Abstract:
:Idiopathic thrombocytopenic purpura (ITP) is a common hematologic disorder manifested by immune-mediated thrombocytopenia. The diagnosis remains one of exclusion, after other thrombocytopenic disorders are ruled out based on history, physical examination, and laboratory evaluation. The goal of treatment is to raise the platelet count into a hemostatically safe range. The disorder is usually chronic, although there is considerable variation in the clinical course and most patients eventually attain safe platelet counts off treatment. However, a subset of patients has severe disease refractory to all treatment modalities, which is associated with considerable morbidity and mortality. This article focuses on the management of primary ITP in adults. We discuss criteria for treatment, the roles of splenectomy and other treatment options along with their side effects, and the management of ITP during pregnancy.
journal_name
Annu Rev Medjournal_title
Annual review of medicineauthors
Cines DB,McMillan Rdoi
10.1146/annurev.med.56.082103.104644subject
Has Abstractpub_date
2005-01-01 00:00:00pages
425-42eissn
0066-4219issn
1545-326Xjournal_volume
56pub_type
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