[Aldose-reductase inhibitors and cataract formation (author's transl)].

Abstract:

:Flavonoids are known as potent inhibitors of aldose reductase, an enzyme that may initiate cataract formation in diabetes. We have tested the inhibitory activity of new flavone derivatives on a homogenate of lens epithelium. Compounds which inhibited the enzyme activity by more than 50 percent at 10(-60) M were then tested on rat lenses perfused in a 0.027 M glucose solution. Our preliminary studies indicate that these new flavone derivatives can prevent or delay the formation of cataract in an in-vitro model.

journal_name

Klin Monbl Augenheilkd

authors

Keller G,Leuenberger PM

doi

10.1055/s-2008-1057488

subject

Has Abstract

pub_date

1980-04-01 00:00:00

pages

514-5

issue

4

eissn

0023-2165

issn

1439-3999

journal_volume

176

pub_type

杂志文章
  • [Damage caused by wearing contact lenses throughout the day].

    abstract::Seventy-eight contact lens patients issued with soft HEMA lenses were examined in order to establish reasons for intolerance. The examination was carried out in conjunction with a questionnaire designed to furnish information about the habits of the contact lens patients. Less than 50% of the patients had been advised...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

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    doi:10.1055/s-2008-1057272

    authors: Bernd HJ

    更新日期:1981-08-01 00:00:00

  • [Bilateral pigmented epi- and submacular membrane].

    abstract:PURPOSE:The aim of this communication is to report a case of epiretinal membrane removal with intra-operative unexpected subretinal extension of the membrane. METHODS:This is an observational case report. An 83-year-old female patient with bilateral pigmented secondary macular pucker after laser coagulation for diabet...

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    doi:10.1055/s-2008-1027237

    authors: Steven P,Klinger M,Hoerauf H

    更新日期:2008-03-01 00:00:00

  • [Abnormal head turn in a patient with Brown's syndrome].

    abstract:BACKGROUND:We report on an eight-year-old boy, who was presented in our clinic because of head turn. The cause of the tortecollis (ocular or general) in this case was and still cannot be explained. Only by applying extensive prism adaptation tests it was possible to prove the ocular character of the head turn. CASE RE...

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    doi:10.1055/s-2008-1027477

    authors: van Waveren M,Krzizok T,Besch D

    更新日期:2008-08-01 00:00:00

  • [Disturbances of the retinal vessels as a result of Purtscher's retinopathy (author's transl)].

    abstract::A 31-year-old patient was buried at canal-building. He sustained Purtscher's retinopathy on his left eye. A fluorescein-angiography displayed six years after the trauma a large neovascular frond and intraretinal neovascular network. These findings demonstrate the severe lesions of the retinal microcirculation caused b...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Prammer G

    更新日期:1976-06-01 00:00:00

  • [Metastatic carcinomata in the anterior uvea as the presenting clinical manifestation (author's transl)].

    abstract::Metastatic carcinomata in the anterior uvea are rare. Some of them may be diagnosed before the primary tumor is clinically detected. We report on three such cases. The vast majority of secondaries in the anterior uvea have their primary in the bronchus. It is rather exceptional that a metastasis in the anterior chambe...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1057611

    authors: Mellin KB

    更新日期:1980-07-01 00:00:00

  • "En face" OCT in Small Pigmented Choroidal Tumors.

    abstract::Background "En face" optical coherence tomography (OCT) is an imaging technique with optic sections parallel to the retinal pigment epithelium (RPE). This study aims to define the use of this technique in the evaluation of small pigmented choroidal tumors. Patients and Methods Investigation of 27 small pigmented choro...

