Evaluation of serum procollagen C-proteinase enhancer 1 level as a fibrosis marker in patients with chronic hepatitis B.

Abstract:

AIM:Although liver biopsy has long been considered the gold standard for staging fibrosis, because of the disadvantages and risks of biopsy, several noninvasive processes such as serum biomarkers have been introduced for the assessment of liver fibrosis. The aim of this study was to assess the diagnostic value of serum procollagen C-proteinase enhancer 1 (PCPE-1) as a noninvasive fibrosis marker in treatment-naive chronic hepatitis B patients. PATIENTS AND METHODS:This study included 126 patients with biopsy-proven hepatitis B and 50 healthy controls. Fibrosis stage was determined using the Ishak scoring system. The PCPE-1 level was measured using the enzyme-linked immunosorbent assay assay, and the aspartate aminotransferase to platelet ratio index and the FIB-4 index were calculated using the formulas described in Appendix 1 (Supplemental digital content 1, http://links.lww.com/EJGH/A277). RESULTS:Serum PCPE-1 levels of chronic hepatitis B patients were found to be significantly lower than those of the healthy control group (4.49±2.74 vs. 42.9±59.6 pg/ml, respectively, P<0.001). There was a statistically significant negative correlation between serum PCPE-1 level and fibrosis stage (P=0.011; r=-0.226). A statistically significant negative correlation was found between serum PCPE-1 level and necroinflammatory activity (P=0.030; r=-0.194). PCPE-1 levels of patients with liver fibrosis scores of F1-2 were statistically significantly lower than those of the healthy control group (P<0.001) (area under the receiver operating characteristic: 0.955). The area under the receiver operating characteristic of the PCPE-1 level was 0.615 for the prediction of fibrosis (F0 vs. F1-6) (P=0.039). CONCLUSION:Serum PCPE-1 might be used as a noninvasive marker of liver fibrosis. Further animal and human studies are needed to assess the utility of this marker.

authors

Gokce O,Ozenirler S,Atak Yucel A,Oruklu N,Yilmaz Esendagli G,Karahan S

doi

10.1097/MEG.0000000000001123

subject

Has Abstract

pub_date

2018-08-01 00:00:00

pages

918-924

issue

8

eissn

0954-691X

issn

1473-5687

journal_volume

30

pub_type

杂志文章
  • Genetic polymorphisms present in IL10, IL23R, NOD2, and ATG16L1 associated with susceptibility to inflammatory bowel disease in Mexican population.

    abstract:OBJECTIVE:Ulcerative colitis and Crohn's disease are the two clinical forms of inflammatory bowel disease (IBD). Diverse studies have shown the association of single nucleotide polymorphism (SNP) in molecules of the immune system and the occurrence of IBD. Here, several SNPs of the immune system with controversial resu...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001540

    authors: Quiroz-Cruz S,Posada-Reyes B,Alatorre-García T,Del Real-Calzada CM,García-Samper X,Escobar-Gutiérrez A,Vázquez-Chacón CA,Martínez-Guarneros JA,Cruz-Rivera M,Vaughan G,Fonseca-Coronado S

    更新日期:2020-01-01 00:00:00

  • The sedation increases the acceptance of repeat colonoscopies.

    abstract:AIM:The aim of this research was to assess how the use of sedation during colonoscopy influences patient anxiety, fear, satisfaction, and acceptance of repeat examinations. MATERIALS AND METHODS:A prospective case-control study quantifying the anxiety and fears of patients appointed for colonoscopy, comparing patients...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e32835376a2

    authors: Baudet JS,Aguirre-Jaime A

    更新日期:2012-07-01 00:00:00

  • Aspartate aminotransferase to platelet ratio index for fibrosis evaluation in chronic viral hepatitis.

    abstract:OBJECTIVE:We assessed the value of the recently developed aspartate aminotransferase to platelet ratio index (APRI) for predicting significant fibrosis or cirrhosis in patients with chronic hepatitis C or HBeAg-negative chronic hepatitis B. METHODS:In total, 489 patients (chronic hepatitis C, 284 patients; HBeAg-negat...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200604000-00012

    authors: Chrysanthos NV,Papatheodoridis GV,Savvas S,Kafiri G,Petraki K,Manesis EK,Archimandritis AJ

