A preliminary study on the efficacy and influencing factors of interferon for the treatment of genotype 1 chronic hepatitis C with different dosage forms.

Abstract:

BACKGROUND AND OBJECTIVE:Nowadays, interferon alfa-2b is still in widespread use for the treatment of chronic hepatitis C in China. In this study, peginterferon alfa-2a plus ribavirin was compared with interferon alfa-2b plus ribavirin for the initial treatment of genotype 1 chronic hepatitis C. MATERIALS AND METHODS:Overall, 168 patients with genotype 1 chronic hepatitis C were assigned peginterferon alfa-2a (135-180 µg subcutaneously/week) plus ribavirin (800-1200 mg/day orally) or interferon alfa-2b (300-500 million units, once every other day) plus ribavirin (800-1200 mg/day). According to HCV RNA levels at weeks 4 and 12, patients were reallocated to receive different interferon dosage forms or different courses of treatment. The primary endpoint was a sustained virological response (SVR). RESULTS:A total of 160 patients completed the entire study and eight cases were lost to follow-up. The SVR rates in patients treated with peginterferon alfa-2a plus ribavirin for 24 and 48 weeks were 67.9% (53/78) and 73.6% (14/19), respectively, whereas in patients treated with interferon alfa-2b plus ribavirin for 24 and 48 weeks the SVR rates were 52.4% (43/82) and 40% (8/20), respectively. The SVR rates in the groups with a rapid virological response (RVR) and without RVR were 68.8 and 16.9%, respectively. The SVR rates in the groups with an early virological response (EVR) and in the groups without EVR were 88.1 and 10.5%, respectively. CONCLUSION:Peginterferon alfa-2a plus ribavirin was more effective than interferon alfa-2b plus ribavirin, with similar safety. RVR can predict a greater chance of SVR. The duration of treatment should be shortened for patients with RVR. Treatment for patients without EVR should be discontinued.

authors

Ma P,Yang JM,Hou W,Song SD,Wang L,Lu W

doi

10.1097/MEG.0b013e32835cc899

subject

Has Abstract

pub_date

2013-05-01 00:00:00

pages

601-5

issue

5

eissn

0954-691X

issn

1473-5687

journal_volume

25

pub_type

杂志文章,多中心研究,随机对照试验
  • Noninvasive assessment of pediatric inflammatory bowel disease with ¹⁸F-fluorodeoxyglucose-positron emission tomography and computed tomography.

    abstract:OBJECTIVES:¹⁸F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) is a less invasive diagnostic tool and promising in detecting gastrointestinal lesions of pediatric inflammatory bowel disease (IBD) patients. Co-registration of low-dose computed tomography (CT) could lead to improvements in the assessment of d...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e3283410222

    authors: Däbritz J,Jasper N,Loeffler M,Weckesser M,Foell D

    更新日期:2011-01-01 00:00:00

  • A radical view of the stomach: the role of oxygen-derived free radicals and anti-oxidants in gastroduodenal disease.

    abstract::Following the discovery of Helicobacter pylori, the last decade has seen major advances in our understanding of gastroduodenal disease. However, our knowledge remains incomplete and the exact mechanism by which H. pylori causes inflammation and ulceration is still not known. The role of H. pylori in relation to other ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:

    authors: Phull PS,Green CJ,Jacyna MR

    更新日期:1995-03-01 00:00:00

  • Defining a proper setting for endoscopy in coeliac disease.

    abstract:OBJECTIVE:As it has been demonstrated that a careful duodenal inspection during upper gastrointestinal endoscopy may be useful in predicting coeliac disease, we tried to define the usefulness of endoscopy in detecting unsuspected coeliac patients. DESIGN AND METHODS:We considered all the first diagnoses of coeliac dis...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200306000-00015

    authors: Vjero K,Martucci S,Alvisi C,Broglia F,Viera FT,Perego M,Corazza GR

    更新日期:2003-06-01 00:00:00

  • How Helicobacter pylori urease may affect external pH and influence growth and motility in the mucus environment: evidence from in-vitro studies.

