Optimizing the planning of intensity-modulated radiotherapy.

abstract：:The purpose of this paper for four-dimensional (4D) computed tomography (CT) is threefold. (1) A new spatiotemporal model is presented from the matrix perspective with the row dimension in space and the column dimension in time, namely the robust PCA (principal component analysis)-based 4D CT model. That is, instead o...

journal_title：Physics in medicine and biology

authors： Gao H,Cai JF,Shen Z,Zhao H

更新日期：2011-06-07 00:00:00

abstract：:Permanent in vivo verification of IMRT photon beam profiles by a radiation detector with spatial resolution, positioned on the radiation entrance side of the patient, has not been clinically available so far. In this work we present the DAVID system, which is able to perform this quality assurance measurement while th...

journal_title：Physics in medicine and biology

authors： Poppe B,Thieke C,Beyer D,Kollhoff R,Djouguela A,Rühmann A,Willborn KC,Harder D

更新日期：2006-03-07 00:00:00

abstract：:Mean glandular dose is the quantity used for dosimetry in mammography and depends on breast-related characteristics, such as thickness and density, and on the x-ray spectrum used for breast imaging. This work aims to present an experimentally-based method to derive polyenergetic normalized glandular dose coefficients ...

journal_title：Physics in medicine and biology

authors： Santos JC,Tomal A,de Barros N,Costa PR

更新日期：2019-05-10 00:00:00

abstract：:The aim of this study is to calculate realistic dose distributions that include the continuous deformation of organs and continuous motion of machine using 4D Monte Carlo methods for both volumetric modulated arc therapy and helical tomotherapy treatments. As part of a previous study, we presented a method to perform ...

journal_title：Physics in medicine and biology

authors： Belec J,Clark BG

更新日期：2013-05-07 00:00:00

abstract：:In recent codes of practice for reference dosimetry in clinical proton beams using ionization chambers, it is recommended to perform the measurement in a water phantom. However, in situations where the positioning accuracy is very critical, it could be more convenient to perform the measurement in a plastic phantom. I...

journal_title：Physics in medicine and biology

authors： Palmans H,Symons JE,Denis JM,de Kock EA,Jones DT,Vynckier S

更新日期：2002-09-07 00:00:00

abstract：:The results of optimization of inverse treatment plans depend on a choice of the objective function. Even when the optimal solution for a given cost function can be obtained, a better solution may exist for a given clinical scenario and it could be obtained with a revised objective function. In the approach presented ...

journal_title：Physics in medicine and biology

authors： Bednarz G,Michalski D,Anne PR,Valicenti RK

更新日期：2004-06-21 00:00:00

abstract：:Automatic cell cycle analysis (DNA histograms) is usually performed with flow cytometry. In cases when only few cells are available, the DNA content has to be measured with a fluorescence microscope combined with sensitive camera systems (SIT, MCP, cooled CCDs) and a frame grabber for image analysis. The fluorescent c...

journal_title：Physics in medicine and biology

authors： Böcker W,Gantenberg HW,Müller WU,Streffer C

更新日期：1996-03-01 00:00:00

abstract：:Beam hardening is inevitable due to the polychromatic X-ray spectrum and energy-dependent attenuation coefficients of materials, leading to the underestimation of artifacts arising from projection data, especially on metal regions. State-of-the-art research on beam-hardening artifacts is based on a numerical method th...

journal_title：Physics in medicine and biology

authors： Hur J,Kim D,Shin YG,Lee H

更新日期：2021-01-26 00:00:00

abstract：:Fixed-pattern noise in electronic portal images (EPIs) is normally eliminated by dividing raw image data by an open-field calibration image (OFCI). However, for successful elimination, there must be exact registration between the two image sets. Any movement within the imaging system, such as that which occurs with ga...

journal_title：Physics in medicine and biology

authors： Kirby MC

更新日期：1996-11-01 00:00:00

abstract：:In treatment planning we depend upon accurate knowledge of geometric and range uncertainties. If the uncertainty model is inaccurate then the plan will produce under-dosing of the target and/or overdosing of OAR. We aim to provide a method for which centre and site-specific population range uncertainty due to inter-fr...

journal_title：Physics in medicine and biology

authors： Holloway SM,Holloway MD,Thomas SJ

更新日期：2017-12-19 00:00:00

abstract：:Results from dielectric studies on the freshwater fish Cyprinus carpio exposed to a sublethal concentration of sodium alkyl benzene sulphonate were compared with those from untreated control fish; recovery from the test solution was also checked. The influence of the anionic detergent on the intracellular matter of fi...

