Assessment of rigid multi-modality image registration consistency using the multiple sub-volume registration (MSR) method.

Abstract:

:Registration of different imaging modalities such as CT, MRI, functional MRI (fMRI), positron (PET) and single photon (SPECT) emission tomography is used in many clinical applications. Determining the quality of any automatic registration procedure has been a challenging part because no gold standard is available to evaluate the registration. In this note we present a method, called the 'multiple sub-volume registration' (MSR) method, for assessing the consistency of a rigid registration. This is done by registering sub-images of one data set on the other data set, performing a crude non-rigid registration. By analysing the deviations (local deformations) of the sub-volume registrations from the full registration we get a measure of the consistency of the rigid registration. Registration of 15 data sets which include CT, MR and PET images for brain, head and neck, cervix, prostate and lung was performed utilizing a rigid body registration with normalized mutual information as the similarity measure. The resulting registrations were classified as good or bad by visual inspection. The resulting registrations were also classified using our MSR method. The results of our MSR method agree with the classification obtained from visual inspection for all cases (p < 0.02 based on ANOVA of the good and bad groups). The proposed method is independent of the registration algorithm and similarity measure. It can be used for multi-modality image data sets and different anatomic sites of the patient.

journal_name

Phys Med Biol

authors

Ceylan C,van der Heide UA,Bol GH,Lagendijk JJ,Kotte AN

doi

10.1088/0031-9155/50/10/N01

subject

Has Abstract

pub_date

2005-05-21 00:00:00

pages

N101-8

issue

10

eissn

0031-9155

issn

1361-6560

pii

S0031-9155(05)90514-9

journal_volume

50

pub_type

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