Abstract:
BACKGROUND:Various procedures are available for the treatment of advanced glaucoma. We examined the efficacy and safety of fractionated cyclophotocoagulation (CPC) with up to ten laser spots for advanced primary open-angle glaucoma (POAG) and pseudoexfoliation (PEX) glaucoma treated with maximal topical therapy or eye-drop intolerance. MATERIAL UND METHODS:This retrospective study evaluated data from 297 eyes with advanced POAG and PEX glaucoma which received 10 applications of CPC between February 2012 and June 2017. Intraocular pressure (IOP), number of topical eye drops and postoperative complications were evaluated. Data were collected preoperatively, four weeks postoperatively, and at the last documented contact (six months postoperative visit). The paired Wilcoxon rank sum test was used to analyse the changes. RESULTS:The IOP for open-angle glaucoma decreased from 16.66 ± 4.36 mmHg preoperatively to 13.87 ± 3.59 mmHg at the last visit (6 months postoperative visit; p < 0.05). The IOP for the PEX glaucoma decreased significantly from 20.76 ± 9.55 mmHg preoperatively to 15.50 ± 5.93 mmHg at the last visit (p < 0.003). The number of hypotensive agents in the POAG was 2.51 ± 1.00 preoperatively and at the last visit 2.27 ± 1.03. In PEX glaucoma, the number of hypotensive agents was 2.46 ± 1.07 preoperatively and at the last visit 1.88 ± 0.97. Treatment-related complications occurred in three eyes - two cases of postoperative macular oedema, which were treated well with systemic steroids, and one case of pretreated anterior chamber irritation with hyphema, which was also treated with topical steroids. CONCLUSION:In our group of patients, the mild CPC performed by us with a maximum of 10 applications (vs. the conventional 20 - 30 applications) produced a good reduction of intraocular pressure, as well as a reduction in topical medication, with a low complication rate. HINTERGRUND:Zur Therapie weit fortgeschrittener Glaukome stehen verschiedene Verfahren zur Verfügung. Wir untersuchten die Effektivität und Therapiesicherheit der fraktionierten Zyklophotokoagulation (CPC) mit bis zu 10 Herden für fortgeschrittene primäre Offenwinkelglaukome (POWG) und Pseudoexfoliationsglaukome (PEX-Glaukome), die mit maximaler topischer Therapie behandelt wurden oder eine Augentropfenunverträglichkeit aufwiesen. MATERIAL UND METHODEN:In dieser retrospektiven Studie wurden die Daten von 297 Augen ausgewertet, die zwischen Feb. 2012 und Jun. 2017 eine CPC von je 10 Herden erhielten und an einem fortgeschrittenen POWG bzw. einem PEX-Glaukom litten. Ausgewertet wurden Augeninnendruck (IOD), Anzahl drucksenkender Wirkstoffe sowie postoperative Komplikationen. Die Daten wurden präoperativ, 4 Wochen postoperativ sowie zum letzten dokumentierten Kontakt (i. d. R. 6 Monate postoperativer Visit) erhoben. Für die Analyse der Änderungen wurde der gepaarte Wilcoxon-Rangsummentest verwendet. ERGEBNISSE:Der IOD ist für die POWG von 16,66 ± 4,36 mmHg präoperativ auf 13,87 ± 3,59 mmHg zum letzten Visit (i. d. R. 6 Monate postoperativer Visit) statistisch signifikant (p < 0,05) gesunken. Der IOD ist für die PEX-Glaukome von 20,76 ± 9,55 mmHg präoperativ auf 15,50 ± 5,93 mmHg zum letzten Visit signifikant (p < 0,003) gesunken. Die Anzahl der drucksenkenden Wirkstoffe lag beim POWG präoperativ bei 2,51 ± 1,00; beim letzten Visit bei 2,27 ± 1,03 sowie beim PEX-Glaukom präoperativ bei 2,46 ± 1,07; beim letzten Visit bei 1,88 ± 0,97. Behandlungsbedürftige Komplikationen traten insgesamt bei 3 Augen auf, es zeigten sich 2 postoperative Makulaödeme, die sich mit systemischen Steroiden gut behandeln ließen, sowie ein therapiebedürftiger Vorderkammerreizzustand mit Hyphäma, der ebenfalls mit topischen Steroiden behandelt wurde. SCHLUSSFOLGERUNG:Auch die von uns durchgeführte milde CPC mit maximal 10 Herden (vs. der oft applizierten 20 – 30 Herde) zeigt in unserem Kollektiv eine gute Augeninnendrucksenkung mit im Mittel einer Reduktion der zu applizierenden topischen Antiglaukomatosa bei geringer Komplikationsrate.
