Abstract:
INTRODUCTION:Chronic hepatitis C-therapy is limited to the combined use of PEG-ylated interferons and ribavirin. Side effects of this therapy include retinal changes that manifest with bleeding, cotton wool spots and/or thrombosis. PATIENT:A 51-year-old man presented with a sudden decrease of visual acuity. Chronic hepatitis C was known for the duration of 6 months and treated for 3 months with a combined therapy of PEG-interferon alpha2B and ribavirin. A sudden visual loss occurred in the right eye and bilateral visual field defects were detected. Ophthalmoscopic examination revealed bilateral papilloedema. After withdrawal of PEG-interferon alpha2B and ribavirin, a standard haemodilution therapy was started without functional improvement. After papilloedema regression, a beginning secondary atrophy of the optic nerve was diagnosed bilaterally. Vision did not improve. CONCLUSION:The ocular side effects of combined hepatitis C therapy with PEG-interferon alpha2B and ribavirin range from mild retinal changes to severely impaired vision. Treatment should be carried out in co-operation with an ophthalmologist. With respect to the uncertain effectiveness of hepatitis C therapy with interferon alpha2B and ribavirin, therapy should be stopped as soon as severe ophthalmological complications occur.
journal_name
Klin Monbl Augenheilkdjournal_title
Klinische Monatsblatter fur Augenheilkundeauthors
Kirchhoff A,Kirchhoff U,Lafrenz M,Guthoff Rdoi
10.1055/s-2004-813607subject
Has Abstractpub_date
2004-09-01 00:00:00pages
791-3issue
9eissn
0023-2165issn
1439-3999journal_volume
221pub_type
杂志文章abstract::The survival rate was calculated using the life table method in 1,501 patients suffering from choroidal melanomas and treated in 10 eye hospitals in the GDR between 1960 and 1979. The results of treatment by (1) enucleation, (2) enucleation with postoperative irradiation of the orbit and (3) local irradiation with 106...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1054399
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND:Long-term follow-up and angiographic findings of serpiginous choroiditis, a chronic disease with recurrences of unknown origin, are reported. PATIENTS AND METHODS:A retrospective analysis of the data of 4 patients with serpiginous choroidopathy, who were treated in the eye clinic of Mainz in the past 10-18 ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2006-926575
更新日期:2006-05-01 00:00:00
abstract::Light phenomena evoked by a Kratz elliptical posterior chamber lens, a Mark Choyce IX anterior chamber lens, and a four-loop Binkhorst anterior chamber lens were investigated in a model with pupils of various sizes. Besides monocular diplopia, the edge of the lens produces scattered light phenomena which vary accordin...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1050471
更新日期:1987-07-01 00:00:00
abstract::Recent technological innovations in cataract surgery have made the procedure even more precise and safe and the odds of having a highly satisfied patient even higher. These innovations include visualisation systems - such as intraoperative aberrometry - which are particularly helpful when it comes to implanting toric ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章,评审
doi:10.1055/s-0042-121423
更新日期:2017-08-01 00:00:00
abstract::On two female patients it was shown that intoxication by sedatives containing part bromecarbamide may result in various ocular diseases. The two patients complained of a sudden inexplicable deterioration of vision; semi-dilated slow-responding pupils were diagnosed. Only in one case could a sudden vertical nystagmus b...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1979-01-01 00:00:00
abstract::A 36-years aged woman suffering from migraine used Ergosanol special-suppositories. An edema of the retina with star figure appeared in both eyes with only a few months distance. After putting away that drug visual acuity restituted completely in spite of a partial neuritic atrophy of the optic nerve in the first suff...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1978-11-01 00:00:00
abstract::Examinations of hormone levels in blind persons compared with almost blind and people with normal vision and hormone evaluation with increased artificial light exposure show a definite stimulating effect of light on the human hormonal balance. The effect of light is mediated by an intact perception of light by the eye...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1977-07-01 00:00:00
abstract::Anti-VEGF injections are widely used "off-label" for the treatment of choroidal neovascularization secondary to pathological myopia based on data generated by multiple case series with small sample sizes. In this review we have analyzed the results of case series with at least 20 patients and a follow-up of ≥ 12 month...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章,meta分析,评审
doi:10.1055/s-0034-1368289
更新日期:2014-04-01 00:00:00
abstract::A case report is given of a vascular disease of right retina of a 37-year-old woman during treatment with contraceptives during 9 years. The retina shows at first a clinical picture of chorioretinitis centralis serosa. After stopping the hormonal preparation and prescription of Dexium (Kalziumdobesilat) the retinal ch...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1976-10-01 00:00:00
abstract::Between january 1986 and december 1989 we prospectively studied 211 patients with branch retinal vein occlusion (BRVO). Documented by fundus photography and fluorescein angiography clinical and angiographic findings were analysed. The age ranged from 28 to 83 with a mean of 63 years. 104 (48.8%) patients were male, 10...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1045901
更新日期:1992-10-01 00:00:00
abstract::Computerized threshold perimetry of the central 30 degrees was performed on 69 eyes of 36 patients (men and women of all age groups and with different types of diabetes) one day before and one month after panretinal photocoagulation by argon laser. An average of 900 spots were placed in a chessboard pattern in three s...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1050103
更新日期:1988-03-01 00:00:00
abstract:BACKGROUND:A pronounced fundus autofluorescence (lipofuscin) occurs in eyes with AMD. Parapapillary lipofuscin accumulation in the retinal pigment epithelial cells was observed in eyes with advanced glaucoma histologically. The aim of this study was to evaluate the parapapillary autofluorescence (PAF) in vivo in health...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2005-858856
更新日期:2006-04-01 00:00:00
abstract::The problems associated with performing penetrating keratoplasty in private practice are briefly discussed: access to an eye bank, high-risk patients, immunosuppressive therapy, complications, and results. One negative aspect is the relatively high incidence (10%) of primary graft failure, but allograft reactions are ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1046177
