A template-based approach to semi-quantitative SPECT myocardial perfusion imaging: Independent of normal databases.

Abstract:

PURPOSE:Normal patient databases (NPDs) are used to distinguish between normal and abnormal perfusion in SPECT myocardial perfusion imaging (MPI) and have gained wide acceptance in the clinical environment, yet there are limitations to this approach. This study introduces a template-based method for semi-quantitative MPI, which attempts to overcome some of the NPD limitations. METHODS:Our approach involves the construction of a 3D digital healthy heart template from the delineation of the patient's left ventricle in the SPECT image. This patient-specific template of the heart, filled with uniform activity, is then analytically projected and reconstructed using the same algorithm as the original image. Subsequent to generating bulls-eye maps for the patient image (PB) and the template image (TB), a ratio (PB/TB) is calculated, which produces a reconstruction-artifact corrected image (CB). Finally, a threshold is used to define defects within CB enabling measurements of the perfusion defect extent (EXT). The SPECT-based template (Ts) measurements were compared to those of a CT-based "ideal" template (TI). Twenty digital phantoms were simulated: male and female, each with one healthy heart and nine hearts with various defects. Four physical phantom studies were performed modeling a healthy heart and three hearts with different defects. The phantom represented a thorax with spine, lung, and left ventricle inserts. Images were acquired on General Electric's (GE) Infinia Hawkeye SPECT/CT camera using standard clinical MPI protocol. Finally, our method was applied to 14 patient MPI rest/stress studies acquired on the GE Infinia Hawkeye SPECT/CT camera and compared to the results obtained from Cedars-Sinai's QPS software. RESULT:In the simulation studies, the true EXT correlated well with the TI (slope= 1.08; offset = -0.40%; r = 0.99) and Ts (slope = 0.90; offset = 0.27%; r = 0.99) methods with no significant differences between them. Similarly, strong correlations were measured for EXT obtained from QPS and the template method for patient studies (slope =0.91; offset = 0.45%; r = 0.98). Mean errors in extent for the Ts method using simulation, physical phantom, and patient data were 2.7% +/- 2.4%, 0.9% +/- 0.5%, 2.0% +/- 2.7%, respectively. CONCLUSIONS:The authors introduced a method for semi-quantitative SPECT MPI, which offers a patient-specific approach to define the perfusion defect regions within the heart, as opposed to the patient-averaged NPD methodology.

journal_name

Med Phys

journal_title

Medical physics

authors

Hughes T,Shcherbinin S,Celler A

doi

10.1118/1.3595112

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

4186-95

issue

7

eissn

0094-2405

issn

2473-4209

journal_volume

38

pub_type

杂志文章
  • Performance characteristics of an orthovoltage x-ray therapy machine.

    abstract::Performance characteristics sufficient to provide physical data base specific to the Siemen's Stabilipan 2 orthovoltage x-ray therapy machine are presented. Operating conditions covering the working range of the unit from 100 to 300 kVp are selected. Beam quality, output, the central axis depth dose, relative output f...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.596016

    authors: Niroomand-Rad A,Gillin MT,Lopez F,Grimm DF

    更新日期:1987-09-01 00:00:00

  • Reverse mapping of normal tissue complication probabilities onto dose volume histogram space: the problem of randomness of the dose volume histogram sampling.

    abstract::A very important issue in contemporary inverse treatment radiotherapy planning is the specification of proper dose-volume constraints limiting the treatment planning algorithm from delivering high doses to the normal tissue surrounding the tumor. Recently we have proposed a method called reverse mapping of normal tiss...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.2198307

    authors: Markov K,Schinkel C,Stavreva N,Stavrev P,Weldon M,Fallone BG

    更新日期:2006-09-01 00:00:00

  • A general algorithm for calculation of recombination losses in ionization chambers exposed to ion beams.

    abstract:PURPOSE:Dosimetry with ionization chambers in clinical ion beams for radiation therapy requires correction for recombination effects. However, common radiation protocols discriminate between initial and general recombination and provide no universal correction method for the presence of both recombination types in ion ...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4962483

    authors: Christensen JB,Tölli H,Bassler N

    更新日期:2016-10-01 00:00:00

  • SU-D-211-06: The Effect of Motion in RapidArc Lung SBRT Delivery.

