High-sensitivity C-reactive protein levels predict survival and are related to haemodynamics in alcoholic cirrhosis.

Abstract:

OBJECTIVES:Inflammation may be implicated in the haemodynamic deterioration and in the development of complications in patients with cirrhosis. High-sensitivity C-reactive protein (hsCRP) is a marker of low-grade inflammation, and predicts outcomes in patients at risk of ischaemic heart disease. Proinflammatory cytokines reflect immune activation and have been found to be elevated in cirrhosis. We investigated a possible association between markers of inflammation and splanchnic and systemic haemodynamics, complications and survival in patients with cirrhosis. METHODS:In 45 stable patients with cirrhosis on the basis of alcohol consumption, we measured hsCRP, as well as monocyte chemoattractant protein-1, tumour necrosis factor-α, interleukin-6, interleukin-8 and vascular endothelial growth factor in patients and in 12 healthy controls. Systemic and splanchnic haemodynamics were investigated in patients. RESULTS:hsCRP levels were significantly higher in patients compared with controls (P<0.05) and the highest in patients belonging to Child-Pugh class C. hsCRP levels correlated with markers of liver dysfunction and with the hepatic venous pressure gradient (r=0.48, P<0.001). hsCRP values above the median level of 5.3 mg/l were associated with a highly increased mortality (P=0.001). Model for End-Stage Liver Disease score (P=0.01) and hsCRP (P<0.05) provided independent prognostic information. Cytokines had no discernible value in predicting survival. CONCLUSION:hsCRP is elevated in patients with cirrhosis and is associated with portal hypertension and decreased survival. hsCRP is a promising prognostic marker in cirrhosis, which may improve the selection of candidates for liver transplantation.

authors

Mortensen C,Andersen O,Krag A,Bendtsen F,Møller S

doi

10.1097/MEG.0b013e328351db6e

subject

Has Abstract

pub_date

2012-06-01 00:00:00

pages

619-26

issue

6

eissn

0954-691X

issn

1473-5687

journal_volume

24

pub_type

杂志文章
  • Validation of [13C]urea breath test for Helicobacter pylori using a simple gas chromatograph-mass selective detector.

    abstract:OBJECTIVE:Isotope ratio mass spectrometry (IRMS) is the accepted method for accurately measuring the 13CO2:12CO2 ratio in the non-invasive and non-radioactive [13C]urea breath test (13C-UBT) for Helicobactor pylori. The IRMS instrument, an expensive and highly specialized analyser, is rarely available. The objective of...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-199807000-00008

    authors: Lee HS,Gwee KA,Teng LY,Kang JY,Yeoh KG,Wee A,Chua BC

    更新日期:1998-07-01 00:00:00

  • Quadruple therapy compared with dual therapy for eradication of Helicobacter pylori in ulcer patients: results of a randomized prospective single-centre study.

    abstract:OBJECTIVE:To assess the efficacy and side-effect profile of two currently advocated treatment regimens for eradicating Helicobacter pylori. DESIGN:A randomized, controlled, open, single-centre study. SETTING:A community hospital in The Netherlands. PARTICIPANTS:Seventy-six consecutive patients with (chronic) ulcer d...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00042737-199512000-00011

    authors: de Boer WA,Driessen WM,Jansz AR,Tytgat GN

    更新日期:1995-12-01 00:00:00

  • Inappropriate use of the faecal occult blood test in a university hospital in the Netherlands.

    abstract:OBJECTIVES:Although all international guidelines state that there is no indication to perform a faecal occult blood test (FOBT) in symptomatic patients, we believe the test is frequently used as a diagnostic test. The objective of this study was to investigate whether the current guidelines for FOBT use are being follo...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e328313bbd3

    authors: van Rijn AF,Stroobants AK,Deutekom M,Lauppe C,Sturk A,Bossuyt PM,Fockens P,Dekker E

    更新日期:2012-11-01 00:00:00

  • Infliximab in refractory coeliac disease.

