Gene therapy for human liver diseases.

Abstract:

:The liver can be considered an ideal target to design gene therapy strategies because of the unique properties of hepatic cells. The great amount of work carried out in this field clearly delineates the quality of the new approaches that have been developed in the last few years and demonstrates the feasibility of this strategy in a wide range of multi-factorial and inherited disorders. However, improvement of current vectors to specifically and efficiently deliver the therapeutic gene into the target cell remains a daunting problem. In this review, we will summarize the most important approaches that are currently under investigation, the pathological conditions that can be treated by this strategy and the most important drawbacks that remain to be overcome in order to achieve long-term and high-level gene expression.

authors

Di Campli C,Wu J,Gasbarrini A,Gasbarrini G,Zern MA

doi

10.1097/00042737-199904000-00011

subject

Has Abstract

pub_date

1999-04-01 00:00:00

pages

421-9

issue

4

eissn

0954-691X

issn

1473-5687

journal_volume

11

pub_type

杂志文章,评审
  • COVID-19 and liver injury: a meta-analysis.

    abstract:BACKGROUND/AIMS:The number of cases with coronavirus disease 2019 (COVID-19) has exceeded seven million worldwide. However, the data describing the global prevalence of liver injury associated with COVID-19 is lacking secondary to the novelty of this ongoing pandemic. Therefore, we conducted a meta-analysis to determin...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001817

    authors: Wijarnpreecha K,Ungprasert P,Panjawatanan P,Harnois DM,Zaver HB,Ahmed A,Kim D

    更新日期:2020-07-03 00:00:00

  • Proton pump inhibitor therapy is associated with reduced survival following first-time transarterial chemoembolization in patients with hepatocellular carcinoma.

    abstract:BACKGROUND AND AIMS:Several studies have reported associations of proton pump inhibitor (PPI) treatment with the incidence of complications and even increased mortality in patients with liver cirrhosis. Up to now, there are no studies on the impact of PPI treatment in patients with hepatocellular carcinoma (HCC). There...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000002018

    authors: Sturm L,Muller L,Schultheiss M,Binder B,Huber JP,Thimme R,Bettinger D

    更新日期:2020-12-14 00:00:00

  • Endoscopic ultrasound-guided liver biopsy using a 20-gauge fine needle biopsy needle with the wet-heparinized suction technique.

    abstract:OBJECTIVES:The primary aim of this study was to evaluate the histological adequacy of the liver tissue specimens obtained with a 20-gauge fine-needle biopsy needle and the secondary aim was to test the safety endoscopic ultrasound-guided liver biopsy with a 20-gauge fine-needle biopsy needle with the wet-heparinized su...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001929

    authors: Sisman G,Barbur E,Saka D,Piyade B,Besli S,Boynukara C,Kirimlioglu H

    更新日期:2020-11-01 00:00:00

  • Hepatitis C virus treatment rates and outcomes in HIV/hepatitis C virus co-infected individuals at an urban HIV clinic.

    abstract:OBJECTIVES:The factors associated with hepatitis C virus (HCV) treatment uptake and responses were assessed among HCV/HIV co-infected individuals referred for HCV therapy at an urban HIV clinic. METHODS:Retrospective review of HIV/HCV patients enrolled in the HCV treatment program at the John Ruedy Immunodeficiency Cl...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e328341ef54

    authors: Murray MC,Barrios R,Zhang W,Hull M,Montessori V,Hogg RS,Montaner JS

    更新日期:2011-01-01 00:00:00

  • Impact of gastroesophageal reflux disease symptoms on the quality of life in pregnant women: a prospective study.

    abstract:OBJECTIVE:Pregnant women often suffer from gastroesophageal reflux disease (GERD). GERD symptoms are known to influence the quality of life; however, there is a lack of data in pregnant women. The aim of this study was to establish the impact of GERD symptoms on health-related quality of life (HRQOL) during pregnancy. ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000905

    authors: Fill Malfertheiner S,Seelbach-Göbel B,Costa SD,Ernst W,Reuschel E,Zeman F,Malfertheiner P,Malfertheiner MV

    更新日期:2017-08-01 00:00:00

  • The association between physical activity and the risk of symptomatic Barrett's oesophagus: a UK prospective cohort study.

    abstract:BACKGROUND:Physical activity affects the functioning of the gastrointestinal system through both local and systemic effects and may play an important role in the aetiology of gastroesophageal reflux disease, Barrett's oesophagus and oesophageal adenocarcinoma. We investigated, for the first time in a large prospective ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000998

    authors: Lam S,Alexandre L,Luben R,Hart AR

    更新日期:2018-01-01 00:00:00

  • Gastrointestinal allergy in adults.

