[Efficacy of a Dexamethasone Implant for the Treatment of Refractory Cystoid Macular Oedema in Non-Infectious Uveitis].

Abstract:

PURPOSE:To evaluate the efficacy of an intravitreal dexamethasone implant (Ozurdex®) in patients with cystoid macular oedema (CME) suffering from non-infectious uveitis. METHODS:Monocentric, retrospective, single-arm analysis in 49 patients (59 implanted eyes) with inactive uveitis, in whom CME had been unresponsive to corticosteroids and/or immunosuppressants and systemic acetazolamide, and who received a dexamethasone implant. Patients were followed up at 6, 12 and 24 weeks after unilateral (n = 39)/bilateral (n = 10) implantation. The primary outcome measure was central foveal thickness (CFT), as measured by Spectralis optical coherence tomography (OCT); secondary outcome measures were improvement in best-corrected visual acuity (BCVA), laser flare photometry and safety measures, including intraocular pressure (IOP) and cataract progression. RESULTS:At 6, 12 and 24 weeks, mean CFT was reduced (≥ 20 %) in 68, 44 and 45 % and BCVA improved (≥ 2 lines) in 47, 40 and 26 %, respectively, as compared to baseline. At 6, 12 and 24 weeks, significant flare reduction was observed in 70, 41, and 42 %, respectively. Cumulative cataract progression was observed in 12, 18 and 31 % at 6, 12 and 24 weeks, respectively. IOP ≥ 22 mmHg was noted in 5 % at baseline and in 21, 3, and 0 % at 6, 12 and 24 weeks, respectively. CONCLUSIONS:In uveitis patients with CME refractory to systemic anti-inflammatory drugs, the dexamethasone implant improves CME transiently. However, IOP increase and cataract progression are common side effects.

journal_name

Klin Monbl Augenheilkd

authors

Breitbach M,Rack D,Dietzel M,Heinz C,Heiligenhaus A

doi

10.1055/s-0042-102058

subject

Has Abstract

pub_date

2016-05-01 00:00:00

pages

601-5

issue

5

eissn

0023-2165

issn

1439-3999

journal_volume

233

pub_type

杂志文章
  • [Evaluation of Changes in Corneal Biomechanics in Patients with Systemic Sclerosis].

    abstract:INTRODUCTION:Our study compares the biomechanical properties of the cornea in patients with long-term pre-existing (for at least 10 years) systemic sclerosis (SSc) with those of healthy suspects. MATERIAL/METHODS:The examination was performed in 14 systemic SSc patients and 38 healthy volunteers. Non-invasive assessme...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-0043-125078

    authors: Zimmermann N,Brandt S,Brünner J,Erb C

    更新日期:2019-06-01 00:00:00

  • [Disorders of binocular vision in amblyopic patients working at computer terminals].

    abstract::For the first time two cases are described with disturbances of binocular vision caused by subjective perception of positive scotomata in the amblyopic eye. The visual strain of working at a terminal leads to a slight increase in the squint angle; as a result, a paracentral scotoma may shift into the middle of the bin...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1054340

    authors: Stangler-Zuschrott E,Harrer S

    更新日期:1985-11-01 00:00:00

  • [Suitability of resorbable sutures in the treatment of corneal wounds].

    abstract::In a series of cataract operations with a corneal incision PDS 10-0 absorbable sutures were tested. In contrast to deeper PDS sutures, such as are used in corneoscleral incisions, the corneal sutures opened as early as between 13 and 30 days postoperatively in 5 out of 7 cases. Postoperative irritation was more severe...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1054984

    authors: Faulborn J,Gülececk O

    更新日期:1983-12-01 00:00:00

  • [Diagonal incision in capsulotomy for extracapsular cataract extraction].

    abstract::From previous experience with all current surgery methods and kinds of anterior capsulotomy as well as of 6-year follow-up observation we developed our own diagonally-shaped (linear) capsulotomy technique. This technique was used in more than 500 successive extracapsular cataract extractions, followed by implantation ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1046104

    authors: Mitschischek E

    更新日期:1991-12-01 00:00:00

  • [Photoastigmatic refractive keratectomy for low, moderate, and high astigmatism using a broad beam excimer laser: evaluataion according to new international criteria].