    更新日期:2006-04-01 00:00:00

  • Postinfective bile acid malabsorption: is this a long-term condition?

    abstract:BACKGROUND:Postinfective bile acid malabsorption comprises a group of patients with a history of an episode of acute gastroenteritis triggering chronic diarrhoea. We identified these patients retrospectively from our medical records and assessed their long-term clinical course. MATERIALS AND METHODS:We examined the re...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e3283457ba6

    authors: Menon S,Jones BJ

    更新日期:2011-04-01 00:00:00

  • Factors predictive of liver cirrhosis in patients with chronic hepatitis B: a multivariate analysis in a longitudinal study.

    abstract:OBJECTIVE AND DESIGN:Chronic hepatitis B virus (HBV) infection may lead to liver cirrhosis; however, factors associated with the development of cirrhosis have been incompletely studied. A total of 516 patients with chronic hepatitis B were followed up longitudinally to determine their outcome. METHODS:The clinical and...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200012060-00019

    authors: Huo T,Wu JC,Hwang SJ,Lai CR,Lee PC,Tsay SH,Chang FY,Lee SD

    更新日期:2000-06-01 00:00:00

  • Telomeres and telomerases: intimations of immortality.

    abstract::There is a constant balance in cancer cells between division and death. The malignant phenotype is associated with a continuing cell cycle or 'immortalization'. Telomeres, structures that cap the chromosomes, are related to cell longevity and are regulated by a ribonucleoprotein called telomerase. This review describe...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 评论,杂志文章

    doi:10.1097/00042737-200108000-00002

    authors: Crocker J

    更新日期:2001-08-01 00:00:00

  • Twenty-four-hour pH measurements in morbid obesity: effects of massive overweight, weight loss and gastric distension.

    abstract:OBJECTIVE:To investigate the influence of untreated (super)morbid obesity and the effects of massive weight loss and chronic gastric distension on gastro-oesophageal reflux. PATIENTS AND METHODS:Seventeen young morbidly obese patients (32 years old; body weight 166.5 kg; body mass index 55 kg/m2) underwent 24-h ambula...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Mathus-Vliegen LM,Tytgat GN

    更新日期:1996-07-01 00:00:00

  • Circulating microRNAs as biomarkers of adult Crohn's disease.

    abstract:OBJECTIVE:Previous studies have found a differential expression of microRNAs (miRNAs) in the blood of patients with Crohn's disease (CD) compared with healthy controls. The aim of this study was to identify circulating miRNAs expressed in CD and assess their performance as biomarkers in patients with clinically suspect...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000430

    authors: Jensen MD,Andersen RF,Christensen H,Nathan T,Kjeldsen J,Madsen JS

    更新日期:2015-09-01 00:00:00

  • Differentiated CaCo-2 cells as an in-vitro model to evaluate de-novo apolipoprotein A-I production in the small intestine.

    abstract:BACKGROUND:Increasing HDL cholesterol concentrations by stimulating de-novo apolipoprotein A-I (apoA-I) production in the liver and/or in the small intestine is a potential strategy to reduce coronary heart disease risk. Although there is quite some knowledge concerning regulatory effects in the liver, less is known co...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/meg.0b013e328321b0c8

    authors: Dullens SP,Mensink RP,Mariman EC,Plat J

    更新日期:2009-06-01 00:00:00

  • Occult obstetric trauma and anal incontinence.

    abstract::Obstetric trauma is by far the commonest cause of anal incontinence in women. Denervation and reinnervation of the pelvic floor and anal sphincter following vaginal delivery has been previously demonstrated. The advent of anal endosonography, however, has enabled the identification of occult anal sphincter defects fol...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:10.1097/00042737-199705000-00002

    authors: Sultan AH,Stanton SL

    更新日期:1997-05-01 00:00:00

  • Transjugular intrahepatic portosystemic stent-shunt (TIPSS) insertion as a prelude to orthotopic liver transplantation in patients with severe portal hypertension.

