Abstract:
:The present study investigated the effects of positive and negative GABA(A) modulators under three different baselines of repeated acquisition in squirrel monkeys in which the monkeys acquired a three-response sequence on three keys under a second-order fixed-ratio (FR) schedule of food reinforcement. In two of these baselines, the second-order FR schedule and the discriminative stimuli for the response sequence were manipulated ("chain-strained" and "tandem-strained"). In the third baseline condition, response-independent tail shock was presented during acquisition of the response sequence. All of these baselines maintained high error levels and produced slow rates of acquisition. Under both the chain-strained and tandem-strained conditions, the positive GABA(A) modulator triazolam (0.0032-0.1 mg/kg) and the negative GABA(A) modulators beta-CCE (ethyl-beta-carboline-3-carboxylate; 0.01-1 mg/kg), beta-CCM (methyl-beta-carboline-3-carboxylate; 0.0032-0.1 mg/kg), and FG-7142 (methyl-beta-carboline-3-carboxamide; 0.18-10 mg/kg) dose-dependently decreased overall response rate compared to administration of saline (control). Under the same two conditions, triazolam and the negative GABA(A) modulators also increased the percentage of errors; however, the effects on accuracy frequently depended on the baseline condition and the particular modulator. In contrast, triazolam only decreased errors and enhanced acquisition in the presence of concurrent response-independent tail shock when compared to saline administration under this condition. The neutral GABA(A) modulator, flumazenil (1 mg/kg), had no effect on rate or accuracy of responding when administered alone, but antagonized the rate-decreasing and error-increasing effects produced by the negative GABA(A) modulators. Together, these data suggest that the effects of both the positive and negative GABAA modulators on acquisition can be similar in squirrel monkeys (i.e., both types of modulator may produce rate-decreasing and error-increasing effects) and that their effects on acquisition depend, in part, on the environmental conditions maintaining acquisition.
journal_name
J Exp Anal Behavjournal_title
Journal of the experimental analysis of behaviorauthors
Campbell UC,Winsauer PJ,Stevenson MW,Moerschbaecher JMdoi
10.1901/jeab.2004.82-37subject
Has Abstractpub_date
2004-07-01 00:00:00pages
37-56issue
1eissn
0022-5002issn
1938-3711journal_volume
82pub_type
杂志文章abstract::In a residential research ward coffee drinking was studied in 9 volunteer human subjects with histories of heavy coffee drinking. A series of five experiments was undertaken to characterize adlibitum coffee consumption and to investigate the effects of manipulating coffee concentration, caffeine dose per cup, and caff...
journal_title:Journal of the experimental analysis of behavior
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1901/jeab.1986.45-133
更新日期:1986-03-01 00:00:00
abstract::Models that generate event records have very general scope regarding the dimensions of the target behavior that we measure. From a set of predicted event records, we can generate predictions for any dependent variable that we could compute from the event records of our subjects. In this sense, models that generate eve...
journal_title:Journal of the experimental analysis of behavior
pub_type: 杂志文章
doi:10.1002/jeab.330
更新日期:2018-05-01 00:00:00
abstract::In behavior analysis, research on stimulus equivalence has been an area of high activity for more than 45 years. Murray Sidman's contribution was crucial in the development of this field, and, thus, it seems informative to highlight the experiments that were necessary in the development of the descriptive model of equ...
journal_title:Journal of the experimental analysis of behavior
pub_type: 杂志文章
doi:10.1002/jeab.663
更新日期:2021-01-01 00:00:00
abstract::The present experiment examined the effects of acute and daily cocaine on spontaneous behavior patterns of pigeons. After determining the acute effects of a range of doses, 9 pigeons were divided into three groups that received one of three doses of cocaine daily, either 1.0, 3.0, or 10.0 mg/kg cocaine. Measures were ...
journal_title:Journal of the experimental analysis of behavior
pub_type: 杂志文章
doi:10.1901/jeab.2010.94-25
更新日期:2010-07-01 00:00:00
abstract::When a neutral cue is followed by a significant event such as food delivery, some animals become engaged with the cue itself and acquire cue-directed behaviors. One type of cue-directed behavior is observed following insertion of a lever used as a conditioned stimulus (CS). Rats showing robust approach behavior to the...
journal_title:Journal of the experimental analysis of behavior
pub_type: 杂志文章
doi:10.1002/jeab.104
更新日期:2014-09-01 00:00:00
abstract::Behavioral pharmacology has become increasingly independent of the experimental analysis of behavior. At its beginning, behavioral pharmacology was closely related to the experimental analysis of behavior, with developments in each field aiding the other. Early attempts to systematize data in behavioral pharmacology c...
journal_title:Journal of the experimental analysis of behavior
pub_type: 杂志文章
doi:10.1901/jeab.1984.42-511
更新日期:1984-11-01 00:00:00
abstract::When either a timeout period (darkening the response key) or a blackout period (darkening both chamber and response key) was alternated with a stimulus associated with variable-interval reinforcement, behavioral contrast was obtained. Either peck contrast or maintained contrast occurred, depending on whether or not re...
