Abstract:
BACKGROUND:This study aimed to evaluate the efficacy and safety of sitagliptin for treating Chinese patients with type 2 diabetes mellitus (T2DM) with nonalcoholic fatty liver disease (NAFLD). METHODS:In total, 72 Chinese T2DM patients with NAFLD were divided randomly into two groups of 36 patients each group. All 72 patients were assigned to receive either sitagliptin or diet and exercise for 52 weeks between January 2013 and December 2015. The outcomes' measurements included serum levels of hemoglobin A1c, fasting plasma glucose, aspartate aminotransferase, and alanine aminotransferase. RESULTS:Seventy patients completed the study. Sitagliptin showed greater efficacy than the diet and exercise in decreasing the hemoglobin A1c and fasting plasma glucose levels at weeks 13, 26, 39, and 52. In addition, no significant changes in the average aspartate aminotransferase and alanine aminotransferase levels were found during the 52-week follow-up in both the sitagliptin and the control groups. CONCLUSION:The results of this study indicate that sitagliptin is an effective and safe treatment for patients with T2DM and NAFLD.
journal_name
Eur J Gastroenterol Hepatoljournal_title
European journal of gastroenterology & hepatologyauthors
Deng XL,Ma R,Zhu HX,Zhu Jdoi
10.1097/MEG.0000000000000780subject
Has Abstractpub_date
2017-03-01 00:00:00pages
297-301issue
3eissn
0954-691Xissn
1473-5687journal_volume
29pub_type
杂志文章,随机对照试验abstract:OBJECTIVE:To elucidate the role of Helicobacter pylori in relapsing disease after partial gastrectomy for peptic ulcer. DESIGN:Retrospective study of gastroscopies between January 1985 and February 1988. SETTING:Department of Surgery, Helsinki University Central Hospital, Finland. PARTICIPANTS:One hundred and fifty-...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:
更新日期:1997-04-01 00:00:00
abstract::Amyloidosis is a group of disorders that can manifest in virtually any organ system in the body and is thought to be secondary to misfolding of extracellular proteins with subsequent deposition in tissues. The precursor protein that is produced in excess defines the specific amyloid type. This requires histopathologic...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章,评审
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abstract:OBJECTIVES:Severe viral hepatitis B is a disease associated with significant morbidity and mortality. Clinical controlled trials show that the efficacy of treatment of severe viral hepatitis B with glucocorticoids remains debatable. Therefore, we carried out this meta-analysis to evaluate the safety, efficacy, and side...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MEG.0b013e32835f4cbd
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:The outcome of primary biliary cholangitis (PBC) is affected by both genetic and environmental factors. OBJECTIVE:The aim of this study was to study the effect of smoking on liver histology and mortality in a genetically homogeneous population having PBC. PATIENTS AND METHODS:Smoking and drinking habits at...
journal_title:European journal of gastroenterology & hepatology
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abstract:OBJECTIVES:Data on heredity, risk factors and comorbidity in microscopic colitis, encompassing collagenous colitis (CC) and lymphocytic colitis (LC), are limited. AIM:The aim was to carry out a case-control study of family history, childhood circumstances, educational level, marital status, smoking and comorbidity in ...
journal_title:European journal of gastroenterology & hepatology
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abstract:OBJECTIVE:We assessed the value of the recently developed aspartate aminotransferase to platelet ratio index (APRI) for predicting significant fibrosis or cirrhosis in patients with chronic hepatitis C or HBeAg-negative chronic hepatitis B. METHODS:In total, 489 patients (chronic hepatitis C, 284 patients; HBeAg-negat...
journal_title:European journal of gastroenterology & hepatology
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abstract::Autoimmune pancreatitis is a clinical entity with many different clinical and biological characteristics that make diagnosis difficult. Sensitive and specific pancreatic antibodies are still lacking to assess the diagnosis as is the availability of interpretable pathological specimens. However, suggestive features con...
journal_title:European journal of gastroenterology & hepatology
pub_type: 评论,杂志文章
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abstract::Radiation enteritis can be challenging to diagnose and treat. We report the case of a 44-year-old woman who was diagnosed with a squamous cell carcinoma of the cervix in 1978 and treated with hysterectomy and post-operative radiotherapy. Over the next 20 years she required multiple intestinal operations resulting in s...
journal_title:European journal of gastroenterology & hepatology
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doi:10.1097/00042737-200606000-00017
更新日期:2006-06-01 00:00:00
abstract:BACKGROUND AND AIMS:The natural history of functional dyspepsia is not well known. We prospectively assess the quality of life and severity of symptoms in a group of Spanish patients with functional dyspepsia. PATIENTS AND METHODS:One hundred and twelve consecutive patients with functional dyspepsia, according to Rome...