    abstract:BACKGROUND:Survival of Helicobacter pylori is dependent upon urease in the cytoplasm and at the bacterial surface. We have sought to clarify how alkaline ammonium salts, released from urea by this enzyme, might alter mucus pH and so affect growth and motility of the bacterium in the gastric mucus environment. METHODS:...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200304000-00010

    authors: Sidebotham RL,Worku ML,Karim QN,Dhir NK,Baron JH

    更新日期:2003-04-01 00:00:00

  • Screening for drug related dyspepsia: an analysis of prescription symmetry.

    abstract:OBJECTIVE:Most patients with severe upper dyspepsia are treated empirically with ulcer drugs. Drug-induced dyspepsia might therefore be reflected in the sequencing of ulcer drugs relative to other medications. Our aim was to screen a large population-base prescription database for evidence of drug-induced dyspepsia. M...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-199801000-00006

    authors: Hallas J,Bytzer P

    更新日期:1998-01-01 00:00:00

  • Gastric adenocarcinoma with leptomeningeal carcinomatosis as the presenting manifestation: an autopsy case report.

    abstract::Leptomeningeal carcinomatosis is a clinically important and severe complication in patients with cancer. Leptomeningeal involvement as a secondary event in gastric carcinoma is rarely reported and usually occurs late in advanced disease. Herein, we report a case of leptomeningeal carcinomatosis as the initial manifest...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200505000-00016

    authors: Braeuninger S,Mawrin C,Malfertheiner P,Schildhaus HU,Seiler C,Dietzmann K,Lins H

    更新日期:2005-05-01 00:00:00

  • Performance of liver biomarkers, in patients at risk of nonalcoholic steato-hepatitis, according to presence of type-2 diabetes.

    abstract:OBJECTIVE:There is a controversy about the performance of blood tests for the diagnostic of metabolic liver disease in patients with type-2-diabetes in comparison with patients without type-2-diabetes. These indirect comparisons assumed that the gold-standard is binary, whereas fibrosis stages, steatosis and nonalcohol...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001606

    authors: Poynard T,Peta V,Deckmyn O,Pais R,Ngo Y,Charlotte F,Ngo A,Munteanu M,Imbert-Bismut F,Monneret D,Housset C,Thabut D,Valla D,Boitard C,Castera L,Ratziu V,FLIP consortium, the FibroFrance Group, the EPIC-3 program and the QU

    更新日期:2020-08-01 00:00:00

  • Omeprazole, but not pantoprazole, reduces the antiplatelet effect of clopidogrel: a randomized clinical crossover trial in patients after myocardial infarction evaluating the clopidogrel-PPIs drug interaction.

    abstract:BACKGROUND:Proton pump inhibitors (PPIs) are usually prescribed to patients undergoing dual antiplatelet therapy to decrease the risk of gastrointestinal bleeding. Recent studies have raised concerns that PPIs could reduce clopidogrel's efficacy by competitive inhibition of cytochrome P450 2C19 isoenzyme. All PPIs are ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MEG.0b013e3283460110

    authors: Fontes-Carvalho R,Albuquerque A,Araújo C,Pimentel-Nunes P,Ribeiro VG

    更新日期:2011-05-01 00:00:00

  • Frequency and risk factors of gastric and duodenal ulcers or erosions in children: a prospective 1-month European multicenter study.

    abstract:UNLABELLED:There are no solid figures of the frequency of ulcer disease during childhood in Europe. We assessed its frequency and analyzed known risk factors. PATIENTS AND METHODS:Ulcers, erosions, indications, and risk factors were recorded in all children undergoing an upper gastrointestinal endoscopy in a prospecti...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MEG.0b013e32833d36de

    authors: Kalach N,Bontems P,Koletzko S,Mourad-Baars P,Shcherbakov P,Celinska-Cedro D,Iwanczak B,Gottrand F,Martinez-Gomez MJ,Pehlivanoglu E,Oderda G,Urruzuno P,Casswall T,Lamireau T,Sykora J,Roma-Giannikou E,Veres G,Wewer V,Ch

    更新日期:2010-10-01 00:00:00

  • Zooming in on Barrett oesophagus using narrow-band imaging: an international observer agreement study.

