Prevalence, incidence, and autoimmune comorbidities of celiac disease: a nation-wide, population-based study in Denmark from 1977 to 2016.

Abstract:

AIM:The aim of this study was to describe and identify potential trends with respect to prevalence, incidence, age, sex, and autoimmune comorbidity of celiac disease (CD). PATIENTS AND METHODS:A Danish nationwide cohort study of CD using data from The National Patient Register. Patients with a primary or secondary diagnosis code of CD during the period 1977 to 2016 were identified. Information on sex, date of birth, death, or immigration was obtained from the Danish Civil Registration System, and autoimmune comorbidities were identified in the Danish National Patient Register. The CD cohort was compared with the general Danish population using a control cohort and aggregated data obtained from Statistics Denmark. RESULTS:The CD cohort consisted of 11 802 (65% women) patients. The median age at diagnosis of CD varied between 30 years in 1980-1984 and 45 years in 1995-1999 and 27 years in 2015-2016. The prevalence of CD in 1986 and 2016 was 14 and 180 per 100 000 persons, respectively, with a female/male ratio changing from 1.3 to 2.0. Incidence rates (per 100 000 person-years) changed from 1.6 in 1980-1984 to 15.2 in 2015-2016, with the largest increase among females aged 0-9 years. In 2016, prevalence of autoimmune comorbidities was 16.4% among the CD patients compared with 5.3% in the general population. CONCLUSION:The prevalence of diagnosed CD has doubled every decade in Denmark from 1986 to 2016, and in the same period the female/male ratio has increased and the median age at diagnosis has decreased. The prevalence of autoimmune comorbidity in 2016 was three times higher among CD patients compared with the general Danish population.

authors

Grode L,Bech BH,Jensen TM,Humaidan P,Agerholm IE,Plana-Ripoll O,Ramlau-Hansen CH

doi

10.1097/MEG.0000000000000992

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

83-91

issue

1

eissn

0954-691X

issn

1473-5687

journal_volume

30

pub_type

杂志文章
  • Therapeutic effects of mucosal tolerance on experimental colitis in rats.

    abstract:OBJECTIVE:To analyze the therapeutic effect of oral tolerance and nasal tolerance singly and in combination with mucosal adjuvant on experimental colitis in rats. METHODS:Rat models were established using trinitrobenzenesulphonic acid enemas. Ovalbumin was used as inducing antigen and lipopolysaccharide as adjuvant. C...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e32830edb29

    authors: Shan-Shan Z,Yu-Lan L

    更新日期:2009-10-01 00:00:00

  • Short article: A randomized-controlled study of sitagliptin for treating diabetes mellitus complicated by nonalcoholic fatty liver disease.

    abstract:BACKGROUND:This study aimed to evaluate the efficacy and safety of sitagliptin for treating Chinese patients with type 2 diabetes mellitus (T2DM) with nonalcoholic fatty liver disease (NAFLD). METHODS:In total, 72 Chinese T2DM patients with NAFLD were divided randomly into two groups of 36 patients each group. All 72 ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MEG.0000000000000780

    authors: Deng XL,Ma R,Zhu HX,Zhu J

    更新日期:2017-03-01 00:00:00

  • Radiolucent pancreatic lithiasis: a precursor stage for calcified pancreatic lithiasis or a new entity?

    abstract:OBJECTIVE:Radiolucent pancreatic lithiasis (RPL) has been identified as a different entity from calcified pancreatic lithiasis. The purpose of this study is to evaluate the frequency, characteristics and evolution of RPL. PATIENTS:Between 1983 and 1995, 278 consecutive patients who presented with pancreatic lithiasis ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-199707000-00010

    authors: Barthet M,Daniel R,Bernard JP,Valantin V,Sahel J

    更新日期:1997-07-01 00:00:00

  • Omeprazole and H2-receptor antagonists in the acute treatment of duodenal ulcer, gastric ulcer and reflux oesophagitis: a meta-analysis.

