Mechanisms of liver cell damage and repair.

Abstract:

:Acute liver failure arises from an imbalance between liver cell death and regeneration. The severity of the insult determines whether liver cells die by apoptosis or necrosis, and this in turn affects the magnitude of the inflammatory reaction. Liver cell death occurs through complex cellular interactions and is mediated by immunological, inflammatory and chemical components. Regeneration of the liver cell mass also depends on cellular interactions, often involving those same mediators implicated in the injury itself. A greater understanding of these processes will lead ultimately to targeted rational therapy in acute liver failure.

authors

Thomson RK,Arthur MJ

doi

10.1097/00042737-199909000-00002

subject

Has Abstract

pub_date

1999-09-01 00:00:00

pages

949-55

issue

9

eissn

0954-691X

issn

1473-5687

journal_volume

11

pub_type

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