Effect of CB 154 (2-bromo-alpha-ergocryptine) on paralysis agitans compared with Madopar in a double-blind, cross-over trial.

Abstract:

:Twenty patients with paralysis agitans took part in a double-blind, cross-over investigation of CB 154 (2-bromo-alpha-ergocryptine) and Madopar (L-Dopa + benserazid (a peripheral decarboxylase inhibitor), dose ratio 4:1). Each treatment phase lasted for 8 weeks. Modapar was found to be significantly superior to CB 154 in the treatment of the Parkinson state as a whole (Webster total score) and the individual symptoms of hypokinesia, rigidity and tremor. Compared with pretreatment score, CB 154 had a weak, but significant effect on tremor, but not on the Webster total score, hypokinesia and rigidity. The effect of CB 154, however, varied: four patients preferred CB 154 to Madopar on account of its satisfactory therapeutic effect and fewer side-effects ("on-off" phenomena, hyperkinesia, psychiatric complications); other patients showed neither therapeutic effect nor side-effects of CB 154, which in some cases may be related to too low a dose-level of CB 154 (median 30 mg daily, range 20-60 mg). In the four cases first mentioned which showed a good effect of CB 154, the ratio between the dose of CB 154 and the dose of L-Dopa (in Madopar) was 3.5-10 mg/100 mg, i.e. in certain cases it must be assumed that the maximum dose of CB 154 lies around 120 mg daily.

journal_name

Acta Neurol Scand

authors

Gerlach J

doi

10.1111/j.1600-0404.1976.tb04337.x

subject

Has Abstract

pub_date

1976-03-01 00:00:00

pages

189-200

issue

3

eissn

0001-6314

issn

1600-0404

journal_volume

53

pub_type

临床试验,杂志文章
  • Ondine's curse in listeria monocytogenes brain stem encephalitis.

    abstract::A case of necrotizing brain stem encephalitis due to listeria monocytogenes is described in a 48-year-old man who had brain stem encephalitis of complicated course and with selective destruction of the vasomotoric and respiratory centers. He developed that very rare Ondine's curse syndrome, being only able to breathe ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1988.tb05949.x

    authors: Jensen TH,Hansen PB,Brodersen P

    更新日期:1988-06-01 00:00:00

  • Cerebrospinal neuron-specific enolase, S-100 and myelin basic protein in neurological disorders.

    abstract::In this study levels of neuron-specific enolase (NSE), S-100 protein (S-100) and myelin basic protein (MBP) in cerebrospinal fluid (CSF) of children and adults with distinct neurological disorders were examined. A previous study from our department demonstrated age related reference values for these brain-specific pro...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1995.tb01696.x

    authors: Lamers KJ,van Engelen BG,Gabreëls FJ,Hommes OR,Borm GF,Wevers RA

    更新日期:1995-09-01 00:00:00

  • EEG findings in diabetic patients with and without retinopathy.

    abstract:OBJECTIVES:We showed previously that temporal low-voltage irregular delta waves (TLID) on EEG are indicative of cerebrovascular dysfunction in its early stages. The present study was designed to determine whether the incidence of this finding is elevated in diabetics as compared to normal controls. METHODS:EEGs of 50 ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1998.tb00618.x

    authors: Inui K,Sannan H,Ota H,Uji Y,Nomura S,Kaige H,Kitayama I,Nomura J

    更新日期:1998-02-01 00:00:00

  • Six-month prospective study of quality of life in Guillain-Barre syndrome.

    abstract:OBJECTIVE:Guillain-Barre syndrome (GBS) is an acute disease of the peripheral nerves and their roots. Quality of life (QoL) in the first year after acute episode of GBS is still underresearched area. The aim of our study was to investigate QoL in GBS patients during a 6-month follow-up period. METHODS:Multicentric, pr...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章,多中心研究

    doi:10.1111/ane.13195

    authors: Djordjevic G,Stojanov A,Bozovic I,Berisavac I,Arsenijevic M,Lukic Rajic S,Dominovic Kovacevic A,Jovanovic D,Basta I,Peric S

    更新日期:2020-03-01 00:00:00

  • Subjective memory decline in healthy community-dwelling elders. What does this complain mean?

    abstract:OBJECTIVES:Subjective feelings of memory decline are fairly common among the elderly. The causes of this are heterogeneous, and may be related to both affective and cognitive disorders. We attempted to explore the associations between subjective and cognitive measures. MATERIALS AND METHODS:Healthy subjects were studi...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2009.01159.x

    authors: Balash Y,Mordechovich M,Shabtai H,Merims D,Giladi N

    更新日期:2010-03-01 00:00:00

  • Quality of life in Parkinson's disease: A gender-specific perspective.

