Abstract:
:Small regulatory RNAs (sRNAs) are well known to command bacterial protein synthesis by modulating the translation and decay of target mRNAs. Most sRNAs are specifically regulated by a cognate transcription factor under certain growth or stress conditions. Investigations of the conserved Hfq-dependent MicM sRNA in Escherichia coli (article by Poul Valentin-Hansen and colleagues in this issue of Molecular Microbiology) and in Salmonella have unravelled a novel type of gene regulation in which the chitobiose operon mRNA acts as an RNA trap to degrade the constitutively expressed MicM sRNA, thereby alleviating MicM-mediated repression of the synthesis of the YbfM porin that is required for chitosugar uptake. The results suggest that 'target' mRNAs might be both prey and also predators of sRNAs.
journal_name
Mol Microbioljournal_title
Molecular microbiologyauthors
Vogel Jdoi
10.1111/j.1365-2958.2009.06806.xsubject
Has Abstractpub_date
2009-09-01 00:00:00pages
737-41issue
5eissn
0950-382Xissn
1365-2958pii
MMI6806journal_volume
73pub_type
评论,杂志文章abstract::Borrelia hermsii, an agent of relapsing fever, avoids the host's immune response by means of multiphasic antigenic variation. Serotype specificity is determined by variable antigens called the Vmp lipoproteins. Through recombination between linear plasmids a formerly silent vmp gene replaces another vmp gene at a telo...
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