Abstract：
:Numerous lines of study have suggested that the Hox genes, encoding putative transcription factors, are key genes in the establishment of the body plan of the mammalian embryo. To examine the role of Hoxa-5 (Hox1.3) gene during development, we have used targeted mutagenesis in embryonic stem cells to produce a strain of mice carrying a disrupted Hoxa-5 allele. The viability of homozygous mutant mice is markedly reduced, with 50% of the mutant animals dying at birth or shortly thereafter. Analysis of the skeleton of Hoxa-5 mutants reveals a number of homeotic transformations restricted to the cervical and thoracic regions. Of these, one of the most frequent morphological abnormalities is the posterior transformation of the seventh cervical vertebra into the likeness of a thoracic vertebra complete with a pair of ribs. These results demonstrate that the Hoxa-5 gene has an important role in the establishment of the skeleton during development and contributes to the process whereby the axial structures are determined.
journal_name
Genes Devjournal_title
Genes & developmentauthors
Jeannotte L,Lemieux M,Charron J,Poirier F,Robertson EJdoi
10.1101/gad.7.11.2085subject
Has Abstractpub_date
1993-11-01 00:00:00pages
2085-96issue
11eissn
0890-9369issn
1549-5477journal_volume
7pub_type
杂志文章abstract：:The mottler of white (mw) locus has been determined to interact with alleles of the white (w) eye color locus which are a subset of the transposable element insertion mutants. The transposable elements belong to six different types, including copia, and are located at several sites within the w gene. Three X-ray-induc...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.3.1.73
更新日期：1989-01-01 00:00:00
abstract：:The RNA polymerase II (RNAPII) C-terminal domain kinase, CDK12, regulates genome stability, expression of DNA repair genes, and cancer cell resistance to chemotherapy and immunotherapy. In addition to its role in mRNA biosynthesis of DNA repair genes, we show here that CDK12 phosphorylates the mRNA 5' cap-binding repr...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.322339.118
更新日期：2019-04-01 00:00:00
abstract：:In the Bar mutation of Drosophila, ommatidial differentiation is known to be suppressed in the anterior portion of the eye. Our structural analysis shows that the Bar region contains a pair of homeo box genes, BarH1 and BarH2. These genes encode polypeptides similar in size and sequence and share a common homeo domain...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.6.1.50
更新日期：1992-01-01 00:00:00
abstract：:The Neurospora crassa clock-controlled gene (ccg-2) is transcriptionally activated by the circadian clock in a time-of-day-specific manner. Transcript and sequence analyses of ccg-2 reveal that the predicted Ccg-2 polypeptide bears significant similarity to a class of low-molecular-weight, cysteine-rich, hydrophobic p...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.6.12a.2382
更新日期：1992-12-01 00:00:00
abstract：:Mammalian cells possess two amino acid-sensing kinases: general control nonderepressible 2 (GCN2) and mechanistic target of rapamycin complex 1 (mTORC1). Their combined effects orchestrate cellular adaptation to amino acid levels, but how their activities are coordinated remains poorly understood. Here, we demonstrate...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.269324.115
更新日期：2015-11-15 00:00:00
abstract：:Direct reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) provides a unique opportunity to derive patient-specific stem cells with potential applications in tissue replacement therapies and without the ethical concerns of human embryonic stem cells (hESCs). However, cellular senescence, which c...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.173922.111
更新日期：2011-11-01 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.10.17.2158
更新日期：1996-09-01 00:00:00
abstract：:The cooperation of oncogenes in the transformation of primary rat Schwann cells is a strikingly synergistic process. We have explored the molecular mechanisms involved. Activation of an inducible Raf kinase results in morphologically transformed cells that are arrested in G1 via the induction of p21(CiP1) and subseque...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.11.5.663
更新日期：1997-03-01 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.292318.116
更新日期：2017-03-15 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1664408
更新日期：2008-07-15 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1977210
更新日期：2010-10-15 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1723609
更新日期：2009-02-01 00:00:00
abstract：:PBAF and BAF are two chromatin-remodeling complexes of the SWI/SNF family essential for mammalian transcription and development. Although these complexes share eight identical subunits, only PBAF can facilitate transcriptional activation by nuclear receptors in vitro. Here we show that these complexes have selectivity...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1323805
更新日期：2005-07-15 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.7.4.546
