Abstract:
BACKGROUND AND AIM:Correa described a stepwise model of changes in the gastric mucosa after Helicobacter pylori infection, from the normal gastric epithelium to chronic gastritis, atrophy, intestinal metaplasia, dysplasia and adenocarcinoma. The aim of this study is to assess the reversibility of these mucosal changes after H. pylori eradication. METHODS:The study sample consisted of 89 patients who underwent at least two gastric biopsies from 1990 to 2000, with a positive finding for H. pylori in the first and a negative finding in the second. Specimens were evaluated for acute and chronic inflammation, lymphoid aggregates, proliferation, mucosal atrophy, intestinal metaplasia, dysplasia, and MUC5AC and MUC6 expression using histochemical and immunohistochemical methods. RESULTS:The average time between biopsies was 23.15 +/- 26.30 months. There was a significant decrease in acute and chronic inflammation scores, from 1.48 +/- 1.10 to 0.23 +/- 0.63 and from 2.67 +/- 0.68 to 1.44 +/- 1.04, respectively (P < 0.001), and in a number of lymphoid follicles, from 42.68% to 21.95% of cases (P < 0.008). The number of glands increased from 39.08 +/- 16.67/mm to 48.86 +/- 17.93/mm after eradication (P = 0.062). Intestinal metaplasia was found in 17.07% of the cases, with no change over time. Dysplasia appeared in one case 2 years after eradication. In 27 patients, the Ki67 labeling index decreased significantly after eradication, while MUC5AC and MUC6 expression increased. CONCLUSION:Our findings, although not conclusive for arrest of the malignant potential, support the importance of H. pylori eradication in the prevention of gastric cancer.
journal_name
Eur J Gastroenterol Hepatoljournal_title
European journal of gastroenterology & hepatologyauthors
Fichman S,Niv Ydoi
10.1097/00042737-200411000-00017subject
Has Abstractpub_date
2004-11-01 00:00:00pages
1183-8issue
11eissn
0954-691Xissn
1473-5687pii
00042737-200411000-00017journal_volume
16pub_type
杂志文章abstract:BACKGROUND:Bosnia and Herzegovina (B&H) is one of the Eastern European countries that lacks data on the epidemiology of ulcerative colitis (UC). AIMS:We aimed to assess the epidemiological and clinical characteristics of UC in Tuzla Canton of B&H during a 12-year period (1995-2006). PATIENTS AND METHODS:We retrospect...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0b013e32832bfe05
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND AND AIM:Monitoring of mucosal inflammation in inflammatory bowel disease (IBD) is of major importance. New noninvasive markers for intestinal inflammation are needed. Previous studies have reported that pancreatitis-associated protein (PAP) correlates with clinical activity in IBD subgroups. Our aim was to i...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0000000000000141
更新日期:2014-08-01 00:00:00
abstract::Treatment of Crohn's disease with infliximab is an important drug therapy for patients with refractory and fistulating disease. There are concerns over its use in a proportion of Crohn's patients with concurrent hepatitis C infection, since there are theoretical risks of accelerated hepatic decompensation due to the i...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-200102000-00016
更新日期:2001-02-01 00:00:00
abstract:BACKGROUND:The immunoreactivity of methionine-enkephalin (Met-enkephalin), one of the endogenous opioid peptides, is expressed in the liver in different types of chronic diseases. This finding suggests that the liver may be a source of endogenous opioids in disease state. In-vitro studies have shown that morphine, whic...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0b013e3283509197
更新日期:2012-04-01 00:00:00
abstract:INTRODUCTION:Patients with gastroesophageal reflux disease (GERD) need long-term treatment with acid-suppressive therapy. Data on long-term follow-up are very rare. For this reason, a study was performed to detect complaints many years after diagnosis. PATIENTS AND METHODS:All patients diagnosed with reflux oesophagit...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0b013e32834b8d18
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND AND AIMS:Proton pump inhibitors (PPIs) may reduce iron absorption and serum ferritin levels in patients with homeostatic iron regulator (HFE)-related hemochromatosis, reducing the need for frequent phlebotomies. Our study aimed to perform for the first time a meta-analysis of existing observational and rando...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0000000000001857
更新日期:2020-08-04 00:00:00
abstract:BACKGROUND:Patients with nonalcoholic fatty liver disease (NAFLD) have sleep disruption. The aim of this study is to understand how underlying factors such as diet, degree of liver disease and morningness-eveningness tendencies contribute to this sleep disruption. METHODS:Patients with NAFLD were recruited from liver ...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0000000000002049
更新日期:2021-01-18 00:00:00
