Abstract:
:Levo-tetrahydropalmatine (l-THP) has shown significant promise in preclinical and clinical studies to treat drug addiction. Pharmacological MRI methods can elucidate the regional cerebral effects of l-THP, but there are potential confounds from the use of general anesthesia. To investigate the possible anesthetic-drug interactions for the pharmacological MRI result of acute l-THP, we examined acute blood oxygen level-dependent responses of both 5 and 20 mg/kg l-THP in naïve rats during general anesthesia achieved with three agents: isoflurane, medetomidine, and urethane. We found that with acute l-THP administration, isoflurane revealed the smallest blood oxygen level-dependent activation areas. In addition, urethane had the most activation areas; however, they were all negative. Medetomidine showed mixed positive and negative activations. Region-specific interactions were found between the l-THP-induced blood oxygen level-dependent responses and the anesthetic agents.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Liu X,Li R,Yang Z,Hudetz AG,Li SJdoi
10.1002/mrm.23243subject
Has Abstractpub_date
2012-08-01 00:00:00pages
552-9issue
2eissn
0740-3194issn
1522-2594journal_volume
68pub_type
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