    abstract:OBJECTIVE:To investigate the impact of preoperative transjugular intrahepatic portosystemic stent-shunt (TIPSS) on patients undergoing liver transplantation. DESIGN:A retrospective non-randomized comparative clinical study. SETTING:Tertiary referral institution. PATIENTS, PARTICIPANTS:Twenty-four patients with liver...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-199612000-00002

    authors: John TG,Jalan R,Stanley AJ,Redhead DN,Sanfey HA,Hayes PC,Garden OJ

    更新日期:1996-12-01 00:00:00

  • Ossification within an adenomatous polyp: a case report and review of the literature.

    abstract::Osseous metaplasia within the gastrointestinal tract is rare and occurs in benign, premalignant, and malignant neoplasms. Here, we report the youngest case of an adenomatous polyp with the presence of ossification and a concomitant review of the literature with regard to ossification of colonic polyps. A 28-year-old m...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:10.1097/MEG.0b013e32834e7fd5

    authors: Bowman EA,Stevens EC,Pfau PR,Spier BJ

    更新日期:2012-02-01 00:00:00

  • Effect of nicotine on large bowel mucus thickness, eicosanoids and faecal proteinase in ferrets.

    abstract:BACKGROUND:Following observations on the effect of subcutaneous nicotine on rectal mucosal eicosanoids and mucus in the rabbit we have repeated the work in ferrets which may be a more suitable animal model. AIMS AND METHODS:The effect of nicotine on mucosal eicosanoids, the adherent mucus layer, and faecal proteinases...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-199702000-00013

    authors: Thomas GA,Pullan RD,Zijlstra FJ,Rankin BJ,Russell MA,Feyerabend C,Allen A,Rhodes J

    更新日期:1997-02-01 00:00:00

  • Hepatic Methionine-enkephalin may interfere with response to antiviral therapy in chronic hepatitis C.

    abstract:BACKGROUND:The immunoreactivity of methionine-enkephalin (Met-enkephalin), one of the endogenous opioid peptides, is expressed in the liver in different types of chronic diseases. This finding suggests that the liver may be a source of endogenous opioids in disease state. In-vitro studies have shown that morphine, whic...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e3283509197

    authors: Floreani A,Antoniazzi S,Mescoli C,Bergasa NV

    更新日期:2012-04-01 00:00:00

  • Should antibiotic treatment of Helicobacter-positive patients with non-ulcer dyspepsia now be recommended?

    abstract::Whether cure of Helicobacter pylori infection leads to sustained improvement of non-ulcer dyspepsia (NUD) symptoms is one of the most important unresolved clinical questions in this area. H. pylori has not helped in explaining pathophysiological abnormalities which may cause dyspepsia symptoms. Currently there is insu...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:10.1097/00042737-199805000-00002

    authors: Veldhuyzen van Zanten SJ,Talley NJ

    更新日期:1998-05-01 00:00:00

  • High-flow-rate haemodiafiltration as a brain-support therapy proceeding to liver transplantation for hyperacute fulminant hepatic failure.

    abstract::In fulminant hepatic failure (FHF), rapidly progressive cerebral oedema remains the main fatal complication and an obstacle in liver transplantation. A 29-year-old Japanese woman presented with sudden-onset hepatic encephalopathy and jaundice. Hepatic encephalopathy deteriorated within 2 days of the onset of jaundice....

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200204000-00018

    authors: Sadamori H,Yagi T,Inagaki M,Shima Y,Matsuda H,Tanaka N,Sakaguchi K,Tsuji T,Matsumi M,Katayama H,Hirakawa N

    更新日期:2002-04-01 00:00:00

  • Gastroduodenal involvement in patients with familial adenomatous polyposis. Prospective study of the nature and evolution of polyps: evaluation of the treatment and surveillance methods applied.

