[Intravitreal anti-VEGF treatment of choroidal neovascularization (CNV) in pathological myopia (PM): a review].

Abstract:

:Anti-VEGF injections are widely used "off-label" for the treatment of choroidal neovascularization secondary to pathological myopia based on data generated by multiple case series with small sample sizes. In this review we have analyzed the results of case series with at least 20 patients and a follow-up of ≥ 12 months. 18 case series were identified in Medline meeting these demands. The mean gain of visual acuity after 12 months was 2.2 ± 0.7 (mean ± 1 standard deviation, case number weighted: 2.0) lines with a mean of 3.0 ± 1.7 injections (case number weighted 2.7). There was no significant difference between bevacizumab and ranibizumab. The mean gain of visual acuity in the first year could be stabilized in the second year with a visual acuity of a mean of 2.2 ± 1.0 lines at the end of follow-up. The mean age of patients at the beginning was 56.0 ± 6.0 (case number weighted: 56.2). The results of this analysis indicate very clearly that a favourable long-term outcome can be achieved with a relatively small number of injections in cases of choroidal neovascularization secondary to pathological myopia.

journal_name

Klin Monbl Augenheilkd

authors

Hefner L,Gerding H

doi

10.1055/s-0034-1368289

subject

Has Abstract

pub_date

2014-04-01 00:00:00

pages

414-7

issue

4

eissn

0023-2165

issn

1439-3999

journal_volume

231

pub_type

杂志文章,meta分析,评审
  • [Optimization of irradiation time in the treatment of malignant melanoma of the choroid with beta applicators (106Ru/106Rh)].

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    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1050770

    authors: Lommatzsch PK,Weise B,Ballin R

    更新日期:1986-08-01 00:00:00

  • [Echographic findings in choroidal detachment].

    abstract::A- and B-scan sonography was performed in 83 patients with choroidal detachment; a serous choroidal detachment is characterized by high, bifurcated echospikes and an echo-free subchoroidal space in A-scan sonography. The B-scan presents a typical arc shape. In hemorrhagic choroidal detachment multiple echoes with low ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1054708

    authors: Rochels R,Hackelbusch R

    更新日期:1983-01-01 00:00:00

  • [Satisfaction of cataract patients].

    abstract:BACKGROUND:Most of the presentations concerning quality assurance following cataract surgery are based upon objective data, as it should be. But the success of an eye-clinic is not limited by such objective data, but on the contentment of the patients and the local colleagues, who direct the patients. Our aim in the fo...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1035305

    authors: Wenzel M,Altgassen G

    更新日期:1996-10-01 00:00:00

  • [Trabeculectomy or Goniotrepanation -- a comparison of the postoperative course (author's transl)].

    abstract::No significant differences could be determined postoperatively between trabeculectomy and goniotrepanation. However, cases of flattened anterior chambers and choroidal detachments were less frequent after goniotrepanation than after trabeculectomy. ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1057716

    authors: Leuenberger AE,Tilen A

    更新日期:1980-12-01 00:00:00

  • [Basics for the Preparation of an Ophthalmological Expert Assessment].

    abstract::The position of the ophthalmologist as an unbiased and impartial expert in the field of tension between the client and the patient is a responsible task that should not be underestimated. Since the ophthalmological expert assessment often has far-reaching legal and financial consequences, it is very important that it ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/a-0889-9523

    authors: von Livonius B

    更新日期:2019-04-18 00:00:00

  • [A contribution of the course of vitreous haemorrhage (author's transl)].

    abstract::After some basic remarks about the physiological adhesions of the vitreous body to its surrounding structures in the anterior part of the eye (lens, ciliary body, pars plana) and the posterior part of the eye (macular, optic disc) the general history of bleeding in the vitreous body and the different possibilities of ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Plange H,Speiser P

    更新日期:1976-10-01 00:00:00

  • [Erythropsia following exposure to toluene].

