Genetic identification of exported proteins in Streptococcus pneumoniae.

abstract：:The DNA sequence of the structural gene (yopE) of one of the Yersinia pseudotuberculosis virulence plas-mid-plB1-encoded proteins, Yop5, is presented. The deduced protein showed a molecular weight of 22971 Daltons. A specific mutant, having a kanamycin-resistance fragment inserted within the yopE gene was no longer vi...

journal_title：Molecular microbiology

authors： Forsberg A,Wolf-Watz H

更新日期：1988-01-01 00:00:00

abstract：:In Xanthomonas campestris pv. phaseoli, a gene for the alkyl hydroperoxide reductase subunit C (ahpC) had unique patterns of regulation by various forms of OxyR. Reduced OxyR repressed expression of the gene, whereas oxidized OxyR activated its expression. This dual regulation of ahpC is unique and unlike all other Ox...

journal_title：Molecular microbiology

authors： Loprasert S,Fuangthong M,Whangsuk W,Atichartpongkul S,Mongkolsuk S

更新日期：2000-09-01 00:00:00

abstract：:Metal ions are crucial trace elements for bacteria infecting the human host. The LraI (lipoprotein receptor-associated antigen I) transporter in Streptococcus spp. belongs to the superfamily of ABC transporters. The transporter consists of a lipoprotein, an ATP-binding protein and a hydrophobic integral membrane prote...

journal_title：Molecular microbiology

authors： Janulczyk R,Pallon J,Björck L

更新日期：1999-11-01 00:00:00

abstract：:Ribosome-tethered chaperones that interact with nascent polypeptide chains have been identified in both prokaryotic and eukaryotic systems. However, these ribosome-associated chaperones share no sequence similarity: bacterial trigger factors (TF) form an independent protein family while the yeast machinery is Hsp70-ba...

journal_title：Molecular microbiology

authors： Rauch T,Hundley HA,Pfund C,Wegrzyn RD,Walter W,Kramer G,Kim SY,Craig EA,Deuerling E

更新日期：2005-07-01 00:00:00

abstract：:Billions of years of evolution have yielded today's complex metabolic networks driven by efficient and highly specialized enzymes. In contrast, the metabolism of the earliest cellular life forms was likely much simpler with only a few enzymes of comparatively low activity. It has been speculated that these early enzym...

journal_title：Molecular microbiology

authors： Seelig B

更新日期：2017-08-01 00:00:00

abstract：:Deletion of gene Rv3676 in Mycobacterium tuberculosis coding for a transcription factor belonging to the cAMP receptor protein (CRP) family caused growth defects in laboratory medium, in bone marrow-derived macrophages and in a mouse model of tuberculosis. Transcript profiling of M. tuberculosis grown in vitro identif...

journal_title：Molecular microbiology

authors： Rickman L,Scott C,Hunt DM,Hutchinson T,Menéndez MC,Whalan R,Hinds J,Colston MJ,Green J,Buxton RS

更新日期：2005-06-01 00:00:00

abstract：:In '5'-translational blockage', significantly reduced yields of proteins are synthesized in Escherichia coli when consecutive low-usage codons are inserted near translation starts of messages (with reduced or no effect when these same codons are inserted downstream). We tested the hypothesis that ribosomes encounterin...

journal_title：Molecular microbiology

authors： Gao W,Tyagi S,Kramer FR,Goldman E

更新日期：1997-08-01 00:00:00

abstract：:The majority of characterized bacterial dipeptide permeases (Dpp) are membrane-associated complexes of five proteins belonging to the ABC-transporter family. They have been found to be involved in the uptake of essential amino acids, haem production, chemotaxis and sporulation. A 5.8 kb genomic DNA fragment of the ser...

journal_title：Molecular microbiology

authors： Podbielski A,Leonard BA

更新日期：1998-06-01 00:00:00

abstract：:Lyme disease is a tick-transmitted infection caused by the spirochete Borrelia burgdorferi. Ticks deposit B. burgdorferi into the dermis of the host, where they eventually become associated with collagen fibres. We demonstrated previously that B. burgdorferi is unable to bind collagen, but can bind the collagen-associ...

journal_title：Molecular microbiology

authors： Guo BP,Brown EL,Dorward DW,Rosenberg LC,Höök M

更新日期：1998-11-01 00:00:00

abstract：:In Caulobacter crescentus the partitioning proteins ParA and ParB operate a molecular switch that couples chromosome partitioning to cytokinesis. Homologues of these proteins have been shown to be important for the stable inheritance of F-plasmids and the prophage form of bacteriophage P1. In C. crescentus, ParB binds...

journal_title：Molecular microbiology

authors： Figge RM,Easter J,Gober JW

更新日期：2003-03-01 00:00:00

abstract：:The translocation of proteins across the bacterial cell membrane is carried out by highly conserved components of the Sec system. Most bacterial species have a single copy of the genes encoding SecA and SecY, which are essential for viability. However, Streptococcus gordonii strain M99 encodes SecA and SecY homologues...