更新日期：1993-04-01 00:00:00
abstract：:A conditional block to transcriptional elongation is an important mechanism for regulating c-myc gene expression. This elongation block within the first c-myc exon was defined originally in mammalian cells by nuclear run-on transcription analyses. Subsequent oocyte injection and in vitro transcription analyses suggest...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.6.11.2201
更新日期：1992-11-01 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.11.22.3096
更新日期：1997-11-15 00:00:00
abstract：:To investigate the relationship between splicing and polyadenylation during the production of vertebrate mRNAs, we examined the effect of mutation of a poly(A) site on splicing of upstream introns. Mutation of the AAUAAA polyadenylation consensus sequence inhibited in vitro splicing of an upstream intron. The magnitud...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.5.11.2086
更新日期：1991-11-01 00:00:00
abstract：:Genetic screening and selection procedures employing a secA-lacZ fusion strain repeatedly have yielded mutations in four genes affecting the protein export pathway of Escherichia coli. These genes are secA, secD, prlA/secY, and secE. We discuss the significance of the failure to find new sec genes after extensive use ...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.3.7.1035
更新日期：1989-07-01 00:00:00
abstract：:Myxococcus xanthus fruiting body development is induced by amino acid limitation. The decision to grow or develop is established by the RelA-dependent stringent response and A-signaling. We identified two new members of this regulatory hierarchy, socE and the C-signaling gene csgA. SocE depletion arrests growth and in...
journal_title：Genes & development
pub_type： 杂志文章
doi：
更新日期：2000-02-15 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.9.24.3177
更新日期：1995-12-15 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.604610
更新日期：2010-11-01 00:00:00
abstract：:Alternative pre-mRNA splicing determines many changes in gene expression during development. Two regulators known to control splicing patterns during neuron and muscle differentiation are the polypyrimidine tract-binding protein (PTB) and its neuronal homolog nPTB. These proteins repress certain exons in early myoblas...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1500707
更新日期：2007-01-01 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.12.17.2724
更新日期：1998-09-01 00:00:00
abstract：:Metazoans start embryogenesis with a relatively naïve genome. The transcriptionally inert, late-replicating heterochromatic regions, including the constitutive heterochromatin on repetitive sequences near centromeres and telomeres, need to be re-established during development. To explore the events initiating heteroch...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.272237.115
更新日期：2016-03-01 00:00:00
abstract：:Small noncoding RNAs, including small interfering RNAs (siRNAs) and micro RNAs (miRNAs) of approximately 21 nucleotides (nt) in length, have emerged as potent regulators of gene expression at both transcriptional and post-transcriptional levels in diverse organisms. Here we report the identification of a novel class o...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1434406
更新日期：2006-07-01 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1060403
更新日期：2003-02-15 00:00:00
abstract：:In response to DNA damage, cells activate a complex signal transduction network called the DNA damage response (DDR). To enhance our current understanding of the DDR network, we performed a genome-wide RNAi screen to identify genes required for resistance to ionizing radiation (IR). Along with a number of known DDR ge...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1934210
更新日期：2010-09-01 00:00:00
abstract：:Inspired by a zebrafish mutation, two recent studies by Creanga and colleagues (pp. 1312-1325) and Tukachinsky and colleagues have shed new light on the way in which lipidated Hedgehog proteins are secreted and released from expressing cells, suggesting a model for the sequential action of the Disp and Scube2 proteins...
journal_title：Genes & development
pub_type： 评论,杂志文章
doi：10.1101/gad.207126.112
更新日期：2012-11-15 00:00:00
abstract：:Sox10 is a high-mobility-group transcriptional regulator in early neural crest. Without Sox10, no glia develop throughout the peripheral nervous system. Here we show that Sox10 is restricted in the central nervous system to myelin-forming oligodendroglia. In Sox10-deficient mice progenitors develop, but terminal diffe...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.215802
更新日期：2002-01-15 00:00:00
abstract：:Nonsense-mediated decay (NMD) is a translation-dependent RNA quality control mechanism that occurs in the cytoplasm. However, it is unknown how NMD regulates the stability of RNAs translated at the endoplasmic reticulum (ER). Here, we identify a localized NMD pathway dedicated to ER-translated mRNAs. We previously ide...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.338061.120
更新日期：2020-08-01 00:00:00
