Abstract:
:Blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) is widely used as a measure of neuronal activity, despite an incomplete understanding of the hemodynamic and neural bases for BOLD signals. Recent work by Lee and colleagues investigated whether activating genetically specified neurons elicits BOLD responses. Integrating optogenetic control of specific cells and fMRI showed that stimulating excitatory neurons triggers a positive BOLD signal with conventional kinetics locally and delayed weaker BOLD signals distally.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Palmer HSdoi
10.1152/jn.00535.2010subject
Has Abstractpub_date
2010-10-01 00:00:00pages
1838-40issue
4eissn
0022-3077issn
1522-1598pii
jn.00535.2010journal_volume
104pub_type
杂志文章,评审abstract::1. Mechanisms of depolarizing synaptic inhibition were investigated at the crayfish giant motor synapse with the use of two-electrode current- and voltage-clamp techniques. Depolarizing inhibitory postsynaptic potentials (d-IPSPs) of between 5 and 15 mV in amplitude are produced there in the motor giant motoneuron (Mo...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1990.64.2.532
更新日期:1990-08-01 00:00:00
abstract::Central pattern generator (CPG) motor circuits underlying rhythmic behaviors provide feedback to the projection neuron inputs that drive these circuits. This feedback elicits projection neuron bursting linked to CPG rhythms. The brief periodic interruptions in projection neuron activity in turn influence CPG output, g...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00772.2016
更新日期:2017-08-01 00:00:00
abstract::The nucleus of the tractus solitarius (NTS) plays an important role in the control of several autonomic reflex functions and has glutamate and GABA as main neurotransmitters. In this work, we used patch-clamp recordings in transverse slice preparations from rats to study whether the glycine binding site of the N-methy...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00927.2004
更新日期:2005-07-01 00:00:00
abstract::The amines dopamine (DA), serotonin (5-HT), and octopamine (Oct) each elicit a distinctive motor pattern from a quiescent pyloric network in the lobster stomatogastric ganglion (STG). We previously have demonstrated that these amines alter the synaptic strength at multiple, distributed sites within the pyloric network...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1997.78.6.3210
更新日期:1997-12-01 00:00:00
abstract::In a recent study, Wang et al. (J Neurophysiol 113: 1989-2001, 2015) used a precision grip force control task to unveil the contribution of feedforward and feedback mechanisms to sensorimotor dysfunction in autism spectrum disorder (ASD). Impairment of both motor control mechanisms was observed, along with significant...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00647.2015
更新日期:2016-03-01 00:00:00
abstract::1. Rat pups were gestated and born in normoxia (inspired O2 pressure 149 mmHg) or chronic hypoxia (insured O2 pressure 80 mmHg) to test whether chronic hypoxia alters carotid body glomus cell calcium currents. Carotid bodies were removed from 5- to 8-day-old-pups under halothane anesthesia, at which time blood hematoc...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1996.76.3.1880
更新日期:1996-09-01 00:00:00
abstract::Rewards in the natural environment are rarely predicted with complete certainty. Uncertainty relating to future rewards has typically been defined as the variance of the potential outcomes. However, the asymmetry of predicted reward distributions, known as skewness, constitutes a distinct but neuroscientifically under...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00471.2011
更新日期:2011-11-01 00:00:00
abstract::Trimming all but two whiskers in adult rats produces a predictable change in cortical cell-evoked responses characterized by increased responsiveness to the two intact whiskers and decreased responsiveness to the trimmed whiskers. This type of synaptic plasticity in rat somatic sensory cortex, called "whisker pairing ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1998.79.6.3216
更新日期:1998-06-01 00:00:00
abstract::Seconds-scale network states, affecting many neurons within a network, modulate neural activity by complementing fast integration of neuron-specific inputs that arrive in the milliseconds before spiking. Nonrhythmic subthreshold dynamics at intermediate timescales, however, are less well characterized. We found, using...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00116.2017
更新日期:2017-08-01 00:00:00
abstract::The hearing ability of five Japanese macaques (Macaca fuscata) was assessed following two-stage bilateral auditory cortex lesions. The animals were tested using a shock-avoidance procedure with a conditioned-suppression procedure used for comparison in two cases. The animals initially were unable to respond to sound, ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1986.55.2.256
更新日期:1986-02-01 00:00:00
abstract::Ablation and single-unit studies in primates have shown that inferior temporal (IT) cortex is important for pattern discrimination. The first paper in this series suggested that single units in IT cortex of alert monkeys respond to a set of two-dimensional patterns with complex temporal modulation of their spike train...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1987.57.1.162
更新日期:1987-01-01 00:00:00
abstract::Facial flushing in rosacea is often induced by trigger events. However, trigger causation mechanisms are currently unclear. This study tested the central hypothesis that rosacea causes sympathetic and axon reflex-mediated alterations resulting in trigger-induced symptomatology. Twenty rosacea patients and age/sex-matc...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00458.2015
更新日期:2015-09-01 00:00:00
abstract::Synaptic transmission at the inner hair cell (IHC) afferent synapse, the first synapse in the auditory pathway, is specialized for rapid and reliable signaling. Here we investigated the properties of a hyperpolarization-activated current (I(h)), expressed in the afferent dendrite of auditory nerve fibers, and its role...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00506.2009
更新日期:2010-05-01 00:00:00
abstract::The present paper investigates the sensory-driven modulations of central pattern generator dynamics that can be expected to reproduce human behavior during rhythmic hybrid tasks. We propose a theoretical model of human sensorimotor behavior able to account for the observed data from the ball-bouncing task. The novel c...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00054.2017
更新日期:2017-10-01 00:00:00