journal_title：Molecular microbiology

authors： Bensing BA,Sullam PM

更新日期：2002-05-01 00:00:00

abstract：:Toxin-antitoxin (TA) systems on the chromosomes of free-living bacteria appear to facilitate cell survival during intervals of stress by inducing a state of reversible growth arrest. However, upon prolonged stress, TA toxin action leads to cell death. They have been implicated in several clinically important phenomena...

journal_title：Molecular microbiology

authors： Prysak MH,Mozdzierz CJ,Cook AM,Zhu L,Zhang Y,Inouye M,Woychik NA

更新日期：2009-03-01 00:00:00

abstract：:Until recently, rare-earth elements (REEs) had been thought to be biologically inactive. This view changed with the discovery of the methanol dehydrogenase XoxF that strictly relies on REEs for its activity. Some methylotrophs only contain xoxF, while others, including the model phyllosphere colonizer Methylobacterium...

journal_title：Molecular microbiology

authors： Ochsner AM,Hemmerle L,Vonderach T,Nüssli R,Bortfeld-Miller M,Hattendorf B,Vorholt JA

更新日期：2019-05-01 00:00:00

abstract：:Kinetoplastid topoisomerase IB is an unusual bisubunit enzyme where reconstitution of the large (LdTOPIL or L) and small (LdTOPIS or S) subunits shows functional activity. It is yet to be deciphered whether one subunit or both navigate the heterodimer to its cellular DNA targets. Tethering a specific DNA-binding prote...

journal_title：Molecular microbiology

authors： BoseDasgupta S,Ganguly A,Das BB,Roy A,Khalkho NV,Majumder HK

更新日期：2008-01-01 00:00:00

abstract：:The inv locus of Yersinia enterocolitica is sufficient to convert a non-invasive Escherichia coli K12 strain into a microorganism that is able to penetrate cultured mammalian cells. The nucleotide sequence of inv reveals an open reading frame corresponding to an 835-amino-acid protein that is homologous to the invasin...

journal_title：Molecular microbiology

authors： Young VB,Miller VL,Falkow S,Schoolnik GK

更新日期：1990-07-01 00:00:00

abstract：:Cell cycle transitions are often triggered by the proteolysis of key regulatory proteins. In Caulobacter crescentus, the G1-S transition involves the degradation of an essential DNA-binding response regulator, CtrA, by the ClpXP protease. Here, we show that another critical cell cycle regulator, SciP, is also degraded...

journal_title：Molecular microbiology

authors： Gora KG,Cantin A,Wohlever M,Joshi KK,Perchuk BS,Chien P,Laub MT

更新日期：2013-03-01 00:00:00

abstract：:We have devised a simple method for the reconstitution of bacterial membrane proteins directly from small (1-20 ml) volumes of cell culture, thus eliminating the preparation of membrane vesicles. Cells are subjected to simultaneous lysozyme digestion and osmotic lysis, and after brief centrifugation ghosts are solubil...

journal_title：Molecular microbiology

authors： Varadhachary A,Maloney PC

更新日期：1990-08-01 00:00:00

abstract：:Protein ubiquitylation plays a major role in the regulation of cellular processes mainly through proteasome-dependent degradation, although it has become increasingly clear that it is also involved in other processes. In the fungus Mucor circinelloides, blue light regulates carotene biosynthesis, with this response co...

journal_title：Molecular microbiology

authors： Silva F,Navarro E,Peñaranda A,Murcia-Flores L,Torres-Martínez S,Garre V

更新日期：2008-11-01 00:00:00

abstract：:We isolated and characterized three spontaneous mutations leading to trimethylamine N-oxide (TMAO)-independent expression of the tor operon encoding the TMAO-reductase anaerobic respiratory system in Escherichia coli. The mutations lie in a new for regulatory gene, the torS gene, which probably encodes a sensor protei...

journal_title：Molecular microbiology

authors： Jourlin C,Bengrine A,Chippaux M,Méjean V

更新日期：1996-06-01 00:00:00

abstract：:Regulation of gene expression in trypanosomatid parasitic protozoa is mainly achieved posttranscriptionally. RNA-binding proteins (RBPs) associate to 3' untranslated regions in mRNAs through dedicated domains such as the RNA recognition motif (RRM). Trypanosoma cruzi UBP1 (TcUBP1) is an RRM-type RBP involved in stabil...

journal_title：Molecular microbiology

authors： Cassola A,Romaniuk MA,Primrose D,Cervini G,D'Orso I,Frasch AC

更新日期：2015-09-01 00:00:00

abstract：:Cytochrome b558 in the cytoplasmic membrane of Bacillus subtilis constitutes the anchor and electron acceptor to the flavoprotein (Fp) and iron-sulphur protein (Ip) in succinate:quinone oxidoreductase, and seemingly contains two haem groups. EPR and MCD spectroscopic data indicate bis-imidazole ligation of the haem. A...