    abstract:OBJECTIVES:The epidemiology, manifestations, and course of Parkinson's disease (PD) may differ in men and women. Assessments of severity of the illness and quality of life (QoL), and the burden on their caregivers (CG) may change as the disease advances. We determined gender differences in assessment by patients with P...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.13095

    authors: Balash Y,Korczyn AD,Migirov AA,Gurevich T

    更新日期:2019-07-01 00:00:00

  • Search for a retrovirus in multiple sclerosis by enzymatic amplification of DNA from brain capillaries, brain tissue and mononuclear cells from peripheral blood.

    abstract::Attempts were made to trace a possible retrovirus in multiple sclerosis (MS) by means of polymerase chain reaction. The primers derived from conserved sequences in the genome of human T cell leukemia/lymphoma virus type I (HTLV-I) and the amplifications were carried out at varying stringency conditions (i.a. annealing...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1992.tb08060.x

    authors: Rasmussen HB,Clausen J

    更新日期:1992-07-01 00:00:00

  • Genetic factors in temporal lobe epilepsy.

    abstract::Genetic investigation of 74 patients with temporal lobe epilepsy, resistant to medication, who underwent unilateral temporal lobectomy 1960-1969. Thirty per cent had a positive family history of epilepsy; 49 per cent of other neurological diseases; and 46 per cent of major psychiatric disorders. Neither of the genetic...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1975.tb05833.x

    authors: Jensen I

    更新日期:1975-11-01 00:00:00

  • Autosomal dominant cortical tremor, myoclonus and epilepsy: many syndromes, one phenotype.

    abstract::The association of cortical tremor, myoclonus and epileptic seizures has been reported in many Japanese and European families with different acronyms. We reviewed the familial cases presenting the clinical picture of autosomal dominant cortical tremor, myoclonus and epilepsy and analysed the phenotypic differences bet...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2005.00385.x

    authors: Striano P,Zara F,Striano S

    更新日期:2005-04-01 00:00:00

  • Clinical and neurophysiological abnormalities before and after reconstruction of the anterior cruciate ligament of the knee.

    abstract:OBJECTIVES:We aimed to study knee proprioception and somatosensory evoked potentials (SEPs) to stimulation of the common peroneal nerve (CPN) in 7 patients with lesion of the anterior cruciate ligament (ACL) before and after ACL reconstruction. MATERIALS AND METHODS:We recorded the spinal N14 and scalp P27 potentials ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1999.tb00680.x

    authors: Valeriani M,Restuccia D,Di Lazzaro V,Franceschi F,Fabbriciani C,Tonali P

    更新日期:1999-05-01 00:00:00

  • Comparison between agarose gel electrophoresis and isoelectric focusing of CSF for demonstration of oligoclonal immunoglobulin bands in neurological disorders.

    abstract::Isoelectric focusing and agarose gel electrophoresis of CSF and serum revealed similar frequencies of oligoclonal bands in multiple sclerosis (100% with both methods), infectious CNS disorders (38 and 23%) and other neurological diseases (8 and 10%). In selected cases with unsure CSF oligoclonal bands on agarose gel e...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1978.tb02874.x

    authors: Laurenzi MA,Link H

    更新日期:1978-09-01 00:00:00

  • Improved detection of auditory P3 abnormality in dementia using a variety of stimuli.

    abstract::The purpose of this study was to test the improved sensitivity of P3 abnormality in the detection of dementia using a variety of auditory stimuli. Improved detection was obtained using auditory stimuli that differed in their cognitive attributes and by using several P3 measures. These measures included P3 latencies an...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1995.tb00474.x

    authors: Attias J,Huberman M,Cott E,Pratt H

    更新日期:1995-07-01 00:00:00

  • Is there a prognostic role for C-reactive protein in ischemic stroke?

    abstract:OBJECTIVES:We investigated the relationship between C-reactive protein (CRP)-values in the acute phase of stroke and the risk of further fatal and non-fatal ischemic events. MATERIALS AND METHODS:We analysed 462 consecutive incident ischemic strokes. Patients were divided into two subgroups on the basis of a CRP cut-o...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2009.01288.x

    authors: Corso G,Bottacchi E,Brusa A,Benedetto MD,Giardini G,Lia C,Reggiani M,Veronese Morosini M

    更新日期:2010-09-01 00:00:00

  • Determinants of post-stroke cognitive impairment: analysis from VISTA.

    abstract:BACKGROUND:Post-stroke cognitive impairment (PSCI) occurs commonly and is linked with development of dementia. We investigated the relationship between demographic, clinical and stroke symptoms at stroke onset and the presence of PSCI at 1 and 3 years after stroke. METHODS:We accessed anonymized data from the Virtual ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.12637

    authors: Arba F,Quinn T,Hankey GJ,Inzitari D,Ali M,Lees KR,VISTA Collaboration.

