Acid-base disturbance in patients with cirrhosis: relation to hemodynamic dysfunction.

Abstract:

PURPOSE:Acid-base disturbances were investigated in patients with cirrhosis in relation to hemodynamic derangement to analyze the hyperventilatory effects and the metabolic compensation. METHODS:A total of 66 patients with cirrhosis and 44 controls were investigated during a hemodynamic study. RESULTS:Hyperventilatory hypocapnia was present in all patients with cirrhosis and progressed from Child class A to C (P<0.01). Arterial pH increased significantly from class A to C (P<0.001) and was correlated inversely to the mean arterial blood pressure (r=-0.30, P<0.02), systemic vascular resistance (r=-0.25, P<0.05), indocyanine green clearance (r=-0.37, P<0.005), and serum sodium (r=-0.38, P<0.002). Metabolic compensation was shown by a reduced standard base excess in all patients (P<0.001). Standard base excess contained elements related to changes in serum albumin, water dilution, and effects of unidentified ions (all P<0.001). A significant hepatic component in the acid-base disturbances could not be identified. CONCLUSION:Hypocapnic alkalosis is related to disease severity and hyperdynamic systemic circulation in patients with cirrhosis. The metabolic compensation includes alterations in serum albumin and water retention that may result in a delicate acid-base balance in these patients.

authors

Henriksen JH,Bendtsen F,Møller S

doi

10.1097/MEG.0000000000000382

subject

Has Abstract

pub_date

2015-08-01 00:00:00

pages

920-7

issue

8

eissn

0954-691X

issn

1473-5687

journal_volume

27

pub_type

杂志文章
  • Effects of dietary education, followed by a tailored fructose-restricted diet in adults with fructose malabsorption.

    abstract:OBJECTIVE:Fructose is absorbed by GLUT transporters in the small intestine. If this process is inadequate, abdominal symptoms because of fructose intolerance may arise. The effect of a tailored fructose-restricted diet on gastrointestinal complaints was assessed in patients with fructose intolerance. MATERIALS AND MET...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000374

    authors: Bonfrate L,Krawczyk M,Lembo A,Grattagliano I,Lammert F,Portincasa P

    更新日期:2015-07-01 00:00:00

  • Feasibility study of colorectal cancer screening by immunochemical faecal occult blood testing: results in a northern Italian community.

    abstract:AIM:Screening by means of faecal occult blood testing (FOBT) has proved to be effective in reducing colorectal cancer incidence and mortality. We performed a pilot screening for colorectal cancer by latex immunological FOBT in two municipalities of the region Valle d'Aosta, Italy, focusing on problems and obtaining ind...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200401000-00006

    authors: Crotta S,Castiglione G,Grazzini G,Valle F,Mosconi S,Rosset R

    更新日期:2004-01-01 00:00:00

  • Mansoura simple scoring system for prediction of spontaneous bacterial peritonitis: lesson learnt.

    abstract:BACKGROUND AND OBJECTIVE:Spontaneous bacterial peritonitis (SBP) is a common bacterial infection with life-threatening sequelae in cirrhotic ascites. The purpose of this retrospective cohort study was to recognize the predictors of SBP to build up a noninvasive system to exclude or establish an episode of SBP. PATIENT...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001364

    authors: Abdel-Razik A,Mousa N,Abdel-Aziz M,Elsherbiny W,Zakaria S,Shabana W,Abed S,Elhelaly R,Elzehery R,Eldars W,El-Bendary M

    更新日期:2019-08-01 00:00:00

  • Idiopathic fibrosing pancreatitis and Crohn's disease: an interesting association.

    abstract::Idiopathic fibrosing pancreatitis is an uncommon condition in children and adolescents of unknown aetiology. This syndrome has been reported in 36 cases so far. To our knowledge none of these cases was definitively associated with Crohn's disease. In this report we describe a young female patient who developed Crohn's...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200012090-00010

    authors: Potamianos S,Koutroubakis IE,Chatzicostas C,Rolles K,Burroughs AK,Kouroumalis EA