abstract:OBJECTIVE:Health expenditure is a marker associated with an advanced healthcare system, which contributes toward the good prognosis of patients. Mortality-to-incidence ratios (MIRs) are one of the predictors that reflect the prognosis of cancer patients. There remains some uncertainty on the correlation of MIRs of live...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0000000000000969
更新日期:2017-12-01 00:00:00
abstract:AIMS AND OBJECTIVES:To ascertain whether therapeutic endoscopic retrograde cholangiopancreatography (ERCP) for benign biliary disease in frail elderly patients with comorbid conditions can be safely undertaken in a district general hospital, and whether the procedure is facilitated by the use of short-acting general an...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-200012040-00014
更新日期:2000-04-01 00:00:00
abstract:OBJECTIVE:Blood tests are usually designed to identify significant fibrosis. We evaluated their diagnostic accuracy, and how to increase it, for the clinically important targets of severe fibrosis and cirrhosis. METHODS:The accuracy for severe fibrosis or cirrhosis of four blood tests was evaluated based on Metavir st...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章,多中心研究,评审
doi:10.1097/MEG.0b013e32830cebd7
更新日期:2009-01-01 00:00:00
abstract::The introduction of expandable metal stents in the mid 1980s led to the development of transjugular intrahepatic portosystemic stent-shunt (TIPSS) as we know it today. Short-lived detrimental effects on the hyperdynamic circulation in cirrhosis accompany the acute reduction in portal pressure following TIPSS creation....
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章,评审
doi:10.1097/01.meg.0000236871.78280.a7
更新日期:2006-11-01 00:00:00
abstract:INTRODUCTION:This preliminary study aimed to investigate the effects of the probiotic Saccharomyces boulardii on proinflammatory and anti-inflammatory cytokines in patients with diarrhea-dominant irritable bowel syndrome (IBS-D). The other objectives were to document any clinical improvement as judged by symptoms, qual...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章,随机对照试验
doi:10.1097/MEG.0000000000000094
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:Patients with achalasia require repeated invasive therapies and may experience multiple complications. The objectives of this study were to determine the incidence of such complications, causes of death, and life expectancy in 253 patients. METHODS:Patients consisted of two groups: group A comprised 177 pat...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0b013e3282fbf5e5
更新日期:2008-10-01 00:00:00
abstract::In this review, the role of chemotherapy in the palliative treatment of advanced gastrointestinal cancer is discussed. Emphasis is placed on chemotherapy-related problems, current chemo-therapy options, and new developments. ...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章,评审
doi:10.1097/00042737-200012040-00004
更新日期:2000-04-01 00:00:00
abstract:OBJECTIVE:A wide range in values of liver stiffness measurement (LSM) is observed among cirrhotic patients. These variations reflect the extent of fibrosis and might influence the risk of hepatocellular carcinoma (HCC) occurrence. METHODS:We compared LSM in 66 Child-Pugh A patients with HCC and alcoholic (n=23) or HCV...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0b013e32830eb8d7
更新日期:2009-02-01 00:00:00
abstract::Whether cure of Helicobacter pylori infection leads to sustained improvement of non-ulcer dyspepsia (NUD) symptoms is one of the most important unresolved clinical questions in this area. H. pylori has not helped in explaining pathophysiological abnormalities which may cause dyspepsia symptoms. Currently there is insu...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章,评审
doi:10.1097/00042737-199805000-00002
更新日期:1998-05-01 00:00:00
abstract:OBJECTIVE:This study was designed to evaluate the role of technetium-99m (99mTc) hexamethyl propylene amine oxime (HMPAO)-labelled leucocyte imaging as an initial screening test in patients suspected of having inflammatory bowel disease (IBD). PATIENTS AND METHODS:Thirty-one patients in whom a final diagnosis of irrit...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-199612000-00012
更新日期:1996-12-01 00:00:00
abstract:AIM:Although liver biopsy has long been considered the gold standard for staging fibrosis, because of the disadvantages and risks of biopsy, several noninvasive processes such as serum biomarkers have been introduced for the assessment of liver fibrosis. The aim of this study was to assess the diagnostic value of serum...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0000000000001123
更新日期:2018-08-01 00:00:00
abstract:INTRODUCTION:Growing evidence suggests that multiple factors, such as insulin resistance, nutritional factors, gut microbiota, and hormones released from the adipose tissue, act together on genetically predisposed individuals. We aimed to investigate whether various single-nucleotide polymorphisms (SNPs) play a role in...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章,多中心研究
