Abstract:
BACKGROUND:Diabetic nephropathy is associated with increased cardiovascular events. Coronary atherosclerosis is responsible for many of these events, but other mechanisms such as impaired flow reserve may be involved. The purpose of this study was to define the prevalence and mechanism of abnormal coronary velocity reserve (CVR) in patients with diabetes mellitus who have nephropathy and a normal coronary artery. METHODS:Patients undergoing catheterization for clinical purposes were enrolled. CVR was measured with a Doppler ultrasound scanning wire in a normal coronary in 32 patients without diabetes mellitus, 11 patients with diabetes mellitus who did not have renal failure, and 21 patients with diabetes mellitus who had nephropathy. A CVR <2.0 was considered to be abnormal. RESULTS:Patients with diabetes mellitus who had renal failure had a higher incidence of hypertension and left ventricular hypertrophy. The average peak velocity (APV) at baseline was higher in patients with diabetes mellitus who had renal failure. At peak hyperemia, APV increased in all 3 groups, with no difference between groups. The mean CVR for patients without diabetes was 2.8 +/- 0.8 and was not different from that in patients with diabetes mellitus who did not have renal failure (2.7 +/- 0.7), but was lower than that in patients with diabetes mellitus who had renal failure (1.6 +/- 0.5; P < 0.001). Abnormal CVR was observed in 9% of patients without diabetes mellitus, 18% of patients with diabetes mellitus who did not have renal failure, and 57% of patients with diabetes mellitus who had renal failure, and abnormal CVR was caused by an elevation of baseline APV in 66% of these cases. The baseline heart rate and the presence of diabetes mellitus with renal failure were independent predictors of abnormal CVR by multivariable analysis. CONCLUSIONS:Patients with diabetic nephropathy have abnormalities in CVR in the absence of angiographically evident coronary disease.
journal_name
Am Heart Jjournal_title
American heart journalauthors
Ragosta M,Samady H,Isaacs RB,Gimple LW,Sarembock IJ,Powers ERdoi
10.1016/j.ahj.2003.07.029subject
Has Abstractpub_date
2004-06-01 00:00:00pages
1017-23issue
6eissn
0002-8703issn
1097-6744pii
S0002870304000171journal_volume
147pub_type
杂志文章abstract::There is evidence that the endothelium plays an important role in the control of human vascular tone by releasing endothelium-derived nitric oxide and, therefore, a defective endothelial function could be involved in the increased peripheral vasoconstriction of patients with chronic congestive heart failure. To invest...
journal_title:American heart journal
pub_type: 杂志文章,评审
doi:10.1016/0002-8703(93)90926-z
更新日期:1993-09-01 00:00:00
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journal_title:American heart journal
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journal_title:American heart journal
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journal_title:American heart journal
pub_type: 杂志文章,meta分析,评审
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abstract:BACKGROUND:The optimal hydration strategy for prevention of contrast-induced acute kidney injury (AKI) remains unknown. The purpose of this meta-analysis is to compare the effectiveness of normal saline (NS) versus sodium bicarbonate hydration (NaHCO(3)) for prevention of contrast-induced AKI. METHODS:We performed a m...
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pub_type: 杂志文章,meta分析
doi:10.1016/j.ahj.2008.05.014
更新日期:2008-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0002-8703(78)90471-4
更新日期:1978-02-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章
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更新日期:2004-07-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章
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journal_title:American heart journal
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journal_title:American heart journal
pub_type: 杂志文章,评审
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更新日期:1989-09-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章
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journal_title:American heart journal
pub_type: 杂志文章,评审
doi:10.1016/0002-8703(94)90132-5
更新日期:1994-02-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(80)90228-8
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更新日期:2016-10-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:American heart journal
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ahj.2019.04.003
更新日期:2019-07-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章
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更新日期:2006-11-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2006-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0002-8703(96)90462-7
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1987-05-01 00:00:00
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doi:10.1067/mhj.2002.123841
更新日期:2002-08-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2011-07-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章,评审
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更新日期:1992-05-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(89)90415-8
更新日期:1989-06-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2016-07-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(80)90654-7
更新日期:1980-10-01 00:00:00
abstract:BACKGROUND:Multidisciplinary disease management programs (MDMP) have demonstrated reduced hospitalizations in motivated pretransplant heart failure populations, but little is known about their effectiveness in largely indigent patients who are not transplant candidates. METHODS AND RESULTS:We studied 35 patients with ...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1067/mhj.2001.111956
更新日期:2001-02-01 00:00:00