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    doi:10.1055/s-0042-123172

    authors: Cotting-Bodmer S,Zografos L,Schalenbourg A

    更新日期:2017-04-01 00:00:00

  • [Group G streptococci as pathogens of postoperative endophthalmitis].

    abstract::We report an exceptional case of fulminant endophthalmitis after uncomplicated extracapsular cataract extraction with posterior chamber lens implantation. The first unusual finding was the causative organisms, group G streptococci. These organisms are commonly found as normal flora of the skin, pharynx and gastrointes...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1046045

    authors: Posenauer B,Funk J

    更新日期:1991-06-01 00:00:00

  • Central serous chorioretinopathy associated with adrenal myelolipoma.

    abstract:BACKGROUND:We describe a case of central serous chorioretinopathy associated with a large adrenal myelolipoma. HISTORY AND SIGNS:A 55-year old man was admitted to our clinic complaining for metamorphopsia and blurred vision in his left eye. Standard ophthalmologic examination and fluorescein angiography established th...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2003-38187

    authors: Katsimpris JM,Vandoros M,Petropoulos IK,Andrikopoulos P

    更新日期:2003-03-01 00:00:00

  • [Functional Results One Year after Implantation of a Bitoric, Trifocal Intraocular Lens].

    abstract:PURPOSE:An evaluation of the visual and refractive results was undertaken one year after implantation of a trifocal diffractive toric intraocular lens (IOL) during cataract surgery. METHODS:In a prospective study patients with a calculated postoperative corneal astigmatism of ≥ 0.75 D received a diffractive trifocal t...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 临床试验,杂志文章

    doi:10.1055/s-0041-103335

    authors: Höhn F,Tandogan T,Breyer DR,Kaymak H,Hagen P,Klabe K,Koss MJ,Gerl M,Auffarth GU,Kretz FT

    更新日期:2015-08-01 00:00:00

  • [Benefits of ambulatory surgery in cataract surgery].

    abstract::We monitored 300 patients who had undergone ambulatory cataract operations. Patients are more and more preferring this type of surgery, which allows them to go home immediately after the operation. We compare ambulatory ECCE and phacoemulsification operations and their complications, advantages and disadvantages. We s...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1035536

    authors: Bovet J,Baumgartner JM

    更新日期:1994-05-01 00:00:00

  • [Selective thrombophilia screening of young patients with retinal vein occlusion].

    abstract:BACKGROUND:The potential impact of coagulation abnormalities on retinal vascular occlusive diseases, individually and in combination with cardiovascular risk factors, remains unclear. PATIENTS AND METHODS:In a prospective case-control study a cohort of 74 young patients with central, hemicentral or branch retinal vein...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-0028-1109195

    authors: Kuhli-Hattenbach C,Scharrer I,Lüchtenberg M,Hattenbach LO

    更新日期:2009-09-01 00:00:00

  • [Ocular changes in MELAS syndrome].

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    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1046280

    authors: Küchle M,Brenner PM,Engelhardt A,Naumann GO

    更新日期:1990-09-01 00:00:00

  • [Centering intraocular lenses with reference to capsular incision].

    abstract:BACKGROUND:Can the capsulotomy with small radial incisions compared to the continuous curvilinear capsulorhexis with perfect IOL centration still be recommended? This problem should be clarified under standard conditions. METHOD:On 100 patients both procedures were applied alternating with corneoscleral incision, phac...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1035520

    authors: Fetscher M,Müller-Jensen K

    更新日期:1994-04-01 00:00:00

  • [Endophthalmitis after intra-oral block of the infraorbital nerve].

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    journal_title:Klinische Monatsblatter fur Augenheilkunde

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    doi:10.1055/s-2008-1035084

    authors: Weinand FS,Pavlovic S,Dick B

    更新日期:1997-06-01 00:00:00

  • [Surgery of the eyelid edge--references for general practice].

    abstract::a) Punctum plasty (eversion of the lacrimal point): This simple method results in a permanently enlarged punctum. A 4-0 silk suture is passed through the vertical part of the canaliculus and the conjunctiva, drawing them together very tightly. The thread falls out after 4-6 weeks. b) Management of trichiasis: Electrol...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1046212

    authors: Keller HH

    更新日期:1990-05-01 00:00:00

  • [Anti-VEGF inhibitors and their role in the treatment of diabetic macular oedema].

