Vasorelaxing effect of the potassium (K+)-channel opener pinacidil in isolated porcine ciliary arteries.

Abstract:

PURPOSE:The aim of this study was to investigate the vasorelaxing properties of pinacidil (a potassium-channel-opener) in isolated porcine ciliary arteries. METHODS:Isometric contractions of isolated porcine ciliary arteries were measured with a myograph system. The vessels were first precontracted with the thromboxane A2 analog U 46619 (0.1 microM), and then exposed, in a cumulative manner, to increasing concentrations of pinacidil (1 nM-100 microM). Relaxations have been expressed in percent of the maximal contraction evoked by U 46619 (0.1 microM). RESULTS:Pinacidil showed a pronounced concentration-dependent relaxing effect in isolated porcine ciliary arteries. The difference between pinacidil and time-control experiments was significant (100 microM: 112 +/- 2% vs. 18 +/- 6%, P < 0.0001). The half-maximal concentration (pD50) value was 5.3 +/- 0.1 (-log M). CONCLUSIONS:The present study indicates that pinacidil has marked vasorelaxing properties in isolated porcine ciliary arteries.

journal_name

Klin Monbl Augenheilkd

authors

Morf T,Zhu P,Flammer J,Haefliger IO

doi

10.1055/s-2001-15894

subject

Has Abstract

pub_date

2001-05-01 00:00:00

pages

338-40

issue

5

eissn

0023-2165

issn

1439-3999

journal_volume

218

pub_type

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