    abstract::The prevalence of food allergy reaches 3% in the adult population. Chronic gastrointestinal allergy is a rare entity: 4.2% of food allergies in adults, and represents 3.2% of all intestinal disorders. Non-specific symptoms are the rule but eosinophilic gastrointestinal disorders are the subject of much interest. Endos...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:10.1097/00042737-200512000-00005

    authors: Moneret-Vautrin AD

    更新日期:2005-12-01 00:00:00

  • Differentiated CaCo-2 cells as an in-vitro model to evaluate de-novo apolipoprotein A-I production in the small intestine.

    abstract:BACKGROUND:Increasing HDL cholesterol concentrations by stimulating de-novo apolipoprotein A-I (apoA-I) production in the liver and/or in the small intestine is a potential strategy to reduce coronary heart disease risk. Although there is quite some knowledge concerning regulatory effects in the liver, less is known co...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/meg.0b013e328321b0c8

    authors: Dullens SP,Mensink RP,Mariman EC,Plat J

    更新日期:2009-06-01 00:00:00

  • Dietary polyamines and non-neoplastic growth and disease.

    abstract::This review presents the data that are now available concerning the effects of dietary polyamines at either postnatal or adult stages in non-neoplastic growth and disease. Polyamines provided by food have a potential role in growth and development of the digestive system in neonatal mammals (and fishes). In humans, th...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:10.1097/00042737-200109000-00005

    authors: Deloyer P,Peulen O,Dandrifosse G

    更新日期:2001-09-01 00:00:00

  • Ulcerative colitis and irritable bowel syndrome: relationships with quality of life.

    abstract:OBJECTIVES:Quality of life is reduced in inflammatory bowel disease. Irritable bowel syndrome (IBS)-like symptoms seem to be common in inflammatory bowel disease patients during the remission phase. We aimed to (i) assess the prevalence of IBS-like symptoms in ulcerative colitis (UC) patients during the remission phase...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e3282f16a62

    authors: Ansari R,Attari F,Razjouyan H,Etemadi A,Amjadi H,Merat S,Malekzadeh R

    更新日期:2008-01-01 00:00:00

  • p53 protein accumulation and colonic adenoma recurrence.

    abstract:OBJECTIVES:The prognostic value of p53 protein accumulation in colonic adenomas is still controversial. The aim of the present study was to determine whether the evaluation of p53 protein accumulation in newly diagnosed colonic adenomas could predict the development of metachronous adenomas. DESIGN/METHODS:Fifty-five ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-199905000-00014

    authors: Triantafyllou K,Paspatis GA,Zizi A,Papatheodoridis GV,Tzouvala M,Chlouverakis GJ,Elemenoglou I,Karamanolis DG

    更新日期:1999-05-01 00:00:00

  • Vitamin B12 absorption after ileorectal anastomosis for Crohn's disease: effect of ileal resection and time span after surgery.

    abstract:OBJECTIVE:To examine the impact of ileorectal anastomosis on vitamin B12 absorption, as measured by the Schilling test, in patients with Crohn's disease. PATIENTS:Eighty-two patients with Crohn's disease who had undergone ileorectal anastomosis. METHODS:Of the 82 patients with Crohn's disease and ileorectal anastomos...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:

    authors: Behrend C,Jeppesen PB,Mortensen PB

    更新日期:1995-05-01 00:00:00

  • Recurrent cardiac tamponade as first manifestation of gastric cancer.

    abstract::Malignant pericardial effusion is an uncommon disorder and is usually caused by far advanced lung cancer, breast cancer, lymphoma and leukaemia. Pericardial effusion in recurrent gastric cancer has been reported in only three patients. We report the case of a 53-year-old male with sudden onset of dyspnoea, pericardial...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-199807000-00018

    authors: Fazeny B,Meghdadi S,Dejaco C,Kastner J,Marosi C,Schmidinger H

    更新日期:1998-07-01 00:00:00

  • Intracellular cytokine expression in peritoneal monocyte/macrophages obtained from patients with cirrhosis and presence of bacterial DNA.

    abstract:BACKGROUND:The detection of bacterial DNA in serum and ascitic fluid from patients with cirrhosis and ascites is interpreted as molecular evidence of intestinal bacterial translocation and considered sufficient to activate the cellular immune response. In vitro studies on ascitic fluid culture have shown a close relati...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200501000-00010

    authors: Francés R,Rodríguez E,Muñoz C,Zapater P,De la ML,Ndongo M,Pérez-Mateo M,Such J

    更新日期:2005-01-01 00:00:00

  • The gastrin receptor antagonist netazepide (YF476) in patients with type 1 gastric enterochromaffin-like cell neuroendocrine tumours: review of long-term treatment.