journal_title:European journal of gastroenterology & hepatology
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更新日期:2003-11-01 00:00:00
abstract::Persistent cough could be caused by various diseases such as postnasal drip syndrome, asthma and gastroesophageal reflux disease (GERD) or adverse event of drugs such as angiotensin-converting enzyme inhibitors. We report a case of persistent cough associated with high plasma levels of the proton pump inhibitor omepra...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0b013e3283320129
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND:Physical activity affects the functioning of the gastrointestinal system through both local and systemic effects and may play an important role in the aetiology of gastroesophageal reflux disease, Barrett's oesophagus and oesophageal adenocarcinoma. We investigated, for the first time in a large prospective ...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0000000000000998
更新日期:2018-01-01 00:00:00
abstract:AIM:Intrahepatic cholestasis of pregnancy (ICP) is associated with safe maternal outcomes but perinatal outcomes have been variable. We assessed clinical factors and impact of bile acid levels on maternal and neonatal outcomes in ICP. METHODS:Patients with ICP (defined as pruritus with serum bile acids ≥ 10 mmol/l) we...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0000000000001954
更新日期:2020-10-29 00:00:00
abstract::Chronic hepatitis B continues to be a major global health burden. It accounts for a substantial impact on health care resources and finances in many parts of the world including Europe. Natural history and disease spectrum are varied, depending on when and how the infection is acquired. The chronic infective state inc...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章,评审
doi:10.1097/MEG.0b013e3283474add
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVES:Proton pump inhibitors(PPIs) are widely prescribed to patients with liver cirrhosis. We hypothesized that long-standing PPI use is associated with spontaneous bacterial peritonitis(SBP) and accelerated development of disease-specific complications and liver-related death. METHODS:A 5-year follow-up observat...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0000000000001499
更新日期:2020-02-01 00:00:00
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journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-200504000-00001
更新日期:2005-04-01 00:00:00
abstract:BACKGROUND/AIMS:Bleeding remains a serious complication after endoscopic submucosal dissection (ESD). Second-look endoscopy for hemostasis helps prevent post-ESD bleeding. We investigated the relationships between patient characteristics, tumor characteristics, and the Forrest classification for exposed vessels on arti...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0000000000000419
更新日期:2015-09-01 00:00:00
abstract:AIM:To assess the impact that a test-and-treat policy with open-access urea breath testing (UBT) has had on the referral rates for endoscopy in a district hospital. Additionally, we examined for any change in the proportion of serious pathology detected endoscopically after adopting the policy. METHODS:Analysis of dat...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-200203000-00009
更新日期:2002-03-01 00:00:00
abstract:BACKGROUND AND AIM:Pancreatitis and hyperamylasaemia are common complications of ERCP and this study was designed to explain which operative and patient factors predispose to them. PATIENTS AND METHODS:A 1 year prospective study of consecutive patients in a single operator centre with detailed attention to technical f...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-199805000-00012
更新日期:1998-05-01 00:00:00
abstract::A growing amount of evidence indicates that the intestinal flora plays a pathogenic role in inflammatory bowel disease (IBD): hence, the use of anti-bacterial agents as ancillary treatment in patients with ulcerative colitis, or Crohn's disease. While the results with anti-tubercular agents remain inconclusive, antibi...
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更新日期:2005-02-01 00:00:00
abstract:BACKGROUND:Adjuvant chemotherapy for stage II colon cancer is a controversial practice and is not recommended by the French Consensus Conference outside of therapeutic trial. OBJECTIVE:To assess, within a well-defined population, the influence of hospital characteristics in this practice. PATIENTS AND METHODS:In the ...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,评审
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journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章,随机对照试验
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更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:There are increasing indications for assessing Helicobacter pylori status by non-invasive means in dyspeptic patients. There is also increasing use of proton pump inhibitor therapy for dyspeptic disease. AIMS:To determine the effect of proton pump inhibitor therapy on the accuracy of the [14C]urea breath te...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
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更新日期:1998-09-01 00:00:00
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journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Hereditary angioneurotic oedema (HAE) is a rare cause of ascites. As acute abdominal attacks of the disease can mimic surgical emergencies, prompt and accurate diagnosis is essential. This study was undertaken to evaluate the usefulness of serial abdominal ultrasound (US) examinations. PATIENTS AND METHODS:...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
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更新日期:2001-10-01 00:00:00
abstract:BACKGROUND:Hepatorenal syndrome (HRS) is a severe complication of liver cirrhosis, with poor survival. Rifaximin is a gut-selective broad-spectrum antibiotic. AIM:The aim of this study was to evaluate the role of rifaximin as a primary prevention of HRS. PATIENTS AND METHODS:Eighty patients with liver cirrhosis and a...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章,随机对照试验
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journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章,多中心研究
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更新日期:2011-08-01 00:00:00
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journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-200308000-00010
更新日期:2003-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-02-01 00:00:00