    abstract::Diabetic macular edema (DME) and proliferative retinopathy are common causes for blindness in middle-aged patients. The gold standard for treatment has been laser coagulation. Limitations of this therapy are refractive DME, ischaemic diabetic maculopathy and complications after laser application. The need for a non-de...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章,评审

    doi:10.1055/s-0029-1245718

    authors: Kakkassery V,Winterhalter S,Joussen AM

    更新日期:2010-09-01 00:00:00

  • [Evaluation of Changes in Corneal Biomechanics in Patients with Systemic Sclerosis].

    abstract:INTRODUCTION:Our study compares the biomechanical properties of the cornea in patients with long-term pre-existing (for at least 10 years) systemic sclerosis (SSc) with those of healthy suspects. MATERIAL/METHODS:The examination was performed in 14 systemic SSc patients and 38 healthy volunteers. Non-invasive assessme...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-0043-125078

    authors: Zimmermann N,Brandt S,Brünner J,Erb C

    更新日期:2019-06-01 00:00:00

  • [Development of the retrocorneal membrane following penetrating keratoplasty (author's transl)].

    abstract::The results of 57 cases with retrocorneal membrane following penetrating keratoplasty are reported and discussed with regard to their clinical and histopathological pictures and pathogenesis. ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Knöbel H,von Domarus D

    更新日期:1979-08-01 00:00:00

  • [Evaluation of glaucomas. Frequently misdiagnosed glaucoma conditions].

    abstract::On the basis of a number of examples the authors describe specific glaucomas which have often reached their final stages by the time the patients are referred to the clinic. They include sub-acute and chronic angle-closure glaucoma, pseudoexfoliation syndrome, and pigmentary glaucoma. An unpleasant feature of these gl...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1046389

    authors: Gloor BP,Robert Y

    更新日期:1989-05-01 00:00:00

  • [Automatic measurement of dye filling of simultaneous digital ICG- and fluorescein angiography sequences].

    abstract:BACKGROUND:The ICG filling is supposed to be faster than Fluorescein filling. Interestingly the filling characteristics of these dyes were never correlated directly using precise quantitative methods. Since ICG and Fluorescein are injected as a mixture, the simultaneous 2-channel angiography provides a suitable method ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2000-10558

    authors: Török B,Hirschi R,Székely G,Brechbühler C,Blass L,Barabás K,Bischoff P

    更新日期:2000-05-01 00:00:00

  • Contact Lenses in the Management of Corneal Dystrophies.

    abstract::Among the group of diseases comprising corneal dystrophies, there are a number for which contact lenses may be considered. For example, soft contact lenses may be beneficial in the management of recurrent corneal erosions and advanced bullous keratopathy and may lead to disease attenuation in some conditions. They als...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章,评审

    doi:10.1055/a-0735-9801

    authors: Farooq AV,Colby K

    更新日期:2020-02-01 00:00:00

  • [Efficiency and Therapy Safety of Fractionated Cyclophotocoagulation with up to Ten Laser Spots for Advanced Primary Open-Angle and Pseudoexfoliation Glaucoma].

    abstract:BACKGROUND:Various procedures are available for the treatment of advanced glaucoma. We examined the efficacy and safety of fractionated cyclophotocoagulation (CPC) with up to ten laser spots for advanced primary open-angle glaucoma (POAG) and pseudoexfoliation (PEX) glaucoma treated with maximal topical therapy or eye-...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/a-1057-9699

    authors: Grohmann C,Farrokhi S,Klemm M

    更新日期:2020-02-03 00:00:00

  • [Autoimmune diseases of the peripheral cornea. Immunopathology, clinical aspects and therapy].

