Abstract:
:Diastolic dysfunction is an important cause of the clinical syndrome of congestive heart failure. Traditionally, the syndrome of pulmonary congestion due to the elevation of left heart filling pressure has been attributed to the depressed ability of the heart to eject blood during systole, with a secondary increase in left ventricular volume. However, heart failure can also occur when the left ventricle fails to receive blood during diastole at low filling pressures. With a mild degree of resistance of the left ventricle to diastolic filling, the initial hemodynamic manifestation may just be the elevation of left ventricular diastolic pressure and pulmonary venous pressure. More severe resistance to left ventricular filling may cause an inadequate extent of diastolic filling and insufficient myofiber stretch, which results in the depression of stroke volume. In this review, the factors contributing to diastolic dysfunction are discussed, with a particular focus on the role of diastolic heart failure in patients with ischemic heart disease or hypertrophy.
journal_name
Annu Rev Medjournal_title
Annual review of medicineauthors
Lorell BHdoi
10.1146/annurev.me.42.020191.002211subject
Has Abstractpub_date
1991-01-01 00:00:00pages
411-36eissn
0066-4219issn
1545-326Xjournal_volume
42pub_type
杂志文章,评审abstract::Cystic diseases of the kidney are common, often progressive disorders. The best of several alternative hypotheses to explain their development cites tubular dilation and compression of adjacent tissue. The initiating event may involve focal proliferation of epithelial cells and a consequent increase in the resistance ...
journal_title:Annual review of medicine
pub_type: 杂志文章,评审
doi:10.1146/annurev.me.39.020188.001153
更新日期:1988-01-01 00:00:00
abstract::It is clear from the preceding material that bacterial infection is a significant threat to the newborn infant. The most common gram-negative organism causing meningitis in the neonate is E. coli, and the invasive capacity of this organism is correlated with its polysaccharide antigen, K1. Careful studies of supportiv...
journal_title:Annual review of medicine
pub_type: 杂志文章,评审
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更新日期:1978-01-01 00:00:00
abstract::Circadian rhythms are major features of adaptation to our environment. In mammals, circadian rhythms are generated and regulated by a circadian timing system. This system consists of entertainment pathways, pacemakers, and pace-maker output to effector systems that are under circadian control. The primary entertainmen...
journal_title:Annual review of medicine
pub_type: 杂志文章,评审
doi:10.1146/annurev.med.48.1.253
更新日期:1997-01-01 00:00:00
abstract::A viral reservoir is a cell type or anatomical site in association with which a replication-competent form of the virus accumulates and persists with more stable kinetic properties than the main pool of actively replicating virus. This article reviews several cell types and anatomical sites proposed as potential reser...
journal_title:Annual review of medicine
pub_type: 杂志文章,评审
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更新日期:2002-01-01 00:00:00
abstract::Catastrophic antiphospholipid syndrome (CAPS) is a potentially lethal disease that presents with rapidly progressive multiple organ thromboses. Anticoagulation, corticosteroids, intravenous immunoglobulin, and plasma exchange are the most commonly used treatments for CAPS patients. However, the high mortality despite ...
journal_title:Annual review of medicine
pub_type: 杂志文章,评审
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更新日期:2017-01-14 00:00:00
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journal_title:Annual review of medicine
pub_type: 杂志文章,评审
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更新日期:1989-01-01 00:00:00
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journal_title:Annual review of medicine
pub_type: 杂志文章,评审
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更新日期:1998-01-01 00:00:00
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journal_title:Annual review of medicine
pub_type: 杂志文章
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更新日期:1987-01-01 00:00:00
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journal_title:Annual review of medicine
pub_type: 杂志文章,评审
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更新日期:1995-01-01 00:00:00
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更新日期:2004-01-01 00:00:00
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journal_title:Annual review of medicine
pub_type: 杂志文章,评审
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更新日期:1985-01-01 00:00:00
abstract::Hypertensive disorders (gestational hypertension, preeclampsia, chronic hypertension, superimposed preeclampsia) are the most common medical complications of pregnancy and constitute a major cause of maternal and perinatal morbidity and mortality. Prediction of those women destined to develop preeclampsia remains elus...