    abstract::Coeliac disease is generally well controlled with gluten-free diet but a small proportion of patients require corticosteroids or immunomodulatory agents. Response to anti-tumour necrosis factor (anti-TNF) agents raises interesting questions about both the pathogenesis of coeliac disease and the mechanism of action of ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:10.1097/00042737-200506000-00002

    authors: Chaudhary R,Ghosh S

    更新日期:2005-06-01 00:00:00

  • Systemic treatment of hepatocellular carcinoma.

    abstract::The results of systemic treatments for hepatocellular carcinoma are currently disappointing. In patients with advanced disease, none of the tested treatments (particularly systemic chemotherapy or hormonal treatment, such as tamoxifen) demonstrated an unequivocal benefit in terms of survival, and the trials including ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:10.1097/00042737-200403000-00005

    authors: Ganne-Carrié N,Trinchet JC

    更新日期:2004-03-01 00:00:00

  • Effects of a supplementary diet with specially processed cereals in patients with short bowel syndrome.

    abstract:OBJECTIVE:Short bowel syndrome patients frequently experience impaired health-related quality of life. This syndrome is also associated with increased costs for the individuals concerned and the community. Intake of specially processed cereals has been demonstrated to decrease intestinal secretion. This study evaluates...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/MEG.0b013e328303c00a

    authors: Pagoldh M,Eriksson A,Heimtun E,Kvifors E,Sternby B,Blomquist L,Lapidus A,Suhr O,Lange S,Karlbom U,Nordström D,Rettrup B

    更新日期:2008-11-01 00:00:00

  • Gene therapy for human liver diseases.

    abstract::The liver can be considered an ideal target to design gene therapy strategies because of the unique properties of hepatic cells. The great amount of work carried out in this field clearly delineates the quality of the new approaches that have been developed in the last few years and demonstrates the feasibility of thi...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:10.1097/00042737-199904000-00011

    authors: Di Campli C,Wu J,Gasbarrini A,Gasbarrini G,Zern MA

    更新日期:1999-04-01 00:00:00

  • Deleterious effect of proton pump inhibitors on the disease course of cirrhosis.

    abstract:OBJECTIVES:Proton pump inhibitors(PPIs) are widely prescribed to patients with liver cirrhosis. We hypothesized that long-standing PPI use is associated with spontaneous bacterial peritonitis(SBP) and accelerated development of disease-specific complications and liver-related death. METHODS:A 5-year follow-up observat...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001499

    authors: Janka T,Tornai T,Borbély B,Tornai D,Altorjay I,Papp M,Vitális Z

    更新日期:2020-02-01 00:00:00

  • Protein misfolding in combination with other risk factors in CEL-HYB1-mediated chronic pancreatitis.

    abstract:OBJECTIVES:The hybrid allele of the carboxyl ester lipase gene (CEL-HYB1) is a genetic risk factor for chronic pancreatitis (CP) although the mechanism promoting disease development is largely unknown. Here, we aimed to clinically describe subjects carrying the CEL-HYB1 allele and to elucidate why the protein product i...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001963

    authors: Tjora E,Gravdal A,Engjom T,Cnop M,Johansson BB,Dimcevski GG,Molven A,Fjeld K

    更新日期:2020-10-16 00:00:00

  • Clinical, metabolic, and psychological characteristics in patients with gastroesophageal reflux disease overlap with irritable bowel syndrome.

    abstract:OBJECTIVES:Gastroesophageal reflux disease (GERD) and irritable bowel syndrome (IBS) are highly prevalent in the general population, with significant symptom overlap, whereas the interaction between both remains poorly understood. We aim to identify the clinical and psychological factors that contribute toward the over...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000334

    authors: Hsu CS,Liu TT,Wen SH,Wang CC,Yi CH,Chen JH,Lei WY,Orr WC,Fabio P,Chen CL

    更新日期:2015-05-01 00:00:00

  • Management of rectal cancer in France in a well-defined population.

    abstract:OBJECTIVE:The aim of this study was to draw a picture of diagnostic assessment and patterns of care for rectal cancer in France using population-based registries data. METHODS:The study included a random sample of 669 cases of rectal cancers diagnosed in 2005. RESULTS:Diagnostic assessment was performed by colonoscop...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000116

    authors: Desgrippes R,Bouvier V,Delafosse P,Robaszkiewicz M,Molinié F,Trétarre B,Lepage C,Faivre J,Jooste V,Bouvier AM