    更新日期:2017-06-01 00:00:00

  • Quantitative EEG in patients with presenile and senile dementia of the Alzheimer type.

    abstract::EEG data obtained from 27 patients with presenile Alzheimer's disease (AD) and 28 patients with senile dementia of the Alzheimer type (SDAT) were compared with data from 30 age- and sex-matched controls. Both patient groups exhibited more pronounced delta and theta activity and less prominent alpha and beta activity t...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:

    authors: Miyauchi T,Hagimoto H,Ishii M,Endo S,Tanaka K,Kajiwara S,Endo K,Kajiwara A,Kosaka K

    更新日期:1994-01-01 00:00:00

  • Subthalamic deep brain stimulation and trunk posture in Parkinson's disease.

    abstract:OBJECTIVES:We sought to assess the efficacy of subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD)-associated trunk posture abnormalities retrospectively analyzing data from 101 patients reporting mild-to-severe trunk posture abnormalities of a cohort of 216 PD patients treated with STN-DBS...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.12889

    authors: Artusi CA,Zibetti M,Romagnolo A,Rizzone MG,Merola A,Lopiano L

    更新日期:2018-05-01 00:00:00

  • Prevalence and risk of thyroid diseases in myasthenia gravis.

    abstract:OBJECTIVES:To estimate the prevalence of thyroid diseases and the cumulative risk of thyroid diseases during a follow-up period after myasthenia gravis (MG) diagnosis compared with non-MG controls. MATERIALS AND METHODS:We used the Taiwan National Health Insurance Database linked to Registry of Catastrophic Illness da...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.13254

    authors: Chou CC,Huang MH,Lan WC,Kong SS,Kuo CF,Chou IJ

    更新日期:2020-09-01 00:00:00

  • Rising mortality from Parkinson's disease in Japan, 1950-1992.

    abstract::The death rate from Parkinson's disease (PD) were analyzed using Japanese vital statistics for 1950-1992. The age-adjusted PD death rate increased statistically significantly with the years between 1950 and 1992 for both sexes. However, decline in the PD death rate were observed among the population under 65 years old...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1995.tb00428.x

    authors: Imaizumi Y,Kaneko R

    更新日期:1995-03-01 00:00:00

  • Coagulopathy and outcome in patients with chronic subdural haematoma.

    abstract:OBJECTIVE:The coincidence of coagulatopathy and chronic subdural haematoma (CSH) requires correction of coagulation to facilitate surgery. We investigated the correlation between coagulopathy and outcome in CSH patients. MATERIAL AND METHODS:We analysed past medical history, surgical treatment and coagulation paramete...

    journal_title:Acta neurologica Scandinavica

    pub_type: 临床试验,杂志文章

    doi:10.1034/j.1600-0404.2003.01340.x

    authors: König SA,Schick U,Döhnert J,Goldammer A,Vitzthum HE

    更新日期:2003-02-01 00:00:00

  • Gap junction protein beta 1 (GJB1) mutations and central nervous system symptoms in X-linked Charcot-Marie-Tooth disease.

    abstract:OBJECTIVES:To clarify the clinical variability, including central nervous system (CNS) involvement, in X-linked Charcot-Marie-Tooth disease (CMTX) patients. MATERIAL AND METHODS:We clinically, pathologically and genetically studied six CMTX patients with distinct symptoms and four different GJB1 mutations. RESULTS:On...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0404.2003.01317.x

    authors: Takashima H,Nakagawa M,Umehara F,Hirata K,Suehara M,Mayumi H,Yoshishige K,Matsuyama W,Saito M,Jonosono M,Arimura K,Osame M

    更新日期:2003-01-01 00:00:00

  • Effect of memantine on CBF and CMRO2 in patients with early Parkinson's disease.

    abstract:OBJECTIVES:Parkinson's disease (PD) may be associated with increased energy metabolism in overactive regions of the basal ganglia. Therefore, we hypothesized that treatment with the N-methyl-d-aspartate receptor (NMDAR) antagonist memantine would decrease regional cerebral blood flow (rCBF) and oxygen metabolism in the...

    journal_title:Acta neurologica Scandinavica

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1600-0404.2007.00943.x

    authors: Borghammer P,Vafaee M,Ostergaard K,Rodell A,Bailey C,Cumming P

    更新日期:2008-05-01 00:00:00

  • Leuko-araiosis and stroke: a case-control study.