    abstract:OBJECTIVES:Analysis of the incidence rate and the evolution of duodenal and stomach polyps in our familial adenomatous polyposis (FAP) patients, the suitability of the surveillance method and the cancer-preventing treatment applied and the analysis of the complications arising from each procedure employed. MATERIALS A...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e3283297cf2

    authors: Cordero-Fernández C,Garzón-Benavides M,Pizarro-Moreno A,García-Lozano R,Márquez-Galán JL,López Ruiz T,Sobrino S,Bozada JM,Laguna OB

    更新日期:2009-10-01 00:00:00

  • Colonic variceal bleeding in a patient with mesenteric venous obstruction due to an ileal carcinoid tumour.

    abstract::Colonic varices are a recognized cause of rectal bleeding in portal hypertension. We report here a patient who presented with melaena several months after resection of an ileal carcinoid tumour. Subsequent colonoscopy for continued episodes of rectal bleeding demonstrated extensive colonic varices. In the absence of p...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:10.1097/00042737-199611000-00020

    authors: Miao YM,Catnach SM,Barrison IG,O'Reilly A,Divers AR

    更新日期:1996-11-01 00:00:00

  • Successful prophylaxis with valaciclovir for relapsing HSV-1 in a girl treated with infliximab for moderate Crohn's disease.

    abstract::Biological agents such as inhibitors of tumour necrosis factor alpha (TNF-alpha ) are associated with the development of opportunistic infections. Although there are no international recommendations for the management of opportunistic infections, their prevention is a key safety issue for patients with inflammatory bo...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e32831de271

    authors: Checchin D,Buda A,Sgarabotto D,Sturniolo GC,D' Incà R

    更新日期:2009-09-01 00:00:00

  • A preliminary study on the efficacy and influencing factors of interferon for the treatment of genotype 1 chronic hepatitis C with different dosage forms.

    abstract:BACKGROUND AND OBJECTIVE:Nowadays, interferon alfa-2b is still in widespread use for the treatment of chronic hepatitis C in China. In this study, peginterferon alfa-2a plus ribavirin was compared with interferon alfa-2b plus ribavirin for the initial treatment of genotype 1 chronic hepatitis C. MATERIALS AND METHODS:...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/MEG.0b013e32835cc899

    authors: Ma P,Yang JM,Hou W,Song SD,Wang L,Lu W

    更新日期:2013-05-01 00:00:00

  • Infrequent p16/CDKN2 alterations in squamous cell carcinoma of the oesophagus.

    abstract::Loss of heterozygosity (LOH) on chromosome 9 and p16 (MTS1/CDKN2) gene mutations have been reported in various human cancers. The present study aimed to determine the prevalence of LOH in 100 oesophageal squamous cell carcinomas (OSCCs) by typing microsatellite loci and mutations of the p16 gene. The methods used incl...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200201000-00004

    authors: Giroux MA,Audrezet MP,Metges JP,Lozac'h P,Volant A,Nousbaum JB,Labat JP,Gouérou H,Ferec C,Robaszkiewicz M

    更新日期:2002-01-01 00:00:00

  • Nomogram for predicting diabetes mellitus after the first attack of acute pancreatitis.

    abstract:BACKGROUND:Diabetes mellitus can occur after acute pancreatitis (AP), but there are currently no tools for evaluating the risk of developing diabetes after an attack of AP. The aim of the study was to develop a nomogram for prediction of new-onset diabetes mellitus after the first attack of AP. PATIENTS AND METHODS:We...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001307

    authors: Ma JH,Yuan YJ,Lin SH,Pan JY

    更新日期:2019-03-01 00:00:00

  • Are floating stools associated with specific functional bowel disorders?

    abstract:BACKGROUND:Functional bowel disorders are recognized as being common, but remain very difficult to diagnose accurately and to differentiate from one another, despite their significant impact on the quality of life of patients.The aim of this study was to evaluate whether the clinical sign of 'floating stools' is associ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000380

    authors: Bouchoucha M,Devroede G,Benamouzig R

    更新日期:2015-08-01 00:00:00

  • Efficacy of albumin-bilirubin score to predict hepatic encephalopathy in patients underwent transjugular intrahepatic portosystemic shunt.