    abstract:PURPOSE:RapidArc is routinely used for stereotactic radiotherapy for lung cancer. While treatment dose is optimized and calculated on a static CT image, the motion of the target in conjunction with the motion of the MLC may Result in a delivered dose deviating from the planed dose. In this study, we investigate the dos...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4734660

    authors: Zou J,Yin L,Shen J,Corradetti M,Kirk M,Rengan R,Teo BK

    更新日期:2012-06-01 00:00:00

  • Anatomical pulmonary magnetic resonance imaging segmentation for regional structure-function measurements of asthma.

    abstract:PURPOSE:Pulmonary magnetic-resonance-imaging (MRI) and x-ray computed-tomography have provided strong evidence of spatially and temporally persistent lung structure-function abnormalities in asthmatics. This has generated a shift in their understanding of lung disease and supports the use of imaging biomarkers as inter...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4948999

    authors: Guo F,Svenningsen S,Eddy RL,Capaldi DPI,Sheikh K,Fenster A,Parraga G

    更新日期:2016-06-01 00:00:00

  • Use of simulated annealing for optimization of alignment parameters in limited MRI acquisition volumes of the brain.

    abstract::Studies suggest that clinical outcomes are improved in repeat trigeminal neuralgia (TN) Gamma Knife radiosurgery if a different part of the nerve from the previous radiosurgery is treated. The MR images taken in the first and repeat radiosurgery need to be coregistered to map the first radiosurgery volume onto the sec...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.1944287

    authors: Li X,Zhang P,Brisman R,Kutcher G

    更新日期:2005-07-01 00:00:00

  • Investigation of the use of MOSFET for clinical IMRT dosimetric verification.

    abstract::(Received 22 October 2001; accepted for publication 26 March 2002; published 22 May 2002) With advanced conformal radiotherapy using intensity modulated beams, it is important to have radiation dose verification measurements prior to treatment. Metal oxide semiconductor field effect transistors (MOSFET) have the advan...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.1481520

    authors: Chuang CF,Verhey LJ,Xia P

    更新日期:2002-06-01 00:00:00

  • Investigations of interference between electromagnetic transponders and wireless MOSFET dosimeters: a phantom study.

    abstract:PURPOSE:To evaluate both the Calypso Systems' (Calypso Medical Technologies, Inc., Seattle, WA) localization accuracy in the presence of wireless metal-oxide-semiconductor field-effect transistor (MOSFET) dosimeters of dose verification system (DVS, Sicel Technologies, Inc., Morrisville, NC) and the dosimeters' reading...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.3578602

    authors: Su Z,Zhang L,Ramakrishnan V,Hagan M,Anscher M

    更新日期:2011-05-01 00:00:00

  • Liquid ionization chambers for absorbed dose measurements in water at low dose rates and intermediate photon energies.

    abstract::Two new liquid ionization chamber (LIC) designs, consisting of cylindrical and plane-parallel configurations, are presented. They are designed to be suitable for high-precision measurements of absorbed dose-to-water at dose rates and photon energies typical for LDR intermediate photon energy brachytherapy sources. The...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.598268

    authors: Wickman G,Johansson B,Bahar-Gogani J,Holmström T,Grindborg JE

    更新日期:1998-06-01 00:00:00

  • Evaluation of three types of reference image data for external beam radiotherapy target localization using digital tomosynthesis (DTS).

    abstract::Digital tomosynthesis (DTS) is a fast, low-dose three-dimensional (3D) imaging approach which yields slice images with excellent in-plane resolution, though low plane-to-plane resolution. A stack of DTS slices can be reconstructed from a single limited-angle scan, with typical scan angles ranging from 10 degrees to 40...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.2756941

    authors: Godfrey DJ,Ren L,Yan H,Wu Q,Yoo S,Oldham M,Yin FF

    更新日期:2007-08-01 00:00:00

  • Characterization of fragmented heavy-ion beams using a three-stage telescope detector: measurements of 670-MeV/amu 20Ne beams.

    abstract::Measurements of a 670-MeV/amu 20Ne beam at the Lawrence Berkeley Laboratory Bevalac heavy-ion accelerator with various thicknesses of water absorber were obtained with the BERKLET. The BERKLET, a simple three-stage solid-state telescope detector, has been described previously. This instrument measures the linear energ...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.596536

    authors: Llacer J,Schmidt JB,Tobias CA

    更新日期:1990-03-01 00:00:00

  • Transverse axial film tomography with a therapy simulator.

    abstract::A tomographic attachment was designed and developed that attaches to our existing simulator. The film tomograms obtained with the aid of this device exhibit very low geometrical distortion and good contrast and resolution for the objects used in this investigation. In addition, our results to date show that adjacent a...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.594662

    authors: Kessaris ND,Harisiadis L

    更新日期:1980-03-01 00:00:00

  • A survey of the information gained from planning treatment with a computer.