更新日期:1990-05-01 00:00:00
abstract:BACKGROUND:We report on an eight-year-old boy, who was presented in our clinic because of head turn. The cause of the tortecollis (ocular or general) in this case was and still cannot be explained. Only by applying extensive prism adaptation tests it was possible to prove the ocular character of the head turn. CASE RE...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1027477
更新日期:2008-08-01 00:00:00
abstract::As a model for our study we selected 11 pseudophacic patients with secondary cataracts who experienced good postoperative visual acuity after extracapsular cataract extraction. Besides best visual acuity and contrast sensitivity Pattern-ERG (PERG) and Contrast-Transfer-Ratio (CTR) were measured before and after YAG-Ka...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1045788
更新日期:1992-05-01 00:00:00
abstract::A report on 70 cases of retraction syndrome (Stilling-Türk-Duane). The patients presented with typical symptoms: severe limitation of abduction, slight limitation of adduction and convergence, which is always accompanied by retraction of the globe, narrowing of the palpebral fissure, vertical deviation and elevated in...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1055309
更新日期:1981-02-01 00:00:00
abstract::Modern resorbent materials are perhaps still not ideal in every respect. Resorbent fibers are an alternative to the non-resorbent synthetic materials and to Barraquer silk, as the author points out with reference to results of operations carried out during the last three years at the ophthalmological clinic in Aarau. ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1054756
更新日期:1983-03-01 00:00:00
abstract:BACKGROUND:Autoregulation is defined as the maintenance of constant blood flow in a vascular system in spite of changes in perfusion pressure (PPm). MATERIALS AND METHODS:PPm was decreased by increasing the intraocular pressure (IOP) with a suction cup and optic nerve blood flow was measured with the laser Doppler flo...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1997-05-01 00:00:00
abstract::.25% Bupranolol in an oily solution decreases corneal sensitivity statistically significant from the 3. to the 15. minute after the application. The maximum of decrease is found between the 6. and the 15. minute in contrast to beta-blockers in aqueous solution (1.-3. minute). The topical subjective compatibility of 0....
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1055/s-2008-1045923
更新日期:1991-01-01 00:00:00
abstract::The present paper exposes the shortcomings of orthoptics and proposes an original system of concomitant squint treatment named diploptics. This system is based on the new conception of the role of bifixation in the physiology and pathology of binocular vision. The major principle of diploptics is to induce diplopia un...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1978-05-01 00:00:00
abstract::The small degree of morbidity and a better postoperative visual acuity are the advantages of pneumatic retinopexy in comparison to encircling procedures in the treatment of retinal detachment. The injection of air or gas into the vitreous cavity can theoretically induce a cataract postoperatively. Two months after pne...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1046024
更新日期:1991-06-01 00:00:00
abstract::No difference in the retinal acetylserotonin-methyltransferase was found in two groups of quail which were exposed to irradiation of 0.1 W/m2 with green and blue light respectively for 1 hour. Decreased retinal enzyme activities (isoelectric point pH 5.0) were observed in response to exposure to green and UVA light co...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1050633
更新日期:1986-04-01 00:00:00
abstract:INTRODUCTION:Numerous studies on the operative therapy for lagophthalmos exist. Reports about postoperative results, however, are rare and most studies include just a small number of patients. Additionally, since 1999a flexible platinum chains has been available as an alternative to the rigid gold implant. The authors ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2007-963790
更新日期:2008-02-01 00:00:00
abstract::A case of probably not congenital dissociated pendular nystagmus is reported in which on the contrary to similar published cases no neurological disorder is present. ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1975-12-01 00:00:00
abstract::The treatment of retinal detachments due to macular holes without further central peripheral holes with intraocular tamponades (SF6, silicone oil) is preferred to episcleral techniques. After treatment of 24 cases of retinal detachments due to macular holes a therapeutic program is proposed. ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1054385
更新日期:1985-12-01 00:00:00
abstract::In the ERG the b-wave and the oscillatory potentials are reduced or nonrecordable in ischemic retinopathy. The photopic b-wave appeared to be more sensitive than the scotopic b-wave. In the EOG the slow oscillation is reduced. These clinical observations are in accordance with the results of experimental studies in rh...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1979-03-01 00:00:00
abstract:PURPOSE:Endothelial cell damage can be found after a phacoemulsification. The reason for this cell damage is not yet known. The temperature rise inside the anterior chamber during the emulsification of the lens is considered as a potential damage mechanism. The aim of this study was to investigate the relationship betw...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-0034-1382848
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:Affections of the lacrimal drainage system are often seen by ophthalmologists. Inspection, palpation, diagnostic rinsing and sounding can distinguish anatomical stops before or after tear sac. For final diagnostics however more apparative examinations are necessary. The ultrasonic examination with contrast m...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1035009
更新日期:1997-01-01 00:00:00
abstract::Flavonoids are known as potent inhibitors of aldose reductase, an enzyme that may initiate cataract formation in diabetes. We have tested the inhibitory activity of new flavone derivatives on a homogenate of lens epithelium. Compounds which inhibited the enzyme activity by more than 50 percent at 10(-60) M were then t...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1057488
更新日期:1980-04-01 00:00:00
abstract:PURPOSE:A peripheral iridotomy (PI) is the treatment of choice for pupillary block. In this study we investigated the effect of enlarging the size of a small PI on the anterior chamber angle in patients with angle closure using ultrasound biomicroscopy (UBM). PATIENTS AND METHODS:Patients who had been treated with las...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1027249
更新日期:2008-05-01 00:00:00