    abstract:BACKGROUND:Photorefractive keratectomy (PRK) is an accepted procedure to correct myopia in Germany. The purpose of this study was to evaluate photoastigmatic refractive keratectomy (PARK) for myopic astigmatism. MATERIAL AND METHODS:PARK using the VISX 20/20 excimer laser was performed in 50 eyes of 36 patients (25 fe...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1034713

    authors: Schnitzler EM,Kohnen T,Steinkamp GW,Ohrloff C

    更新日期:1999-11-01 00:00:00

  • [Comparative results of deep sclerectomy transformed to trabeculectomy and classical trabeculectomy].

    abstract:OBJECTIVE:To study the learning risk of a new surgical technique, the deep sclerectomy (DS), which may be complicated with a perforation of the trabeculodescemetic membrane. To do so, we compared the results and the complications of patients who underwent DS transformed in trabeculectomy (DSt) and those of patients who...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1035050

    authors: Sanchez E,Schnyder CC,Mermoud A

    更新日期:1997-05-01 00:00:00

  • [A convex-concave contact lens for vitreoretinal operations with the BIOM].

    abstract::A new convex-concave contact lens for wide-angle vitreoretinal surgery with the BIOM was developed. Placed on an eye, in which silicone oil is injected, it prevents the formation of an optically disturbing oil-water-film on the surface of the cornea. Thus the new contact lens leads to an essential improvement of the f...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1045932

    authors: Eckardt C,Wiechens B

    更新日期:1991-01-01 00:00:00

  • ["Blow-out" orbital trauma and diplopia. Conservative or surgical approach?].

    abstract::The treatment of orbital fractures, type blow-out, has always been discussed about. One hundred-twenty patients, subdivided in four groups were examined. Incarceration of the peri-muscular structures or not. Surgical or conservative treatment. These four groups have been studied with the purpose of establishing a trea...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1045799

    authors: Magnocavallo M,Klainguti G

    更新日期:1992-05-01 00:00:00

  • [Retinopathy of prematurity].

    abstract::This review summarizes the knowledge and highlights recent advances in clinical research of retinopathy of prematurity (ROP). This disease is still important, because improvements in neonatal intensive care during the last years have increased the survival of the most immature newborns, but did not diminish the ROP fr...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章,评审

    doi:10.1055/s-2004-812886

    authors: Jandeck C,Kellner U,Foerster MH

    更新日期:2004-03-01 00:00:00

  • [Hemicentral retinal artery occlusion due to oral contraceptives].

    abstract:BACKGROUND:Low-dose oral contraceptives can still cause thromboembolic disorders with serious neurologic or ocular disabilities. PATIENT:A 22-year-old woman having used oral contraceptives for several months noticed sudden painless visual loss in her left eye. One tablet of her contraceptive contained ethinylestradiol...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-0031-1273197

    authors: Schmidt D,Kramer-Zucker A

    更新日期:2011-08-01 00:00:00

  • [Computer tomography in unilateral exophthalmos caused by an osteomas of the orbital wall (author's transl)].

    abstract::A 67-year-old woman patient presented with protrusion of the right globe of unknown origin. Computer tomography revealed a probably benign space-occupying lesion (osteoma) originating in the orbital wing portion of the sphenoidal bone and extending to the orbital roof of the frontal bone. ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1057477

    authors: Kleifeld O

    更新日期:1980-03-01 00:00:00

  • [Perimetry in chiasmal syndrome -Liminal and surpraliminal stimuli (author's transl)].

    abstract::The value of static and kinetic perimetry with white and colored stimuli in chiasmal syndrome seems to be equal. The presentation of evenly moving supraliminal targets allows for an evaluation of sensory disturbance. This procedure is even more subjective, variable and difficult to perform accurately. It may reveal, h...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Dannheim F

    更新日期:1977-09-01 00:00:00

  • [Epidemiology of uveitis in juvenile idiopathic arthritis from a national paediatric rheumatologic and ophthalmologic database].

    abstract:BACKGROUND:Uveitis is a frequent and potentially vision-threatening manifestation of juvenile idiopathic arthritis (JIA). There are only a few population-based studies providing data on the frequency and severity of uveitis. METHODS:Documentation of patients with JIA was collected in a national database. An analysis o...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2005-858753

    authors: Heiligenhaus A,Niewerth M,Mingels A,Ganser G,Thon A,Pleyer U,Greiner K,Minden K

    更新日期:2005-12-01 00:00:00

  • [Vision disorders in children with acquired severe brain damage].