    abstract:OBJECTIVE:Netazepide (YF476) is a recently developed, orally active gastrin receptor antagonist that, in short trials in patients with type 1 gastric enterochromaffin-like cell neuroendocrine tumours, has been shown to induce a significant reduction in the number and size of tumours as well as serum chromogranin A (CgA...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000713

    authors: Sagatun L,Mjønes P,Jianu CS,Boyce M,Waldum HL,Fossmark R

    更新日期:2016-11-01 00:00:00

  • Incontinence and anorectal dysfunction in patients with diabetes mellitus.

    abstract::The elucidation of the pathogenesis of faecal incontinence in patients with advanced diabetes mellitus has progressed during the last 15 years. In contrast to earlier concepts which promoted the concept that high stool volumes overwhelm normal continence mechanisms, recent studies indicate that the vast majority of di...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:

    authors: Wald A

    更新日期:1995-08-01 00:00:00

  • COX-2 polymorphisms and colorectal cancer risk: a strategy for chemoprevention.

    abstract:OBJECTIVE:COX-2, the inducible isoenzyme, was found to be overexpressed in approximately 85% of colorectal adenocarcinomas, contributing to key steps in tumor development. COX-2 polymorphisms that might modify the levels of protein expression would be anticipated to have a substantial influence on disease phenotype. Th...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e3283352cbb

    authors: Pereira C,Pimentel-Nunes P,Brandão C,Moreira-Dias L,Medeiros R,Dinis-Ribeiro M

    更新日期:2010-05-01 00:00:00

  • Do we need to screen for de-novo diabetes mellitus in chronic hepatitis C patients after a sustained virological response?

    abstract:BACKGROUND AND AIM:There are millions of chronic hepatitis C (CHC) virus-infected patients who have been treated with a combination therapy (interferon and ribavirin) and have achieved a virological response (SVR) worldwide. The aim of this study is to evaluate the risk factors for de-novo diabetes mellitus in CHC pati...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000929

    authors: Mousa N,Abdel-Razik A,Farag R,Shabana W,Elgamal A,El-Wakeel N,Elzehery R,Elkashef W,Eldars W

    更新日期:2017-09-01 00:00:00

  • Consumption of gluten-free products: should the threshold value for trace amounts of gluten be at 20, 100 or 200 p.p.m.?

    abstract:OBJECTIVE:The threshold of gluten contamination in gluten-free products of both dietary and normal consumption is under debate. The objective of this study was to gather information on consumption of gluten-free products intended for dietary use of people under a gluten-free diet. This information is essential to ascer...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/01.meg.0000236884.21343.e4

    authors: Gibert A,Espadaler M,Angel Canela M,Sánchez A,Vaqué C,Rafecas M

    更新日期:2006-11-01 00:00:00

  • Meta-analysis: eradication of Helicobacter pylori infection is associated with the development of endoscopic gastroesophageal reflux disease.

    abstract:OBJECTIVE:The role of Helicobacter pylori infection in the pathogenesis of gastroesophageal reflux disease (GORD) is controversial. We aimed to confirm the negative association between H. pylori infection and endoscopic GORD and further determine whether eradication of the infection is associated with the development o...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,meta分析

    doi:10.1097/MEG.0b013e328363e2c7

    authors: Xie T,Cui X,Zheng H,Chen D,He L,Jiang B

    更新日期:2013-10-01 00:00:00

  • The prevalence of occult hepatitis B virus infection in type 2 diabetes mellitus patients.

    abstract:AIM:The prevalence of occult hepatitis B virus (HBV) infection is relatively frequent among patients with immune suppression. The impairment of the immune system is well demonstrated in diabetics. We aimed to investigate the prevalence of occult HBV infection among hepatitis B core antibody (HbcAb)+/- hepatitis B surfa...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e3282f55e1e

    authors: Demir M,Serin E,Göktürk S,Ozturk NA,Kulaksizoglu S,Ylmaz U

    更新日期:2008-07-01 00:00:00

  • Thrombotic risk factors in Chinese nonmalignant and noncirrhotic patients with portal vein thrombosis: an observational study with a systematic review of the literature.

    abstract:BACKGROUND:Until now, no data on the routine screening for thrombotic risk factors in Chinese nonmalignant and noncirrhotic patients with portal vein thrombosis (PVT) have been reported. METHODS:A total of 141 nonmalignant and noncirrhotic patients with PVT who underwent screening tests for thrombotic risk factors bet...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:10.1097/MEG.0000000000000221

    authors: Qi X,Wu F,He C,Fan D,Han G

    更新日期:2015-01-01 00:00:00

  • Perceptions of gastroenterologists and nurses regarding irritable bowel syndrome and inflammatory bowel disease.