    abstract::We designed a questionnaire to be filled out by the physicist at the time of planning treatment with the aid of a computer in order to assess what was learned during the course of the planning session. We analyzed the results to gauge the impact of the 70 treatment planning sessions conducted during the one month peri...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.596302

    authors: Doppke KP,Goitein M

    更新日期:1988-03-01 00:00:00

  • SU-E-T-283: Carbon Ion Therapy Innovations in Dosimetry and Dose Delivery.

    abstract:OBJECTIVE:Carbon ion particle therapy delivers sharp Bragg's peaks, and hence can produce dose delivery of very high precision and conformality. To complement this characteristic, particle therapy centers implement a number of technologies unique to these centers, and are not commonly known to the medical physics commu...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4735351

    authors: Cernica G,Mun S

    更新日期:2012-06-01 00:00:00

  • Optimized knot placement for B-splines in deformable image registration.

    abstract:PURPOSE:To develop an automatic knot placement algorithm to enable the use of NonUniform Rational B-Splines (NURBS) in deformable image registration. METHODS:The authors developed a two-step approach to fit a known displacement vector field (DVF). An initial fit was made with uniform knot spacing. The error generated ...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.3609416

    authors: Jacobson TJ,Murphy MJ

    更新日期:2011-08-01 00:00:00

  • Experimental investigation on the accuracy of plastic scintillators and of the spectrum discrimination method in small photon fields.

    abstract:PURPOSE:To investigate the accuracy of output factor measurements using a commercial (Exradin W1, SI) and a prototype, "in-house" developed, plastic scintillation dosimeter (PSD) in small photon fields. METHODS:Repetitive detector-specific output factor OFdet measurements were performed in water (parallel to the CAX) ...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1002/mp.12064

    authors: Papaconstadopoulos P,Archambault L,Seuntjens J

    更新日期:2017-02-01 00:00:00

  • Innovative methodology for intercomparison of radionuclide calibrators using short half-life in situ prepared radioactive sources.

    abstract:PURPOSE:An original radionuclide calibrator method for activity determination is presented. The method could be used for intercomparison surveys for short half-life radioactive sources used in Nuclear Medicine, such as(99m)Tc or most positron emission tomography radiopharmaceuticals. METHODS:By evaluation of the resul...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4884035

    authors: Oliveira PA,Santos JA

    更新日期:2014-07-01 00:00:00

  • A localization algorithm and error analysis for stereo x-ray image guidance.

    abstract::Stereo x-ray radiography attracts increasing attention in major clinical applications. The purpose of this paper is to analyze the 3D localization error for breast biopsy procedures and provide guidelines for improving its accuracy. Our prototype is a CCD based digital stereo x-ray imaging system. The mathematical mod...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.598953

    authors: Jiang H,Liu H,Wang G,Chen W,Fajardo LL

    更新日期:2000-05-01 00:00:00

  • Resolution modeling in PET imaging: theory, practice, benefits, and pitfalls.

    abstract::In this paper, the authors review the field of resolution modeling in positron emission tomography (PET) image reconstruction, also referred to as point-spread-function modeling. The review includes theoretical analysis of the resolution modeling framework as well as an overview of various approaches in the literature...

    journal_title:Medical physics

    pub_type: 杂志文章,评审

    doi:10.1118/1.4800806

    authors: Rahmim A,Qi J,Sossi V

    更新日期:2013-06-01 00:00:00

  • Impact of calibration methods for color medical displays on interpreting brain SPECT images.

    abstract:PURPOSE:Color images are visualized on medical monitors that are adjusted by a grayscale standard display function (GSDF) or γ2.2. Although the GSDF is visually displayed as a linear graded grayscale, it does not specify how color medical images should be presented. On the other hand, the usual gamma setting for color ...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1002/mp.13532

    authors: Shibutani T,Onoguchi M,Yoneyama H,Nakajima K,Matsuo S,Bamba Y,Saito S

    更新日期:2019-06-01 00:00:00

  • Objective performance characteristics of a new asymmetric screen-film system.

    abstract::A study of the objective imaging characteristics of a new asymmetric screen-film system is presented herein. The system is characterized by high x-ray absorption asymmetric screens, and a low-noise, high-contrast asymmetric film having near-zero crossover. Comparisons are made with the imaging characteristics of two w...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.597407

    authors: Van Metter R,Dickerson R

    更新日期:1994-09-01 00:00:00

  • Anthropomorphic 1H MRS head phantom.

