Prostaglandin E1 does not accelerate rTPA-induced thrombolysis in acute myocardial infarction.

abstract：BACKGROUND:ST-elevation myocardial infarctions (STEMI) caused by proximal left-anterior descending (LAD) lesions have more myocardium at risk and worse outcomes than those located in other segments. The aim is to compare outcomes of patients with STEMI and proximal-LAD lesions treated with bare-metal stents (BMS) versu...

journal_title：American heart journal

authors： Gomez-Lara J,Brugaletta S,Gomez-Hospital JA,Ferreiro JL,Roura G,Romaguera R,Martin-Yuste V,Masotti M,Iñiguez A,Serra A,Hernandez-Antolin R,Mainar V,Valgimigli M,Tespili M,den Heijer P,Bethencourt A,Vazquez N,Serruys P,

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Familial hypertrophic cardiomyopathy (HCM) is a clinically and genetically heterogeneous disease of the sarcomere. Molecular genetic studies have shown that familial HCM involves mutations in 8 different genes that encode proteins of the myofibrillar apparatus. METHODS:We thoroughly searched these genes to ...

journal_title：American heart journal

authors： Lee W,Hwang TH,Kimura A,Park SW,Satoh M,Nishi H,Harada H,Toyama J,Park JE

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND:Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is associated with an increased risk of stroke, heart failure, and death. Data on contemporary treatment patterns and outcomes associated with AF in clinical practice are limited. METHODS/DESIGN:The Outcomes Registry for Better Inf...

journal_title：American heart journal

authors： Piccini JP,Fraulo ES,Ansell JE,Fonarow GC,Gersh BJ,Go AS,Hylek EM,Kowey PR,Mahaffey KW,Thomas LE,Kong MH,Lopes RD,Mills RM,Peterson ED

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:High-sensitivity C-reactive protein (hsCRP) is promoted as an independent predictor of atherosclerotic risk. In addition, cardiorespiratory fitness is inversely related to hsCRP in single-sex cross-sectional analyses. Our objective was to determine if modulating fitness with exercise training imposes changes...

journal_title：American heart journal

authors： Huffman KM,Samsa GP,Slentz CA,Duscha BD,Johnson JL,Bales CW,Tanner CJ,Houmard JA,Kraus WE

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:The aim of this study was to compare rate of onset, magnitude, and consistency of platelet inhibition after administration of prasugrel or clopidogrel and to relate platelet inhibition to systemic exposure to each active metabolite. Thienopyridines are prodrugs, metabolized in vivo to active metabolites that...

journal_title：American heart journal

authors： Brandt JT,Payne CD,Wiviott SD,Weerakkody G,Farid NA,Small DS,Jakubowski JA,Naganuma H,Winters KJ

更新日期：2007-01-01 00:00:00

abstract：:After injecting 125I- or 131I-labeled lipoproteins, plasma was subjected to discontinuous density gradient centrifugation, which separates low-density lipoproteins (LDL) into three subfractions. Analysis of changes in apolipoprotein B-specific activity with time showed that light LDL is normally the product of interme...

journal_title：American heart journal

authors： Thompson GR,Teng B,Sniderman AD

更新日期：1987-02-01 00:00:00

abstract：:This study sought to determine whether early treatment with angiotensin-converting enzyme (ACE) inhibitors in patients with acute myocardial infarction (AMI) is useful for the improvement of fibrinolytic function, as well as left ventricular function. This study was designed to examine the levels of plasma plasminogen...

journal_title：American heart journal

authors： Oshima S,Ogawa H,Mizuno Y,Yamashita S,Noda K,Saito T,Sumida H,Suefuji H,Kaikita K,Soejima H,Yasue H

更新日期：1997-11-01 00:00:00

abstract：:Short-term follow-up after percutaneous aortic balloon valvuloplasty shows a high incidence of restenosis. Yet a high percentage of patients with restenosis continue to show symptomatic improvement. Those with decreased left ventricular function originally tend to have a recurrence of symptoms. In this study Doppler-d...

journal_title：American heart journal

authors： Barbosa MM,Nishimura RA,Holmes DR Jr,Reeder GS,Ilstrup DM,Tajik AJ

更新日期：1992-05-01 00:00:00

abstract：OBJECTIVES:We aim to review the studies comparing coronary calcification across different ethnic groups. BACKGROUND:There is still uncertainty regarding ethnic differences in the prevalence, progression, and risk of coronary artery disease. Clues to possible racial differences in rates of coronary heart disease (CHD) ...

journal_title：American heart journal

authors： Orakzai SH,Orakzai RH,Nasir K,Santos RD,Edmundowicz D,Budoff MJ,Blumenthal RS