abstract::Successful motor performance relies on our ability to adapt to changes in the environment by learning novel mappings between motor commands and sensory outcomes. Such adaptation is thought to involve two distinct mechanisms: an implicit, error-based component linked to slow learning and an explicit, strategic componen...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00113.2018
更新日期:2018-10-01 00:00:00
abstract::1. The effects of inhibitory amino acid transmitters on horizontal cells in the superfused amphibian retina were studied by the use of conventional intracellular recording techniques. 2. Gamma-aminobutyric acid (GABA) caused a calcium-independent depolarization of horizontal cells in mud puppy and tiger salamander. Th...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1991.65.3.680
更新日期:1991-03-01 00:00:00
abstract::For human locomotion, varying environments require adjustments of the motor system. We asked whether age affects gait balance recovery adaptation, its retention over months, and the transfer of adaptation to an untrained reactive balance task. Healthy adults (26 young, 27 middle-aged, and 25 older; average ages 24, 52...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00380.2019
更新日期:2019-11-01 00:00:00
abstract::1. The rostromesial agranular frontal cortex of macaque monkey (Macaca fuscata), traditionally defined as the supplementary motor area (SMA), was studied using various physiological techniques to delineate two different areas rostrocaudally. 2. Field and unitary responses to electrical stimulation of the primary motor...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1992.68.3.653
更新日期:1992-09-01 00:00:00
abstract::Slowness of voluntary movements in patients with multiple sclerosis (MS) may be due to various factors, including attentional and cognitive deficits, delays in motor conduction time, and impairment of specific central nervous system circuits. In 13 healthy volunteers and 20 mildly disabled, relapsing-remitting MS pati...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00591.2014
更新日期:2015-03-01 00:00:00
abstract::Visual response properties of neurons in the dorsolateral geniculate nucleus (dLGN) have been well described in several species, but not in rats. Analysis of responses from the unanesthetized rat dLGN will be needed to develop quantitative models that account for visual behavior of rats. We recorded visual responses f...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00812.2014
更新日期:2016-06-01 00:00:00
abstract::Peroneal motoneurons were recorded intracellularly in anesthetized cats during sustained submaximal contractions of peroneus brevis muscle (PB) elicited by repetitive electrical stimulation of motor axons in the distal portion of cut ventral root filaments. Mechanical stimulation of the territory innervated by the sup...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2000.83.6.3201
更新日期:2000-06-01 00:00:00
abstract::1. The goal of this study was to compare the relative effectiveness of intrinsic inhibitory synaptic inputs in different layers of the cat motor cortex. Postsynaptic potentials (PSPs) were evoked in neurons located in the superficial (layer II-III) or deep layers (layer V) by local extracellular stimulation in vitro. ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1995.74.3.1149
更新日期:1995-09-01 00:00:00
abstract::1. The question of whether active uptake limits the duration of action of the inhibitory transmitter glycine has been addressed in vivo at inhibitory synapses on the goldfish Mauthner (M) cell. The kinetics of inhibitory postsynaptic potentials and inhibitory postsynaptic currents (IPSCs) evoked antidromically and by ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1996.75.4.1738
更新日期:1996-04-01 00:00:00
abstract::Neocortical circuits exhibit a rich dynamic repertoire, and their ability to achieve entrainment (adjustment of their frequency to match the input frequency) is thought to support many cognitive functions and indicate functional flexibility. Although previous studies have explored the influence of various circuit prop...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00401.2019
更新日期:2020-03-01 00:00:00
abstract::The ventromedial medulla is implicated in a variety of functions including nociceptive and cardiovascular modulation and the control of thermoregulation. To determine whether single microinjections into the ventromedial medulla elicit changes in one or multiple functional systems, the GABA(A) receptor antagonist bicuc...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00089.2004
更新日期:2004-07-01 00:00:00
abstract::Beyond being essential for long-term motor-skill development, movement repetition has immediate benefits on performance, increasing speed and accuracy of a second execution. While repetition effects have been reported for single reaching movements, it has yet to be determined whether they also occur for movement seque...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00054.2020
更新日期:2020-05-01 00:00:00
abstract::1. The spatial and temporal response characteristics of direction-selective neurons in the nucleus of the optic tract and dorsal terminal nucleus of the accessory optic system (NOT-DTN) of the wallaby were established using moving sinusoidal gratings. This is the first comprehensive investigation of the spatiotemporal...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1994.72.6.2927
更新日期:1994-12-01 00:00:00
abstract::The ability of individuals to adapt locomotion to constraints associated with the complex environments normally encountered in everyday life is paramount for survival. Here, we tested the ability of 24 healthy young adults to adapt to a rightward prism shift (∼11.3°) while either walking and stepping to targets (i.e.,...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01040.2010
更新日期:2011-08-01 00:00:00
abstract::The hypocretin/orexins (Hcrt/Orxs) are hypothalamic neuropeptides that regulate stress, addiction, feeding, and arousal behaviors. They depolarize many types of central neurons and can increase [Ca2+]i in some, including those of the dorsal raphe (DR) and laterodorsal tegmental (LDT) nuclei-two structures likely to co...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01388.2007
更新日期:2008-10-01 00:00:00
abstract::We studied two human subjects with total deafferentation of one upper limb secondary to traumatic multiple cervical root avulsions. Both subjects developed a phantom limb and underwent elective amputation of the paralyzed, deafferentated limb. Psychophysical study revealed in each subject an area of skin in the pector...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1997.77.5.2753
更新日期:1997-05-01 00:00:00