    abstract:OBJECTIVE:Irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) have similar symptoms, and both adversely affect patients' quality of life. The objective of this study was to compare the perceptions of physicians and nurses regarding IBS and IBD. METHODS:The Illness Perception Questionnaire Revised, adap...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e328348a552

    authors: Dickman R,Segev M,Levi S,Reicher-Atir R,Steinmetz A,Horev N,Niv Y

    更新日期:2011-09-01 00:00:00

  • Risk factors for perforation of gastric endoscopic submucosal dissection: a systematic review and meta-analysis.

    abstract::The aim of this systematic review and meta-analysis was to identify significant risk factors for perforation in gastric endoscopic submucosal dissection. Studies published in the English language were searched for in Embase, WEB OF SCIENCE, Medline (PubMed and Ovid) and the Cochrane Central Register of Controlled Tria...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,meta分析

    doi:10.1097/MEG.0000000000001543

    authors: Ding X,Luo H,Duan H

    更新日期:2019-12-01 00:00:00

  • A systematic review and meta-analysis on outcomes after Rx or R1 endoscopic resection of superficial gastric cancer.

    abstract:OBJECTIVE:Endoscopic resection is a standard treatment for gastric superficial lesions. A positive or a nonevaluable margin is considered a noncurative criterion. We aimed to systematically review recurrence, residual disease, lymph node metastasis (LNM) and cancer-related death following Rx/R1 resection of gastric les...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MEG.0000000000000440

    authors: Figueiredo PC,Pimentel-Nunes P,Libânio D,Dinis-Ribeiro M

    更新日期:2015-11-01 00:00:00

  • Hepcidin and inflammatory bowel disease: dual role in host defence and iron homoeostasis.

    abstract:OBJECTIVE:Hepcidin is an endogenous antimicrobial peptide with a key role in iron homoeostasis. Hepcidin is similar to defensin, the deficiency of which is associated with Crohn's disease. To date there has been no validated method to reliably assay serum hepcidin. We studied iron indices in inflammatory bowel disease ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e32830e2885

    authors: Arnold J,Sangwaiya A,Bhatkal B,Geoghegan F,Busbridge M

    更新日期:2009-04-01 00:00:00

  • Deleterious effect of proton pump inhibitors on the disease course of cirrhosis.

    abstract:OBJECTIVES:Proton pump inhibitors(PPIs) are widely prescribed to patients with liver cirrhosis. We hypothesized that long-standing PPI use is associated with spontaneous bacterial peritonitis(SBP) and accelerated development of disease-specific complications and liver-related death. METHODS:A 5-year follow-up observat...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001499

    authors: Janka T,Tornai T,Borbély B,Tornai D,Altorjay I,Papp M,Vitális Z

    更新日期:2020-02-01 00:00:00

  • Optimizing assessment and treatment for hepatitis C virus infection in illicit drug users: a novel model incorporating multidisciplinary care and peer support.

    abstract:OBJECTIVES:We evaluated assessment and treatment for hepatitis C virus (HCV) among illicit drug users accepting referral to a weekly HCV peer-support group at a multidisciplinary community health centre. METHODS:From March 2005 to 2008, HCV-infected individuals were referred to a weekly peer-support group and assessed...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/meg.0b013e32832a8c4c

    authors: Grebely J,Knight E,Genoway KA,Viljoen M,Khara M,Elliott D,Gallagher L,Storms M,Raffa JD,DeVlaming S,Duncan F,Conway B

    更新日期:2010-03-01 00:00:00

  • Halothane-induced acute liver failure: continuing occurrence and use of liver transplantation.

    abstract:BACKGROUND/AIMS:This study was aimed at determining if the frequency and pattern of acute liver failure (ALF) following halothane anaesthesia had decreased during the last 11 years in comparison with a previous series of 48 patients referred between 1965 and 1984 and whether clinical outcome had been altered by the int...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:

    authors: Lo SK,Wendon J,Mieli-Vergani G,Williams R

    更新日期:1998-08-01 00:00:00

  • Should relatives of coeliacs with mild clinical complaints undergo a small-bowel biopsy despite negative serology?

    abstract:BACKGROUND AND OBJECTIVES:Small intestinal lesions in coeliac disease (CD) have a variable severity. Early diagnosis of CD is important because treatment allows a normal psycho-physical development, especially in children, and can avoid associated disorders. The aim of this study was to evaluate the predictive value of...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200012010-00010

    authors: Rostami K,Mulder CJ,van Overbeek FM,Kerckhaert J,Meijer JW,von Blomberg MB,Heymans HS

    更新日期:2000-01-01 00:00:00