    abstract::A patient who had been exposed to toluol for ten years developed acute erythropsia. The examinations leading to the diagnosis and the possible differential diagnosis are discussed. ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1046214

    authors: Prünte-Glowazki A

    更新日期:1990-05-01 00:00:00

  • [Myelinization of the optic nerve in the albino mouse (the Agnes Bluhm Jena-Halle strain)].

    abstract::Knowledge of normal differentiations is indispensable for interpreting developmental disturbances in animal experiments. Accordingly, the investigations described in the present paper were aimed at explaining the process of myelinization of the optic nerve in the domestic mouse breed Agnes Bluhm Jena-Halle. First sign...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1054917

    authors: Bernstein E,Tost M,Holzhausen HJ

    更新日期:1983-10-01 00:00:00

  • [Observations on cataract incision dehiscence (author's transl)].

    abstract::24 patients with rupturing corneal incisions were observed within 6 years from 1971 until 1976. 19 patients had already had cataract extractions performed by us. This complication occurred in 0.5% of cases. All ruptures were investigated regarding the period of time after the cataract extraction, and possible precipit...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Bleckmann H

    更新日期:1977-05-01 00:00:00

  • [Experiences with the implantation of anterior chamber lenses (author's transl)].

    abstract::On account of the good results with the new generation of anterior chamber lenses reported by C.D. Binkhorst, the implantation of lenses was begun in 1969 at the Department of Ophthalmology in Bremen and 350 anterior chamber lenses were implanted till 1st Febr. 1977. After the presentation of indications and the opera...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章,评审

    doi:

    authors: Draeger J,Koudelka A,Modzanowski P

    更新日期:1978-03-01 00:00:00

  • [Results of Cüpper's "thread fixation" in squinters with inconstant angle (author's transl)].

    abstract::The results of strabismus operations on strabismus patients with variable angles are presented. The so-called "Fadenfixation" (Cüppers) is compared with the usual recess-resect method. Of the 62 cases of strabismus with variable angle which were operated without the "Fixation", only 3 cases were parallel post-operatio...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Behrens-Baumann W,Wölz U

    更新日期:1978-12-01 00:00:00

  • [Abnormal head turn in a patient with Brown's syndrome].

    abstract:BACKGROUND:We report on an eight-year-old boy, who was presented in our clinic because of head turn. The cause of the tortecollis (ocular or general) in this case was and still cannot be explained. Only by applying extensive prism adaptation tests it was possible to prove the ocular character of the head turn. CASE RE...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1027477

    authors: van Waveren M,Krzizok T,Besch D

    更新日期:2008-08-01 00:00:00

  • [Postherpetic neuralgia].

    abstract:BACKGROUND:In the last years, new findings from the research on pain diseases and the enhancement of therapeutic options have drastically changed the treatment of postherpetic neuralgia (PHN). This disease, belonging to the neuropathic pain syndromes, needs an adequate pain therapy at an early stage to prevent pain chr...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章,评审

    doi:10.1055/s-0029-1245273

    authors: Mahn F,Baron R

    更新日期:2010-05-01 00:00:00

  • [Silent sinus syndrome: an unusual cause of vertical diplopia].

    abstract:BACKGROUND:Causes of transient vertical diplopia include myasthenia, dysthyroid orbitopathy, multiple sclerosis, decompensation of a pre-existing state. PURPOSE:To describe an unusual cause of transient diplopia, silent sinus syndrome. METHODS:Clinical, radiological and pathology findings from a 55-year-old man with ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1034917

    authors: Durig J,Borruat FX,Jaques B

    更新日期:1998-05-01 00:00:00

  • [Are prism glasses a sensible measure in treatment of dyslexia?].

    abstract::A short summary of the characteristics of speaking, reading and writing is given, followed by the respective anatomical, physiological and neuropsychological counterparts, which are to be described as the "Hör-Denk-Sprech-Seh-Schreib-Organismus" (H-D-S-S-SCH-O). Various disorders occurring in the H-D-S-S-SCH-O as well...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1045842

    authors: Schwarz C

    更新日期:1992-05-01 00:00:00

  • [Visual acuity following Descemet-membrane endothelial keratoplasty (DMEK): first 100 cases operated on for Fuchs endothelial dystrophy].