    更新日期:2014-07-01 00:00:00

  • Cytokine and clinical response to Saccharomyces boulardii therapy in diarrhea-dominant irritable bowel syndrome: a randomized trial.

    abstract:INTRODUCTION:This preliminary study aimed to investigate the effects of the probiotic Saccharomyces boulardii on proinflammatory and anti-inflammatory cytokines in patients with diarrhea-dominant irritable bowel syndrome (IBS-D). The other objectives were to document any clinical improvement as judged by symptoms, qual...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MEG.0000000000000094

    authors: Abbas Z,Yakoob J,Jafri W,Ahmad Z,Azam Z,Usman MW,Shamim S,Islam M

    更新日期:2014-06-01 00:00:00

  • Histological changes in the gastric mucosa after Helicobacter pylori eradication.

    abstract:BACKGROUND AND AIM:Correa described a stepwise model of changes in the gastric mucosa after Helicobacter pylori infection, from the normal gastric epithelium to chronic gastritis, atrophy, intestinal metaplasia, dysplasia and adenocarcinoma. The aim of this study is to assess the reversibility of these mucosal changes ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200411000-00017

    authors: Fichman S,Niv Y

    更新日期:2004-11-01 00:00:00

  • Infliximab therapy for Crohn's disease in the presence of chronic hepatitis C infection.

    abstract::Treatment of Crohn's disease with infliximab is an important drug therapy for patients with refractory and fistulating disease. There are concerns over its use in a proportion of Crohn's patients with concurrent hepatitis C infection, since there are theoretical risks of accelerated hepatic decompensation due to the i...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200102000-00016

    authors: Campbell S,Ghosh S

    更新日期:2001-02-01 00:00:00

  • Transforming growth factor betas and their receptors in human liver cirrhosis.

    abstract:BACKGROUND:Transforming growth factor betas (TGF-betas) are a group of homologous polypeptides that exert pleiotropic effects on various cell types and stimulate the formation of extracellular matrix and fibrosis. To evaluate whether TGF-beta isoforms (TGF-beta1, TGF-beta2 and TGF-beta3) and their receptors (types I-II...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-199812000-00009

    authors: Baer HU,Friess H,Abou-Shady M,Berberat P,Zimmermann A,Gold LI,Korc M,Büchler MW

    更新日期:1998-12-01 00:00:00

  • Early transjugular intrahepatic portosystemic shunt in cirrhotic patients with acute variceal bleeding: a systematic review and meta-analysis of controlled trials.

    abstract:INTRODUCTION:There is conflicting evidence on the benefit of early transjugular intrahepatic portosystemic shunt (TIPSS) on the survival of patients with acute variceal bleeding (AVB). AIM:To assess the effect of early TIPSS on patient prognosis. MATERIALS AND METHODS:We carried out a meta-analysis of trials evaluati...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MEG.0000000000000403

    authors: Deltenre P,Trépo E,Rudler M,Monescillo A,Fraga M,Denys A,Doerig C,Fournier N,Moreno C,Moradpour D,Bureau C,Thabut D

    更新日期:2015-09-01 00:00:00

  • Acid-base disturbance in patients with cirrhosis: relation to hemodynamic dysfunction.

    abstract:PURPOSE:Acid-base disturbances were investigated in patients with cirrhosis in relation to hemodynamic derangement to analyze the hyperventilatory effects and the metabolic compensation. METHODS:A total of 66 patients with cirrhosis and 44 controls were investigated during a hemodynamic study. RESULTS:Hyperventilator...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000382

    authors: Henriksen JH,Bendtsen F,Møller S

    更新日期:2015-08-01 00:00:00

  • Higher quality of life after metal stent placement compared with plastic stent placement for malignant extrahepatic bile duct obstruction: a randomized controlled trial.

