Abstract:
:The customization of brachytherapy dose distributions for gynecologic malignancies is limited by the spatial positioning of the applicators. We tested the hypothesis that applicator-guided intensity modulated radiation therapy (AGIMRT) has the potential to deliver highly conformal dose distributions to cervical tumors, representing improvement over distributions obtained with intracavitary brachytherapy. A commercial three-dimensional (3-D) treatment planning system was used to create plans for ten cervical cancer patients treated at our institution. Dose distributions of conventionally designed high dose rate (HDR) plans were compared against those of AGIMRT. Tumor delineation was based on a previously published binary threshold technique, using image intensity on positron emission tomography (PET) scans. AGIMRT treatment schedules were designed using two fraction sizes: 6.5 Gy, to directly reproduce the HDR fractionation, and 1.8 Gy, to simulate traditional external beam fractionation. The average minimum tumor dose was significantly greater for the AGIMRT dose distributions than for the HDR distributions (64.2 Gy vs 33.6 Gy; p = 0.005). The mean percent tumor volume at the prescription dose was higher for the AGIMRT plans (90.0% vs 58.2%; p = 0.005). Using AGIMRT, the mean percent volume at the tolerance limit was decreased for the bladder (6.1% vs 16.6%; p = 0.047) but increased for the rectum (4.1% vs 2.2%; p = 0.646). Our study suggests that there may be conceptual and dosimetric advantages to replacing HDR with AGIMRT for patients with large-volume cervical tumors. This investigation is being expanded using sequential PET images to model tumor regression and compare brachytherapy and AGIMRT throughout the course of therapy.
journal_name
Med Physjournal_title
Medical physicsauthors
Wahab SH,Malyapa RS,Mutic S,Grigsby PW,Deasy JO,Miller TR,Zoberi I,Low DAdoi
10.1118/1.1645678subject
Has Abstractpub_date
2004-04-01 00:00:00pages
734-43issue
4eissn
0094-2405issn
2473-4209journal_volume
31pub_type
临床试验,杂志文章相关文献
MEDICAL PHYSICS文献大全abstract::In order to use negative pions for the treatment of large deep-seated tumors in radiotherapy, it is necessary to produce depth-dose distributions tailored to specific shapes. We present here a method of beam shaping which utilizes a fluid-filled piston having a programmable, computer-controlled, time-dependent thickne...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.594313
更新日期:1977-09-01 00:00:00
abstract:PURPOSE:In cardiac ablation therapy, accurate anatomic guidance is necessary to create effective tissue lesions for elimination of left atrial fibrillation. While fluoroscopy, ultrasound, and electroanatomic maps are important guidance tools, they lack information regarding detailed patient anatomy which can be obtaine...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4861712
更新日期:2014-02-01 00:00:00
abstract:PURPOSE:This work concerns computed tomography (CT)-based cardiac functional analysis (CFA) with a reduced radiation dose. As CT-CFA requires images over the entire heartbeat, the scans are often performed at 10-20% of the tube current settings that are typically used for coronary CT angiography. A large image noise th...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1002/mp.12425
更新日期:2017-09-01 00:00:00
abstract::Accurate segmentation of microcalcifications in mammography is crucial for the quantification of morphologic properties by features incorporated in computer-aided diagnosis schemes. A novel segmentation method is proposed implementing active rays (polar-transformed active contours) on B-spline wavelet representation t...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.2991286
更新日期:2008-11-01 00:00:00
abstract::Effective radioimmunotherapy may depend on a priori knowledge of the radiation absorbed dose distribution obtained by trace imaging activities administered to a patient before treatment. A new, fast, and effective treatment planning approach is developed to deal with a heterogeneous activity distribution. Calculation ...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.598422
更新日期:1998-11-01 00:00:00
abstract:PURPOSE:The collimator monitoring fill factor (CM-FF) introduced by Stelljes et al. (2017) and the FWHM fill factor (FWHM-FF) introduced by Gago-Arias et al. (2012) were determined using the measured photon fluence response functions of various 2D-arrays. The error detection capabilities of 2D-arrays were studied by co...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1002/mp.13417
更新日期:2019-04-01 00:00:00
abstract:PURPOSE:To quantitatively characterize the interfractional anatomic variations in post-operative radiation therapy (RT) for prostate bed, so that appropriate strategy that can fully address these variations can be developed. METHODS:A total of 102 daily pre-treatment CT acquired using an in-room CT (CTVision, Siemens)...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4734844
更新日期:2012-06-01 00:00:00