    abstract:BACKGROUND:Several classifications of mucosal morphology have been proposed in Barrett oesophagus using narrow-band imaging (NBI). We evaluated a simplified classification in which only the regularity of mucosal and vascular patterns were evaluated. AIM:To assess the inter and intraobserver agreement and the correlati...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MEG.0b013e3283271e87

    authors: Alvarez Herrero L,Curvers WL,Bansal A,Wani S,Kara M,Schenk E,Schoon EJ,Lynch CR,Rastogi A,Pondugula K,Weusten B,Sharma P,Bergman JJ

    更新日期:2009-09-01 00:00:00

  • Glass and antimony electrodes for oesophageal pH monitoring in distressed infants: how different are they?

    abstract:OBJECTIVE:Although antimony electrodes are by far the most popular for performing oesophageal pH monitoring, there are few data comparing the accuracy of glass and antimony electrodes. Therefore, we tested the accuracy of both electrodes in the prediction of oesophagitis. METHOD:pH monitoring using a glass electrode a...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200412000-00015

    authors: Vandenplas Y,Badriul H,Verghote M,Hauser B,Kaufman L

    更新日期:2004-11-01 00:00:00

  • Elevation of endoglin (CD105) concentrations in serum of patients with liver cirrhosis and carcinoma.

    abstract:OBJECTIVE:Liver cirrhosis is considered as a premalignant state, as about 80% of hepatocellular carcinoma (HCC) is associated with liver cirrhosis. Although alpha-fetoprotein (AFP) has a high negative predictive value, its sensitivity for detecting HCC is poor. The aim of this study was to evaluate circulating endoglin...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MEG.0b013e3282202bea

    authors: Yagmur E,Rizk M,Stanzel S,Hellerbrand C,Lammert F,Trautwein C,Wasmuth HE,Gressner AM

    更新日期:2007-09-01 00:00:00

  • Clinical phenotype and mortality in patients with idiopathic small bowel villous atrophy: a dual-centre international study.

    abstract:OBJECTIVE:Causes of small-bowel villous atrophy (VA) include coeliac disease (CD), its complications and other rare non-coeliac enteropathies. However, forms of VA of unknown aetiology may also exist. We defined them as idiopathic VA (IVA). To retrospectively classify the largest cohort of IVA patients and compare thei...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001726

    authors: Schiepatti A,Sanders DS,Aziz I,De Silvestri A,Goodwin J,Key T,Quaye L,Giuffrida P,Vanoli A,Paulli M,Cross SS,Vergani P,Betti E,Maiorano G,Ellis R,Snowden JA,Di Sabatino A,Corazza GR,Biagi F

    更新日期:2020-08-01 00:00:00

  • Hepatitis C and hepatitis C-related advanced liver disease hospitalisation trends before and after the Strategic Plan for Tackling Hepatitis C in the National Health System.

    abstract:INTRODUCTION:This work evaluates the burden and trends of hepatitis C virus (HCV)-associated hospitalisations in Spain before and after the implementation of the Strategic Plan for Tackling Hepatitis C in the National Health System in 2015. METHODS:HCV-related hospitalisation discharges from 2005 to 2017 were obtained...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001841

    authors: Garrido-Estepa M,Latasa P,Flores-Herrera J,García Comas L

    更新日期:2020-07-29 00:00:00

  • Sclerosing peritonitis complicated by sepsis: a potential cause of portal hypertension.

    abstract::A 27-year-old woman with chronic renal failure, who had been treated with chronic ambulatory peritoneal dialysis and had developed sclerosing peritonitis, was admitted to the hospital with intra-abdominal sepsis. In spite of antibiotic therapy, sepsis recurred and was associated with intrahepatic cholestasis. In addit...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-199801000-00017

    authors: Jones EA,Bronkhorst CM,de Jonge E,ten Kate FJ

    更新日期:1998-01-01 00:00:00

  • Clostridium difficile caused changes in fatty acids profile and resolvin D1 content in plasma of infected patients.

    abstract:OBJECTIVES:Clostridium difficile infection (CDI) is an acute gastrointestinal infection caused by anaerobic, toxin-producing bacteria. During the course of CDI, there is a general inflammatory state. In order to gain a deeper understanding of the role of fatty acids (FAs) in the pathogenesis of acute infection we analy...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001600

    authors: Dróżdż M,Gdula-Argasińska J,Biesiada G,Jurczyszyn A,Perucki W,Wołkow P,Borys A,Sroczyńska K,Zając A,Librowski T,Garlicki A,Czepiel J