    abstract:PURPOSE:The aim of this study was to evaluate the visual outcome and endothelial cell density in the first series of 100 eyes after Descemet membrane endothelial keratoplasty (DMEK) for the treatment of Fuchs endothelial dystrophy. DESIGN:This was a non-randomised prospective clinical trial. METHODS:The first 100 con...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 临床试验,杂志文章

    doi:10.1055/s-0029-1245446

    authors: Droutsas K,Ham L,Dapena I,Geerling G,Oellerich S,Melles G

    更新日期:2010-06-01 00:00:00

  • [Intraocular pressure measurements with the Proview self-tonometer in comparison of Goldmann applanation tonometry in healthy and glaucomatous eyes].

    abstract:BACKGROUND:The aim of this study was to compare the results of intraocular pressure (IOP) measurements obtained using the pressure phosphene tonometer Proview with those from Goldmann applanation tonometer (GAT) in normal and glaucomatous eyes. PATIENTS AND METHODS:The IOP in 150 eyes of 62 healthy volunteers and 88 p...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2006-927094

    authors: Meyer MW,Yevelenko V,Hoy L,Meyer A,Erb C

    更新日期:2006-11-01 00:00:00

  • [Minimizing induction of astigmatism in preoperative spherical cornea a. by mini-incision surgery with foldable IOL and b. by corneal tunnel incision with limbal relaxing incision].

    abstract:BACKGROUND:In case of a spheric cornea preoperatively the refractive effect of a clear corneal cataract incision is undesirable. We studied two actual techniques to minimize the surgically induced astigmatism. PATIENTS AND METHODS:Temporal clear corneal incision was performed in 77 patients with practically spherical ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 临床试验,杂志文章

    doi:10.1055/s-2008-1034692

    authors: Müller-Jensen K,Fischer P

    更新日期:1999-09-01 00:00:00

  • [Preferred techniques of eyelid reconstruction].

    abstract::The trend of lid reconstruction is to use less lid sharing operations. Free tarsoconjunctival or composite grafts in conjunction with covering skin muscle transplants have allowed suitable and cosmetically acceptable methods of full lid repairs. Our preferred surgical techniques are provided. Such methods of reconstru...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章,评审

    doi:10.1055/s-2008-1045933

    authors: Beyer-Machule CK

    更新日期:1991-02-01 00:00:00

  • Central serous chorioretinopathy associated with adrenal myelolipoma.

    abstract:BACKGROUND:We describe a case of central serous chorioretinopathy associated with a large adrenal myelolipoma. HISTORY AND SIGNS:A 55-year old man was admitted to our clinic complaining for metamorphopsia and blurred vision in his left eye. Standard ophthalmologic examination and fluorescein angiography established th...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2003-38187

    authors: Katsimpris JM,Vandoros M,Petropoulos IK,Andrikopoulos P

    更新日期:2003-03-01 00:00:00

  • [Keratoplasty in private practice].

    abstract::The problems associated with performing penetrating keratoplasty in private practice are briefly discussed: access to an eye bank, high-risk patients, immunosuppressive therapy, complications, and results. One negative aspect is the relatively high incidence (10%) of primary graft failure, but allograft reactions are ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1046177

    authors: Witmer R

    更新日期:1990-05-01 00:00:00

  • [Perimetric diagnosis of chiasmal injury after contusion of skull and brain (author's transl)].

    abstract::After a discussion of the pathomechanism of skull trauma by a blow leading to chiasmal lesion, frontobasal injuries of the skull are considered; it is shown that typical defects of the visual field resulting from chiasmal damage can be revealed not only in cases of serious industrial or traffic accidents with brain co...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Fulmek R

    更新日期:1976-11-01 00:00:00

  • [Colour Doppler imaging in normal pressure glaucoma patients].