更新日期：2006-11-01 00:00:00

abstract：:Mitral valve prolapse (MVP) is a common cardiac valve abnormality that affects women more frequently than men. We have previously shown that mild dehydration induces echocardiographic signs of MVP in approximately 50% of healthy asthenic women with previously normal cardiac findings. The present study was designed to ...

journal_title：American heart journal

authors： Aufderheide S,Lax D,Goldberg SJ

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:Concerns raised regarding adverse cardiovascular (CV) outcomes with new therapies for type 2 diabetes mellitus (T2DM) have led to several large-scale CV outcome trials. The EXAMINE trial confirmed noninferiority of the dipeptidyl dipeptidase 4 inhibitor alogliptin to placebo on major adverse cardiac event ra...

journal_title：American heart journal

authors： Shimada YJ,Cannon CP,Liu Y,Wilson C,Kupfer S,Menon V,Cushman WC,Mehta CR,Bakris GL,Zannad F,White WB,EXAMINE Investigators.

更新日期：2016-05-01 00:00:00

abstract：:Compared with pathologic studies coronary angiography is a relatively insensitive technique to detect early atherosclerosis. Coronary angioscopy is a new technique providing direct information on luminal vessel surface. To determine whether coronary angioscopy may detect the presence of atherosclerotic disease on angi...

journal_title：American heart journal

authors： Alfonso F,Goicolea J,Hernandez R,Segovia J,Silva JC,Perez-Vizcayno MJ,Rollan MJ,Bañuelos C,Macaya C

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:The incidence of end-stage renal disease (ESRD) has been consistently shown to be higher among blacks and Hispanics compared to whites with unmeasured risk factors and access to care as suggested explanations. In a high-risk cohort with frequent protocol-directed follow-up, we evaluated the influence of race...

journal_title：American heart journal

authors： Lewis EF,Claggett B,Parfrey PS,Burdmann EA,McMurray JJ,Solomon SD,Levey AS,Ivanovich P,Eckardt KU,Kewalramani R,Toto R,Pfeffer MA

更新日期：2015-08-01 00:00:00

abstract：:The single-dose pharmacokinetics of amiodarone have been studied in volunteer subjects given 400 mg doses by the intravenous and oral routes. The data show the compound to have a very large volume of distribution, a low total clearance, and a long and variable terminal elimination half-life. In patients the terminal e...

journal_title：American heart journal

authors： Holt DW,Tucker GT,Jackson PR,Storey GC

更新日期：1983-10-01 00:00:00

abstract：BACKGROUND:Exercise training is now an accepted component of the therapeutic regimen in patients with heart failure and underlying ischemia, but few data are available on the effects of training in patients with nonischemic dilated cardiomyopathy. METHODS:Twenty-four patients (mean age 55 +/- 9 years, mean ejection fr...

journal_title：American heart journal

authors： Myers J,Wagner D,Schertler T,Beer M,Luchinger R,Klein M,Rickli H,Muller P,Mayer K,Schwitter J,Dubach P

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND:The transmission of 12-lead electrocardiograms from remote locations to hand-held computers of cardiologists is now possible with the development of wireless technology and computer software. This investigation determined whether the cardiologist's decisions regarding reperfusion therapy for patients with sy...

journal_title：American heart journal

authors： Leibrandt PN,Bell SJ,Savona MR,Pettis KS,Selvester RH,Maynard C,Warner R,Wagner GS

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:Late prognosis after infective endocarditis has not been systematically studied in large series of patients with different underlying heart conditions in recent years. METHODS:We studied an inception cohort study of 420 patients discharged after treatment of endocarditis from a university tertiary care hosp...

journal_title：American heart journal

authors： Mansur AJ,Dal Bó CM,Fukushima JT,Issa VS,Grinberg M,Pomerantzeff PM

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:A strategy using coronary artery calcium (CAC) screening to refine coronary heart disease risk assessment in moderately high risk (MHR) subjects (10-year risk 10%-20%) has been suggested. The potential impact of this strategy is unknown. METHODS:Coronary artery calcium screening strategies focused on MHR su...

journal_title：American heart journal

authors： Patel MJ,de Lemos JA,McGuire DK,See R,Lindsey JB,Murphy SA,Grundy SM,Khera A

更新日期：2009-06-01 00:00:00

abstract：:We report the angiographic studies of 53 consecutive patients with angiographic coronary artery disease (CAD) and recurrent sustained ventricular tachycardia occurring at least 6 weeks remote from an acute myocardial infarction. Triple-vessel disease was present in 25 patients (47%), double-vessel disease in 19 patien...

journal_title：American heart journal

authors： Lam W,Pietras R,Bauernfeind R,Swiryn S,Strasberg B,Palileo E,Rosen KM

更新日期：1983-06-01 00:00:00

abstract：:The associations between socioeconomic status, ethnic origin, and risk factors for CHD were studied in 2,591 white and black children from two socioeconomically dissimilar populations in the New York City area. The study subjects were selected from all fourth graders in 44 elementary schools. Blood pressure, plasma li...