    abstract:BACKGROUND AND AIMS:The occurrence of hepatic encephalopathy is one of the main factors limiting the development and application of transjugular intrahepatic portosystemic shunt (TIPS). Our study aimed to verify the efficacy of the albumin-bilirubin score, an objective and simple scoring system, to predict post-TIPS he...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001801

    authors: Lin X,Gao F,Wu X,Cai W,Chen X,Huang Z

    更新日期:2020-06-11 00:00:00

  • Helicobacter pylori, gastric cancer and gastric epithelial kinetics: a review.

    abstract:AIM:To review the evidence that Helicobacter pylori promotes gastric carcinogenesis, with particular reference to gastric epithelial proliferation. MATERIALS AND METHODS:Gastric epithelial kinetics were reviewed and a series of studies of gastric mucosal proliferation in H. pylori-associated gastritis were performed i...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:

    authors: Lynch DA,Axon AT

    更新日期:1995-08-01 00:00:00

  • Human leucocyte antigen and TNFalpha polymorphism association in microscopic colitis.

    abstract:OBJECTIVES:Coeliac disease (CD) is common in patients with microscopic colitis (MC). The human leucocyte antigen (HLA)-DR3-DQ2 haplotype is strongly associated with CD, and there is evidence for an association with MC. We analysed the genetic background of MC by assessing the haplotypes of HLA-DR3-DQ2 and HLA-DR4-DQ8. ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e3282f2468d

    authors: Koskela RM,Karttunen TJ,Niemelä SE,Lehtola JK,Ilonen J,Karttunen RA

    更新日期:2008-04-01 00:00:00

  • Renal involvement in Crohn's disease: granulomatous inflammation in the form of mass lesion.

    abstract::Extraintestinal manifestations of Crohn's disease (CD) are varied and concentrated mainly to the skin and eye. Urinary tract or renal involvement is extremely rare. Herein we report on a case of renal lesion of a 50-year-old woman with a 15-year history of CD. Abdominal computed tomography scan of the patient identifi...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e32834b956b

    authors: Semjén D,Fábos Z,Pakodi F,Vincze A,Szabó I,Degrell P,Csete M,Tornóczky T

    更新日期:2011-11-01 00:00:00

  • Five minute endoscopic urea breath test with 25 mg of (13)C-urea in the management of Helicobacter pylori infection.

    abstract:OBJECTIVE:The endoscopic (13)C-urea breath test ((13)C-EUBT), which combines the urea breath test (UBT) with endoscopy, provides high accuracy for the detection of Helicobacter pylori. This study was conducted to determine whether the (13)C-EUBT using low doses of urea and short sampling times could preserve accuracy i...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00042737-200210000-00010

    authors: Isomoto H,Inoue K,Shikuwa S,Furusu H,Nishiyama T,Omagari K,Mizuta Y,Murase K,Murata I,Enjoji A,Kanematsu T,Kohno S

    更新日期:2002-10-01 00:00:00

  • Cancer of the pancreas: from concordant classification to standardized treatment. International Symposium at Kloster Irsee, Germany, 2-5 October 1996.

    abstract::There has been a slow but steady improvement in the results of treatment for exocrine pancreatic cancer in the last decade. One obstacle to further improvement has been lack of standardization for reporting of results, from classification to surgery and follow-up. This four-day symposium was organized in order to brid...

    journal_title:European journal of gastroenterology & hepatology

    pub_type:

    doi:10.1097/00042737-199710000-00013

    authors: Löhr M,Andrén-Sandberg A

    更新日期:1997-10-01 00:00:00

  • The effect of intra-gastric acidity and flora on the concentration of N-nitroso compounds in the stomach.

    abstract:BACKGROUND:Correa's hypothesis proposes that gastric carcinogenesis is due to atrophic gastritis and hypochlorhydria which permit gastric bacterial colonization, the reduction of dietary nitrates to nitrites and the formation of potentially carcinogenic N-nitroso compounds (NOCs). OBJECTIVE:To test the hypothesis that...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200012020-00006

    authors: Viani F,Siegrist HH,Pignatelli B,Cederberg C,Idström JP,Verdu EF,Fried M,Blum AL,Armstrong D

    更新日期:2000-02-01 00:00:00