    abstract::This paper is a meta-analysis of 30 published, double-blind clinical trials comparing omeprazole with ranitidine or cimetidine for the treatment of duodenal ulcer, gastric ulcer and reflux oesophagitis. These studies compare the recommended doses of omeprazole with those for ranitidine and cimetidine, and the confiden...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,meta分析

    doi:

    authors: Eriksson S,Långström G,Rikner L,Carlsson R,Naesdal J

    更新日期:1995-05-01 00:00:00

  • The sedation increases the acceptance of repeat colonoscopies.

    abstract:AIM:The aim of this research was to assess how the use of sedation during colonoscopy influences patient anxiety, fear, satisfaction, and acceptance of repeat examinations. MATERIALS AND METHODS:A prospective case-control study quantifying the anxiety and fears of patients appointed for colonoscopy, comparing patients...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e32835376a2

    authors: Baudet JS,Aguirre-Jaime A

    更新日期:2012-07-01 00:00:00

  • Effects of endoscopic papillary balloon dilation and endoscopic sphincterotomy on bacterial contamination of the biliary tract.

    abstract:BACKGROUND AND STUDY AIMS:Although endoscopic papillary balloon dilation (EPBD) has appeared with the expectation of better preserving sphincter of Oddi function than endoscopic sphincterotomy (EST), whether it can more effectively prevent bacterial contamination of the biliary tract than EST is controversial. To addre...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e328348c0bf

    authors: Natsui M,Honma T,Genda T,Nakadaira H

    更新日期:2011-09-01 00:00:00

  • Do metabolic alterations serve as biochemical markers in the diagnosis of malignant biliary obstruction? An observational study.

    abstract:OBJECTIVES:The aim of this study was to investigate the changes in serum lipid profiles in biliary obstruction associated with benign and malignant conditions and to find whether they can be used as adjunctive biochemical tumor markers in the differential diagnosis. METHODS:One hundred and twenty patients (60 malignan...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e32833036c3

    authors: Kurt M,Onal IK,Parlak E,Shorbagi A,Kekilli M,Ibis M,Hayran M,Sasmaz N

    更新日期:2010-01-01 00:00:00

  • Levofloxacin based regimens for the eradication of Helicobacter pylori.

    abstract:BACKGROUND:A 7 day treatment scheme based on rabeprazole/levofloxacin/amoxycillin or tinidazole achieved an eradication rate over 90%. However, the combination of drugs and duration of treatment for the correct use of levofloxacin in the eradication of are still unclear. OBJECTIVE:To compare the efficacy and tolerabil...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00042737-200212000-00004

    authors: Di Caro S,Zocco MA,Cremonini F,Candelli M,Nista EC,Bartolozzi F,Armuzzi A,Cammarota G,Santarelli L,Gasbarrini A

    更新日期:2002-12-01 00:00:00

  • Octreotide in the treatment of intestinal lymphangiectasia.

    abstract::Primary intestinal lymphangiectasia is characterized by dilated small bowel lymphatics and loss of lymph into the bowel lumen resulting in hypoproteinaemia and oedema. Some patients have a more generalized lymphatic abnormality associated with lymphoedema of the limbs and chylous pleural effusions. There is no specifi...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:

    authors: Ballinger AB,Farthing MJ

    更新日期:1998-08-01 00:00:00

  • Short article: Hepatitis delta in patients with resolved hepatitis B virus infection.

    abstract:BACKGROUND:The hepatitis delta virus (HDV) causes the most aggressive form of chronic viral hepatitis. As HDV replication requires hepatitis B virus (HBV), HDV screening is limited to HBsAg+ carriers. To date, individuals with HDV-antibodies and markers of resolved hepatitis B are considered cured. However, a subset sh...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001187

    authors: Aguilera A,Rodríguez-Calviño J,de Mendoza C,Soriano V

    更新日期:2018-09-01 00:00:00

  • Anticardiolipin antibodies in chronic viral hepatitis. Do they have clinical consequences?

