Treatment of travellers' diarrhoea: zaldaride compared with loperamide and placebo.

Abstract:

OBJECTIVE:To compare zaldaride maleate, a calmodulin inhibitor with gastrointestinal antisecretory properties, with loperamide and a placebo in the treatment of travellers' diarrhoea. DESIGN:Randomized, double-blind, double-dummy study. SETTING:Study clinic staffed by European residents on Nile cruise ships. PATIENTS:Tourists (n = 436) who acquired travellers' diarrhoea during the Nile cruise. INTERVENTIONS:(1) Zaldaride 20 mg four times daily, (2) zaldaride 2 x 20 mg as initial loading dose followed by three doses of 20 mg on the first day and four doses of 20 mg on the second day, (3) loperamide 2 x 2 mg loading dose following by a flexible dosage of 2 mg after each unformed stool (maximum of 16 mg daily), (4) placebo. MAIN OUTCOME MEASURES:Number of unformed stools, rate of improvement of patients with diarrhoea, rate of relief from diarrhoea. RESULTS:Among the 331 compliant and fully evaluated patients, the zaldaride with loading dose group showed no significant differences in cure rates from the loperamide group. For most parameters, zaldaride without a loading dose and the placebo resulted in significantly lower cure rates. CONCLUSIONS:A zaldaride regimen including a loading dose was shown to be well tolerated and as effective as loperamide.

authors

Silberschmidt G,Schick MT,Steffen R,Kilpatrick ME,Murphy JR,Oyofo BA,el-Etr S,Gyurech D,Mourad AS,Mathewson JT

subject

Has Abstract,Author List Incomplete

pub_date

1995-09-01 00:00:00

pages

871-5

issue

9

eissn

0954-691X

issn

1473-5687

journal_volume

7

pub_type

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