journal_title：American heart journal

authors： Walter HJ,Hofman A

更新日期：1987-03-01 00:00:00

abstract：:Fourteen fetuses with atrioventricular canal malformations were examined by two-dimensional echocardiography, pulsed-wave Doppler echocardiography, and color Doppler flow mapping. Eleven fetuses had complete and three fetuses had partial atrioventricular canal malformations. Nonimmune hydrops fetalis was associated wi...

journal_title：American heart journal

authors： Gembruch U,Knöpfle G,Chatterjee M,Bald R,Redel DA,Födisch HJ,Hansmann M

更新日期：1991-05-01 00:00:00

abstract：:We altered the mechanical activity of the atrial myocardium in open-chest dogs and measured changes in coronary blood flow distribution, using the radioactive microsphere technique. When left and right atrial pressures were decreased to 2 mm Hg by hypovolemia, atrial coronary blood flow fell to values nearly 50% below...

journal_title：American heart journal

authors： Neill WA,Sewell DH,Gosalia KP,Kingsley EM,Oxendine JM

更新日期：1983-09-01 00:00:00

abstract：:1. A 4-year-old boy with the congenital partial defect of the left pericardium who presented with myocardial infarction, died of incarceration of the left ventricle. 2. This is the fourth reported case of death from this anomaly in the world. 3. Because this anomaly occasionally causes sudden death, it is important to...

journal_title：American heart journal

authors： Saito R,Hotta F

更新日期：1980-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The pathogenesis of human coronary artery disease (CAD) is likely to require the transcription of many different genes. We report here the differential gene expression profiling of human CAD using copy DNA (cDNA)/nylon array hybridization techniques. METHODS AND RESULTS:Human coronary arteries...

journal_title：American heart journal

authors： Satterthwaite G,Francis SE,Suvarna K,Blakemore S,Ward C,Wallace D,Braddock M,Crossman D

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:Diabetic nephropathy is associated with increased cardiovascular events. Coronary atherosclerosis is responsible for many of these events, but other mechanisms such as impaired flow reserve may be involved. The purpose of this study was to define the prevalence and mechanism of abnormal coronary velocity res...

journal_title：American heart journal

authors： Ragosta M,Samady H,Isaacs RB,Gimple LW,Sarembock IJ,Powers ER

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:Coronary artery disease in women appears 10 to 15 years later than in men. To test the hypothesis that the effects of estrogen may manifest themselves as histologic differences in coronary plaques, we examined the hearts of premenopausal and postmenopausal women who died suddenly from coronary artery disease...

journal_title：American heart journal

authors： Burke AP,Farb A,Malcom G,Virmani R

更新日期：2001-02-01 00:00:00

abstract：:We studied 16 patients with chronic aortic insufficiency to compare a method for measuring regurgitant volume with color Doppler flow mapping to stroke count ratio determined by radionuclide ventriculography and to ventricular volumes assessed by two-dimensional echocardiography. A real-time color flow map of the left...

journal_title：American heart journal

authors： Bouchard A,Yock P,Schiller NB,Blumlein S,Botvinick EH,Greenberg B,Cheitlin M,Massie BM

更新日期：1989-05-01 00:00:00

abstract：BACKGROUND:Recent studies suggest that class III antiarrhythmic agents may have enhanced efficacy in the treatment of ventricular tachycardia. This study describes the first clinical assessment of the new class III agent ibutilide to suppress inducible monomorphic ventricular tachycardia (VT) in human beings. METHODS ...

journal_title：American heart journal

authors： Wood MA,Stambler BS,Ellenbogen KA,Gilligan DM,Perry KT,Wakefield LK,VanderLugt JT

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND:Long-term treatment with beta-blockers reduces mortality after acute myocardial infarction (AMI). Whether beta-blockers exert a class effect is unknown. METHODS:We analyzed mortality after AMI in Canadian patients 65 years or older who were discharged from hospital with a diagnosis of AMI from April 1996 to...

journal_title：American heart journal

authors： Rinfret S,Abrahamowicz M,Tu J,Humphries K,Eisenberg MJ,Richard H,Austin PC,Pilote L

更新日期：2007-02-01 00:00:00

abstract：:Besides reperfusion treatment, which is the most powerful approach to the underlying pathophysiological cause of myocardial infarction, adjunctive therapies should be considered to reduce clinical symptoms, and improve left ventricular function and mortality rates. Randomized clinical trials and overviews of adjunctiv...

journal_title：American heart journal

authors： Maggioni AP,Latini R

更新日期：1999-08-01 00:00:00