    abstract:OBJECTIVE:For palliation of extrahepatic bile duct obstruction, self-expandable metal stents (SEMS) are superior to plastic stents in terms of stent patency and occurrence of stent dysfunction. We assessed health-related quality of life (HRQoL) after stent placement to investigate whether this also results in a differe...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/MEG.0000000000000762

    authors: Walter D,van Boeckel PG,Groenen MJ,Weusten BL,Witteman BJ,Tan G,Brink MA,Nicolai J,Tan AC,Alderliesten J,Venneman NG,Laleman W,Jansen JM,Bodelier A,Wolters FL,van der Waaij LA,Breumelhof R,Peters FT,Scheffer RC,Stey

    更新日期:2017-02-01 00:00:00

  • Linitis-like squamous esophageal cancer diagnosed by endoscopic ultrasonography-guided fine-needle aspiration cytology: report of two cases.

    abstract::Endoscopic ultrasonography-guided fine-needle aspiration cytology (EUS-FNA) may provide full-thickness biopsies, adequate for cytology and histology. In the present case report, we describe the first cases of a rare well-differentiated squamous esophageal carcinoma (verrucous esophageal cancer), finally diagnosed by E...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e3283643dfb

    authors: Adrián-de-Ganzo Z,Gimeno-García AZ,Elwassief A,Paquin S,Sahai AV,García-Castro C,Nicolás-Pérez D,Brito-García A,Martín-Corriente Mdel C,Garièpy G,Quintero E

    更新日期:2013-12-01 00:00:00

  • Granulocyte colony-stimulating factor improves function of neutrophils from patients with acute liver failure.

    abstract:OBJECTIVE:To evaluate the in vitro effects of granulocyte colony-stimulating factor (G-CSF) on function of neutrophils in acute liver failure (ALF). METHODS:Neutrophil functions (superoxide and hydrogen peroxide production; phagocytosis and killing; complement receptor expression) were determined simultaneously in 23 ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200012100-00011

    authors: Rolando N,Clapperton M,Wade J,Panetsos G,Mufti G,Williams R

    更新日期:2000-10-01 00:00:00

  • Treatment of travellers' diarrhoea: zaldaride compared with loperamide and placebo.

    abstract:OBJECTIVE:To compare zaldaride maleate, a calmodulin inhibitor with gastrointestinal antisecretory properties, with loperamide and a placebo in the treatment of travellers' diarrhoea. DESIGN:Randomized, double-blind, double-dummy study. SETTING:Study clinic staffed by European residents on Nile cruise ships. PATIENT...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Silberschmidt G,Schick MT,Steffen R,Kilpatrick ME,Murphy JR,Oyofo BA,el-Etr S,Gyurech D,Mourad AS,Mathewson JT

    更新日期:1995-09-01 00:00:00

  • Internal anal sphincter myopathy causing proctalgia fugax and constipation: further clinical and radiological characterization in a patient.

    abstract::We report a case of a distinctive familial internal anal sphincter myopathy with unique histological and radiological features. A 67-year-old woman presented with a 20-year history of proctalgia fugax and outlet obstruction; other family members were similarly affected. Computed tomograpy and magnetic resonance imagin...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-199702000-00023

    authors: Guy RJ,Kamm MA,Martin JE

    更新日期:1997-02-01 00:00:00

  • Genetic polymorphisms present in IL10, IL23R, NOD2, and ATG16L1 associated with susceptibility to inflammatory bowel disease in Mexican population.

    abstract:OBJECTIVE:Ulcerative colitis and Crohn's disease are the two clinical forms of inflammatory bowel disease (IBD). Diverse studies have shown the association of single nucleotide polymorphism (SNP) in molecules of the immune system and the occurrence of IBD. Here, several SNPs of the immune system with controversial resu...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001540

    authors: Quiroz-Cruz S,Posada-Reyes B,Alatorre-García T,Del Real-Calzada CM,García-Samper X,Escobar-Gutiérrez A,Vázquez-Chacón CA,Martínez-Guarneros JA,Cruz-Rivera M,Vaughan G,Fonseca-Coronado S

    更新日期:2020-01-01 00:00:00

  • Inflammatory bowel disease in children: the role of a positive family history.

