Activation of metabotropic glutamate 2/3 receptors reverses the effects of NMDA receptor hypofunction on prefrontal cortex unit activity in awake rats.

abstract：:Electrical activation of mouse dorsal root ganglion (DRG) neurons in cultures for 1-2 days produced a downregulation of voltage sensitive calcium currents, which persisted for > or = 24 h after stimulation was terminated. This regulation varied with different patterns of activation. Both the magnitude and time course ...

journal_title：Journal of neurophysiology

authors： Li M,Jia M,Fields RD,Nelson PG

更新日期：1996-10-01 00:00:00

abstract：:An orthodromically evoked late hyperpolarizing potential (LHP) was studied using intracellular recording techniques in rat hippocampal CA1 pyramidal cells in vitro. Several tests indicated that the LHP is not blocked by GABA antagonists, but rather comprises the initial portion of the stimulation-induced burst afterhy...

journal_title：Journal of neurophysiology

authors： Alger BE

更新日期：1984-11-01 00:00:00

abstract：:Sexually dimorphic behaviors develop under the influence of sex steroids, which induce reversible changes in the underlying neural network of the brain. However, little is known about the proteins that mediate these activational effects of sex steroids. Here, we used a proteomics approach for large-scale identificatio...

journal_title：Journal of neurophysiology

authors： Zupanc GK,Ilies I,Sîrbulescu RF,Zupanc MM

更新日期：2014-04-01 00:00:00

abstract：:Adaptation is a prominent feature of the human motor system and has been studied extensively in reaching movements. This study characterizes adaptation and generalization during isometric reaching in which the arm remains stationary and the participant controls a virtual cursor via force applied by the hand. We measur...

journal_title：Journal of neurophysiology

authors： Rotella MF,Nisky I,Koehler M,Rinderknecht MD,Bastian AJ,Okamura AM

更新日期：2015-03-15 00:00:00

abstract：:This study reexamined the perceptual equivalence of active and passive touch using a computer-controlled force-feedback device. Nine subjects explored a 6 x 10-cm workspace, with the index finger resting on a mobile flat plate, and experienced simulated Gaussian ridges and troughs (width, 15 mm; amplitude, 0.5 to 4.5 ...

journal_title：Journal of neurophysiology

authors： Smith AM,Chapman CE,Donati F,Fortier-Poisson P,Hayward V

更新日期：2009-12-01 00:00:00

abstract：:1. We describe a four-layered neural network (Fig. 1), based on the input organization of a collision signaling neuron in the visual system of the locust, the lobula giant movement detector (LGMD). The 250 photoreceptors ("P" units) in layer 1 are excited by any change in illumination, generated when an image edge pas...

journal_title：Journal of neurophysiology

authors： Rind FC,Bramwell DI

更新日期：1996-03-01 00:00:00

abstract：:Membrane-permeable arachidonic acid (AA) is liberated in a Ca2+-dependent way inside cells. By using whole cell patch clamp we show that intracellular AA (1 pM) selectively reduces IA in rat hippocampal neurons, whereas extracellular application requires a 10(6)-fold concentration. The nonmetabolized AA analogue ETYA ...

journal_title：Journal of neurophysiology

authors： Bittner K,Müller W

更新日期：1999-07-01 00:00:00

abstract：:In songbirds, the basal ganglia outflow nucleus LMAN is a cortical analog that is required for several forms of song plasticity and learning. Moreover, in adults, inactivating LMAN can reverse the initial expression of learning driven via aversive reinforcement. In the present study, we investigated how LMAN contribut...

journal_title：Journal of neurophysiology

authors： Warren TL,Tumer EC,Charlesworth JD,Brainard MS

更新日期：2011-10-01 00:00:00

abstract：:The activity of the crayfish abdominal postural motoneurons and their associated neurons (the accessory neuron(s) and the MRO(1)) were examined with the aid of techniques for the analysis of simultaneously recorded spike trains. A means of reliably identifying the spikes of the individual motoneurons based on their re...

journal_title：Journal of neurophysiology

authors： Sokolove PG,Tatton WG

更新日期：1975-03-01 00:00:00

abstract：:Precisely synchronized neuronal activity has been commonly observed in the mammalian visual pathway. Spike timing correlations in the lateral geniculate nucleus (LGN) often take the form of phase synchronized oscillations in the high gamma frequency range. To study the relations between oscillatory activity, synchrony...