    abstract::Antiphospholipid antibodies are a heterogeneous group of acquired autoantibodies that react with anionic phospholipids, such as cardiolipin. Anticardiolipin antibodies (ACAs) are frequently found in patients with systemic lupus erythematosus and other autoimmune disorders and can react with the phospholipid alone or b...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 评论,杂志文章

    doi:10.1097/01.meg.0000059144.68845.61

    authors: Yuste JR,Prieto J

    更新日期:2003-07-01 00:00:00

  • Combination amoxycillin and metronidazole with famotidine in the eradication of Helicobacter pylori--a randomized, double-blind comparison of a three times daily and twice daily regimen.

    abstract:OBJECTIVES:To determine the efficacy of a three times daily (t.i.d.) versus a twice daily (b.i.d.) regimen of combination amoxycillin and metronidazole and famotidine in the eradication of Helicobacter pylori and the influence of metronidazole resistance on the outcome of treatment. PATIENTS:Patients selected had uneq...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00042737-199711000-00012

    authors: Goh KL,Parasakthi N,Chuah SY,Toetsch M

    更新日期:1997-11-01 00:00:00

  • Detection of nodules in liver cirrhosis: spiral computed tomography or magnetic resonance imaging? A prospective study of 88 nodules in 34 patients.

    abstract::Detection and characterization of all focal lesions in the liver are critical for screening patients with chronic liver disease. The aim of this prospective study was to investigate the accuracy of magnetic resonance imaging (MRI) and spiral computed tomography for the diagnosis of hepatic nodules in cirrhotic patient...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200202000-00010

    authors: de Lédinghen V,Laharie D,Lecesne R,Le Bail B,Winnock M,Bernard PH,Saric J,Couzigou P,Balabaud C,Bioulac-Sage P,Drouillard J

    更新日期:2002-02-01 00:00:00

  • Determination of hepatitis C virus genotypes circulating in different districts of Punjab (Pakistan).

    abstract:INTRODUCTION:Hepatitis C virus (HCV) is a principal cause of severe liver diseases worldwide and a possible source of significant morbidity and fatality in the long term. Information on the genotype is more significant because it has prognostic value in the response to antiviral therapy. OBJECTIVES:This study aimed to...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,meta分析

    doi:10.1097/MEG.0b013e328362dc3f

    authors: Waqar M,Khan AU,Rehman HU,Idrees M,Wasim M,Ali A,Niaz Z,Ismail Z,Rehman MU,Tariq M,Shah M,Murtaza BN

    更新日期:2014-01-01 00:00:00

  • Prevalence and indicators of use of complementary and alternative medicine in Austrian patients with inflammatory bowel disease.

    abstract:OBJECTIVE:Complementary and alternative medicine (CAM) seems to be frequently used among patients with inflammatory bowel disease (IBD). We aimed to determine the prevalence and indicators of CAM use in Austrian IBD patients. METHODS:In a multicentre cross-sectional study, adult patients with IBD attending 18 Austrian...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001533

    authors: Gröchenig HP,Waldhör T,Haas T,Wenzl H,Steiner P,Koch R,Feichtenschlager T,Eckhardt G,Mayer A,Kirchgatterer A,Ludwiczek O,Platzer R,Papay P,Gartner J,Fuchssteiner H,Miehsler W,Peters PG,Reicht G,Kutschera M,Dejaco C

    更新日期:2019-10-01 00:00:00

  • Prevalence of hepatitis B and C and factors for infection and nonimmune in inflammatory bowel disease patients in China.

    abstract:OBJECTIVE:The aims of this study were to investigate the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection in inflammatory bowel disease (IBD) patients and the risk factors related to the infection and nonimmune status. METHODS:A retrospective study was carried out at two clinical centers. Th...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MEG.0000000000000838

    authors: Chen D,Luo S,Ben Q,Lu L,Wan X,Wu J

    更新日期:2017-05-01 00:00:00

  • One-week low-dose triple therapy for the eradication of Helicobacter pylori infection.