journal_name
Klin Monbl Augenheilkdjournal_title
Klinische Monatsblatter fur Augenheilkundeauthors
Grohmann C,Farrokhi S,Klemm Mdoi
10.1055/a-1057-9699subject
Has Abstractpub_date
2020-02-03 00:00:00eissn
0023-2165issn
1439-3999pub_type
杂志文章abstract::A thirty year old patient with central serous chorioretinopathy on his right eye is presented. The signs of his disease were exsudative retinal detachment with shifting fluid, rip of the retinal pigmentepithelium and a mass of whitish-yellowish subretinal protein. After the diagnosis was made light-coagulation was per...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1046114
更新日期:1991-12-01 00:00:00
abstract::Following a brief review of various interpretations of the disease and its treatment, the author's observations in 13 cases (18 eyes) treated during a period of ten years are reported. The data (Tables 2 and 3) are discussed with reference to the different forms of clinical manifestation of the disease (Table 4). Ther...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1057662
更新日期:1980-10-01 00:00:00
abstract::Hopeless glaucoma cases fluctuate between excessive pressures and phthisis. Due to the underlying disease (neovascularization in the chamber angle, chronic inflammation, dysgenesis, aphakia) the customary surgical pressure-lowering operations often fail and medication is also useless. As a "last-ditch" measure, there ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1046201
更新日期:1990-05-01 00:00:00
abstract::Die Tränendrüse kann von einer Vielzahl neoplastischer, infektiöser und autoimmunologischer Erkrankungen betroffen sein. Eine radiologische Charakterisierung der Veränderungen kann Hinweise für die differenzialdiagnostische Einordnung liefern. Erkrankungen der ableitenden Tränenwege, insbesondere Tränenwegsverschlüsse...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-0033-1358102
更新日期:2015-03-01 00:00:00
abstract::36 malignant tumours of the eyelids (basaliomas, basal-cell carcinomas and squamous-cell carcinomas) have been treated by intrapalpebral injections of a 5% to 25% solution of urea as recommended by E.D. Danopoulos. 1.5 to 3.0 ml of the solutions were injected around the tumours twice per week. Six malignant tumours di...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1976-07-01 00:00:00
abstract:BACKGROUND:Age-related macular degeneration (AMD) is a disease with high social impact that severely hinders the quality of life of the affected patients. The aim of our study is to examine the ultrastructural changes in the choroidal neovascular membranes occurring after the intravitreal administration of Avastin. MA...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 临床试验,杂志文章
doi:10.1055/s-0028-1109429
更新日期:2009-06-01 00:00:00
abstract::In 20 cases of herpes simplex keratitis the efficacy of Vidarabin ointment has been tested, in 19 cases after corneal abrasion. The eyes were treated once a day and padded until the epithelial defects had closed. Thereafter the ointment was applied 4 times per day for about one week more. On the average epithelial clo...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 临床试验,杂志文章
doi:
更新日期:1978-02-01 00:00:00
abstract::A case report is given of a vascular disease of right retina of a 37-year-old woman during treatment with contraceptives during 9 years. The retina shows at first a clinical picture of chorioretinitis centralis serosa. After stopping the hormonal preparation and prescription of Dexium (Kalziumdobesilat) the retinal ch...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1976-10-01 00:00:00
abstract::Diabetic tractional detachment of the retina is caused by shrinking processes of the vitreous, which at most detaches only partially, and by shrinking of epiretinal proliferations. The shrinking of the vitreous results in tractional forces working centripetally and toward the base of the vitreous. The shrinking of the...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1054438
更新日期:1984-03-01 00:00:00
abstract:BACKGROUND:Data from real-life studies on neovascular AMD (nvAMD) generally fall significantly behind respective data from interventional prospective trials. This can be attributed at least partially to differences in patient cohorts concerning both stages of AMD (including consecutive scarring or atrophy), as well as ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-0041-107672
更新日期:2016-08-01 00:00:00
abstract::This report covers 310 patients with concomitant convergent strabismus and anomalous retinal correspondence. In 36 cases tenomyotomy alone was responsible for normalization of correspondence. This is best achieved in cases of bilateral converging strabismus without vertical divergence. ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1979-08-01 00:00:00
abstract:BACKGROUND:Modern intraocular lens surgery has made great progress over the last few years towards creating independency of spectacles in daily life. Especially in the areas of distant and near visual acuity, optimisation has been possible. Nevertheless, with new media and requirements in professional life, there is an...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/a-0600-2826
更新日期:2018-08-01 00:00:00
abstract::In anophthalmos the forces which stimulate development and growth of the bony orbit are absent. As a result these cases have not only a tiny socket but also an underdeveloped bony orbit, which cannot retain an artificial eye. The small conjunctival sac and bony orbit can be mechanically enlarged by means of Hema socke...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1050502
更新日期:1987-09-01 00:00:00
abstract::BACKGROUND Many peptides now identified in the brain were previously thought of as exclusively peripheral hormones. Among those, the renin-angiotensin system (RAS) is not only found to be of great importance in peripheral vasomotor and electrolyte homeostasis but also acts as neurotransmitter or modulator in the centr...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章,评审
doi:10.1055/s-2008-1045478
更新日期:1994-06-01 00:00:00
abstract::By means of fluorescein angiography extensive defects in the pigmented epithelium found in choroideremia can be shown to be present in the first ten years of life. The degeneration of the vessels of the choroid and the functional damage to the retina do not seem to take place until later. ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1979-04-01 00:00:00