journal_title：Journal of neurophysiology

authors： Ito H,Maldonado PE,Gray CM

更新日期：2010-12-01 00:00:00

abstract：:Prefrontal cortex (PFC) dopamine D1/5 receptors modulate long- and short-term neuronal plasticity that may contribute to cognitive functions. Synergistic to synaptic strength modulation, direct postsynaptic D1/5 receptor activation also modulates voltage-dependent ionic currents that regulate spike firing, thus alteri...

journal_title：Journal of neurophysiology

authors： Chen L,Bohanick JD,Nishihara M,Seamans JK,Yang CR

更新日期：2007-03-01 00:00:00

abstract：:The intrinsic properties of tonically firing neurons in the cochlear nucleus contribute to representing average sound intensity by favoring synaptic integration across auditory nerve inputs, reducing phase locking to fine temporal acoustic structure and enhancing envelope locking. To determine whether tonically firing...

journal_title：Journal of neurophysiology

authors： Kreeger LJ,Arshed A,MacLeod KM

更新日期：2012-11-01 00:00:00

abstract：:1. The synaptic pathways underlying tectal influence over pinna movements were studied using an acute electrophysiological approach. Under pentobarbital anesthesia, postsynaptic potentials were recorded intracellularly in antidromically identified, cat facial motoneurons following electrical stimulation of the superio...

journal_title：Journal of neurophysiology

authors： Vidal PP,May PJ,Baker R

更新日期：1988-08-01 00:00:00

abstract：:1. The effects of the di- and trivalent trace metal cations, Pb2+, Zn2+, and Al3+, on voltage-activated calcium channel currents recorded from cultured rat dorsal root ganglion neurons were determined. 2. All three cations blocked transient and sustained components of the voltage-gated calcium channel currents elicite...

journal_title：Journal of neurophysiology

authors： Büsselberg D,Platt B,Michael D,Carpenter DO,Haas HL

更新日期：1994-04-01 00:00:00

abstract：:1. Voltage-clamp experiments were used to study N-methyl-D-aspartic acid (NMDA) receptor antagonists applied by fast perfusion to mouse hippocampal neurons in dissociated culture. 2. Preincubation with the NMDA antagonists zinc (3-30 microM) and magnesium (30-300 microM) reduced subsequent responses to 100 microM NMDA...

journal_title：Journal of neurophysiology

authors： Benveniste M,Mienville JM,Sernagor E,Mayer ML

更新日期：1990-06-01 00:00:00

abstract：:The lateral superior olive (LSO) is the primary auditory nucleus for processing of interaural sound level differences, which is one of the major cues for sound localization. During development, survival and maturation of LSO neurons critically depend on synaptic activity and intracellular calcium signaling. Before hea...

journal_title：Journal of neurophysiology

authors： Ene FA,Kalmbach A,Kandler K

更新日期：2007-05-01 00:00:00

abstract：:Previous analysis of the firing of individual rat hippocampal place cells has shown that their firing rate increases when they enter a place field and that their phase of firing relative to the ongoing theta oscillation (7-12 Hz) varies systematically as the rat traverses the place field, a phenomenon termed the theta...

journal_title：Journal of neurophysiology

authors： Jensen O,Lisman JE

更新日期：2000-05-01 00:00:00

abstract：:Motor control relies on multiple sources of information. To estimate the position and motion of the hand, the brain uses both vision and body-position (proprioception and kinesthesia) senses from sensors in the muscles, tendons, joints, and skin. Although performance is better when more than one sensory modality is pr...

journal_title：Journal of neurophysiology

authors： Wong T,Henriques DY

更新日期：2009-02-01 00:00:00

abstract：:Blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) is widely used as a measure of neuronal activity, despite an incomplete understanding of the hemodynamic and neural bases for BOLD signals. Recent work by Lee and colleagues investigated whether activating genetically specified neuro...

journal_title：Journal of neurophysiology

authors： Palmer HS

更新日期：2010-10-01 00:00:00

abstract：:Spontaneous negative-going potentials occurring at an average frequency of 0.7 Hz were recorded from the dentate gyrus of slices prepared from the temporal hippocampus of young adult rats. These events (here termed "dentate waves") in several respects resembled the dentate spikes described for freely moving rats durin...

