1EO, NP2EO), and bisphenol A (BPA)] and five estrogens [estrone (E1), β-estradiol (E2), estriol (E3) 17α-ethynylestradiol (EE2), and diethyl...
journal_title:Archives of environmental contamination and toxicology
pub_type: 杂志文章
doi:10.1007/s00244-014-9998-5
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abstract::Surface residue disappearance rates of dioxathion, malathion, oxydemetonmethyl, and dialifor were the same for fruit and leaves, and they increase with temperature. Disappearance rates were in the order of malathion greater than or equal to oxydemetonmethyl greater than dialifor greater than or equal to dioxathion. Ma...
journal_title:Archives of environmental contamination and toxicology
pub_type: 杂志文章
doi:10.1007/BF01055445
更新日期:1981-07-01 00:00:00
abstract::Although concentrations of organochlorine compounds (OCs) in birds from most of the United States and Canada have decreased over the last 30 years, there is still concern that migrant birds might be exposed to elevated concentrations of OCs during migration in Latin America. The Lerma-Chapala Basin in west-central Mex...
journal_title:Archives of environmental contamination and toxicology
pub_type: 杂志文章
doi:10.1007/s00244-007-9124-z
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abstract::Twenty-seven pesticide workers with elevated blood levels of dieldrin (greater than or equal to 15 ppb) were involved in a case-control study which included history and physical examination, comprehensive neurological evaluation, laboratory tests, and psychological and psychomotor testing. No clinically important diff...
journal_title:Archives of environmental contamination and toxicology
pub_type: 杂志文章
doi:10.1007/BF01057573
更新日期:1981-01-01 00:00:00
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journal_title:Archives of environmental contamination and toxicology
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journal_title:Archives of environmental contamination and toxicology
pub_type: 杂志文章
doi:10.1007/s00244-006-0229-6
更新日期:2007-08-01 00:00:00
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doi:10.1007/s00244-010-9550-1
更新日期:2011-04-01 00:00:00
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doi:10.1007/s00244-016-0273-9
更新日期:2016-05-01 00:00:00
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journal_title:Archives of environmental contamination and toxicology
pub_type: 杂志文章
doi:10.1007/s002449900455
更新日期:1999-02-01 00:00:00
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journal_title:Archives of environmental contamination and toxicology
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doi:10.1007/s00244-018-0560-8
更新日期:2018-11-01 00:00:00
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journal_title:Archives of environmental contamination and toxicology
pub_type: 杂志文章
doi:10.1007/s00244-018-0544-8
更新日期:2018-11-01 00:00:00
abstract::Agricultural edge-of-field runoff usually contaminates surface waters with particle-associated pesticides. However, the acute and chronic effects on the aquatic macroinvertebrate communities have rarely been addressed. Outdoor flow-through stream microcosms were exposed for 1 h in triplicate to approximately 3.1 g/L o...
journal_title:Archives of environmental contamination and toxicology
pub_type: 杂志文章
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更新日期:2001-05-01 00:00:00
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journal_title:Archives of environmental contamination and toxicology
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abstract::Seasonal changes in metal (Cu, Fe, Mn, Pb, and Zn) concentrations were observed in the digestive gland of the Mediterranean mussel, Mytilus galloprovincialis, from both a polluted and a non-polluted population. Digestive gland of mussels from the polluted site showed metal concentrations appreciably higher than in non...
journal_title:Archives of environmental contamination and toxicology
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journal_title:Archives of environmental contamination and toxicology
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journal_title:Archives of environmental contamination and toxicology
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更新日期:2007-10-01 00:00:00
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journal_title:Archives of environmental contamination and toxicology
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doi:10.1007/s002449910043
更新日期:2000-04-01 00:00:00
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journal_title:Archives of environmental contamination and toxicology
pub_type: 杂志文章
doi:10.1007/BF00214259
更新日期:1994-08-01 00:00:00
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journal_title:Archives of environmental contamination and toxicology
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journal_title:Archives of environmental contamination and toxicology
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journal_title:Archives of environmental contamination and toxicology
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journal_title:Archives of environmental contamination and toxicology
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doi:10.1007/s00244-009-9331-x
更新日期:2010-01-01 00:00:00
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journal_title:Archives of environmental contamination and toxicology
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更新日期:1998-04-01 00:00:00
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journal_title:Archives of environmental contamination and toxicology
pub_type: 杂志文章
doi:10.1007/s00244-009-9298-7
更新日期:2009-10-01 00:00:00
abstract::Eight species of birds (129 individuals) were collected from three agricultural areas with long histories of pesticide use in northwestern Mexico. Plucked carcasses were analyzed for organochlorine (OC) pesticides and polychlorobiphenyls (PCBs). DDE was found in all of the samples and at higher levels than other OCs. ...
journal_title:Archives of environmental contamination and toxicology
pub_type: 杂志文章
doi:10.1007/BF01183876
更新日期:1991-11-01 00:00:00