    更新日期:2000-09-01 00:00:00

  • Granulocyte colony-stimulating factor improves function of neutrophils from patients with acute liver failure.

    abstract:OBJECTIVE:To evaluate the in vitro effects of granulocyte colony-stimulating factor (G-CSF) on function of neutrophils in acute liver failure (ALF). METHODS:Neutrophil functions (superoxide and hydrogen peroxide production; phagocytosis and killing; complement receptor expression) were determined simultaneously in 23 ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200012100-00011

    authors: Rolando N,Clapperton M,Wade J,Panetsos G,Mufti G,Williams R

    更新日期:2000-10-01 00:00:00

  • Survival analysis after gastrostomy: a single-centre, observational study comparing radiological and endoscopic insertion.

    abstract:OBJECTIVES:Percutaneous endoscopic gastrostomy (PEG) using the pull through technique is the most widely used insertion method. An alternative is a per-oral image-guided gastrostomy (PIG), which may be advantageous in high-risk patients. As there are no large studies comparing PEG against PIG, we wished to analyse mort...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e328332d2dd

    authors: Leeds JS,McAlindon ME,Grant J,Robson HE,Lee FK,Sanders DS

    更新日期:2010-05-01 00:00:00

  • Antimicrobial host defense in the upper gastrointestinal tract.

    abstract:BACKGROUND:With the exception of fungi, microbial infections are rare in the oesophagus. Herein, we aimed to systematically assess the distribution and quantity of different antimicrobial host factors as well as, for the first time, functional mucosal antimicrobial activity in the upper gastrointestinal tract. METHODS...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e3283052ddb

    authors: Hosaka Y,Koslowski M,Nuding S,Wang G,Schlee M,Schäfer C,Saigenji K,Stange EF,Wehkamp J

    更新日期:2008-12-01 00:00:00

  • Calcium carbonate treatment of diarrhoea in intestinal bypass patients.

    abstract:OBJECTIVE:To study the effect of supplemental calcium carbonate on faecal water, calcium, bile acid and lipid concentration and output in intestinal bypass subjects with diarrhoea. DESIGN:Prospective, single-arm treatment trial of oral calcium carbonate, 2400 or 3600 mg Ca2+ per day, given for 12 weeks. METHODS:Faeca...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 临床试验,杂志文章

    doi:10.1097/00042737-199606000-00012

    authors: Steinbach G,Lupton J,Reddy BS,Lee JJ,Kral JG,Holt PR

    更新日期:1996-06-01 00:00:00

  • Propofol alone prevents worsening hepatic encephalopathy rather than midazolam alone or combined sedation after esophagogastroduodenoscopy in compensated or decompensated cirrhotic patients.

    abstract:BACKGROUND:This study was conducted to determine which type and dose of sedative drugs should be given to cirrhotic patients with compensation or decompensation during esophagogastroduodenoscopy (EGD) to prevent hepatic encephalopathy (HE) after sedation. METHODS:We reviewed the medical records of cirrhotic patients c...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001755

    authors: Jeong J,Jung K,Seo KI,Yun BC,Han BH,Lee SU,Moon W

    更新日期:2020-08-01 00:00:00

  • Gastric ulcers and Helicobacter heilmannii.

    abstract:OBJECTIVE:To compare 14 patients with gastric ulcer and Helicobacter heilmannii with other patients with gastric ulcer: age and sex matched patients, patients colonized by Helicobacter pylori and patients on nonsteroidal anti-inflammatory drugs (NSAIDs). SETTING:The endoscopy unit of a university-affiliated hospital. ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-199803000-00011

    authors: Debongnie JC,Donnay M,Mairesse J,Lamy V,Dekoninck X,Ramdani B

    更新日期:1998-03-01 00:00:00

  • Superior mesenteric artery syndrome caused by celiac axis compression syndrome: a case report and review of the literature.