    abstract::27 children with severe brain injuries were examined by an ophthalmologist and had several paediatric examinations during an eight or ten weeks' course of rehabilitation. With highly reduced levels of consciousness they had hardly any cortical visual function but frequently had brainstem controlled reactions of eyelid...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1045861

    authors: Piper HF,Kalbe U

    更新日期:1992-07-01 00:00:00

  • [Peripapillary melanoma; 10-year follow-up].

    abstract:UNLABELLED:In early stages choroidal peripapillary choroidal melanoma may be confused with a choroidal nevus or melanocytoma. CASE REPORT:A 41-year old female was diagnosed having a choroidal nevus in close proximity to the optic nerve head. Unfortunately the patient did not show up for annual review of this lesion. T...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2000-9576

    authors: Fischer P,Müller-Jensen K,Frenzel H

    更新日期:2000-12-01 00:00:00

  • [Drug side-effects of the eye--a contribution to quality assurance in ophthalmology].

    abstract:BACKGROUND:The aim of this research is to catalogue the increasing number of side effects of medications on the eyes and, by putting this catalogue into a data bank, to make it available for use in hospitals. Here a deliberate search is made for medications, which could possibly cause certain side effects as well as a ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章,评审

    doi:10.1055/s-2008-1035248

    authors: Dangelmaier S,Weindler J,Ruprecht KW

    更新日期:1996-05-01 00:00:00

  • [Surgery of strabismus and rupture of the blood-aqueous barrier (ischemia of the anterior segment)].

    abstract:BACKGROUND:First described in 1957, anterior segment ischemia (ASI) following extraocular muscle surgery for non paralytic or paralytic strabismus is a rare but serious complication. Systemic and anatomical risk factors can be identified and vesselsparing surgical techniques used. The aim of this study is to evaluate t...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1034887

    authors: Sanchez E,Klainguti G,Herbort CP

    更新日期:1998-05-01 00:00:00

  • Postoperative Behaviour after Primary Strabismus Surgery in Children: Is There an Influence of Intraoperative Topical Anaesthesia?

    abstract:INTRODUCTION:The course of the recovery phase after general anaesthesia, during which consciousness and pain gradually return, is essentially determined by the choice of anaesthetic drug, and its total dose or duration of application. This phase is often complicated by more or less severe agitation, especially in child...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章,随机对照试验

    doi:10.1055/a-1260-3023

    authors: Karstädt N,Crozier TA,Horn M,Naxer S,Schittkowski MP

    更新日期:2020-10-01 00:00:00

  • [Trabeculotomy and trabeculectomy (author's transl)].

    abstract::After recalling the aim of trabeculotomy and trabeculectomy, the author mentions similar techniques, which were in use before the microsurgical era. Some details of the two techniques, performed at Zurich University Eye Clinic exclusively under the operating microscope, are presented, as well as their indications and ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1057206

    authors: Martenet AC

    更新日期:1981-04-01 00:00:00

  • [The predictive value of a classification for proliferative diabetic vitreoretinopathy].

    abstract:BACKGROUND:Kroll's classification of proliferative diabetic vitreoretinopathy (PDVR) defines stage A (vitreoretinal proliferations without retinal detachment), stage B (partially detached retina not involving the macula), stage C (partially detached macula) and stage D (completely detached macula). The purpose of this ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2002-23500

    authors: Hesse L,Heller G,Kraushaar N,Wesp A,Schroeder B,Kroll P

    更新日期:2002-01-01 00:00:00

  • [Management of childhood glaucoma associated with Sturge-Weber syndrome].

    abstract:PURPOSE:Sturge-Weber syndrome is a rare congenital disorder consisting of cutaneous, leptomeningeal and ocular vascular malformations. Glaucoma occurs in 30-70 % of patients. Treatment is challenging due to a high risk of severe complications such as expulsive haemorrhage, massive choroidal effusion and serous retinal ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章,评审

    doi:10.1055/s-0032-1315217

    authors: Greslechner R,Helbig H,Oberacher-Velten IM

    更新日期:2012-10-01 00:00:00

  • Painless indirect argon laser in high risk proliferative diabetic retinopathy.