    abstract:OBJECTIVES:The aim of this study was to evaluate any potential influence of a family history of inflammatory bowel disease (IBD) on the clinical phenotypes and the course of IBD in children. METHODS:In this retrospective study, the notes of 411 children with the diagnosis of IBD, 244 (59.4%) with ulcerative colitis, 1...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e32832e2bd8

    authors: Roma ES,Panayiotou J,Pachoula J,Constantinidou C,Polyzos A,Zellos A,Lagona E,Mantzaris GJ,Syriopoulou VP

    更新日期:2010-06-01 00:00:00

  • Cholescintigraphy in patients with acute cholecystitis before and after percutaneous gallbladder drainage.

    abstract:OBJECTIVE:To investigate gallbladder function by use of cholescintigraphy in patients with acute cholecystitis before and after percutaneous gallbladder drainage. DESIGN:A cholescintigraphy was performed in 40 patients with acute cholecystitis before and after the performance of percutaneous gallbladder drainage. Duri...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-199511000-00013

    authors: Borly L,Stage JG,Grønvall S,Højgaard L

    更新日期:1995-11-01 00:00:00

  • p53 protein accumulation and colonic adenoma recurrence.

    abstract:OBJECTIVES:The prognostic value of p53 protein accumulation in colonic adenomas is still controversial. The aim of the present study was to determine whether the evaluation of p53 protein accumulation in newly diagnosed colonic adenomas could predict the development of metachronous adenomas. DESIGN/METHODS:Fifty-five ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-199905000-00014

    authors: Triantafyllou K,Paspatis GA,Zizi A,Papatheodoridis GV,Tzouvala M,Chlouverakis GJ,Elemenoglou I,Karamanolis DG

    更新日期:1999-05-01 00:00:00

  • Liver steatosis in patients with chronic hepatitis B infection: host and viral risk factors.

    abstract:BACKGROUND:Liver steatosis (LS) and chronic infection with hepatitis B virus (HBV) are two common causes of chronic liver disease in Iran. LS is also a common histopathological feature of chronic hepatitis B (CHB). Association of chronic HBV infection and LS has not been extensively studied. AIM:We investigated the pr...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e328326792e

    authors: Minakari M,Molaei M,Shalmani HM,Mohammad Alizadeh AH,Jazi AH,Naderi N,Shavakhi A,Mashayekhi R,Zali MR

    更新日期:2009-05-01 00:00:00

  • Faecal microbiota transplantation: what's beyond Clostridium difficile infection?

    abstract::Over the last decade, major advancements have been made in our understanding of both the beneficial and detrimental role that microorganisms play in our innate functioning. Research into the intestinal microbiota has moved from the laboratory into our medical clinics and is being put forth as an effective therapy for ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001938

    authors: Tamilarasan AG,Krishnananthan T

    更新日期:2020-11-10 00:00:00

  • Qualitative and quantitative clinical evaluation of the laser-assisted ratio analyser for detection of Helicobacter pylori infection by (13)C-urea breath tests.

    abstract:OBJECTIVES:Currently, the (13)C-urea breath test is the reference method for non-invasive diagnosis of Helicobacter pylori infection and therapy control. Therefore, new technologies have been developed to measure the ratio of (13)CO(2)/(12)CO(2) in breath. The laser-assisted ratio analyser (LARA) device is based on opt...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200107000-00008

    authors: Braden B,Gelbmann C,Dietrich CF,Caspary WF,Schölmerich J,Lock G

    更新日期:2001-07-01 00:00:00

  • IL28B favorable genotype and ultrarapid viral response as the earliest treatment predictors of a sustained viral response in a Georgian cohort infected with the hepatitis C genotype 1.

    abstract:OBJECTIVES:The early identification of factors contributing to the successful treatment of hepatitis C infection is important for researchers and clinicians. Studies carried out on the role of an ultrarapid viral response (URVR) for the prediction of a sustained viral response (SVR) have shown its high positive predict...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e328353fd11

    authors: Karchava M,Sharvadze L,Chkhartishvili N,Nelson K,Gochitashivli N,Gatserelia L,Dvali N,Dolmazashvili E,Dzigua L,Badridze N,Zhamutashvili M,Tsertsvadze T

    更新日期:2012-07-01 00:00:00