journal_title:Annual review of medicine
pub_type: 杂志文章,评审
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更新日期:1997-01-01 00:00:00
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journal_title:Annual review of medicine
pub_type: 杂志文章,评审
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更新日期:2017-01-14 00:00:00
abstract::The International HapMap Project produced a genome-wide database of human genetic variation for use in genetic association studies of common diseases. The initial output of these studies has been overwhelming, with over 150 risk loci identified in studies of more than 60 common diseases and traits. These associations ...
journal_title:Annual review of medicine
pub_type: 杂志文章,评审
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更新日期:2009-01-01 00:00:00
abstract::Alzheimer's disease (AD) is unique in medicine in that millions of people suffer from what appears to be the same form of disease, and unlike most other late-onset diseases, the genetic etiologies have been well identified. Three early onset forms of AD inherited as autosomal dominant traits account for less than 2% o...
journal_title:Annual review of medicine
pub_type: 杂志文章,评审
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更新日期:1996-01-01 00:00:00
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journal_title:Annual review of medicine
pub_type: 杂志文章,评审
doi:10.1146/annurev-med-011209-153129
更新日期:2010-01-01 00:00:00
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journal_title:Annual review of medicine
pub_type: 杂志文章,评审
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更新日期:2013-01-01 00:00:00
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journal_title:Annual review of medicine
pub_type: 杂志文章,评审
doi:10.1146/annurev-med-100312-135931
更新日期:2014-01-01 00:00:00
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journal_title:Annual review of medicine
pub_type: 杂志文章,评审
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更新日期:1992-01-01 00:00:00
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journal_title:Annual review of medicine
pub_type: 杂志文章,评审
doi:10.1146/annurev.me.43.020192.001435
更新日期:1992-01-01 00:00:00
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journal_title:Annual review of medicine
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更新日期:2015-01-01 00:00:00
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journal_title:Annual review of medicine
pub_type: 杂志文章,评审
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更新日期:2009-01-01 00:00:00
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journal_title:Annual review of medicine
pub_type: 杂志文章,评审
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更新日期:1994-01-01 00:00:00
abstract::The incretin-based therapies, dipeptidyl peptidase-4 (DPP4) inhibitors and glucagon-like peptide-1 (GLP-1) analogs, are important new classes of therapy for type 2 diabetes mellitus (T2DM). These agents prolong the action of the incretin hormones, GLP-1 and glucose-dependent insulinotropic polypeptide (GIP), by inhibi...
journal_title:Annual review of medicine
pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
abstract::This chapter reviews the biology of gastroesophageal reflux disease, relating pathophysiology to medical and surgical therapy. Various definitions of the disease are presented and workable criteria are developed to identify patients with the disease. The central importance of the lower esophageal high-pressure zone as...
journal_title:Annual review of medicine
pub_type: 杂志文章,评审
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更新日期:1999-01-01 00:00:00
abstract::The genomic era is changing the understanding of cancer, although translation of the vast amount of data available into decision-making algorithms is far from reality. Molecular profiling of hepatocellular carcinoma (HCC), the most common cause of death among cirrhotic patients and a fast-growing malignancy in Western...
journal_title:Annual review of medicine
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更新日期:2010-01-01 00:00:00
abstract::Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart disease characterized by fibrofatty replacement of the ventricular myocardium, a high risk of ventricular arrhythmias, and progressive ventricular dysfunction. The clinical course is highly variable, and optimal approaches to management remai...
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pub_type: 杂志文章,meta分析
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abstract::Although safe and effective agents are currently available to treat osteoporosis, fragility fractures remain a significant problem worldwide. Recent improvements in the understanding of the cellular, biochemical, and molecular pathways of bone biology have led to the development of newer agents to treat osteoporosis, ...
journal_title:Annual review of medicine
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更新日期:2011-01-01 00:00:00
abstract::Idiopathic thrombocytopenic purpura (ITP) is a common hematologic disorder manifested by immune-mediated thrombocytopenia. The diagnosis remains one of exclusion, after other thrombocytopenic disorders are ruled out based on history, physical examination, and laboratory evaluation. The goal of treatment is to raise th...
journal_title:Annual review of medicine
pub_type: 杂志文章,评审
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更新日期:2005-01-01 00:00:00
abstract::The standard of care for the evaluation of axillary nodal involvement remains complete lymph node dissection. Lymphatic mapping and sentinel lymph node (SLN) biopsy are changing this long-held paradigm; indeed, several leading institutions already reserve complete axillary dissection for patients with metastasis to th...
journal_title:Annual review of medicine
pub_type: 杂志文章
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更新日期:2000-01-01 00:00:00