    abstract::Noninfectious ulceration of the peripheral cornea remains a major diagnostic and therapeutic challenge. The pathogenesis in most of these disorders is unclear, however, on the basis of systemic connective tissue diseases, autoimmune mechanisms are most likely involved. The peripheral cornea has distinct morphological ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章,评审

    doi:10.1055/s-2008-1035173

    authors: Pleyer U,Bergmann L,Krause A,Hartmann C

    更新日期:1996-02-01 00:00:00

  • [Measles retinitis in an immunocompetent child].

    abstract:BACKGROUND:Measles retinitis is rare in immunocompetent patients and has recently been only sporadically described. This case report reveals the clinical picture, the course of the disease and the prognosis of this entity. HISTORY AND FINDINGS:One month after a diagnosed measles infection, a 12-year-old girl presented...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1045509

    authors: Neppert B

    更新日期:1994-09-01 00:00:00

  • Vasorelaxing effect of the potassium (K+)-channel opener pinacidil in isolated porcine ciliary arteries.

    abstract:PURPOSE:The aim of this study was to investigate the vasorelaxing properties of pinacidil (a potassium-channel-opener) in isolated porcine ciliary arteries. METHODS:Isometric contractions of isolated porcine ciliary arteries were measured with a myograph system. The vessels were first precontracted with the thromboxan...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2001-15894

    authors: Morf T,Zhu P,Flammer J,Haefliger IO

    更新日期:2001-05-01 00:00:00

  • [Treatment of senile maculopathy with etaretin].

    abstract::The results of parenteral treatment with Etaretin in 40 patients (79 eyes) suffering from senile maculopathy are reported. In 84% of the cases there was a degeneration of the dry type and in 16% a disciform exudative maculopathy. The cases of dry maculopathy responded well within a floow-up period of 8 to 18 months. ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1050732

    authors: Varga M,Gábriel I,Follmann P

    更新日期:1986-06-01 00:00:00

  • [Bilateral vascular papillitis following ergotamin medication (author's transl)].

    abstract::A 36-years aged woman suffering from migraine used Ergosanol special-suppositories. An edema of the retina with star figure appeared in both eyes with only a few months distance. After putting away that drug visual acuity restituted completely in spite of a partial neuritic atrophy of the optic nerve in the first suff...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Wollensak J,Grajewski O

    更新日期:1978-11-01 00:00:00

  • [Gene replacement therapy in achromatopsia type 2].

    abstract::Achromatopsia is an autosomal recessive inherited retinal disease caused by a complete loss of cone photoreceptor function. About 80 % of achromatopsia patients show mutations in the alpha or beta subunit (A3 and B3) of the cGMP controlled cation channel CNG (cyclic nucleotide-gated channel) of cone photoreceptors. Ho...

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    pub_type: 杂志文章,评审

    doi:10.1055/s-0034-1368180

    authors: Mühlfriedel R,Tanimoto N,Seeliger MW

    更新日期:2014-03-01 00:00:00

  • [Experimental studies of the significance of the renin-angiotensin system in the retina. A review].

    abstract::BACKGROUND Many peptides now identified in the brain were previously thought of as exclusively peripheral hormones. Among those, the renin-angiotensin system (RAS) is not only found to be of great importance in peripheral vasomotor and electrolyte homeostasis but also acts as neurotransmitter or modulator in the centr...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章,评审

    doi:10.1055/s-2008-1045478

    authors: Jacobi PC,Jurklies B,Kohler K,Zrenner E

    更新日期:1994-06-01 00:00:00

  • [Echographic findings in choroidal detachment].

    abstract::A- and B-scan sonography was performed in 83 patients with choroidal detachment; a serous choroidal detachment is characterized by high, bifurcated echospikes and an echo-free subchoroidal space in A-scan sonography. The B-scan presents a typical arc shape. In hemorrhagic choroidal detachment multiple echoes with low ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1054708

    authors: Rochels R,Hackelbusch R

    更新日期:1983-01-01 00:00:00