    更新日期:2020-03-01 00:00:00

  • Capsule endoscopy in real life: a four-centre experience of 160 consecutive patients in Israel.

    abstract:OBJECTIVE:The Given Capsule procedure is a new system designed to aid the gastroenterologist in diagnosing small-bowel disease. Capsule endoscopy has provided gastroenterologists with easy access to small-bowel mucosa for examination by direct visualisation. The aim of our prospective study was to determine the indicat...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/00042737-200409000-00019

    authors: Fireman Z,Eliakim R,Adler S,Scapa E

    更新日期:2004-09-01 00:00:00

  • Endoscopic sedation and monitoring practices in Portugal: a nationwide web-based survey.

    abstract:BACKGROUND:National surveys have been used to obtain information on sedation and monitoring practices in endoscopy in several countries. AIMS:To provide data from Portugal and query the Portuguese endoscopists on nonanesthesiologist administration of propofol. MATERIALS AND METHODS:A 31-item web survey was sent to al...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000245

    authors: Ferreira AO,Torres J,Dinis-Ribeiro M,Cravo M

    更新日期:2015-03-01 00:00:00

  • Sleep disruption in nonalcoholic fatty liver disease: What is the role of lifestyle and diet?

    abstract:BACKGROUND:Patients with nonalcoholic fatty liver disease (NAFLD) have sleep disruption. The aim of this study is to understand how underlying factors such as diet, degree of liver disease and morningness-eveningness tendencies contribute to this sleep disruption. METHODS:Patients with NAFLD were recruited from liver ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000002049

    authors: Akram ST,Ewy MW,Said A

    更新日期:2021-01-18 00:00:00

  • The association of nonalcoholic fatty liver disease with genetic polymorphisms: a multicenter study.

    abstract:INTRODUCTION:Growing evidence suggests that multiple factors, such as insulin resistance, nutritional factors, gut microbiota, and hormones released from the adipose tissue, act together on genetically predisposed individuals. We aimed to investigate whether various single-nucleotide polymorphisms (SNPs) play a role in...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MEG.0000000000000813

    authors: Uygun A,Ozturk K,Demirci H,Oztuna A,Eren F,Kozan S,Yilmaz Y,Kurt O,Turker T,Vatansever S,Alper E,Unsal B

    更新日期:2017-04-01 00:00:00

  • Cutaneous amyloidosis associated with primary biliary cirrhosis.

    abstract::Primary cutaneous amyloidosis is defined as the deposition of amyloid in the skin in the absence of systemic involvement. The association between primary cutaneous amyloidosis and other diseases, although rare, has been documented for connective tissue disorders such as systemic sclerosis, systemic lupus erythematosus...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e32811ec024

    authors: Tafarel JR,Lemos LB,Oliveira PM,Lanzoni VP,Ferraz ML

    更新日期:2007-07-01 00:00:00

  • How patients with long-term experience of living with irritable bowel syndrome manage illness in daily life: a qualitative study.

    abstract:OBJECTIVES:Irritable bowel syndrome (IBS) is a chronic, disabling and functional gastrointestinal disorder. Effective treatments are lacking. Self-care and coping with symptoms are considered important but little is known about what patients with IBS actually do to manage their illness. The aim of this study was to exp...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e328365abd3

    authors: Jakobsson Ung E,Ringstrom G,Sjövall H,Simrén M

    更新日期:2013-12-01 00:00:00

  • Prospective evaluation of a clinical score for 60-day mortality after transjugular intrahepatic portosystemic stent-shunt: Bonn TIPSS early mortality analysis.

    abstract:OBJECTIVE:Transjugular intrahepatic portosystemic stent-shunt (TIPSS) is increasingly used to treat complications of portal hypertension, but proven tools for risk assessment of early mortality are lacking. DESIGN:The prospective evaluation of a new 60-day mortality score. PATIENTS AND METHODS:In a tertiary medical c...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200207000-00003

    authors: Brensing KA,Raab P,Textor J,Görich J,Schiedermaier P,Strunk H,Paar D,Schepke M,Sudhop T,Spengler U,Schild H,Sauerbruch T

