Soluble interleukin-2 receptors and beta 2-microglobulin in patients with primary glomerulonephritis.

Abstract:

:Serum levels of soluble interleukin-2 receptors (IL2R) and of beta 2-microglobulin (beta 2M) were studied with the immunoenzymatic technique in 38 patients with primary glomerulonephritis (GN), in 10 patients with essential hypertension (EH) and in 30 healthy subjects. IL2R correlated with beta 2M (p < 0.05). IL2R and beta 2M were higher in patients with GN (p < 0.003, p < 0.001, respectively) and in patients with EH (p < 0.003, p < 0.01, respectively) than in healthy subjects. IL2R and beta 2M correlated with serum creatinine, but not with proteinuria. Our data would suggest the existence of lymphocyte activation in patients with GN. Only speculations can be advanced with regard to the observed increase in these parameters in EH patients.

journal_name

Am J Nephrol

authors

Rollino C,Roccatello D,Amprimo MC,Cavalli G,Aimo G,Beltrame G,Basolo B,Martina G,Piccoli G

doi

10.1159/000168627

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

244-8

issue

4

eissn

0250-8095

issn

1421-9670

journal_volume

13

pub_type

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