journal_title：Molecular microbiology

authors： Fridén H,Hederstedt L

更新日期：1990-06-01 00:00:00

abstract：:Small regulatory RNAs (sRNAs) are well known to command bacterial protein synthesis by modulating the translation and decay of target mRNAs. Most sRNAs are specifically regulated by a cognate transcription factor under certain growth or stress conditions. Investigations of the conserved Hfq-dependent MicM sRNA in Esch...

journal_title：Molecular microbiology

authors： Vogel J

更新日期：2009-09-01 00:00:00

abstract：:Myxococcus xanthus is a Gram-negative bacterium capable of complex developmental processes involving vegetative swarming and fruiting body formation. Social (S-) gliding motility, one of the two motility systems used by M. xanthus, requires at least two cell surface structures: type IV pili (TFP) and extracellular pol...

journal_title：Molecular microbiology

authors： Yang Z,Lux R,Hu W,Hu C,Shi W

更新日期：2010-06-01 00:00:00

abstract：:We have found a simple relationship between bacterial growth rate and the translation elongation rate. Thus, for a set of defined ribosomal protein S12 mutations which reduce the efficiency of the ternary complex ribosome interaction (and restrict the frequency of translational errors) there is a linear relationship b...

journal_title：Molecular microbiology

authors： Tubulekas I,Hughes D

更新日期：1993-01-01 00:00:00

abstract：:Pregnancy-associated malaria (PAM) is caused by Plasmodium falciparum-infected erythrocytes (IEs) that bind to chondroitin sulphate A (CSA) in the placenta by PAM-associated clonally variant surface antigens (VSA). Pregnancy-specific VSA (VSA(PAM)), which include the PfEMP1 variant VAR2CSA, are targets of IgG-mediated...

journal_title：Molecular microbiology

authors： Barfod L,Bernasconi NL,Dahlbäck M,Jarrossay D,Andersen PH,Salanti A,Ofori MF,Turner L,Resende M,Nielsen MA,Theander TG,Sallusto F,Lanzavecchia A,Hviid L

更新日期：2007-01-01 00:00:00

abstract：:Bacterial biofilms contain subpopulations of cells that are dormant and highly tolerant to antibiotics. While dormant, the bacteria must maintain the integrity of macromolecules required for resuscitation. Previously, we showed that hibernation promoting factor (HPF) is essential for protecting Pseudomonas aeruginosa ...

journal_title：Molecular microbiology

authors： Akiyama T,Williamson KS,Franklin MJ

更新日期：2018-10-01 00:00:00

abstract：:The S box transcription termination control system regulates expression of genes involved in methionine metabolism. Expression of the S box regulon, comprised of 11 transcriptional units in Bacillus subtilis, is induced in response to starvation for methionine. We previously demonstrated that S-adenosylmethionine (SAM...

journal_title：Molecular microbiology

authors： McDaniel BA,Grundy FJ,Henkin TM

更新日期：2005-08-01 00:00:00

abstract：:Rifampicin resistance, a defining attribute of multidrug-resistant tuberculosis, is conferred by mutations in the β subunit of RNA polymerase. Sequencing of rifampicin-resistant (RIF-R) clinical isolates of Mycobacterium tuberculosis revealed, in addition to RIF-R mutations, enrichment of potential compensatory mutati...

journal_title：Molecular microbiology

authors： Song T,Park Y,Shamputa IC,Seo S,Lee SY,Jeon HS,Choi H,Lee M,Glynne RJ,Barnes SW,Walker JR,Batalov S,Yusim K,Feng S,Tung CS,Theiler J,Via LE,Boshoff HI,Murakami KS,Korber B,Barry CE 3rd,Cho SN

更新日期：2014-03-01 00:00:00

abstract：:The development of new drugs for treating Pneumocystis carinii infections in AIDS patients is hampered by the lack of long-term culture systems, and by our generally limited knowledge of this organism. Recently, however, we observed significant activity of various benzimidazoles against growth of this organism in shor...

journal_title：Molecular microbiology

authors： Edlind TD,Bartlett MS,Weinberg GA,Prah GN,Smith JW

更新日期：1992-11-01 00:00:00

abstract：:In response to nitrate availability, Escherichia coli regulates the synthesis of a number of enzymes involved in anaerobic respiration and fermentation. When nitrate is present, nitrate reductase (narGHJI) gene expression is induced, while expression of the DMSO/TMAO reductase (dmsABC), fumarate reductase (frdABCD) an...

journal_title：Molecular microbiology

authors： Chiang RC,Cavicchioli R,Gunsalus RP

更新日期：1992-07-01 00:00:00