    abstract::Celiac axis compression syndrome (CACS) is a rare entity of mesenteric ischemia, secondary to inadequate blood supply to the intestine, resulting in weight loss because of postprandial abdominal pain. Superior mesenteric artery (SMA) syndrome is an uncommon cause of intestinal obstruction manifesting with epigastric p...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:10.1097/MEG.0b013e3282f172fa

    authors: Tseng CK,Su WB,Lai HC,Chou JW,Feng CL,Peng CY,Chen YF

    更新日期:2008-06-01 00:00:00

  • Should relatives of coeliacs with mild clinical complaints undergo a small-bowel biopsy despite negative serology?

    abstract:BACKGROUND AND OBJECTIVES:Small intestinal lesions in coeliac disease (CD) have a variable severity. Early diagnosis of CD is important because treatment allows a normal psycho-physical development, especially in children, and can avoid associated disorders. The aim of this study was to evaluate the predictive value of...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200012010-00010

    authors: Rostami K,Mulder CJ,van Overbeek FM,Kerckhaert J,Meijer JW,von Blomberg MB,Heymans HS

    更新日期:2000-01-01 00:00:00

  • Comparison of three urease tests for detection of Helicobacter pylori in gastric biopsy specimens.

    abstract:OBJECTIVE:To propose two modified urease tests for the detection of Helicobacter pylori in gastric biopsy specimens. PATIENTS AND METHODS:The presence of H. pylori infection was determined in 237 patients undergoing upper gastrointestinal endoscopy. Three media were used for the urease tests: Christensen's 2% urea bro...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:

    authors: Boyanova L,Stancheva I,Todorov D,Kumanova R,Petrov S,Vladimirov B,Pehlivanov N,Mitova R,Chakarski I,Churchev I

    更新日期:1996-09-01 00:00:00

  • Chronic hepatitis C infection and sicca syndrome: a clear association with HLA DQB1*02.

    abstract:BACKGROUND:Hepatitis C virus infection is a major cause of nonA, nonB hepatitis worldwide. A high prevalence of immunological abnormalities has been shown to occur in patients with chronic hepatitis C virus infection. AIM:The aim of this study was to assess the development of sicca syndrome in a cohort of patients inf...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e328010687d

    authors: Smyth CM,McKiernan SM,Hagan R,Pilkington R,O'Regan M,Lawlor E,Kelleher D

    更新日期:2007-06-01 00:00:00

  • Do metabolic alterations serve as biochemical markers in the diagnosis of malignant biliary obstruction? An observational study.

    abstract:OBJECTIVES:The aim of this study was to investigate the changes in serum lipid profiles in biliary obstruction associated with benign and malignant conditions and to find whether they can be used as adjunctive biochemical tumor markers in the differential diagnosis. METHODS:One hundred and twenty patients (60 malignan...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e32833036c3

    authors: Kurt M,Onal IK,Parlak E,Shorbagi A,Kekilli M,Ibis M,Hayran M,Sasmaz N

    更新日期:2010-01-01 00:00:00

  • Late-onset Crohn's disease: a comparison of disease behaviour and therapy with younger adult patients: the Italian Group for the Study of Inflammatory Bowel Disease 'AGED' study.

    abstract:BACKGROUND:Disease phenotype and outcome of late-onset Crohn's disease are still poorly defined. METHODS:In this Italian nationwide multicentre retrospective study, patients diagnosed ≥65 years (late-onset) were compared with young adult-onset with 16-39 years and adult-onset Crohn's disease 40-64 years. Data were col...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001546

    authors: Viola A,Monterubbianesi R,Scalisi G,Furfaro F,Rea M,Saibeni S,Aratari A,Bringiotti R,Casella G,Cantoro L,Frankovic I,Calella F,Pugliese D,Orlando S,Samperi L,Cappello M,Mocci G,Manetti N,Annese V,Privitera AC,Inse

    更新日期:2019-11-01 00:00:00

  • Clinical identification and long-term surveillance of 22 hereditary non-polyposis colon cancer Italian families.

