Immunological aspects of a case of posttransplant lymphoproliferative disorder.

Abstract:

:We describe a female renal transplant recipient with cytomegalovirus and Epstein-Barr virus (EBV) infections who developed aggressive polymorphous polyclonal B cell proliferation. She received two courses of OKT3. We found a majority of transformed B cells bearing EBV membrane receptor CR2 and EBV nuclear antigen. Posttransplant lymphoproliferative disorders may be associated with a significant immunological activation, detected in this case by the sudden increase of beta 2-microglobulin and immunoglobulin levels, including immunoglobulin D. These raised levels persisted throughout the short and rapid course of the disease.

journal_name

Am J Nephrol

authors

Franco A,Muñoz C,Aranda I,Cabezas A,Perdiguero M,Prados C

doi

10.1159/000168818

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

137-41

issue

2

eissn

0250-8095

issn

1421-9670

journal_volume

15

pub_type

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