doi:10.1097/MEG.0000000000000813
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVES:Nitric oxide (NO) is involved in the control of pancreatic blood flow and secretion, and its role in the maintenance of pancreatic tissue has been suggested. The aim of our study was to evaluate the influence of NO on pancreatic trophic parameters during acute pancreatitis induction and the pancreas recovery...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-199909000-00012
更新日期:1999-09-01 00:00:00
abstract:OBJECTIVES:The prognostic value of p53 protein accumulation in colonic adenomas is still controversial. The aim of the present study was to determine whether the evaluation of p53 protein accumulation in newly diagnosed colonic adenomas could predict the development of metachronous adenomas. DESIGN/METHODS:Fifty-five ...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-199905000-00014
更新日期:1999-05-01 00:00:00
abstract:BACKGROUND AND AIMS:The diagnosis of spontaneous bacterial peritonitis (SBP) in patients with ascites is established by definition with a polymorphonuclear (PMN) cell count in the ascitic fluid greater than 0.250 g/l determined via cytological (microscopic) examination. In this study, we correlated the automatically as...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-200602000-00011
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND:Heterotopic gastric mucosa is found in the proximal oesophagus, just below the upper oesophageal sphincter, and is encountered when the oesophagus is examined carefully during endoscopy. AIMS:In this study on paediatric patients, we aimed to determine the endoscopic prevalence of heterotopic gastric mucosa ...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0000000000000177
更新日期:2014-10-01 00:00:00
abstract::Ulcerative colitis (UC) is an inflammatory disease of the colon. Involvement of the small bowel is limited to backwash ileitis or pouch-related conditions. Here, we report two men with UC who presented with small bowel inflammation and even perforation, within 1 month after subtotal colectomy. Endoscopy showed diffuse...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章,评审
doi:10.1097/MEG.0b013e32831bc400
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND AND AIMS:Endoscopic variceal band ligation (EVBL) aims to eradicate high-risk oesophageal varices. There is a small risk of precipitating bleeding from EVBL-induced oesophageal ulceration, which is associated with significant mortality. We explore the risk factors and outcome of EVBL-induced ulcer bleeding. ...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0000000000000387
更新日期:2015-08-01 00:00:00
abstract:OBJECTIVES:Spontaneous bacterial peritonitis (SBP) is a prevalent and high mortality complication of cirrhosis. We aimed to describe these patients' clinical and microbiological characteristics and evaluate their impact on outcomes. METHODS:This was a retrospective cohort study including 139 consecutive patients with ...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/MEG.0000000000000700
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND/AIMS:As a module of a standard ultrasound imaging device, acoustic radiation force impulse (ARFI) is a new technology for liver stiffness evaluation (LSE). We aimed to evaluate accuracy, feasibility, reproducibility, and training effect of ARFI for liver fibrosis evaluation. METHODS:One hundred and one pati...
journal_title:European journal of gastroenterology & hepatology
pub_type: 临床试验,杂志文章
doi:10.1097/MEG.0b013e328339e0a1
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVE:To examine the influence of dietary factors in Italian patients with ulcerative colitis and Crohn's disease. DESIGN:We studied dietary habits immediately prior to the onset of disease in 104 patients enrolled in a prospective, epidemiological study of the incidence of inflammatory bowel disease in Italy. ME...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:Laser-induced shock-wave lithotripsy (LISL) is successfully used for the treatment of difficult bile duct stones. The aim of this study was to assess the long-term risk for a symptomatic bile duct stone recurrence after LISL and to detect risk factors predicting recurrence. METHODS:Between 1993 and 2001, 80...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-200605000-00003
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND:Transforming growth factor betas (TGF-betas) are a group of homologous polypeptides that exert pleiotropic effects on various cell types and stimulate the formation of extracellular matrix and fibrosis. To evaluate whether TGF-beta isoforms (TGF-beta1, TGF-beta2 and TGF-beta3) and their receptors (types I-II...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
doi:10.1097/00042737-199812000-00009
更新日期:1998-12-01 00:00:00