journal_title：Journal of neurophysiology

authors： Colgin LL,Kubota D,Brucher FA,Jia Y,Branyan E,Gall CM,Lynch G

更新日期：2004-12-01 00:00:00

abstract：:The neuronal mechanism which gives rise to the synchronization of motor-unit discharges has been inferred from an analysis of the interspike intervals of individual motor-unit discharges recorded from the soleus muscle. The motor units were divided into two groups on the basis of characteristic changes in their spike ...

journal_title：Journal of neurophysiology

authors： Mori S

更新日期：1975-07-01 00:00:00

abstract：:Response adaptation is the change of the firing rate of neurons induced by a preceding stimulus. It can be found in many sensory systems and throughout the auditory pathway. We investigated response adaptation in the external nucleus of the inferior colliculus (ICX) of barn owls ( Tyto furcata), a nocturnal bird of pr...

journal_title：Journal of neurophysiology

authors： Ferger R,Pawlowsky K,Singheiser M,Wagner H

更新日期：2018-03-01 00:00:00

abstract：:Behavioral studies have shown that object recognition becomes severely impaired at fast presentation rates, indicating a limitation in temporal processing capacity. Here, we studied whether this behavioral limit in object recognition reflects limitations in the temporal processing capacity of early visual areas tuned ...

journal_title：Journal of neurophysiology

authors： McKeeff TJ,Remus DA,Tong F

更新日期：2007-07-01 00:00:00

abstract：:Recent findings indicate that monkeys can report their confidence in perceptual decisions and that this information is encoded in neurons involved in making decisions, including the lateral intraparietal area (LIP) and the supplementary eye field (SEF). A key issue to consider when studying confidence is that decision...

journal_title：Journal of neurophysiology

authors： Grimaldi P,Cho SH,Lau H,Basso MA

更新日期：2018-11-01 00:00:00

abstract：:When a movement results in error, the nervous system amends the motor commands that generate the subsequent movement. Here we show that this adaptation depends not just on error, but also on passage of time between the two movements. We observed that subjects learned a reaching task faster, i.e., with fewer trials, wh...

journal_title：Journal of neurophysiology

authors： Huang VS,Shadmehr R

更新日期：2007-06-01 00:00:00

abstract：:In humans with temporal lobe epilepsy and kainate-treated rats, the mossy fibers of the dentate granule cells send collateral axons into the inner molecular layer. Prior investigations on kainate-treated rats demonstrated that abnormal hilar-evoked events can occasionally be observed in slices with mossy fiber sprouti...

journal_title：Journal of neurophysiology

authors： Patrylo PR,Dudek FE

更新日期：1998-01-01 00:00:00

abstract：:Peroneal motoneurons were recorded intracellularly in anesthetized cats during sustained submaximal contractions of peroneus brevis muscle (PB) elicited by repetitive electrical stimulation of motor axons in the distal portion of cut ventral root filaments. Mechanical stimulation of the territory innervated by the sup...

journal_title：Journal of neurophysiology

authors： Perrier JF,Lamotte D'Incamps B,Kouchtir-Devanne N,Jami L,Zytnicki D

更新日期：2000-06-01 00:00:00

abstract：:We hypothesized that epilepsy affects the activity of the autonomic nervous system even in the absence of seizures, which should manifest as differences in heart rate variability (HRV) and cardiac cycle. To test this hypothesis, we investigated ECG traces of 91 children and adolescents with generalized epilepsy and 25...

journal_title：Journal of neurophysiology

authors： Sivakumar SS,Namath AG,Tuxhorn IE,Lewis SJ,Galán RF

更新日期：2016-04-01 00:00:00

abstract：:An in vitro brain stem-spinal cord preparation from an adult urodele (Pleurodeles waltl) was developed in which two fictive rhythmic motor patterns were evoked by bath application of N-methyl-D-aspartate (NMDA; 2.5-10 microM) with D-serine (10 microM). Both motor patterns displayed left-right alternation. The first pa...

journal_title：Journal of neurophysiology

authors： Delvolvé I,Branchereau P,Dubuc R,Cabelguen JM

更新日期：1999-08-01 00:00:00

abstract：:We measured the timing of spontaneous membrane potential fluctuations and action potentials of medial and lateral agranular corticostriatal and striatal neurons with the use of in vivo intracellular recordings in urethan-anesthetized rats. All neurons showed spontaneous subthreshold membrane potential shifts from 7 to...

journal_title：Journal of neurophysiology

authors： Stern EA,Kincaid AE,Wilson CJ

更新日期：1997-04-01 00:00:00