journal_title:Journal of the experimental analysis of behavior
pub_type: 杂志文章
doi:10.1901/jeab.1973.19-499
更新日期:1973-05-01 00:00:00
abstract::Three experiments compared the amounts of behavioral variability generated with two reinforcement rules. In Experiments 1 and 2 pigeons received food whenever they generated a sequence of eight pecks, distributed over two keys, provided that the sequence contained a certain number of change-overs between the keys. Alt...
journal_title:Journal of the experimental analysis of behavior
pub_type: 杂志文章
doi:10.1901/jeab.1997.68-1
更新日期:1997-07-01 00:00:00
abstract::Eight albino rats, conditioned to press a lever to escape shock, continued to lever press during short inescapable shocks presented subsequently. The rate of this behavior was found to be higher for higher shock intensities regardless of the order in which shock values were presented. Relative to the immediately prece...
journal_title:Journal of the experimental analysis of behavior
pub_type: 杂志文章
doi:10.1901/jeab.1969.12-1045
更新日期:1969-11-01 00:00:00
abstract::In three experiments pigeons played (i.e., chose between two colored keys) iterated prisoner's dilemma and other 2 x 2 games (2 participants and 2 options) against response strategies programmed on a computer. Under the prisoner's dilemma pay-off matrix, the birds generally defected (i.e., pecked the color associated ...
journal_title:Journal of the experimental analysis of behavior
pub_type: 杂志文章
doi:10.1901/jeab.1995.64-1
更新日期:1995-07-01 00:00:00
abstract::Responding of three pigeons was maintained under conjunctive fixed-ratio, fixed-interval schedules where a key peck produced food after both schedule requirements were completed. The individual schedule requirements were then successively removed and reinstated with responding maintained under the following conditions...
journal_title:Journal of the experimental analysis of behavior
pub_type: 杂志文章
doi:10.1901/jeab.1975.24-23
更新日期:1975-07-01 00:00:00
abstract::Four pigeons responded under a fixed-interval 8-min schedule of food delivery in which the amount of food delivered at the end of each interval depended on performance during the interval (i.e., a correlated schedule). Specifically, duration of access to grain was contingent upon the number of responses made during th...
journal_title:Journal of the experimental analysis of behavior
pub_type: 杂志文章
doi:10.1901/jeab.2001.76-217
更新日期:2001-09-01 00:00:00
abstract::The present study used within-session transitions between two concurrent schedules to evaluate choice in transition. Eight female Long-Evans rats were trained to respond under concurrent schedules of reinforcement during experimental sessions that lasted 22 hr. The generalized matching equation was used to model stead...
journal_title:Journal of the experimental analysis of behavior
pub_type: 杂志文章
doi:10.1901/jeab.2009.91-319
更新日期:2009-05-01 00:00:00
abstract::Three experiments were conducted to study the effect of an imperfect substitute for food on demand for food in a closed economy. In Experiments 1 and 2, rats pressed a lever for their entire daily food ration, and a fixed ratio of presses was required for each food pellet. In both experiments, the fixed ratio was held...
journal_title:Journal of the experimental analysis of behavior
pub_type: 杂志文章
doi:10.1901/jeab.1996.65-401
更新日期:1996-03-01 00:00:00
abstract::Choice between signaled and unsignaled response-independent food schedules was assessed in three experiments using a commitment procedure. In Experiment 1, subjects tested with a 5-s visual signal consistently changed from the signaled to the unsignaled schedule. Changing from the unsignaled to the signaled schedule w...
journal_title:Journal of the experimental analysis of behavior
pub_type: 杂志文章
doi:10.1901/jeab.1984.42-279
更新日期:1984-09-01 00:00:00
abstract::Two experiments investigated the effect of observing responses that enabled college students to emit more efficient distributions of reinforced responses. In Experiment 1, the gains of response efficiency enabled by observing were minimized through use of identical low-effort response requirements in two alternating v...
journal_title:Journal of the experimental analysis of behavior
pub_type: 杂志文章
doi:10.1901/jeab.1985.43-289
更新日期:1985-05-01 00:00:00
abstract::Subjects pressed a telegraph key to illuminate a meter dial on which pointer deflections appeared at fixed intervals. Upon detecting a deflection they were required to press another key to reset the pointer to zero. This detecting and resetting operation reinforced the behavior of pressing the light-flashing key (i.e....
journal_title:Journal of the experimental analysis of behavior
pub_type: 杂志文章
doi:10.1901/jeab.1963.6-431
更新日期:1963-07-01 00:00:00
abstract::Two multiple-schedule experiments with pigeons examined the effect of adding food reinforcement from an alternative source on the resistance of the reinforced response (target response) to the decremental effects of satiation and extinction. In Experiment 1, key pecks were reinforced by food in two components accordin...
journal_title:Journal of the experimental analysis of behavior
pub_type: 杂志文章
doi:10.1901/jeab.1990.53-359
更新日期:1990-05-01 00:00:00
abstract::Three experiments using human participants varied the distribution of point-gain reinforcers or point-loss punishers in two-alternative signal-detection procedures. Experiment 1 varied the distribution of point-gain reinforcers for correct responses (Group A) and point-loss punishers for errors (Group B) across condit...