journal_title：Physics in medicine and biology

authors： Bielinska I,Terlecki J

更新日期：1984-05-01 00:00:00

abstract：:Radiation dose calculation using models of the human anatomy has been a subject of great interest to radiation protection, medical imaging, and radiotherapy. However, early pioneers of this field did not foresee the exponential growth of research activity as observed today. This review article walks the reader through...

journal_title：Physics in medicine and biology

authors： Xu XG

更新日期：2014-09-21 00:00:00

abstract：:The current UK code of practice for high-energy photon therapy dosimetry (Lillicrap et al 1990 Phys. Med. Biol. 35 1355-60) gives instructions for measuring absorbed dose to water under reference conditions for megavoltage photons. The reference conditions and the index used to specify beam quality require that a mach...

journal_title：Physics in medicine and biology

authors： Thomas SJ,Aspradakis MM,Byrne JP,Chalmers G,Duane S,Rogers J,Thomas RA,Tudor GS,Twyman N,IPEM Working Party.

更新日期：2014-03-21 00:00:00

abstract：:Evaluation of the radioisotopic purity of technetium-99m (99mTc) produced in GBq amounts by proton bombardment of enriched molibdenum-100 (100Mo) metallic targets at low proton energies (i.e. within 15-20 MeV) is conducted. This energy range was chosen since it is easily achievable by many conventional medical cyclotr...

journal_title：Physics in medicine and biology

authors： Uzunov NM,Melendez-Alafort L,Bello M,Cicoria G,Zagni F,De Nardo L,Selva A,Mou L,Rossi-Alvarez C,Pupillo G,Di Domenico G,Uccelli L,Boschi A,Groppi F,Salvini A,Taibi A,Duatti A,Martini P,Pasquali M,Loriggiola M,Mare

更新日期：2018-09-19 00:00:00

abstract：:A pencil beam model for the calculation of the lateral scattering in water of protons for any therapeutic energy and depth is presented. It is based on the full Molière theory, taking into account the energy loss and the effects of mixtures and compounds. Concerning the electromagnetic part, the model has no free para...

journal_title：Physics in medicine and biology

authors： Bellinzona EV,Ciocca M,Embriaco A,Ferrari A,Fontana A,Mairani A,Parodi K,Rotondi A,Sala P,Tessonnier T

更新日期：2016-02-21 00:00:00

abstract：:Four dimensional cone beam computed tomography (4DCBCT) uses a constant gantry speed and imaging frequency that are independent of the patient's breathing rate. Using a technique called respiratory motion guided 4DCBCT (RMG-4DCBCT), we have previously demonstrated that by varying the gantry speed and imaging frequency...

journal_title：Physics in medicine and biology

authors： O'Brien RT,Stankovic U,Sonke JJ,Keall PJ

更新日期：2017-06-07 00:00:00

abstract：:In this work, we propose a framework for optimizing spectral CT imaging parameters and hardware design with regard to material classification tasks. Compared with conventional CT, many more parameters must be considered when designing spectral CT systems and protocols. These choices will impact material classification...

journal_title：Physics in medicine and biology

authors： Rigie DS,La Rivière PJ

更新日期：2016-06-21 00:00:00

abstract：:Uncertainties in determining clinically used relative biological effectiveness (RBE) values for ion beam therapy carry the risk of absolute and relative misestimations of RBE-weighted doses for clinical scenarios. This study assesses the consequences of hypothetical misestimations of input parameters to the RBE modell...

journal_title：Physics in medicine and biology

authors： Böhlen TT,Brons S,Dosanjh M,Ferrari A,Fossati P,Haberer T,Patera V,Mairani A

更新日期：2012-12-07 00:00:00

abstract：:Compact gamma cameras with a square-shaped monolithic scintillator crystal and an array of silicon photomultipliers (SiPMs) are actively being developed for applications in areas such as small animal imaging, cancer diagnostics and radiotracer guided surgery. Statistical methods of position reconstruction, which are p...

journal_title：Physics in medicine and biology

authors： Morozov A,Alves F,Marcos J,Martins R,Pereira L,Solovov V,Chepel V

更新日期：2017-05-07 00:00:00

abstract：:The advent of real-time ultrasound in the 1970s, together with a growing interest in tissue characterization, led to a number of investigators using the nature of tissue motion to distinguish healthy from diseased tissue. Our group at the (then) Ultrasonics Institute demonstrated the use of phase methods for detecting...

