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Antroduodenal manometry: 24-hour ambulatory monitoring versus short-term stationary manometry in patients with functional dyspepsia.

Abstract：

OBJECTIVES:To examine the interdigestive and postprandial antroduodenal motility patterns of patients with functional dyspepsia using prolonged ambulatory antroduodenal manometry and to compare these findings with conventional stationary manometry. METHODS:Prolonged ambulatory and short-term stationary antroduodenal manometry were performed in 10 patients with functional dyspepsia and in 10 healthy volunteers (controls). RESULTS:During stationary manometry only a few interdigestive motor complex (MMC) cycles were recorded. Using the ambulatory technique, fewer MMC cycles were observed in patients than in controls (2.2 +/- 0.63 and 4.1 +/- 0.54, respectively; P = 0.030). During phase II of the MMC, both techniques showed a higher antral motility index in patients (P = 0.017 and P = 0.049 for stationary and ambulatory manometry, respectively). The postprandial antral motility index was similar for patients and controls using stationary manometry. With the ambulatory technique, the antral motility index 1-1.5 h after breakfast was lower in patients than in controls (P = 0.020). Both techniques showed that the patients had a higher duodenal motility index after dinner and after breakfast (P < 0.05). Both techniques revealed more burst activity in patients than in controls (stationary: 10.7 versus 1.8% of the time; ambulatory: 1.7 versus 0.2% of the time; P = 0.004 and P = 0.051, respectively). Using a 10-min window period before the onset of symptoms, seven symptom episodes (33.3%) were found to be related to burst activity and retrograde or non-propagated phase III activity. CONCLUSIONS:Ambulatory manometry is superior to stationary manometry for evaluating patients with functional dyspepsia, because patients can be studied for a prolonged period (allowing adequate evaluation of interdigestive abnormalities) and under physiological conditions. Prolonged monitoring also allows assessment of the relationship between symptoms and motor abnormalities.

journal_name

Eur J Gastroenterol Hepatol

journal_title

European journal of gastroenterology & hepatology

authors

Jebbink RJ,vanBerge-Henegouwen GP,Akkermans LM,Smout AJ

subject

Has Abstract

pub_date

1995-02-01 00:00:00

pages

109-16

issue

eissn

0954-691X

issn

1473-5687

journal_volume

pub_type

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Antroduodenal manometry: 24-hour ambulatory monitoring versus short-term stationary manometry in patients with functional dyspepsia.