abstract:PURPOSE:The aim of this study was to assess the suitability of Gafchromic EBT3 films for reference dose measurements in the beam of a prototype high dose-per-pulse linear accelerator (linac), capable of delivering electron beams with a mean dose-rate (Ḋm ) ranging from 0.07 to 3000 Gy/s and a dose-rate in pulse (Ḋp ) o...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1002/mp.12066
更新日期:2017-02-01 00:00:00
abstract::The optimum x-ray spectra for acquisition of digital mammographic images using an amorphous selenium (a-Se) photoconductor are investigated. The recorded images consist of latent charge distributions on the surface of an a-Se plate, which are then read out using two methods, laser discharge, or flat panel recharge. Th...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.597688
更新日期:1996-04-01 00:00:00
abstract:PURPOSE:Couch and MLC tracking are two promising methods for real-time motion compensation during radiation therapy. So far, couch and MLC tracking experiments have mainly been performed by different research groups, and no direct comparison of couch and MLC tracking of volumetric modulated arc therapy (VMAT) plans has...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4946815
更新日期:2016-05-01 00:00:00
abstract:PURPOSE:Tumor motion during radiotherapy can cause a reduction in target dose coverage and an increase in healthy tissue exposure. Tumor motion is not strictly translational and often exhibits complex six degree-of-freedom (6DoF) translational and rotational motion. Although the dosimetric impact of prostate tumor tran...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1002/mp.14502
更新日期:2020-12-01 00:00:00
abstract:PURPOSE:Respiratory motion in the chest region during single photon emission computed tomography (SPECT) is a major degrading factor that reduces the accuracy of image quantification. This effect is more notable when the tumor is very small, or the spatial resolution of the imaging system is less than the respiratory m...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1002/mp.13807
更新日期:2019-11-01 00:00:00
abstract:PURPOSE:There is evidence that computed tomography (CT) and positron emission tomography (PET) imaging metrics are prognostic and predictive in nonsmall cell lung cancer (NSCLC) treatment outcomes. However, few studies have explored the use of standardized uptake value (SUV)-based image features of nodal regions as pre...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4926755
更新日期:2015-08-01 00:00:00
abstract::A method for the in vivo determination of the isocenter dose, Diso, and mid-plane dose, Dm, using the transmitted signal St measured by 25 central pixels of an aSi-based EPID is here reported. The method has been applied to check the conformal radiotherapy of pelvic tumors and supplies accurate in vivo dosimetry avoid...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.2360014
更新日期:2006-11-01 00:00:00
abstract:PURPOSE:Currently applied calibration approaches lead to satisfying 3D roadmapping overlay and 3D reconstruction accuracies; however, the required calibration times are extensive. The aim of this paper is the introduction of a novel model-based approach for geometric system calibrations, leading to a significant reduct...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4931964
更新日期:2015-11-01 00:00:00
abstract:UNLABELLED:The following question is investigated: How narrow do the leaves of a multileaf collimator have to be such that further reduction of the leaf width does not lead to physical improvements of the dose distribution. Because of the physical principles of interaction between radiation and matter, dose distributio...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.1319524
更新日期:2000-11-01 00:00:00
abstract::Volumetric modulated arc therapy (VMAT) has recently been used to improve the dose distribution and efficiency of treatment delivery over the standard intensity-modulated radiotherapy (IMRT) technique. This study compares the dosimetry between RapidArc plan and standard IMRT plan for head and neck cancer. Three head a...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4740174
更新日期:2012-07-01 00:00:00
abstract:PURPOSE:Two diodes which do not require correction factors for small field relative output measurements are designed and validated using experimental methodology. This was achieved by adding an air layer above the active volume of the diode detectors, which canceled out the increase in response of the diodes in small f...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4894728
更新日期:2014-10-01 00:00:00
abstract::Performance characteristics sufficient to provide physical data base specific to the Siemen's Stabilipan 2 orthovoltage x-ray therapy machine are presented. Operating conditions covering the working range of the unit from 100 to 300 kVp are selected. Beam quality, output, the central axis depth dose, relative output f...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.596016
更新日期:1987-09-01 00:00:00
abstract::A cumulative dose histogram is the graph of an integral function integrated over a domain VCR3 and is dubbed the dose-volume histogram (DVH), the dose-surface histogram (DSH) or the dose-wall histogram (DWH), depending on the dimension and structure of the region V. This paper presents a comparative study of the three...
