GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2.

abstract：:The senescence-associated secretory phenotype (SASP) is a major trait of senescent cells, but the molecular regulators of SASP factor secretion are poorly understood. Mass spectrometry analysis revealed that secretory carrier membrane protein 4 (SCAMP4) levels were strikingly elevated on the surface of senescent cells...

journal_title：Genes & development

authors： Kim KM,Noh JH,Bodogai M,Martindale JL,Pandey PR,Yang X,Biragyn A,Abdelmohsen K,Gorospe M

更新日期：2018-07-01 00:00:00

abstract：:Caenorhabditis elegans let-7, a founding member of the microRNA family, is predicted to bind to six sites in the 3'UTR of the mRNA of its target gene, lin-41, to down-regulate LIN-41. Here, we demonstrate that wild-type let-7 microRNA binds in vitro to RNA from the lin-41 3'UTR. This interaction is dependent on two co...

journal_title：Genes & development

authors： Vella MC,Choi EY,Lin SY,Reinert K,Slack FJ

更新日期：2004-01-15 00:00:00

abstract：:Metastasis accounts for the vast majority of cancer-related deaths, yet the molecular mechanisms that drive metastatic spread remain poorly understood. Here we report that Tks5, which has been linked to the formation of proteolytic cellular protrusions known as invadopodia, undergoes an isoform switch during metastati...

journal_title：Genes & development

authors： Li CM,Chen G,Dayton TL,Kim-Kiselak C,Hoersch S,Whittaker CA,Bronson RT,Beer DG,Winslow MM,Jacks T

更新日期：2013-07-15 00:00:00

abstract：:Mesoderm induction assays in Xenopus have implicated growth factors such as activin, Vg1, Xwnt-8, and noggin as important in directing the formation of dorsal mesoderm (Spemann's organizer). Because these growth factors are structurally very different, they presumably act through distinct cell surface receptors that i...

journal_title：Genes & development

authors： Watabe T,Kim S,Candia A,Rothbächer U,Hashimoto C,Inoue K,Cho KW

更新日期：1995-12-15 00:00:00

abstract：:The formins constitute a set of protein isoforms encoded by the alternatively spliced transcripts arising from the limb deformity (ld) locus of the mouse. Mutations in this locus disrupt formation of the anteroposterior axis of the embryonic limb. Although ld transcripts are widely expressed during embryogenesis, we h...

journal_title：Genes & development

authors： Jackson-Grusby L,Kuo A,Leder P

更新日期：1992-01-01 00:00:00

abstract：:In this issue of Genes & Development, Dowen and colleagues (pp. 1515-1528) elegantly unify two previously unconnected aspects of physiology. The investigators provide significant genetic evidence to support a critical link between developmental timing decisions and the regulation of lipid mobilization at the transitio...

journal_title：Genes & development

authors： Weaver BP,Sewell AK,Han M

更新日期：2016-07-01 00:00:00

abstract：:Deregulated expression of the c-myc proto-oncogene can lead to apoptosis under certain physiological conditions. By introducing a conditionally active Myc allele into primary embryo fibroblasts null for p53, and into fibroblasts without endogenous p53 expression but ectopically expressing a temperature-sensitive p53 a...

journal_title：Genes & development

authors： Wagner AJ,Kokontis JM,Hay N

更新日期：1994-12-01 00:00:00

abstract：:Cohesin is a chromosome-associated multisubunit protein complex that is highly conserved in eukaryotes and has close homologs in bacteria. Cohesin mediates cohesion between replicated sister chromatids and is therefore essential for chromosome segregation in dividing cells. Cohesin is also required for efficient repai...

journal_title：Genes & development

authors： Peters JM,Tedeschi A,Schmitz J

更新日期：2008-11-15 00:00:00

abstract：:The neurogenic loci of Drosophila are required for proper partitioning of ectodermal cells into epidermal versus neural lineages. The loci appear to encode components of a developmental pathway involving cellular communication. In an effort to understand the role of the neurogenic locus mastermind in these processes, ...

journal_title：Genes & development

authors： Smoller D,Friedel C,Schmid A,Bettler D,Lam L,Yedvobnick B

更新日期：1990-10-01 00:00:00

abstract：:The rpoH gene of Escherichia coli encodes sigma 32, the 32-kD sigma-factor responsible for the heat-inducible transcription of the heat shock genes. rpoH is transcribed from at least three promoters. Two of these promoters are recognized by RNA polymerase containing sigma 70, the predominant sigma-factor. We purified ...

journal_title：Genes & development

authors： Erickson JW,Gross CA

更新日期：1989-09-01 00:00:00

abstract：:The incretin hormone GLP1 promotes islet-cell survival via the second messenger cAMP. Here we show that mice deficient in the activity of CREB, caused by expression of a dominant-negative A-CREB transgene in pancreatic beta-cells, develop diabetes secondary to beta-cell apoptosis. Remarkably, A-CREB severely disrupted...