journal_title:Journal of the experimental analysis of behavior
pub_type: 杂志文章
doi:10.1901/jeab.2009.92-17
更新日期:2009-07-01 00:00:00
abstract::Two successive studies were conducted to determine the possibility of operant reinforcement of nonspecific galvanic skin resistance responses. In the first study, with five experimental and three control subjects who served for 20 to 30 min a day for 10 days, all experimental subjects learned to emit more nonspecific ...
journal_title:Journal of the experimental analysis of behavior
pub_type: 杂志文章
doi:10.1901/jeab.1967.10-119
更新日期:1967-01-01 00:00:00
abstract::Analytic methods of signal detection theory were employed to assess the utility of reinforcers. Four pigeons were trained to detect the presence or absence of a stimulus by pecking one of two side keys in a trial-by-trial choice paradigm. The relative rate of positive reinforcement for correct choices was varied to of...
journal_title:Journal of the experimental analysis of behavior
pub_type: 杂志文章
doi:10.1901/jeab.1974.21-373
更新日期:1974-03-01 00:00:00
abstract::Sixteen children were given four successive circle-size discrimination problems with luminance as the fading stimulus. Children who were first presented with a difficult size discrimination failed to acquire this discrimination. Those who first received an easy discrimination learned the difficult discrimination. At t...
journal_title:Journal of the experimental analysis of behavior
pub_type: 杂志文章
doi:10.1901/jeab.1979.31-177
更新日期:1979-03-01 00:00:00
abstract::Pigeons could produce food by pecking exactly four times on each of two keys, in any order. In the first experiment, these response sequences were reinforced on a series of multiple schedules of variable-interval reinforcement. In the second experiment, these response sequences were reinforced on a series of concurren...
journal_title:Journal of the experimental analysis of behavior
pub_type: 杂志文章
doi:10.1901/jeab.1986.45-283
更新日期:1986-05-01 00:00:00
abstract::An interresponse time analysis was used to study the effects of variable-ratio punishment schedules on the temporal pattern of reinforced responding. Twelve pigeons responded on a baseline variable-interval schedule of food reinforcement. A variable-ratio ten schedule of electric shock punishment was then introduced. ...
journal_title:Journal of the experimental analysis of behavior
pub_type: 杂志文章
doi:10.1901/jeab.1981.35-55
更新日期:1981-01-01 00:00:00
abstract::Responding under fixed-interval schedules usually generates either scalloped or break-and-run cumulative records. Earlier, it was generally accepted that the characteristic pattern was the scallop, but in recent years there has been an increasing emphasis on the break-and-run pattern. The break-and-run pattern has bee...
journal_title:Journal of the experimental analysis of behavior
pub_type: 杂志文章
doi:10.1901/jeab.1978.29-67
更新日期:1978-01-01 00:00:00
abstract::Three pigeons were trained to discriminate a 5.0 mg/kg dose of pentobarbital from saline under a two-key concurrent schedule with responding on the key associated with the presession injection, under both stimulus conditions, producing four times as many reinforcers as responding on the other key. This concurrent sche...
journal_title:Journal of the experimental analysis of behavior
pub_type: 杂志文章
doi:10.1901/jeab.1996.65-495
更新日期:1996-05-01 00:00:00
abstract::Food-deprived golden hamsters in a large enclosure received food every 30 sec contingent on lever pressing, or free while their behavior was continuously recorded in terms of an exhaustive classification of motor patterns. As with other species in other situations, behavior became organized into two main classes. One ...
journal_title:Journal of the experimental analysis of behavior
pub_type: 杂志文章
doi:10.1901/jeab.1977.27-33
更新日期:1977-01-01 00:00:00
abstract::Using a color-tracking procedure with responses reinforced under a second-order schedule, the discriminative-stimulus properties of phencyclidine were studied in pigeons maintained at 70%, 80%, or 90% of their free-feeding weights. The generalization curves for phencyclidine were similar at all three body weights. Gen...
journal_title:Journal of the experimental analysis of behavior
pub_type: 杂志文章
doi:10.1901/jeab.1987.47-233
更新日期:1987-03-01 00:00:00
abstract::Three experiments assessed the impact of sample duration on pigeons' delayed matching as a function of whether or not the samples themselves signaled how long they would remain on. When duration was uncorrelated with the sample appearing on each matching trial, the typical effect of duration was observed: Choice accur...
journal_title:Journal of the experimental analysis of behavior
pub_type: 杂志文章
doi:10.1901/jeab.1999.72-279
更新日期:1999-11-01 00:00:00
abstract::Pigeons were trained on a non-spatial delayed alternation task in which the color not pecked on the previous trial was correct. When varying delays were interposed between trials, alternation accuracy decreased as a function of delay, but remained greater than chance with a 45-sec delay. Successful alternation on the ...
journal_title:Journal of the experimental analysis of behavior
pub_type: 杂志文章
doi:10.1901/jeab.1971.16-15
更新日期:1971-07-01 00:00:00