    abstract:OBJECTIVE:To evaluate the efficacy and safety of two 1-week low-dose triple therapy regimens for the treatment of Helicobacter pylori infection. PATIENTS AND METHODS:Eighty patients with H. pylori infection and peptic ulcer disease (n = 64) or functional dyspepsia (n = 16), with similar demographic and clinical charac...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 临床试验,杂志文章

    doi:

    authors: Labenz J,Stolte M,Rühl GH,Becker T,Tillenburg B,Sollböhmer M,Börsch G

    更新日期:1995-01-01 00:00:00

  • Effects of a supplementary diet with specially processed cereals in patients with short bowel syndrome.

    abstract:OBJECTIVE:Short bowel syndrome patients frequently experience impaired health-related quality of life. This syndrome is also associated with increased costs for the individuals concerned and the community. Intake of specially processed cereals has been demonstrated to decrease intestinal secretion. This study evaluates...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/MEG.0b013e328303c00a

    authors: Pagoldh M,Eriksson A,Heimtun E,Kvifors E,Sternby B,Blomquist L,Lapidus A,Suhr O,Lange S,Karlbom U,Nordström D,Rettrup B

    更新日期:2008-11-01 00:00:00

  • Long-term rifaximin therapy as a primary prevention of hepatorenal syndrome.

    abstract:BACKGROUND:Hepatorenal syndrome (HRS) is a severe complication of liver cirrhosis, with poor survival. Rifaximin is a gut-selective broad-spectrum antibiotic. AIM:The aim of this study was to evaluate the role of rifaximin as a primary prevention of HRS. PATIENTS AND METHODS:Eighty patients with liver cirrhosis and a...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MEG.0000000000000967

    authors: Ibrahim ES,Alsebaey A,Zaghla H,Moawad Abdelmageed S,Gameel K,Abdelsameea E

    更新日期:2017-11-01 00:00:00

  • Guidelines for the management of dyspepsia.

    abstract::Dyspepsia is a common problem necessitating strategies for investigation and management because of the scarcity of available resources for investigation, i.e. endoscopy, and the need to focus on those at risk of serious disease. It is agreed that those in the older age group, with the presence of alarm symptoms or non...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 评论,杂志文章

    doi:10.1097/00042737-199903000-00001

    authors: Mullins PD,Colin-Jones DG

    更新日期:1999-03-01 00:00:00

  • Recurrent cardiac tamponade as first manifestation of gastric cancer.

    abstract::Malignant pericardial effusion is an uncommon disorder and is usually caused by far advanced lung cancer, breast cancer, lymphoma and leukaemia. Pericardial effusion in recurrent gastric cancer has been reported in only three patients. We report the case of a 53-year-old male with sudden onset of dyspnoea, pericardial...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-199807000-00018

    authors: Fazeny B,Meghdadi S,Dejaco C,Kastner J,Marosi C,Schmidinger H

    更新日期:1998-07-01 00:00:00

  • A systematic review and meta-analysis on outcomes after Rx or R1 endoscopic resection of superficial gastric cancer.

    abstract:OBJECTIVE:Endoscopic resection is a standard treatment for gastric superficial lesions. A positive or a nonevaluable margin is considered a noncurative criterion. We aimed to systematically review recurrence, residual disease, lymph node metastasis (LNM) and cancer-related death following Rx/R1 resection of gastric les...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MEG.0000000000000440

    authors: Figueiredo PC,Pimentel-Nunes P,Libânio D,Dinis-Ribeiro M

    更新日期:2015-11-01 00:00:00

  • Five minute endoscopic urea breath test with 25 mg of (13)C-urea in the management of Helicobacter pylori infection.

    abstract:OBJECTIVE:The endoscopic (13)C-urea breath test ((13)C-EUBT), which combines the urea breath test (UBT) with endoscopy, provides high accuracy for the detection of Helicobacter pylori. This study was conducted to determine whether the (13)C-EUBT using low doses of urea and short sampling times could preserve accuracy i...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00042737-200210000-00010

    authors: Isomoto H,Inoue K,Shikuwa S,Furusu H,Nishiyama T,Omagari K,Mizuta Y,Murase K,Murata I,Enjoji A,Kanematsu T,Kohno S