journal_title：Genes & development

authors： Jhala US,Canettieri G,Screaton RA,Kulkarni RN,Krajewski S,Reed J,Walker J,Lin X,White M,Montminy M

更新日期：2003-07-01 00:00:00

abstract：:The Saccharomyces cerevisiae protein kinase Rim15p was identified previously as a stimulator of meiotic gene expression. Here, we show that loss of Rim15p causes an additional pleiotropic phenotype in cells grown to stationary phase on rich medium; this phenotype includes defects in trehalose and glycogen accumulation...

journal_title：Genes & development

authors： Reinders A,Bürckert N,Boller T,Wiemken A,De Virgilio C

更新日期：1998-09-15 00:00:00

abstract：:During embryonic development in vertebrates, the endoderm becomes patterned along the anteroposterior axis to produce distinct derivatives. How this regulation is controlled is not well understood. We report that the zebrafish hairy/enhancer of split [E(spl)]-related gene her5 plays a critical role in this process. At...

journal_title：Genes & development

authors： Bally-Cuif L,Goutel C,Wassef M,Wurst W,Rosa F

更新日期：2000-07-01 00:00:00

abstract：:Animals alter their reproductive programs to accommodate changes in nutrient availability, yet the connections between known nutrient-sensing systems and reproductive programs are underexplored, and whether there is a mechanism that senses nucleotide levels to coordinate germline proliferation is unknown. We establish...

journal_title：Genes & development

authors： Chi C,Ronai D,Than MT,Walker CJ,Sewell AK,Han M

更新日期：2016-02-01 00:00:00

abstract：:H4K20 methylation is a broad chromatin modification that has been linked with diverse epigenetic functions. Several enzymes target H4K20 methylation, consistent with distinct mono-, di-, and trimethylation states controlling different biological outputs. To analyze the roles of H4K20 methylation states, we generated c...

journal_title：Genes & development

authors： Schotta G,Sengupta R,Kubicek S,Malin S,Kauer M,Callén E,Celeste A,Pagani M,Opravil S,De La Rosa-Velazquez IA,Espejo A,Bedford MT,Nussenzweig A,Busslinger M,Jenuwein T

更新日期：2008-08-01 00:00:00

abstract：:Although Apc is well characterized as a tumor-suppressor gene in the intestine, the precise mechanism of this suppression remains to be defined. Using a novel inducible Ahcre transgenic line in conjunction with a loxP-flanked Apc allele we, show that loss of Apc acutely activates Wnt signaling through the nuclear accu...

journal_title：Genes & development

authors： Sansom OJ,Reed KR,Hayes AJ,Ireland H,Brinkmann H,Newton IP,Batlle E,Simon-Assmann P,Clevers H,Nathke IS,Clarke AR,Winton DJ

更新日期：2004-06-15 00:00:00

abstract：:The mottler of white (mw) locus has been determined to interact with alleles of the white (w) eye color locus which are a subset of the transposable element insertion mutants. The transposable elements belong to six different types, including copia, and are located at several sites within the w gene. Three X-ray-induc...

journal_title：Genes & development

authors： Birchler JA,Hiebert JC,Rabinow L

更新日期：1989-01-01 00:00:00

abstract：:Erasure and subsequent reinstatement of DNA methylation in the germline, especially at imprinted CpG islands (CGIs), is crucial to embryogenesis in mammals. The mechanisms underlying DNA methylation establishment remain poorly understood, but a number of post-translational modifications of histones are implicated in a...

journal_title：Genes & development

authors： Stewart KR,Veselovska L,Kim J,Huang J,Saadeh H,Tomizawa S,Smallwood SA,Chen T,Kelsey G

更新日期：2015-12-01 00:00:00

abstract：:Several previously known transcription cofactors have been demonstrated in vitro recently to be histone acetyltransferases and deacetyltransferases, suggesting that remodeling of chromatin through histone acetylation plays a fundamental role in gene regulation. Clear evidence has not yet been obtained, however, to dem...

journal_title：Genes & development

authors： Wang L,Liu L,Berger SL

更新日期：1998-03-01 00:00:00

abstract：:Nuclear export factor 1 (NXF1) exports mRNA to the cytoplasm after recruitment to mRNA by specific adaptor proteins. How and why cells use numerous different export adaptors is poorly understood. Here we critically evaluate members of the SR protein family (SRSF1-7) for their potential to act as NXF1 adaptors that cou...

journal_title：Genes & development

authors： Müller-McNicoll M,Botti V,de Jesus Domingues AM,Brandl H,Schwich OD,Steiner MC,Curk T,Poser I,Zarnack K,Neugebauer KM