journal_title：Physics in medicine and biology

authors： Wilson LS,Robinson DE,Dadd MJ

更新日期：2000-06-01 00:00:00

abstract：:A theoretical analysis is presented of the biologically effective dose of the solar long wave ultraviolet radiation (UVA) received by patients who are being treated for psoriasis by oral psoralen photochemotherapy. It is shown that patients treated during the summer months in the UK may well receive a UV dose which is...

journal_title：Physics in medicine and biology

authors： Diffey BL

更新日期：1981-11-01 00:00:00

abstract：:The widely applied single-interaction analytic expression characterizing the energy resolution component of the angular resolution precision for an electronically collimated point source is extended to include multiple-interaction Compton scatter sequences as well as sequences terminated by photoelectric absorption. T...

journal_title：Physics in medicine and biology

authors： Durkee JW Jr,Antich PP,Tsyganov EN,Constantinescu A,Kulkarni PV,Smith BJ,Arbique GM,Lewis MA,Nguyen T,Raheja A,Thambi G,Parkey RW

更新日期：1998-10-01 00:00:00

abstract：:The development of alpha-emitting radiopharmaceuticals using 211At requires quantitative determination of the time-dependent nature of the 211At biodistribution. However, imaging-based methods for acquiring this information with 211At have not found wide-spread use because of its low abundance of decay emissions suita...

journal_title：Physics in medicine and biology

authors： Crawford JR,Robertson AKH,Yang H,Rodríguez-Rodríguez C,Esquinas PL,Kunz P,Blinder S,Sossi V,Schaffer P,Ruth TJ

更新日期：2018-02-21 00:00:00

abstract：:The measured attenuation correction technique is widely used in cardiac positron tomographic studies. However, the success of this technique is limited because of insufficient counting statistics achievable in practical transmission scan times, and of the scattered radiation in transmission measurement which leads to ...

journal_title：Physics in medicine and biology

authors： Yu SK,Nahmias C

更新日期：1996-10-01 00:00:00

abstract：:A three-dimensional spherical inclusion model that approximates a lesion bonded to a tissue matrix is proposed for biomedical elastography. Analytical formulae describing spatial strain and stress distributions generated in infinite media by uniform loading are given under a linear, homogeneous, isotropic elasticity a...

journal_title：Physics in medicine and biology

authors： Bilgen M,Insana MF

更新日期：1998-01-01 00:00:00

abstract：:The signal properties of polycrystalline mercuric iodide (HgI2) film detectors, under irradiation conditions relevant to mammographic, radiographic, fluoroscopic and radiotherapy x-ray imaging, are reported. Each film detector consists of an approximately 230 to approximately 460 microm thick layer of HgI2 (fabricated...

journal_title：Physics in medicine and biology

authors： Su Z,Antonuk LE,El-Mohri Y,Hu L,Du H,Sawant A,Li Y,Wang Y,Yamamoto J,Zhao Q

更新日期：2005-06-21 00:00:00

abstract：:A step and shoot sequencer was developed that can be integrated into an IMRT optimization algorithm. The method uses non-uniform fluence steps and is adopted to the constraints of an MLC. It consists of a clustering, a smoothing and a segmentation routine. The performance of the algorithm is demonstrated for eight mat...

journal_title：Physics in medicine and biology

authors： Bär W,Alber M,Nüsslin F

更新日期：2001-07-01 00:00:00

abstract：:The degradation of low energy electrons in a methane based, tissue equivalent gas was studied experimentally by ionization chamber experiments and theoretically by Monte Carlo electron transport simulation in the energy range between 25 eV and 5 keV. From measured ionization yields and calculated ionization and energy...

journal_title：Physics in medicine and biology

authors： Waibel E,Grosswendt B

更新日期：1992-05-01 00:00:00

abstract：:In this study, we explore the potential of compressed sensing (CS) accelerated broadband 3D phase-encoded turbo spin-echo (3D-PE-TSE) for the purpose of geometrically undistorted imaging in the presence of field inhomogeneities. To achieve this goal 3D-PE-SE and 3D-PE-TSE sequences with broadband rf pulses and dedicat...

journal_title：Physics in medicine and biology

authors： van Gorp JS,Bakker CJ,Bouwman JG,Smink J,Zijlstra F,Seevinck PR

更新日期：2015-01-21 00:00:00

abstract：:The first trimester fetal ultrasound scan is important to confirm fetal viability, to estimate the gestational age of the fetus, and to detect fetal anomalies early in pregnancy. First trimester ultrasound images have a different appearance than for the second trimester scan, reflecting the different stage of fetal de...

journal_title：Physics in medicine and biology

authors： Ryou H,Yaqub M,Cavallaro A,Papageorghiou AT,Alison Noble J

更新日期：2019-09-17 00:00:00