    abstract:AIM:Ocular hemodynamics is of great interest in glaucoma, especially since vascular disturbances may play a pathogenetic role in disease development. To investigate the hemodynamic differences between normal pressure glaucoma patients and normal volunteers, flow velocities of the retrobulbar vessels were measured by co...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2005-858706

    authors: Huber KK,Plange N,Arend O,Remky A

    更新日期:2006-02-01 00:00:00

  • [A method for recording the network topology of human retinal vessels].

    abstract::Network analysis of the human retinal vessels must be based on a thorough knowledge of the topology of the network. This derives from the numerical composition of the network's individual components. Using histologic specimens, centrifugal and centripetal ordering methods were compared. It was found necessary to use a...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1046240

    authors: Schröder S,Schmid-Schönbein GW,Schmid-Schönbein H,Brub M,Reim M

    更新日期:1990-07-01 00:00:00

  • [The usefulness of echography in retinal surgery (author's transl)].

    abstract::Upon utilization of echography one certainly will not be able to detect retinal defects; however, other parameters of retinal detachment which by means of solely optical examination techniques may remain undiagnosed can be evaluated successfully. This concerns not only the diagnosis of retinal detachment alone but als...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Freyler H

    更新日期:1979-03-01 00:00:00

  • [Clinical and pathologic-anatomical results following the application of a mobile argon-laser beam in aphakic pupillary block glaucoma (author's transl)].

    abstract::In the last four years we have treated with the mobile argon-laser beam 25 cases of aphakic pupillary block glaucoma (p. b. g.). According to the time of manifestation of the p. b. g. the patients were divided into an "early" and a "late" group. In the "early" group (17 eyes) the glaucoma manifested itself 1--4 days a...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Theodossiadis G,Kouris-Bairaktari E,Velissaropoulos P

    更新日期:1979-08-01 00:00:00

  • [Long-term follow-up of 700 trabeculectomies].

    abstract:BACKGROUND:A major focus of our study was to determine the value of postoperative intraocular pressure (IOP) in predicting the outcome of trabeculectomy (TE). PATIENTS AND METHODS:The medical charts of 547 patients undergoing glaucoma filtering surgery at the Department of Ophthalmology of the University of Cologne fr...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2000-10376

    authors: Khalili MA,Diestelhorst M,Krieglstein GK

    更新日期:2000-07-01 00:00:00

  • [NF2: ocular, neural and genetic manifestations].

    abstract::Neurofibromatosis 2 is an autosomal-dominant disease, which is characterized by vestibular schwannomas, cataract, retinal hamartomas as well as tumors of the peripheral and central nerve system, demonstrating a variety of expression. The ophthalmologist plays an important role in making the diagnosis, as several ocula...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章,评审

    doi:10.1055/s-2005-857956

    authors: Feucht M,Mautner VF,Richard G

    更新日期:2005-04-01 00:00:00

  • [Ocular manifestations of rheumatic diseases. Cooperation between internist/ophthalmologist].

    abstract::A red or painful eye may be the clue to a systemic condition, many of which are of a rheumatological or immunological nature. Conjunctivitis may occur in Sjögren's Syndrome, Reiter's Syndrome (and other sero negative spondyloarthropathies) and with infections such as chlamydia and viruses. 70% of cases of episcleritis...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章,评审

    doi:10.1055/s-2008-1045602

    authors: Tyndall A,Steiger U

    更新日期:1993-05-01 00:00:00

  • Internal Limiting Membrane Flap Techniques for the Repair of Large Macular Holes: a Short-Term Follow-up of Anatomical and Functional Outcomes.

    abstract::Background To evaluate the technique of inverted internal limiting membrane (ILM) flaps for the management of large macular holes and autologous ILM free flaps for non-closing macular holes. Patients and methods All macular holes were treated with pars plana vitrectomy and dual blue assisted ILM flap technique. The in...

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    pub_type: 杂志文章

    doi:10.1055/s-0042-119694

    authors: Guber J,Lang C,Valmaggia C

    更新日期:2017-04-01 00:00:00