更新日期：2016-03-01 00:00:00

abstract：:During development of the somatic macronucleus of Tetrahymena thermophila, the rDNA is excised from its germ-line chromosome, rearranged into a palindrome, and amplified to 10(4) copies. We have identified a cis-acting germ-line mutation, rmm11/6, that prevents amplification of the rDNA in all but approximately 1 in 1...

journal_title：Genes & development

authors： Kapler GM,Blackburn EH

更新日期：1994-01-01 00:00:00

abstract：:Apoptosis is an important mechanism to eliminate potentially tumorigenic cells. The tumor suppressor p53 plays a pivotal role in this process. Many tumors harbor mutant p53, but others evade its tumor-suppressive effects by altering the expression of proteins that regulate the p53 pathway. ASPP1 (apoptosis-stimulating...

journal_title：Genes & development

authors： Aylon Y,Ofir-Rosenfeld Y,Yabuta N,Lapi E,Nojima H,Lu X,Oren M

更新日期：2010-11-01 00:00:00

abstract：:The mechanisms of RNA replication of plus-strand RNA viruses are still unclear. Here, we identified the first promoter element for RNA synthesis described in a flavivirus. Using dengue virus as a model, we found that the viral RdRp discriminates the viral RNA by specific recognition of a 5' element named SLA. We demon...

journal_title：Genes & development

authors： Filomatori CV,Lodeiro MF,Alvarez DE,Samsa MM,Pietrasanta L,Gamarnik AV

更新日期：2006-08-15 00:00:00

abstract：:Genetic screening and selection procedures employing a secA-lacZ fusion strain repeatedly have yielded mutations in four genes affecting the protein export pathway of Escherichia coli. These genes are secA, secD, prlA/secY, and secE. We discuss the significance of the failure to find new sec genes after extensive use ...

journal_title：Genes & development

authors： Schatz PJ,Riggs PD,Jacq A,Fath MJ,Beckwith J

更新日期：1989-07-01 00:00:00

abstract：:Unusually for a eukaryote, genes transcribed by RNA polymerase II (pol II) in Trypanosoma brucei are arranged in polycistronic transcription units. With one exception, no pol II promoter motifs have been identified, and how transcription is initiated remains an enigma. T. brucei has four histone variants: H2AZ, H2BV, ...

journal_title：Genes & development

authors： Siegel TN,Hekstra DR,Kemp LE,Figueiredo LM,Lowell JE,Fenyo D,Wang X,Dewell S,Cross GA

更新日期：2009-05-01 00:00:00

abstract：:Morphogen gradients of secreted molecules play critical roles in the establishment of the spatial pattern of gene expression. During midgut development in Drosophila, secreted molecules of Decapentaplegic (Dpp) and Wingless (Wg) establish unique transcriptional regulation within target cells to specify the resultant c...

journal_title：Genes & development

authors： Nakagoshi H,Hoshi M,Nabeshima Y,Matsuzaki F

更新日期：1998-09-01 00:00:00

abstract：:The lysosomal storage disorder galactosialidosis results from a primary deficiency of the protective protein/cathepsin A (PPCA), which in turn affects the activities of beta-galactosidase and neuraminidase. Mice homozygous for a null mutation at the PPCA locus present with signs of the disease shortly after birth and ...

journal_title：Genes & development

authors： Zhou XY,Morreau H,Rottier R,Davis D,Bonten E,Gillemans N,Wenger D,Grosveld FG,Doherty P,Suzuki K,Grosveld GC,d'Azzo A

更新日期：1995-11-01 00:00:00

abstract：:The organizer region, or dorsal blastopore lip, plays a central role in the initiation of gastrulation and the formation of the body axis during Xenopus development. A similar process can also be induced in ectodermal explants by activin or by injection of activin mRNA into embryos. We have searched early embryo-speci...

journal_title：Genes & development

authors： Dirksen ML,Jamrich M

更新日期：1992-04-01 00:00:00

abstract：:Endospores of Bacillus subtilis are encased in a two-layer protein shell known as the coat, which consists of a lammellar-like inner layer and an electron-dense outer layer. We report the cloning of the structural gene (designated cotE) for an alkali-soluble coat protein of 24 kD and show that the cotE gene product is...

journal_title：Genes & development

authors： Zheng LB,Donovan WP,Fitz-James PC,Losick R

更新日期：1988-08-01 00:00:00

abstract：:A cDNA library enriched for transcripts that accumulate from embryonic day 7 until day 1 posthatching was constructed from poly(A)+ RNA of chick optic lobe tissue. From this library, three recombinants were isolated that correspond to neural mRNAs appearing during the major period of synaptogenesis in the retinotectal...

journal_title：Genes & development

authors： Zopf D,Hermans-Borgmeyer I,Gundelfinger ED,Betz H

更新日期：1987-09-01 00:00:00