    abstract:OBJECTIVE:To assess the efficacy of a hereditary non-polyposis colon cancer (HNPCC) identification and surveillance policy. METHODS:Familial clustering of colorectal cancer (CRC) and extracolonic cancers (ECs) was investigated in 1520 consecutive CRC patients and relatives. HNPCC was identified by Amsterdam criteria, ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200502000-00013

    authors: Arrigoni A,Sprujevnik T,Alvisi V,Rossi A,Ricci G,Pennazio M,Spandre M,Cavallero M,Bertone A,Foco A,Rossini FP

    更新日期:2005-02-01 00:00:00

  • Laparoscopic surgery for treatment of splenic disorders: an update.

    abstract::Laparoscopic splenectomy is a feasible and safe technique in the hands of skilled laparoscopic surgeons. The special characteristics of the spleen, a fragile solid organ with a rich vascularization, pose a number of technical questions (patient position, organ mobilization and retrieval) which have been successfully r...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:10.1097/00042737-199708000-00003

    authors: Trías M,Targarona EM,Benarroch G,Fernández-Cruz L

    更新日期:1997-08-01 00:00:00

  • Aspects of hepatitis C virus infection relating to liver transplantation.

    abstract::End-stage liver disease caused by the hepatitis C virus (HCV) is a major indication for liver transplantation. HCV re-infection after transplantation is almost constant, and recent data confirm that it significantly impairs patient and graft survival. Factors that may influence disease severity and consequent progress...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:10.1097/00042737-200604000-00002

    authors: Roche B,Samuel D

    更新日期:2006-04-01 00:00:00

  • Histological changes in the gastric mucosa after Helicobacter pylori eradication.

    abstract:BACKGROUND AND AIM:Correa described a stepwise model of changes in the gastric mucosa after Helicobacter pylori infection, from the normal gastric epithelium to chronic gastritis, atrophy, intestinal metaplasia, dysplasia and adenocarcinoma. The aim of this study is to assess the reversibility of these mucosal changes ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200411000-00017

    authors: Fichman S,Niv Y

    更新日期:2004-11-01 00:00:00

  • Deoxycholic acid stimulates migration in colon cancer cells.

    abstract:BACKGROUND:Deoxycholic acid and other secondary bile acids have long been considered tumour promoters in the colon. However, their effect on cell migration, known to play an important role in colon carcinogenesis, has not been studied so far. OBJECTIVE:To investigate the possible effects of deoxycholic acid on colon c...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200108000-00012

    authors: Milovic V,Teller IC,Murphy GM,Caspary WF,Stein J

    更新日期:2001-08-01 00:00:00

  • Ossification within an adenomatous polyp: a case report and review of the literature.

    abstract::Osseous metaplasia within the gastrointestinal tract is rare and occurs in benign, premalignant, and malignant neoplasms. Here, we report the youngest case of an adenomatous polyp with the presence of ossification and a concomitant review of the literature with regard to ossification of colonic polyps. A 28-year-old m...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:10.1097/MEG.0b013e32834e7fd5

    authors: Bowman EA,Stevens EC,Pfau PR,Spier BJ

    更新日期:2012-02-01 00:00:00

  • A radical view of the stomach: the role of oxygen-derived free radicals and anti-oxidants in gastroduodenal disease.

    abstract::Following the discovery of Helicobacter pylori, the last decade has seen major advances in our understanding of gastroduodenal disease. However, our knowledge remains incomplete and the exact mechanism by which H. pylori causes inflammation and ulceration is still not known. The role of H. pylori in relation to other ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:

    authors: Phull PS,Green CJ,Jacyna MR

    更新日期:1995-03-01 00:00:00

  • Immunoglobulin coating of faecal bacteria in inflammatory bowel disease.

    abstract:OBJECTIVE:An inappropriate mucosal immune response to the commensal bacterial flora may play a role in the pathogenesis of inflammatory bowel disease (IBD). In this study we determined the percentage of immunoglobulin-coated bacteria in the stools of patients and controls. METHODS:Faecal samples were obtained from 18 ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/01.meg.0000108346.41221.19

    authors: van der Waaij LA,Kroese FG,Visser A,Nelis GF,Westerveld BD,Jansen PL,Hunter JO