journal_title:Medical physics
pub_type: 临床试验,杂志文章
doi:10.1118/1.1852811
更新日期:2005-02-01 00:00:00
abstract::Computer-aided diagnosis (CAD) has been a major field of research for the past few decades. CAD uses machine learning methods to analyze imaging and/or nonimaging patient data and makes assessment of the patient's condition, which can then be used to assist clinicians in their decision-making process. The recent succe...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1002/mp.13764
更新日期:2020-06-01 00:00:00
abstract:PURPOSE:Concurrent irradiation of the prostate and pelvic lymph nodes is technically challenging due to treating one moving target and one immobile target. The purposes of this article are to propose a new management strategy and to compare this strategy to the conventional isocenter shift method and the previously pro...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.3480505
更新日期:2010-09-01 00:00:00
abstract:PURPOSE:To develop a computer-driven and thus less user-dependent method, allowing for a simple and straightforward generation of a Monte Carlo (MC) beam model of a scanned proton and carbon ion beam delivery system. METHODS:In a first step, experimental measurements were performed for proton and carbon ion energies i...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1002/mp.14647
更新日期:2020-12-07 00:00:00
abstract::When an (exposure) calibrated ionization chamber is used for the determination of absorbed dose from a photon beam, the reading of the instrument must be multiplied by a number of factors, one of which is an attenuation correction for phantom material displaced by the chamber. the magnitude of this correction must dep...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.594817
更新日期:1980-11-01 00:00:00
abstract:PURPOSE:This study developed and validated a Motion Artifact Quantification algorithm to automatically quantify the severity of motion artifacts on coronary computed tomography angiography (CCTA) images. The algorithm was then used to develop a Motion IQ Decision method to automatically identify whether a CCTA dataset ...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1002/mp.13243
更新日期:2018-12-01 00:00:00
abstract:PURPOSE:This work describes the performance characterization of a cone-beam CT-guided radiosurgery device, the Gamma Knife® Icon™. METHODS:The performance tests have been categorized into: (a) image quality and mechanical integrity; (b) image coregistration fidelity; (c) adaptive treatment delivery quality; (d) high d...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1002/mp.13073
更新日期:2018-06-29 00:00:00
abstract:PURPOSE:Normal patient databases (NPDs) are used to distinguish between normal and abnormal perfusion in SPECT myocardial perfusion imaging (MPI) and have gained wide acceptance in the clinical environment, yet there are limitations to this approach. This study introduces a template-based method for semi-quantitative M...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.3595112
更新日期:2011-07-01 00:00:00
abstract::In this study, we present an algorithm for three-dimensional (3-D) dose reconstruction using portal images obtained with an electronic portal imaging device (EPID). For this purpose an algorithm for 2-D dose reconstruction, which was previously developed in our institution, was adapted. The external contour of the pat...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.1589496
更新日期:2003-09-01 00:00:00
abstract::A contrast-detail (CD) experiment was performed to study the effect of lossy compression on computed radiographic (CR) images. Digital CR images of a phantom were compressed by quantizing the full-frame discrete cosine transform and Huffman encoding the result. Since low-contrast detectability is directly linked to an...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.597489
更新日期:1995-06-01 00:00:00
abstract::Extensive information has been made available relative to the physical aspects necessary for calculation of radiation absorbed dose from radiopharmaceuticals. A similar data base for the biological factors involved in these calculations has not been documented as thoroughly. The authors present an extensive literature...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.594679
更新日期:1980-05-01 00:00:00