Optogenetic fMRI sheds light on the neural basis of the BOLD signal.

Abstract:

:Blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) is widely used as a measure of neuronal activity, despite an incomplete understanding of the hemodynamic and neural bases for BOLD signals. Recent work by Lee and colleagues investigated whether activating genetically specified neurons elicits BOLD responses. Integrating optogenetic control of specific cells and fMRI showed that stimulating excitatory neurons triggers a positive BOLD signal with conventional kinetics locally and delayed weaker BOLD signals distally.

journal_name

J Neurophysiol

authors

Palmer HS

doi

10.1152/jn.00535.2010

subject

Has Abstract

pub_date

2010-10-01 00:00:00

pages

1838-40

issue

4

eissn

0022-3077

issn

1522-1598

pii

jn.00535.2010

journal_volume

104

pub_type

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