    abstract:OBJECTIVE:Association of leuko-araiosis (LA) with certain risk factors has been reported in Western patients. This is a case-control study to determine the risk factors and the type of stroke associated with LA in Saudi patients. DESIGN AND SETTING:398 consecutive Saudi patients with the diagnosis of stroke admitted o...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1996.tb00054.x

    authors: Awada A,Omojola MF

    更新日期:1996-12-01 00:00:00

  • Quality-of-life perception by Parkinson's disease patients and caregivers.

    abstract:BACKGROUND:The quality-of-life (QoL) perception by Parkinson's disease (PD) patients and their caregivers (CG) has not been studied in depth. OBJECTIVE:To examine patient/proxy agreements on the PD QoL Questionnaire (PDQ-39), the Scale of Quality of Life of Care-Givers (SQLC) and the Multidimensional Caregiver Strain ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.12726

    authors: Balash Y,Korczyn AD,Knaani J,Migirov AA,Gurevich T

    更新日期:2017-08-01 00:00:00

  • Intrathecal origin of CSF ribonuclease. Differences between infectious processes of the nervous system and multiple sclerosis.

    abstract::A CSF Poly(C)-avid ribonuclease (RNase) activity was determined in serum and CSF of 11 controls and 75 neurological patients (34 multiple sclerosis (MS), 18 infectious processes and 23 other neurological diseases (OND]. In controls, the blood-CSF ratio of RNase activity is low. This fact and the absence of correlation...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:

    authors: Allinquant B,Musenger C,Schuller E

    更新日期:1984-07-01 00:00:00

  • Diffuse cerebral sclerosis, melanoderma and adrenal insufficiency (adreno-leukodystrophy).

    abstract::Two cases of adrenoleukodystrophy are described. The pathological picture was consistent with earlier observations about the disease with the difference that the brain tissue revealed material which stained metachromatically with toluidine blue and was insoluble in fat solvents. ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1978.tb02870.x

    authors: Hormia M

    更新日期:1978-08-01 00:00:00

  • Effect of sympathetic denervation on chronic cold injuries in rabbit brain. A microangiographical and histological study.

    abstract::Sympathetic denervation of the brain vessels was performed uni- or bilaterally in 13 adult rabbits, and cortical cold lesions were induced bilaterally 10-18 days afterwards. After a further 4-35 days the vascular and morphological changes in the lesion areas were studied histologically and with angiography. No differe...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1976.tb04801.x

    authors: West KA,Hassler O

    更新日期:1976-09-01 00:00:00

  • Vigabatrin-associated retinal damage: potential biochemical mechanisms.

    abstract::Vigabatrin (VGB), an irreversible inhibitor of gamma-aminobutyric acid (GABA) transaminase, is approved as adjunct treatment of refractory partial seizures as well as infantile spasms. Although VGB has been proven to be effective, its use is limited by the risk of retinopathy and associated peripheral visual field def...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1111/j.1600-0404.2012.01684.x

    authors: Heim MK,Gidal BE

    更新日期:2012-10-01 00:00:00

  • Cerebral blood flow, cerebrovascular resistance and cerebral metabolic rate of oxygen in severe arterial hypoxia in dogs.

    abstract::Cerebral blood flow and cerebral oxygen uptake were studied during severe arterial hypoxia in anesthetized dogs. It was shown that the hypoxic vasodilatation in the brain reaches a limit at an arterial oxygen saturation at about 25% and that this vasodilatation is less than that which may be induced by hypercapnia. A ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1979.tb02948.x

    authors: Ekström-Jodal B,Elfverson J,von Essen C

    更新日期:1979-07-01 00:00:00

  • The HMGB1 is increased in CSF of patients with an Anti-NMDAR encephalitis.

    abstract:BACKGROUND:Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune disorder of the central nervous system (CNS). Interleukin (IL)-6 and IL-17A may play important roles in the pathogenesis of this disease. High-mobility group box protein 1 (HMGB1), a small but highly conserved ubiquitous protein, is rec...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.12850

    authors: Ai P,Zhang X,Xie Z,Liu G,Liu X,Pan S,Wang H

    更新日期:2018-02-01 00:00:00

  • Immunological and genetic studies in primary generalized corticoreticular epilepsy.

    abstract::Serum immunoglobulin and HLA investigations were carried out in 21 probands with primary generalized corticoreticular epilepsy (PGCE) and in 26 of their first degree relatives. The mean serum levels of IgG, IgA and IgM in the epileptic probands were not significantly different from controls. In the relatives, however,...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1986.tb07867.x

    authors: Eeg-Olofsson O,Janjua NA,Andermann E,Guttmann RD,Osterland K

    更新日期:1986-12-01 00:00:00