    abstract:BACKGROUND:Proliferative retinopathy is an important cause of vision loss in diabetic patients. Incomplete panretinal photocoagulation (PRP) can lead to recurrent proliferation of new vessels. PATIENTS AND METHODS:We retrospectively analysed the outcome of patients with high risk proliferative diabetic retinopathy (PD...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章,随机对照试验

    doi:10.1055/s-0035-1545795

    authors: Ambresin A,Strueven V,Pournaras JA

    更新日期:2015-04-01 00:00:00

  • [Clinical applications of molecular diagnosis of retinoblastoma ain 15 families].

    abstract:PURPOSE:In 40% retinoblastoma (Rb) results from a hereditary mutation of the Rb susceptibility gene (RB1). In this study, we tested the usefulness of intragenic DNA analysis for ophthalmologic follow-up in affected families. METHODS:Molecular analysis was performed on 103 DNA samples of 15 Rb families. We used 7 intra...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1035456

    authors: Lendi B,Pescia G,Thonney F,Balmer A,Munier F

    更新日期:1995-05-01 00:00:00

  • [Spontaneous hematocornea after keratitis of various etiology].

    abstract:BACKGROUND:Corneal blood staining may occur as a serious complication of persisting hyphema. In our two cases the corneal blood staining is a result of direct bleeding in the corneal stroma. HISTORY AND SIGNS:A female patient presented with a corneal blood staining through rupture of reopened vessels in interstitial k...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1035098

    authors: Giessler S,Gross M,Struck HG

    更新日期:1997-07-01 00:00:00

  • [Orthoptic exercises - a historical survey (author's transl)].

    abstract::A survey is presented of orthoptic exercises practiced over the last 120 years. An attempt is made to deduce attitudes to the exercises from contemporary sensory theories. The currently prevalent nihilistic attitude toward orthoptic training is discussed. ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 历史文章,杂志文章

    doi:10.1055/s-2008-1057189

    authors: Dannheim E

    更新日期:1981-03-01 00:00:00

  • [Tear film diagnosis in contact lens wearers].

    abstract::Contact lenses have an intimate relationship with the precorneal tear film and it is important to attempt to prognosticate the likelihood of successful contact lens wear by evaluating, both quantitative and qualitative aspects of the precorneal tear film. Aspects of history diagnostic methods and general aspects which...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章,评审

    doi:10.1055/s-2008-1046269

    authors: Lemp MA,Gold JB

    更新日期:1990-09-01 00:00:00

  • [Refractive benefit and incremental costs of LASIK: results of a cost benefit study in two universities' LASIK departments].

    abstract:BACKGROUND:No data is available to date on the cost effectiveness of laser in situ keratomileusis (LASIK) with regard to the German-speaking health care system. Hence we compared the clinical outcome and cost data of two German LASIK centres in respect of procedure cost effectiveness from the patient perspective. MATE...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章,多中心研究

    doi:10.1055/s-2003-39424

    authors: Krummenauer F,Roden M,Knorz MC,Dick HB

    更新日期:2003-05-01 00:00:00

  • [Malignancies in relatives of retinoblastoma patients (author's transl)].

    abstract::In 14 out of 25 patients with retinoblastoma there was a family history of malignancies. Most of the malignant tumours had been carcinomas. In 2 families relatives died because of leukaemia; in these cases the tumour was a so-called diffuse retinoblastoma occurring in elder children. A third family with a retinoblasto...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Stefani FH

    更新日期:1976-05-01 00:00:00

  • [Syphilis-associated uveitis in Switzerland].

    abstract:BACKGROUND:In spite of the worldwide declining number of syphilis cases, there has been stable rate of syphilis infections in Switzerland from 2006 - 2008. In the year 2008 672 case were reported. Uveitis is the most common ocular finding in syphilis. It occurs in 2.5 %-5 % of all cases. HISTORY AND SIGNS:Six patients...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-0031-1273229

    authors: Jäger S,Meier FM

    更新日期:2011-04-01 00:00:00

  • [Clinical and fluorescein angiography findings in patients with retinal vein occlusion. A unicenter study of 211 patients].

    abstract::Between january 1986 and december 1989 we prospectively studied 211 patients with branch retinal vein occlusion (BRVO). Documented by fundus photography and fluorescein angiography clinical and angiographic findings were analysed. The age ranged from 28 to 83 with a mean of 63 years. 104 (48.8%) patients were male, 10...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1045901

    authors: Lang GE,Freissler K

    更新日期:1992-10-01 00:00:00