abstract:INTRODUCTION:Prevention of cardiovascular disease is an important goal in clinical medicine and public health. In the process, the diagnosis of early end-organ damage is a priority beside the treatment of classic cardiovascular risk factors. To achieve this, the ophthalmoscopic examination of the retinal vessels plays ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-0031-1273199
更新日期:2011-11-01 00:00:00
abstract::In 64 eyes the combined procedure (group I) and in 67 aphacic eyes a trabeculotomy (group II) was performed. There were different types of glaucoma. Re-examinations wer done 6 months and 1--10 years postoperatively. No definite differences of operative or postoperative complications existed between the two groups. In ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1978-10-01 00:00:00
abstract::The ultrasonographic findings in 39 cases of malignant melanoma of the choroid has been correlated with histopathological results. Tumors with hemorrhages and/or necrosis showed a lower reflectivity than those with a higher amount of connection tissue. B-scan ultrasonography was found to be reliable for the measuremen...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1057322
更新日期:1981-11-01 00:00:00
abstract::Für die (Früh-)Diagnose einer Glaukomerkrankung ist die Beurteilung der Papille von entscheidender Bedeutung. Das Spektrum von High-Tech-Geräten zur Papillenbeurteilung hat sich in den letzten Jahren erweitert und die Anwendung ist in der klinischen Praxis angekommen 1. Voraussetzung für die sinnvolle Anwendung und In...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-0033-1358179
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:Presented is a patient whose history showed that during a hammer-blow on a piece of iron something had flown into his left eye. Clinical investigation revealed a 9-mm long, horizontal, paracentrally located, penetrating corneal wound. Temporally in the same region the iris was torn in its entire width. The l...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2005-857910
更新日期:2005-02-01 00:00:00
abstract:BACKGROUND:Additive manufacturing and 3D printing create new paths for the design and manufacturing of implants. Technologies with high resolution are required for the development of microstructured eye implants. In the present study, we demonstrate how these technologies can be used during the design development and m...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-0041-107883
更新日期:2015-12-01 00:00:00
abstract::A 46 year old AIDS-patient, who had developed CMV-retinitis was treated with the virostatic drug dihydroxypropoxymethylguanine (DHPG, Ganciclovir) over a period of 16 months until he died due to a pneumonia. After the DHPG-treatment was initiated the retinitis improved markedly, however there still was a very slow pro...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1046305
更新日期:1990-11-01 00:00:00
abstract:INTRODUCTION:Our study compares the biomechanical properties of the cornea in patients with long-term pre-existing (for at least 10 years) systemic sclerosis (SSc) with those of healthy suspects. MATERIAL/METHODS:The examination was performed in 14 systemic SSc patients and 38 healthy volunteers. Non-invasive assessme...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-0043-125078
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVE:The aim of this study is to describe the effectiveness of aflibercept in treatment-naive patients with neovascular age related macular degeneration (nAMD) and the impact of patients' residential distance to the clinic and patients' mobility on therapy in a pro re nata regime. METHODS:A retrospective dataset ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/a-1008-9357
更新日期:2020-06-01 00:00:00
abstract::A 67-year-old woman patient presented with protrusion of the right globe of unknown origin. Computer tomography revealed a probably benign space-occupying lesion (osteoma) originating in the orbital wing portion of the sphenoidal bone and extending to the orbital roof of the frontal bone. ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1057477
更新日期:1980-03-01 00:00:00
abstract::Defects of the medial canthal area with partial full-thickness loss of the upper and lower eye-lid can be repaired by the following technique: closure of the larger lid defect by a free transplant of tarsus and lid margin from the opposite lower lid and a sliding skin flap. The minor lid defect is closed by a pedicled...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1976-08-01 00:00:00
abstract::The assessment of visual field findings is fundamental in neuro-ophthalmological functional diagnostics: By means of perimetry, functional and topodiagnostic considerations in case of unexplained visual loss or suspected lesions of the visual pathway are possible in a non-invasive manner. Repeated examinations allow f...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章,评审
doi:10.1055/a-0668-5971
更新日期:2018-11-01 00:00:00
abstract::The disciform macular degeneration is in rare cases preceded by well-known diseases which have in common the destruction of the Bruch's membrane, recurrent haemorrhages with exudation from the choriocapillaris and later on ingrown of fibrovascular tissue into the subretinal space. The authors report on cases with chor...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1976-02-01 00:00:00
abstract::Contact lenses have an intimate relationship with the precorneal tear film and it is important to attempt to prognosticate the likelihood of successful contact lens wear by evaluating, both quantitative and qualitative aspects of the precorneal tear film. Aspects of history diagnostic methods and general aspects which...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章,评审
doi:10.1055/s-2008-1046269
更新日期:1990-09-01 00:00:00
abstract:BACKGROUND:Infections of the orbit and of the periorbital region are not uncommon. Even today they constitute a serious problem, in spite of modern antibiotic treatment, with a potential risk of lethal complications. Orbital infections are most prevalent in children and adolescents. The acute orbit has many causes, but...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章,评审
doi:10.1055/s-2004-813682
更新日期:2004-11-01 00:00:00