    abstract::An anthropomorphic 1H MRS head phantom has been developed which mimics the in vivo structure, metabolite concentrations, and relaxation times (for both water and metabolites) of human brain tissue. Different brain regions and two tumor types, fluid-containing ventricles, and air-filled sinus, and subcutaneous fat are ...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.598306

    authors: Rice JR,Milbrandt RH,Madsen EL,Frank GR,Boote EJ,Blechinger JC

    更新日期:1998-07-01 00:00:00

  • SU-E-T-162: Rapid Assessment of Cyberknife IRIS Variable Collimator Performance Using a Commercial Diode Array.

    abstract:PURPOSE:To describe an efficient method for verifying the size and centering of the radiation field from the Cyberknife IRIS variable collimator with sub-millimeter accuracy using a general purpose commercially available diode array. METHODS:We present a technique using a conventional diode array (Sun Nuclear Profiler...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4735220

    authors: Gibbs G,White G,Bulz G

    更新日期:2012-06-01 00:00:00

  • Depth dose characteristics of 24-MV x-ray beams at extended SSD.

    abstract::Depth dose characteristics of 24-MV beams from a medical linear accelerator at various SSDs have been measured. The dose buildup, percent depth dose (PDD), and output were measured using ionization chambers and a diode detector under full scatter. Surface dose ranged from 8% to 51% depending upon the collimator settin...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.596673

    authors: Jani SK,Pennington EC

    更新日期:1991-03-01 00:00:00

  • An investigation of a new amorphous silicon electronic portal imaging device for transit dosimetry.

    abstract::The relationship between the pixel value and exit dose was investigated for a new commercially available amorphous silicon electronic portal imaging device. The pixel to dose mapping function was established to be linear for detector distances between 116.5 cm to 150 cm from the source, radiation field sizes from 5 x ...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.1508108

    authors: Grein EE,Lee R,Luchka K

    更新日期:2002-10-01 00:00:00

  • Calculation of photon dose distributions in an inhomogeneous medium using convolutions.

    abstract::A formulation of the single energy photon transport problem is cast in the form of a series of convolutions over the primary fluence distribution with invariant kernels. A method is developed for compensating for the variant intervoxel attenuation in the scattered dose distribution by means of an invariant correction ...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.595964

    authors: Boyer AL,Mok EC

    更新日期:1986-07-01 00:00:00

  • Effect of Contrast Agent Administration on Water Equivalent Diameter in CT.

    abstract:PURPOSE:Water equivalent diameter (WED) is the preferred surrogate for patient size in CT. It is better than geometric size surrogates and patient weight/height/BMI/age because it correlates the best with x-ray attenuation. The administration of oral/IV contrast agents increases a patient's attenuation and should there...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1002/mp.14721

    authors: Viggiano B,Rose S,Szczykutowicz TP

    更新日期:2021-01-13 00:00:00

  • Comments on "Sampling techniques for the evaluation of treatment plans" [Med. Phys. 20, 151-161 (1993)].

    abstract::We believe that, for the purpose of evaluation and optimization of treatment plans, quasirandom sampling is superior to grid sampling and should be the method of choice. We believe it to be on average more efficient than grid sampling (i.e., more accurate for any given number of dose estimates) and, even more importan...

    journal_title:Medical physics

    pub_type: 评论,信件

    doi:10.1118/1.597103

    authors: Niemierko A,Goitein M

    更新日期:1993-09-01 00:00:00

  • An experimental palladium-103 seed (OptiSeedexp) in a biocompatible polymer without a gold marker: characterization of dosimetric parameters including the interseed effect.

    abstract::Permanent implantation of 125I (iodine) or 103Pd (palladium) sources is a popular treatment option in the management of early stage prostate cancer. New sources are being developed, some of which are being marketed for different clinical applications. A new technique of adjuvant stereotactic permanent seed breast impl...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.3006151

    authors: Abboud F,Scalliet P,Vynckier S

    更新日期:2008-12-01 00:00:00

  • Objective characterization of GE discovery CT750 HD scanner: gemstone spectral imaging mode.

    abstract:PURPOSE:To objectively characterize the performance of the gemstone spectral imaging (GSI) mode of GE CT750 HD scanner from a user's perspective. METHODS:A regular scan protocol that approximates the adult abdomen scan protocol frequently used in the authors' institute was selected as the baseline, and a GSI protocol ...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.3551999

    authors: Zhang D,Li X,Liu B

    更新日期:2011-03-01 00:00:00