Abstract:
:The effects of both parathion and methyl parathion on the inhibition of plasma cholinesterase were elaborated in a rat model employing a modified isocratic reverse-phase HPLC method coupled with UV detection for the determination of the urinary metabolite p-nitrophenol (U-4NP). A linearity of r2 > 0.995 was found for a standard curve ranging from 0.06 to 0.96 microg/mL with a % relative error of = +/- 10% and a recovery of 89 +/- 2%. The % CV at all levels was = 11%. A linear correlation was observed between the oral administration of parathion and methyl parathion for both the percent inhibiton of cholinesterase as well as the urinary elimination of 4NP. It is tentatively recommended that an U-4NP of 2. 0 mg/g creatinine be established as a biological exposure index (BEI) for methyl parathion.
journal_name
Arch Environ Contam Toxicoljournal_title
Archives of environmental contamination and toxicologyauthors
Chang MJ,Chen YC,Yang HJdoi
10.1007/s002449900207subject
Has Abstractpub_date
1997-05-01 00:00:00pages
422-5issue
4eissn
0090-4341issn
1432-0703journal_volume
32pub_type
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