    更新日期:2004-07-01 00:00:00

  • Prognosis of patients with gastric variceal bleeding after endoscopic variceal obturation according to the type of varices.

    abstract:BACKGROUND AND AIMS:This study was performed to evaluate the treatment efficacy of endoscopic variceal obturation (EVO) in patients with gastric variceal bleeding (GVB) according to the type of varices. PATIENTS AND METHODS:All patients who were treated with EVO for bleeding from gastric varices (GVs) were included. P...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001271

    authors: Lee HA,Chang JM,Goh HG,Kim TH,Lee YS,Suh SJ,Jung YK,Choi HS,Kim ES,Kim JH,An H,Seo YS,Yim HJ,Jeen YT,Yeon JE,Chun HJ,Byun KS,Um SH,Kim CD,Korean Portal Hypertension Study Group.

    更新日期:2019-02-01 00:00:00

  • Early transjugular intrahepatic portosystemic shunt in cirrhotic patients with acute variceal bleeding: a systematic review and meta-analysis of controlled trials.

    abstract:INTRODUCTION:There is conflicting evidence on the benefit of early transjugular intrahepatic portosystemic shunt (TIPSS) on the survival of patients with acute variceal bleeding (AVB). AIM:To assess the effect of early TIPSS on patient prognosis. MATERIALS AND METHODS:We carried out a meta-analysis of trials evaluati...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MEG.0000000000000403

    authors: Deltenre P,Trépo E,Rudler M,Monescillo A,Fraga M,Denys A,Doerig C,Fournier N,Moreno C,Moradpour D,Bureau C,Thabut D

    更新日期:2015-09-01 00:00:00

  • Hepatitis C in a Mobile Low-Threshold Methadone Program.

    abstract:INTRODUCTION:Data on the epidemiology of hepatitis C among individuals who use drugs in low-threshold settings are lacking, although crucial to assess the burden of disease and aid in the design of treatment strategies. OBJECTIVE:The aim of this study was to characterize the epidemiology and disease related to hepatit...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000843

    authors: Silva MJ,Pereira C,Loureiro R,Balsa C,Lopes P,Água-Doce I,Belo E,Martins HC,Coutinho R,Pádua E

    更新日期:2017-06-01 00:00:00

  • Total ascitic fluid leukocyte count for reliable exclusion of spontaneous bacterial peritonitis in patients with ascites.

    abstract:BACKGROUND AND AIMS:The diagnosis of spontaneous bacterial peritonitis (SBP) in patients with ascites is established by definition with a polymorphonuclear (PMN) cell count in the ascitic fluid greater than 0.250 g/l determined via cytological (microscopic) examination. In this study, we correlated the automatically as...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200602000-00011

    authors: Link BC,Ziske CG,Schepke M,Schmidt-Wolf IG,Sauerbruch T

    更新日期:2006-02-01 00:00:00

  • Value of technetium-99m HMPAO-labelled leucocyte scintigraphy as an initial screening test in patients suspected of having inflammatory bowel disease.

    abstract:OBJECTIVE:This study was designed to evaluate the role of technetium-99m (99mTc) hexamethyl propylene amine oxime (HMPAO)-labelled leucocyte imaging as an initial screening test in patients suspected of having inflammatory bowel disease (IBD). PATIENTS AND METHODS:Thirty-one patients in whom a final diagnosis of irrit...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-199612000-00012

    authors: Giaffer MH,Tindale WB,Holdsworth D

    更新日期:1996-12-01 00:00:00

  • A predictive index for the diagnosis of cirrhosis in hepatitis C based on clinical, laboratory, and ultrasound findings.

    abstract:OBJECTIVE:To develop and validate a non-invasive index to predict the presence of cirrhosis in patients with chronic hepatitis C on the basis of clinical, laboratory, and ultrasound findings. MATERIALS AND METHODS:Data from the complete history and physical examination, serologic studies, liver ultrasound, and liver b...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200601000-00010

    authors: Obrador BD,Prades MG,Gómez MV,Domingo JP,Cueto RB,Rué M,Real J,Guiteras PM

    更新日期:2006-01-01 00:00:00