Abstract:
:The concept of placebo has evolved over time. Generally believed to be the basis of the premodern pharmacopoeia, the placebo has been adopted in practice as a harmless but unscientific approach towards alleviating symptoms. Currently, many medical scientists view placebos pejoratively as confounding elements in the analysis of randomized control trials.This article examines the changing attitudes towards placebos and the persistent controversies that surround their administration. The possible role of the placebo response as a functional salutogenic brain mechanism is considered, and elements of Edelman's neurobiological model of self and attractor theory are combined to explain how a unitary response by the central nervous system might yield diverse placebo effects. It is concluded that placebo responses are rooted in the complexity of mind/body interactions and that their underlying physiological mechanisms may be elucidated via methods that directly examine brain activity as the basis of subjective experience.
journal_name
Perspect Biol Medjournal_title
Perspectives in biology and medicineauthors
Kradin RLdoi
10.1353/pbm.2004.0053subject
Has Abstractpub_date
2004-07-01 00:00:00pages
328-38issue
3eissn
0031-5982issn
1529-8795pii
S1529879504303285journal_volume
47pub_type
杂志文章abstract::After almost 50 years in science, I believe that there is an acceptable, often advantageous chasm between open-ended basic research-free exploration without a practical destination and in which the original ideas may fade into new concepts-and translational research or clinical research. My basic research on crystalli...
journal_title:Perspectives in biology and medicine
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journal_title:Perspectives in biology and medicine
pub_type: 传,历史文章,杂志文章
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journal_title:Perspectives in biology and medicine
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journal_title:Perspectives in biology and medicine
pub_type: 传,历史文章,杂志文章
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journal_title:Perspectives in biology and medicine
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journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2013.0039
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journal_title:Perspectives in biology and medicine
pub_type: 传,历史文章,杂志文章
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journal_title:Perspectives in biology and medicine
pub_type: 杂志文章,评审
doi:
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journal_title:Perspectives in biology and medicine
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更新日期:2002-07-01 00:00:00
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journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
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journal_title:Perspectives in biology and medicine
pub_type: 历史文章,杂志文章
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journal_title:Perspectives in biology and medicine
pub_type: 历史文章,杂志文章
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journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2011.0022
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journal_title:Perspectives in biology and medicine
pub_type: 传,历史文章,杂志文章
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更新日期:2004-04-01 00:00:00