    更新日期:2002-07-01 00:00:00

  • Relationship between pre-sarcopenia and quality of life in patients with chronic liver disease: a cross-sectional study.

    abstract:AIM:This study aimed to clarify the relationship between pre-sarcopenia (PS) and quality of life (QOL) in patients with chronic liver disease (CLD). PATIENTS AND METHODS:This cross-sectional study evaluated 335 patients with CLD. PS was diagnosed on the basis of the assessment criteria by the Japan Society of Hepatolo...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001415

    authors: Ohashi K,Ishikawa T,Imai M,Suzuki M,Hoshii A,Abe H,Koyama F,Nakano T,Ueki A,Noguchi H,Hasegawa E,Hirosawa S,Kobayashi M,Hirosawa H,Sato K,Munakata M,Yoshida T

    更新日期:2019-11-01 00:00:00

  • Gastrointestinal allergy in adults.

    abstract::The prevalence of food allergy reaches 3% in the adult population. Chronic gastrointestinal allergy is a rare entity: 4.2% of food allergies in adults, and represents 3.2% of all intestinal disorders. Non-specific symptoms are the rule but eosinophilic gastrointestinal disorders are the subject of much interest. Endos...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:10.1097/00042737-200512000-00005

    authors: Moneret-Vautrin AD

    更新日期:2005-12-01 00:00:00

  • Mechanisms of liver cell damage and repair.

    abstract::Acute liver failure arises from an imbalance between liver cell death and regeneration. The severity of the insult determines whether liver cells die by apoptosis or necrosis, and this in turn affects the magnitude of the inflammatory reaction. Liver cell death occurs through complex cellular interactions and is media...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:10.1097/00042737-199909000-00002

    authors: Thomson RK,Arthur MJ

    更新日期:1999-09-01 00:00:00

  • Thrombotic risk factors in Chinese nonmalignant and noncirrhotic patients with portal vein thrombosis: an observational study with a systematic review of the literature.

    abstract:BACKGROUND:Until now, no data on the routine screening for thrombotic risk factors in Chinese nonmalignant and noncirrhotic patients with portal vein thrombosis (PVT) have been reported. METHODS:A total of 141 nonmalignant and noncirrhotic patients with PVT who underwent screening tests for thrombotic risk factors bet...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:10.1097/MEG.0000000000000221

    authors: Qi X,Wu F,He C,Fan D,Han G

    更新日期:2015-01-01 00:00:00

  • Patient-reported experience measure in pancreatobiliary endoscopy: a systematic review to highlight areas for improvement.

    abstract:OBJECTIVE:Increasing attention is paid to measure patient's experience using specific patient-reported experience measures (PREMs) as tool to assess the overall quality of care provided. The European Society of Gastrointestinal Endoscopy and the United European Gastroenterology have recognized the measure of quality of...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001957

    authors: Apadula L,Capurso G,Arcidiacono PG

    更新日期:2020-10-29 00:00:00

  • Should anti-Helicobacter therapy be different in patients with dyspepsia compared with patients with peptic ulcer diathesis?

    abstract::Physicians should try to reach an optimal cure rate with initial anti-Helicobacter therapy. Helicobacter pylori infection in patients with peptic ulcer disease (PUD) is more likely to be cured then in patients with 'functional' dyspepsia (FD). Differences in cure rates of 5-15% are usually reported, which is considere...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 评论,杂志文章

    doi:10.1097/00042737-200111000-00002

    authors: de Boer WA,Tytgat GN

    更新日期:2001-11-01 00:00:00

  • Impact of gastroesophageal reflux disease symptoms on the quality of life in pregnant women: a prospective study.

    abstract:OBJECTIVE:Pregnant women often suffer from gastroesophageal reflux disease (GERD). GERD symptoms are known to influence the quality of life; however, there is a lack of data in pregnant women. The aim of this study was to establish the impact of GERD symptoms on health-related quality of life (HRQOL) during pregnancy. ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000905

    authors: Fill Malfertheiner S,Seelbach-Göbel B,Costa SD,Ernst W,Reuschel E,Zeman F,Malfertheiner P,Malfertheiner MV

    更新日期:2017-08-01 00:00:00