    更新日期:2002-10-01 00:00:00

  • Molecular and immunohistochemical profile of a basaloid (cloacogenic) carcinoma of the sigmoid colon: possible predictive value for clinical outcomes.

    abstract::A 61-year-old woman was hospitalized with a 5-week history of abdominal discomfort, change in bowel habits, and weight loss. Colonoscopy showed a protruded tumor of the sigmoid colon first diagnosed as undifferentiated carcinoma. Surgical resection of the sigmoid colon was performed. Histological examination of the su...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000064

    authors: Gurzu S,Szentirmay Z,Bara T,Bara T Jr,Iurcsuk O,Jung I

    更新日期:2014-05-01 00:00:00

  • Unusual manifestation of brucellosis: liver abscess and pancytopenia caused by Brucella melitensis.

    abstract::Brucellosis is a zoonosis with a worldwide distribution, and still endemic in Greece. Although hepatic involvement is common, cholecystitis and hepatic abscesses represent rare complications of the disease. Hematological manifestations of brucellosis include various abnormalities such as anemia and leucopenia, but the...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e3282ef9493

    authors: Starakis I,Polyzogopoulou E,Siagris D,Mazokopakis E,Gogos CA

    更新日期:2008-04-01 00:00:00

  • Mannose-binding lectin deficiency does not increase the prevalence of Helicobacter pylori seropositivity.

    abstract:BACKGROUND:Mannose-binding lectin is an immune molecule that can bind to pathogens and initiate the complement cascade. In certain clinical situations, often characterized by immune compromise, mannose-binding lectin deficiency can increase the risk of infectious complications. Helicobacter pylori is one of the most co...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e3280106729

    authors: Worthley DL,Mullighan CG,Dean MM,Gordon DL,Phillips P,Heatley S,Young GP,Bardy PG

    更新日期:2007-02-01 00:00:00

  • Gastric hepatoid adenocarcinoma and familial investigation: does it always produce alpha-fetoprotein?

    abstract::We present the case of a 68-year-old Caucasian man with gastric hepatoid adenocarcinoma without increased levels of alpha-fetoprotein (AFP) in the serum. The patient had a strong history of gastric cancer in his family, affecting seven members, including a brother and a sister. The patient underwent subtotal gastrecto...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:10.1097/00042737-200311000-00015

    authors: Trompetas V,Varsamidakis N,Frangia K,Polimeropoulos V,Kalokairinos E

    更新日期:2003-11-01 00:00:00

  • Incontinence and anorectal dysfunction in patients with diabetes mellitus.

    abstract::The elucidation of the pathogenesis of faecal incontinence in patients with advanced diabetes mellitus has progressed during the last 15 years. In contrast to earlier concepts which promoted the concept that high stool volumes overwhelm normal continence mechanisms, recent studies indicate that the vast majority of di...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:

    authors: Wald A

    更新日期:1995-08-01 00:00:00

  • Total bile acid levels are associated with left atrial volume and cardiac output in patients with cirrhosis.

    abstract:BACKGROUND AND AIMS:Bile acids (BAs) are potent signaling molecules involved in the regulation of several metabolic and functional aspects of cardiovascular homeostasis. BA pool alteration in cirrhosis may contribute toward the development of hemodynamic and cardiac disturbances. We aimed to investigate the association...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001043

    authors: Voiosu AM,Wiese S,Voiosu TA,Hove J,Bendtsen F,Møller S

    更新日期:2018-04-01 00:00:00

  • One-week therapy with pantoprazole versus ranitidine bismuth citrate plus two antibiotics for Helicobacter pylori eradication.

    abstract:AIM:A combination of omeprazole plus amoxycillin (Amo) and clarithromycin (CIa) for 7 days has been studied extensively. However, the role of other proton pump inhibitors, such as pantoprazole (Pan), in this therapy is not well known. On the other hand, ranitidine bismuth citrate (RBC) also seems to be effective when c...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00042737-200012050-00003

    authors: Gisbert JP,Carpio D,Marcos S,Gisbert JL,García Grávalos R,Pajares JM

    更新日期:2000-05-01 00:00:00