Abstract:
:Continuous arterial spin labeling (CASL) was used to obtain an index of cerebral blood flow (ICBF) in the normal mouse brain and in an orthotopic mouse model of human U87 high-grade glioma at 8.5 T. Under the assumption of a constant tissue:blood partition coefficient for water in different tissues, the mean ICBF (n = 14) was found to be 50 +/- 9 mL/100g/min for tumor core and 209 +/- 11 mL/100g/min for normal tissue. The apparent T(1) (T(1app)) was 2.01 +/- 0.06 sec for tumor core and 1.66 +/- 0.03 sec for normal tissue. The ICBF and the T(1app) values were significantly different (P < 0.001) between these two regions. The detailed changes of ICBF and T(1app) in the transition from the tumor core through the tumor periphery to surrounding tissue were studied. Immunohistochemistry indicated that tumor vascularity was not uniform, with microvessel density highest in normal brain and the tissue surrounding the tumor and lowest in the tumor core. The large difference in ICBF between the tumor core and normal tissue suggests that this index might be useful for the assessment of the efficacy of antiangiogenic therapy.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Sun Y,Schmidt NO,Schmidt K,Doshi S,Rubin JB,Mulkern RV,Carroll R,Ziu M,Erkmen K,Poussaint TY,Black P,Albert M,Burstein D,Kieran MWdoi
10.1002/mrm.20029subject
Has Abstractpub_date
2004-05-01 00:00:00pages
893-9issue
5eissn
0740-3194issn
1522-2594journal_volume
51pub_type
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